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Unique immunological profile in patients with COVID-19

Cellular & Molecular Immunology 2021年第3期18卷 604-612页

作者： Stefania Varchetta Dalila Mele Barbara Olivier Stefania Mantovani Serena Ludovisi Antonella Cerino raffaele bruno Alberto Castelli Mario Mosconi Marco Vecchia Silvia Roda Michele Sachs Catherine Klersy Mario U.Mondelli Division of Infectious Diseases Ⅱ and Immunology Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Internal Medicine and Therapeutics University of PaviaPaviaItaly Division of Infectious Diseases I Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Clinical SurgicalDiagnosticand Pediatric SciencesUniversity of PaviaPaviaItaly Division of Orthopaedics and Traumatology Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Clinical-Surgical Diagnostic and Pediatric SciencesUniversity of PaviaPaviaItaly Clinical Epidemiology&Biometry Unit IRCCS Fondazione Polidinico San MatteoPaviaItaly

The relationship between severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)and host immunity is poorly *** performed an extensive analysis of immune responses in 32 patients with severe COVID-19,some of whom succumbed A control population of healthy subjects was *** with COVID-19 had an altered distribution of peripheral blood lymphocytes,with an increased proportion of mature natural killer(NK)cells and low T-cell *** cells and CD8^(+)T cells overexpressed T-cellimmunoglobulin and mucin domain-3(TIM-3)and *** cell exhaustion was attested by increased frequencies of programmed cell death protein 1(PD-1)positive cells and reduced frequencies of natural killer group 2 member D(NKG2D)-,DNAX accessory molecule-1(DNAM-1)-and sialic acid-binding Ig-like lectin 7(Siglec-7)-expressing NK cells,associated with a reduced ability to secrete interferon(IFN)γ.Patients with poor outcome showed a contraction of immature CD56^(bright) and an expansion of mature CD57^(+)F_(CEI)Rlγ^(eng) adaptive NK cells compared to *** serum levels of IL-6 were also more frequently identified in deceased patients compared to *** note,monocytes secreted abundant quantities of IL-6,IL-8,and IL-1β which persisted at lower levels several weeks after recovery with concomitant normalization of CD69,PD-1 and TIM-3 expression and restoration of CD8^(+)T cell numbers.A hyperactivated/exhausted immune response dominate in severe SARS-CoV-2 infection,probably driven by an uncontrolled secretion of inflammatory cytokines by *** findings unveil a unique immunological profile in COVID-19 patients that will help to design effective stage-specific treatments for this potentially deadly disease.

关键词： C0VID-19 NK cells TIM-3 IL6 Monocytes

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Helicobacter pylori and functional dyspepsia: An unsolved issue?

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World Journal of Gastroenterology 2014年第27期20卷 8957-8963页

作者： Angelo Zullo Cesare Hassan Vincenzo De Francesco Alessro Repici raffaele Manta Silverio Tomao bruno Annibale Dino Vaira Gastroenterology and Digestive Endoscopy "Nuovo Regina Margherita" Hospital Gastroenterology Unit "Riuniti" Hospital Digestive Endoscopy Unit "IRCCS Istituto Clinico Humanitas" 20089 Milan Italy Gastroenterology and Endoscopy Unit "Nuovo S Agostino" Hospital Oncology Unit "SM Goretti" Hospital Latina "Sapienza" University Department of Digestive and Liver Diseases "Sant’Andrea" Hospital "Sapienza" University Department of Internal Medicine and Gastroenterology University of Bologna

Patients with Helicobacter pylori (H. pylori) infection may complain of dyspeptic symptoms without presence of macroscopic lesions on gastroduodenal mucosa. Such a condition is usually recognized as functional dyspepsia, and different pathogenetic mechanisms are involved. The role of H. pylori in these patients is controversial. Several trials assessed the potential role of H. pylori eradication in improving dyspeptic symptoms, and data of some meta-analyses demonstrated that cure of infection is associated with a small (10%), but significant therapeutic gain as compared to placebo. The reason for which dyspeptic symptoms regress in some patients following bacterial eradication, but persist in others remains unclear. Regrettably, trials included in the meta-analyses are somewhat different for study design, definition of symptoms, assessment of symptoms changes, and some may be flawed by potential pitfalls. Consequently, the information could be not consistent. We critically reviewed the main available trials, attempting to address future research in this field

关键词： Helicobacter pylori Dyspepsia Symptoms Therapy Pathogenesis

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Needle-based confocal endomicroscopy in the discrimination of mucinous from non-mucinous pancreatic cystic lesions

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World Journal of Gastrointestinal Endoscopy 2021年第11期13卷 555-564页

作者： Helga Bertani raffaele Pezzilli Flavia Pigo Mauro bruno Claudio De Angelis Guido Manfredi Gabriele Delconte Rita Conigliaro Elisabetta Buscarini Gastroenterology and Digestive Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41124Italy Department of Internal Medicine Policlinico S.Orsola MalpighiBologna 40121Italy Gastroenterology and Digestive Endoscopy Unit AOU Cittàdella Salute e della ScienzaUniversity of TurinTurin 10100Italy Gastroenterology and Digestive Endoscopy Department Ospedale MaggioreCrema 26013Italy Department of Diagnostic Endoscopy and Endoscopic Surgery Istituto Nazionale TumoriMilano 20019Italy

