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Robot-assisted endoscopic inguinal lymphadenectomy:A review of current outcomes

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Asian journal of Urology 2021年第1期8卷 20-26页

作者： Gilberto jose´Rodrigues Giuliano Betoni Guglielmetti Marcelo Orvieto Kulthe Ramesh Seetharam Bhat Vipul R.Patel rafael Ferreira Coelho Sao Paulo State Cancer Institute University of Sao Paulo School of MedicineSao PauloBrazil Clı´nica Alemana SantiagoChile Department of Urology AdventHealth Global Robotics InstituteCelebrationFLUnited States

Objective:To review the role of robot-assisted endoscopic inguinal lymphadenectomy(RAIL)in the management of penile ***:A PubMed search for all relevant publications regarding RAIL series up until August 2019 was performed using the keyword“robotic”,“inguinal lymph node dissection”,and“penile cancer”.Weighted mean was calculated in the largest series for all outcomes using the number of patients included in each study as the weighting ***:We identified 23 articles,of note the three largest series that included 102,27,and 20 RAIL in 51,14,and 10 patients,*** vein was spared in 88.93%of RAIL cases in these series and node yield was 11.42 per groin;35.28%of patients had positive pathological *** weighted mean of operative time was 87.98 min per RAIL and the estimated blood loss was 37.08 mL per *** mean length of hospital stay was 1.29 days and the drain was kept in place for 17.02 days;the major complication rate was only 5.31%in these *** mean follow-up was 33.46 months with a recurrence-free survival of 96.33%.Conclusion:The literature regarding RAIL describes promising results,although it has shorter follow-up and higher costs when compared to historically series from the open *** series reported lower cutaneous complications compared to conventional approach,without compromising oncological ***,long-term results and larger trials are crucial to validate those findings.

关键词： Penile tumor Minimally invasive surgery Robotic-assisted inguinal lymphadenectomy

Plant latent defense response to microbial non-pathogenic factors antagonizes compatibility

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National Science Review 2022年第8期9卷 26-34页

作者： yu yang Shenglan Chen Xiaoxuan Wu Li Peng juan I.Vílchez Richa Kaushal Xiaomin Liu Sunil K.Singh Danxia He Fengtong yuan Suhui Lv rafael j.L.Morcillo Wei Wang Weichang Huang Mingguang Lei jian-Kang Zhu Paul W.Paré Huiming Zhang Shanghai Center for Plant Stress Biology Center for Excellence in Molecular Plant Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Chenshan Botanical Garden Department of Chemistry and Biochemistry Texas Tech University

Unlike microbe-associated molecular patterns(MAMPs) that are readily targeted by host immunity,microbial non-pathogenic factors(NPFs) appear negligible as they do not elicit defense. Little is known about whether and how NPFs may be monitored by hosts to control compatibility. Herein, a forward genetic screening isolated an Arabidopsis mutant with a loss of plant-rhizobacteria mutualism, leading to the disclosure of a plant latent defense response(LDR) to NPFs. The activation of LDR in the mutant,named rol1 for regulator of LDR 1, is triggered by several non-pathogenic volatile organic compounds and antagonizes plant compatibility with the beneficial bacterium Bacillus amyloliquefaciens GB03. The activation of LDR in rol1 is mediated through the prokaryotic pathway of chloroplastic lipid *** rol1 root microbiome showed a reduced proportion of the Bacillaceae family. We propose that, parallel to the forefront immunity to MAMPs, LDR to certain NPFs provides a hidden layer of defense for controlling compatibility with commensal or beneficial microbes.

