COVID-19-related liver injury:Focus on genetic and drug-induced perspectives
作者机构：Department of BiochemistryAll India Institute of Medical SciencesRajkot 360001India
出 版 物：《World Journal of Virology》 (世界病毒学杂志)
年 卷 期：2023年第12卷第1期
页 面：53-67页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：SARS-CoV-2 Liver injury Genetic prospective Drug-induced liver injury Prognosis COVID-19
摘 要：BACKGROUND Empirical use of potentially hepatotoxic drugs in the management of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is considered as one of the major etiopathogenetic factors for liver *** evidence has shown that an underlying genetic factor may also ***,it is important to understand the host genetics and iatrogenic-based mechanisms for liver dysfunction to make timely remedial *** To investigate drug-induced and genetic perspectives for the development of coronavirus disease 2019(COVID-19)-related liver *** Reference Citation Analysis,PubMed,Google Scholar and China National Knowledge Infrastructure were searched by employing the relevant MeSH keywords and pertaining data of the duration,site and type of study,sample size with any subgroups and drug-induced liver injury *** aspects were extracted from the most current pertinent *** In all studies,the hepatic specific aminotransferase and other biochemical indices were more than their prescribed upper normal limit in COVID-19 patients and were found to be significantly related with the gravity of disease,hospital stay,number of COVID-19 treatment drugs and worse clinical *** addition,membrane bound O-acyltransferase domain containing 7 rs641738,rs11385942 GGA at chromosome 3 gene cluster and rs657152 CA at ABO blood locus was significantly associated with severity of livery injury in admitted SARS-CoV-2 *** Hepatic dysfunction in SARS-CoV-2 infection could be the result of individual drugs or due to drug-drug interactions and may be in a subset of patients with a geneticpropensity. Thus, serial estimation of hepatic indices in hospitalized SARS-CoV-2 patients shouldbe done to make timely corrective actions for iatrogenic causes to avoid clinical *** molecular and translational research is warranted in this regard.
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