BACKGROUND Pancreatic cystic lesions(PCLs)are considered a precursor of pancreatic ***-based confocal endomicroscopy(nCLE)is an imaging technique that enables visualization of the mucosal layer to a micron *** application has demonstrated promising results in the distinction of *** study evaluated the utility of nCLE in patients with indeterminate PCLs undergoing endoscopic ultrasound fine-needle aspiration(EUS-FNA)to distinguish mucinous from non-mucinous *** To evaluate the accuracy of nCLE in indeterminate PCLs undergoing EUS-FNA to distinguish mucinous from non-mucinous *** Patients who required EUS-FNA between 2015 and 2017 were enrolled *** EUS-FNA,confocal imaging,analyses of the tumor markers carcinoembryonic antigen and amylase,and cytologic examination were *** patients were followed for at least 12 mo and underwent laboratory testing and computed tomography scanning or magnetic resonance *** videos were independently reviewed by 6 observers to reach a final diagnosis(mucinous vs non-mucinous)based on criteria derived from previous studies;if there was disagreement>20%,a final diagnosis was discussed after consensus *** sensitivity,specificity,and accuracy of nCLE were *** events were *** Fifty-nine patients were included in this *** diagnoses were derived from surgery in 10 patients,cytology in 13,and imaging and multidisciplinary team review in *** patients were excluded from final diagnosis due to problems with nCLE ***-six patients were included in the final *** sensitivity,specificity,and accuracy of nCLE were 80%[95%confidence interval(CI):65-90],100%(95%CI:72-100),and 84%(95%CI:72-93),*** acute pancreatitis occurred in 5%.CONCLUSION EUS-nCLE performs better than standard EUS-FNA for the diagnosis of indeterminate PCL.

关键词： Needle-based confocal endomicroscopy Pancreatic cystic lesion Pancreatic adenocarcinoma Endoscopic ultrasound Endoscopic ultrasound fine-needle aspiration Intraductal papillary mucinous neoplasm Serous cyst adenoma

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Effect of Phenolic Compounds on the Growth and L-Malic Acid Metabolism of Oenococcus oeni

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Journal of Life Sciences 2012年第11期6卷 1225-1231页

作者： Silvia Jane Lombardi Patrizio Tremonte Mariantonietta Succi bruno Testa Gianfranco Pannella Luca Tipaldi Elena Sorrentino raffaele Coppola Massimo Iorizzo Department of Agriculture Food and Environment University of Molise Campobasso 86100 Italy Institute of Food and Nutrition National Research Council Avellino 83100 Italy

The effect of some phenolic compounds recurrent in wines on technological features of Oenococcus oeni was studied in order to individuate those strains to be utilized as starter in the deacidification of aged red wines. For this purpose, the growth and the L-malic acid metabolism of 100O. oeni strains, previously isolated from different wines, was assayed in a synthetic medium added with ethanol, malic acid and phenol carboxylic （gallic, caffeic, p-coumaric and ferulic） acids or flavonoids （catechin and quercetin） at different concentrations. Results evidenced a different sensitivity of strains to each assayed compound. All the compounds restrained or stimulated the growth of 57 and 11 strains respectively, while no effect was detected on 6 strains. The remaining 26 strains showed a different behaviour： all were restrained by ferulic acid and stimulated by gallic acid and catechin. As for caffeic acid, 17 out of 26 strains were restrained, while 9 strains were stimulated. The main result obtained in this study was the establishment of a relationship between the effect of phenolic compounds on the O. oeni growth and the behaviour of the malolactic fermentation. This study may enrich the selection criteria of strains for the deacidification of aged red wines.

关键词： Phenol carboxylic acids flavonoids lactic acid bacteria malic acid metabolism.

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Initial failures of anti-tau antibodies in Alzheimer’s disease are reminiscent of the amyloid-βstory

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Neural Regeneration Research 2023年第1期18卷 117-118页

作者： bruno P.Imbimbo Claudia Balducci Stefania Ippati Mark Watling Department of Research&Development Chiesi FarmaceuticiParmaItaly Department of Neuroscience Istituto di Ricerche Farmacologiche“Mario Negri”IRCCSMilanItaly San raffaele Scientific Institute San Raffaele HospitalMilanItaly CNS&Pain Department TranScrip Ltd.ReadingUK

Tau is an important protein of the central nervous system formed by 352-441 amino acids and encoded by the MAPT(microtubule-associated protein tau)gene on chromosome 17 which generates 6 *** is located in axons,dendrites,nucleus,cell membrane,and synapses of *** protein is also expressed to a lesser extent in astrocytes and oligodendrocytes,although its role in these cells has been little *** protein is also present in the interstitial fluid and can cross into the cerebrospinal fluid(CSF)and reach the systemic circulation.

关键词： tau Alzheimer cerebrospinal

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Direct myocardial and coronary effects of full length Chromogranin-A

Direct myocardial and coronary effects of full length Chromo...

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第十六届嗜铬细胞国际学术会议

作者： Tommaso Angelone Stefano Gentile Angelo Corti Maria C Cerra bruno Tota Dept of Cell Biology University of Calabria DIBIT-Division of Molecular Oncology San raffaele Scientific Institute Dept of Pharmaco-Biology University of Calabria

＜正＞Clinical and laboratory investigations revealed a relationship between CgA and cardiovascular *** fact,in man plasma CgA levels increase in the presence of essential hypertension,heart failure,myocardial infarction,decompensated and hypertrophic heart,acute coronary syndromes,and acute destabilized heart failure(Pieroni et al.,2007 and

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