关键词： microbial non-pathogenic factors latent defense response compatibility plant-beneficial bacteria chloroplastic lipid biosynthesis

Acute Care/Trauma Surgeon＇s role in obstetrical/ gynecologic emergencies (The OBCAT Alert)

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World journal of Emergency Medicine 2016年第4期7卷 274-277页

作者： Seong K. Lee Eddy H. Carrillo Andrew Rosenthal rafael Sanchez Chauniqua Kiffin Dafney L. Davare Division of Acute Care Surgery and Trauma Memorial Regional Hospital Hollywood FL 33021 USA

BACKGROUND:Overwhelming hemorrhage or other intra-abdominal complications may be associated with obstetrical or gynecologic(OB/GyN) procedures and may require the surgical training of an Acute Care/Trauma *** OB Critical Assessment Team(OBCAT Alert) was developed at our institution to facilitate a multidisciplinary response to complex OB/GyN *** sought to review and characterize the Acute Care/Trauma Surgeon's role in these ***:We conducted a retrospective review of all emergency consults during an OB/GyN case at our institution from 2008 to *** OBCAT is a hospital based alert system designed to immediately notify OB/GyN,anesthesiology,Acute Care/Trauma,the intensive care unit(ICU),and the blood bank of a potential emergency during an OB/GyN ***:There were 7±3 OBCAT alerts/*** patients required Acute Care/Trauma surgery intervention for *** patients required damage control packing during their *** loss averaged 6.8±5.5 L and patients received a total of 21±14units during deliveries with *** were 17 other surgical interventions not related to hemorrhage;seven of these cases were related to adhesions or intestinal *** additional cases required evaluation post routine OB/GyN procedure;the most common reason was for severe wound *** were three deaths during this study ***:Emergency OB/GyN cases are associated with high morbidity and may require damage control or other surgical techniques in cases of overwhelming *** Care/Trauma Surgeons have a key role in the treatment of these complex cases.

关键词： Obstetric hemorrhage Postpartum hemorrhage Damage control packing Acute care surgery OBCAT

Learning Matter:Materials Design with Machine Learning andAtomistic Simulations

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Accounts of Materials Research 2022年第3期3卷 343-357页

作者： Simon Axelrod Daniel Schwalbe-Koda Somesh Mohapatra james Damewood Kevin P.Greenman rafael Gómez-Bombarelli Department of Chemistry and Chemical Biology Harvard UniversityCambridgeMassachusetts 02138United States Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139United States

CONSPECTUS:Designing new materials is vital for addressing pressing societal challenges in health,energy,and *** combination of physicochemical laws and empirical trial and error has long guided material design,but this approach is limited by the cost of experiments and the difficulty of deriving complex guiding *** space of hypothetical materials to be considered is incredibly large,and only a small fraction of possible compounds can ever be tested *** computational techniques of atomistic simulation and machine learning(ML)offer an avenue to rapidly invent new materials and navigate this enormous ***,they can be used to infer complex design principles and identify high-quality candidates more rapidly than trial-and-error *** this Account,we review our group’s recent contributions to simulation and ML for materials *** begin by discussing the numerical representation of materials for use in *** can be produced through deterministic algorithms,learnable encodings,or physics-based methods and lead to vector,graph,and matrix *** describe how these different approaches offer distinct material-and application-specific *** provide demonstrations from our own work on small-molecule drugs,macromolecules,dyes,electrolytes,and *** several cases,we show how the appropriate representation led to guiding principles that facilitated experimental materials ***,we highlight the development of ML methods for enhancing atomistic *** advances help to improve simulation accuracy and expand the time and length scales that can be *** include differentiable atomistic simulations in which ensemble-averaged quantities are differentiated with respect to system parameters,and novel autoregressive methods for enhanced sampling of challenging physical *** developments include learnable coarse-grained models,which can accelerate molecula

关键词： zeolite differentiable latter

Pronuclear formation by ICSI using chemically activated ovine oocytes and zona pellucida bound sperm

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journal of Animal Science and Biotechnology 2017年第2期8卷 370-377页

作者： j.E.Hernández-Pichardo y.Ducolomb S.Romo M.E.Kjelland R.Fierro F.Casillas M.Betancourt División de Ciencias Biológicas y de la Salud Departamento de Producción Agrícola y AnimalUniversidad Autónoma Metropolitana-XochimilcoCiudad de MexicoMexico Division de Ciencias Biologicas y de la Salud Departamento de Ciencias de la SaludUniversidad Autónoma Metropolitana-IztapalapaSan Rafael Atlixco 186CP 09340 Ciudad de MexicoMexico Departamento de Ciencias Pecuarias Facultad de EstudiosSuperiores CuautitlanUNAMCiudad de MexicoEstado de MexicoMexico Conservation Genetics&BiotechLLCValley CityNDUSA Division de Ciencias Biologicas y de la Salud Departamento de Biologia de la ReproduccionUniversidad Autonoma Metropolitana-lztapalapaCiudad de MexicoMexico Doctorado en Biologia Experimental Universidad Autonoma Metropolitana-lztapalapaCiudad de MexicoMexico

Background： In order to improve ICSI, appropiate sperm selection and oocyte activation is necessary. The objective of the present study was to determine the efficiency of fertilization using ICSI with chemically activated ovine oocytes and sperm selected by swim up（SU） or swim up ＋ zona pellucida（SU ＋ ZP） ***： Experiment 1, 4–20 replicates with total 821 in vitro matured oocytes were chemically activated with ethanol, calcium ionophore or ionomycin, to determine oocyte activation（precense of one PN）. Treatments showed similar results（54, 47, 42 %, respectively） but statistically differents（P 0.05）.Conclusions： Chemical activation induces higher ovine oocyte activation than mechanical activation. Ethanol slightly displays higher oocyte activation than calcium ionophore and ionomicine. Sperm selection with SU ＋ ZP increased AR/A and AR/D rates in comparison with SU in fresh and frozen-thawed sperm. According to this, in terms of fertilization rates, chemical activation after ICSI increased oocyte PN formation compared to mechanical activation. Also, fresh sperm treated with SU and SU ＋ ZP were significantly different than frozen-thawed sperm,but between sperm treatments no significant differences were obtained.

关键词： Ethanol ICSI Oocyte activation Ovine Pronucleus Zona pellucida

Seasonal variation in native hydraulic conductivity between two deciduous oak species

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journal of Plant Ecology 2020年第1期13卷 78-86页

作者： Dilia Mota-Gutiérrez Guadalupe Arreola-González rafael Aguilar-Romero Horacio Paz jeannine Cavender-Bares Ken Oyama Antonio Gonzalez-Rodriguez Fernando Pineda-García Facultad de Biología Universidad Michoacana de San Nicolás de Hidalgo.Edificio RCiudad UniversitariaGral.Francisco J.Múgica S/N A-1Felicitas de Río58030 MoreliaMichoacánMexico Escuela Nacional de Estudios Superiores Unidad MoreliaUniversidad Nacional Autónoma de México.Antigua Carretera a Pátzcuaro 8701Ex-Hacienda de San Joséde La Huerta58190 MoreliaMichoacánMexico Instituto de Investigaciones en Ecosistemas y Sustentabilidad Campus MoreliaUniversidad Nacional Autónoma de México.Antigua Carretera a Pátzcuaro 8701Ex-Hacienda de San Joséde La Huerta58190 MoreliaMichoacánMexico Deparment of Ecology Evolution and BehaviorUniversity of MinnesotaSaint PaulMN 55108USA

Aims Mechanisms of plant drought resistance include both tolerance and *** vulnerability to embolism and turgor loss point are considered traits that confer tolerance,while leaf abscission and deciduousness characterizes the avoidance *** these mechanisms are thought to trade-off expressing a continuum among species,little is known on how variation in the timing and duration of leaf shedding in response to drought affect the relationship between xylem and leaf *** the present study,we explored the extent to which drought tolerance differs between two oak(Quercus)species that exhibit different leaf shedding ***,we predicted that *** Trel.,which loses leaves at the end of the dry season(late-deciduous)and is thus exposed to a greater risk of cavitation,would be more drought tolerant and more conservative in its water use than *** Liebm.,which loses its leaves for only a short period of time in the middle of the dry season(brevideciduous).Methods The study was conducted in central Mexico in a single population of each of the two oak species,separated from each other by a distance of 1.58 km,and by an altitudinal difference of 191 *** deserticola(late deciduous)is more frequent down slope,while ***(brevideciduous)tends to occur at higher elevations along the *** assessed seasonal differences(rainy versus dry season)in native stem hydraulic conductivity,and tested for variation in xylem vulnerability to cavitation,leaf water use and leaf turgor loss point between the two *** Findings The two oak species did not differ in traits conferring drought tolerance,including xylem vulnerability to embolism,leaf turgor loss point,or stomatal ***,both species had different performance during the dry season;the brevideciduous species had lower negative impact in the xylem function than the late-deciduous ***,seasonal changes in plant physiological performance

关键词： Quercus hydraulic conductivity embolisms leaf phenology

First Late Triassic Record of a Paleoentomofauna from South America(Malargüe Basin,Mendoza Province,Argentina)

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Acta Geologica Sinica(English Edition) 2010年第4期84卷 915-924页

作者： Carsten BRAUCKMANN Oscar F.GALLEGO Norbert HAUSCHKE rafael G.MARTINS-NETO Elke GROENING jan-M.ILGER María B.LARA Geology and Palaeontology Clausthal University of TechnologyLeibnizstrasse 10D-38678 Clausthal-ZellerfeldGermany Micropaleontology(Faculty of Natural Sciences-National Northeast University) 3400 Corrientes-Argentina Palaeontology Area(Center of Applied Ecology of the Litoral-National Research Council) 3400 Corrientes-Argentina Geosciences Martin Luther University Halle-WittenbergVon-Seckendorff-Platz 3D-06120 Halle(Saale)Germany Federal University from Ceara Cariri/FUNCAPPresident Brazilian Paleoarthropodological SocietyBrazil

Late Middle Triassic to early Late Triassic insects from Argentina have been previously described from the Bermejo and Cuyana Basins where they have been recovered from the Ischichuca-Los Rastros and Potrerillos-Cacheuta Formations, respectively. The insect fauna discussed herein was collected during field studies in 1986/1987 from the Llantenes section （Norian to Rhaetian？ Late Triassic）, which is situated in the Malargiie Basin in southern Mendoza province. The insect remains were found in the upper part of the Llantenes section （Llantenes Formation）, which is built up of two coarsening-upwards cycles reflecting a deltaic progradation of a fluvial into a lacustrine environment （lower part）, succeeded by repeated progradatious into a floodplaindominated environment （upper part; with finds of insects, conchostracans, fish remains, plant fragments, and drifted logs）. The new finds represent the youngest Triassic insect records described from Argentina and even from South America in its entirety. There is only one contemporaneous fossil assemblage in Gondwana： in the Ciarence/Moreton Basin （Aberdare Conglomerate; Late Norian） in Australia. The new Triassic insects include an impression of an isolated Mecopterida-like wing （Mendozachorista volkheimeri gen. et sp. nov.; Mendozachoristidae fam. nov.）, coleopteran elytra of the Permosynidae （Ademosyne rosenfeldi sp. nov. and Ademosyne Uantenesensis sp. nov.） and other isolated body fragments. This new Late Triassic entomofauna from Argentina is of considerable importance in the reconstruction of the biotic recovery of continental environments in Gondwana after the catastrophic mass extinction at the P/T boundary.

关键词： Mecopterida Coleoptera Late Triassic Liantenes Formation Malargiie Basin Argentina

Diffusion tensor imaging-derived measures of fractional anisotropy across the pyramidal tract are influenced by the cerebral hemisphere but not by gender in young healthy volunteers： a split-plot factorial analysis of variance

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Chinese Medical journal 2012年第12期125卷 2180-2187页

作者： Ernesto Roldan-Valadez Edgar Rios-Piedra rafael Favila Sarael Alcauter Camilo Rios Magnetic Resonance Unit Medica Sur Clinical FoundationMexico CityMexico Tecnologico de Monterrey Health Sciences DivisionMexico City CampusMexico GE Healthcare Mexico CityMexico Imagenes Cerebrales Instituto Nacional de Psiquiatria Ramon dela Fuente Ciudad de MexicoMexico Department of Neurochemistry National Institute of Neurologyand NeurosurgeryMexico CityMexico

Background Diffusion tensor imaging （DTI） permits quantitative examination within the pyramidal tract （PT） by measuring fractional anisotropy （FA）. To the best of our knowledge, the inter-variability measures of FA along the PT remain unexplained. A clear understanding of these reference values would help radiologists and neuroscientists to understand normality as well as to detect early pathophysiologic changes of brain diseases. The aim of our study was to calculate the variability of the FA at eleven anatomical landmarks along the PT and the influences of gender and cerebral hemisphere in these measurements in a sample of young, healthy volunteers. Methods A retrospective, cross-sectional study was performed in twenty-three right-handed healthy volunteers who underwent magnetic resonance evaluation of the brain. Mean FA values from eleven anatomical landmarks across the PT （at centrum semiovale, corona radiata, posterior limb of internal capsule （PLIC）, mesencephalon, pons, and medulla oblongata） were evaluated using split-plot factorial analysis of variance （ANOVA）. Results We found a significant interaction effect between anatomical landmark and cerebral hemisphere （F （10, 32）=4.516, P=0.001; Wilks＇ Lambda 0.415, with a large effect size （partial η2=0.585））. The influence of gender and age was non-significant. On average, the midbrain and PLIC FA values were higher than pons and medulla oblongata values; centrum semiovale measurements were higher than those of the corona radiata but lower than PLIC. Conclusions There is a normal variability of FA measurements along PT in healthy individuals, which is influenced by regions of interest location （anatomical landmarks） and cerebral hemisphere. FA measurements should be reported for comparing same-side and same-landmark PT to help avoid comparisons with the contralateral PT; ideally, normative values should exist for a clinically significant age group. A standardized package of selected DTI processing tools would al

关键词： anisotropy diffusion tensor imaging magnetic resonance imaging multivariate analysis analysis of variance

Alterations in renin-angiotensin receptors are not responsible for exercise preconditioning of skeletal muscle fibers

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Sports Medicine and Health Science 2021年第3期3卷 148-156页

作者： Branden L.Nguyen Toshinori yoshihara rafael Deminice jensen Lawrence mustafa ozdemir Hayden Hyatt Scott K.Powers Department of Applied Physiology and Kinesiology University of FloridaGainesville32611FloridaUSA Department of Exercise Physiology Juntendo UniversityTokyo270-1695Japan Department of Physical Education University of Estadual of LondrinaLondrina10011Brazil

Endurance exercise training promotes a protective phenotype in skeletal muscle known as exercise *** preconditioning protects muscle fibers against a variety of threats including inactivity-induced muscle *** mechanism(s)responsible for exercise preconditioning remain unknown and are explored in these ***,we investigated the impact of endurance exercise training on key components of the renin-angiotensin system(RAS).The RAS was targeted because activation of the classical axis of the RAS pathway via angiotensinⅡtypeⅠreceptors(AT1Rs)promotes muscle atrophy whereas activation of the non-classical RAS axis via Mas receptors(MasRs)inhibits the atrophic signaling of the classical RAS *** by prior studies,we hypothesized that an exercise-induced decrease in AT1Rs and/or increases in MasRs in skeletal muscle fibers is a potential mechanism responsible for exercise *** endurance exercise training in rats,we examined the abundance of AT1Rs and MasRs in both locomotor and respiratory *** results indicate that endurance exercise training does not alter the protein abundance of AT1Rs or MasRs in muscle fibers from the diaphragm,plantaris,and soleus muscles compared to sedentary controls(p>0.05).Furthermore,fluorescent angiotensinⅡ(AngⅡ)binding analyses confirm our results that exercise pre-conditioning does not alter the protein abundance of AT1Rs in the diaphragm,plantaris,and soleus(p>0.05).This study confirms that exercise-induced changes in RAS receptors are not a key mechanism that contributes to the beneficial effects of exercise preconditioning in skeletal muscle fibers.

关键词： Exercise preconditioning Renin-angiotensin system Skeletal muscle disuse atrophy Skeletal muscle