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Antitumor Effect of Cationic INKKI Peptide from Bovine <i>β</i>-Casein on Melanoma B16F10

Journal of Cancer Therapy 2012年第4期3卷 237-244页

作者： Ricardo Alexandre Azevedo Adilson Kleber Ferreira Aline Vivian Vatti Auada Kerly Fernanda Mesquita Pasqualoto rafael marques-porto Durvanei Augusto Maria Ivo Lebrun Butantan Institute Biochemistry and Biophysical Laboratory Sao Paulo Brazil

Cationic peptide with the sequence INKKI 41-45 was isolated from bovine β-casein after tryptic hydrolysis and synthetized. The aim of this work was to evaluate the antiproliferative activity in vitro and antitumor effect in animal model. The in vitro cytotoxicity was evaluated on B16F10 melanoma cells by MTT assay. Detection of apoptosis was measured using the annexin V/PI double staining and cell cycle analysis performed flow cytometry. Caspase-3 activity was analyzed with substrate specific fluorogenic DEVD-MCA. In vivo, antitumor activity was evaluated in B16F10 melanoma tumor-bearing C57BL/6J mice. The animals were treated with 55 mg/kg INKKI administered into peritumoral region, while control group received saline solution. The following antitumor parameters were examined: tumor volume, number of metastases, tumor delayed time, tumor doubling time. Histological analyses were performed with H & E staining. The results showed that INKKI induced dose-response cytotoxicity selective for B16F10 melanoma cells (IC50 1.7 μM) and did not present cytotoxic effects for FN1 fibroblast cells. INKKI-induced apoptosis detected trough of annexin V/PI assay and it was accompanied with an increase of sub-G1 apoptotic fractions and significant increase of caspase-3 cleavage. The tumor-bearing mice treated with INKKI showed a significant reduction in tumor volume of 72.62% and decreased of metastasis number loci. In addition, INKKI caused a significant delay in tumor growth and prolonged the tumor doubling time. Histological analysis revealed an increased of necrosis areas and reduction of tumor cells in tumor treated with INKKI, it was a many hallmark of its antitumor effects observed from in vivo experiments. In conclusion, we show that INKKI is a peptide that could be considered a new putative candidate development to anticancer therapy drug.

关键词： β-Casein Peptide Apoptosis Metastasis Tumor Growth Melanoma

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An Application of Decision Trees Algorithm to Project Hourly Electricity Spot Price as Support for Decision Making on Electricity Trading in Brazil

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Energy and Power Engineering 2022年第8期14卷 327-342页

作者： Cosme Rodolfo R. dos Santos Roberto Castro rafael marques State University of Campinas School of Electrical and Computer Engineering Campinas Brazil Independent Consultant Vinhedo/SP Brazil Brazilian Association of Photovoltaic Solar Energy (ABSOLAR) S&atilde o Paulo Brazil

Estimating the price of a financial asset or any tradable product is a complex task that depends on the availability of a reasonable amount of data samples. In the Brazilian electricity market environment, where spot prices are centrally calculated by computational models, the projection of hourly energy prices at the spot market is essential for decision-making, and with the particularities of this sector, this task becomes even more complex due to the stochastic behavior of some variables, such as the inflow to hydroelectric power plants and the correlation between variables that affect electricity generation, traditional statistical techniques of time series forecasting present an additional complexity when one tries to project scenarios of spot prices on different time horizons. To address these complexities of traditional forecasting methods, this study presents a new approach based on Machine Learning methodology applied to the electricity spot prices forecasting process. The model’s Learning Base is obtained from public information provided by the Brazilian official computational models: NEWAVE, DECOMP, and DESSEM. The application of the methodology to real cases, using back-testing with actual information from the Brazilian electricity sector demonstrates that the research is promising, as the adherence of the projections with the realized values is significant.

关键词： Artificial Intelligence Machine Learning Price Estimation Energy Planning Spot Electricity Market Spot Prices Forecast

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Efficient first-principles prediction of solid stability:Towards chemical accuracy

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npj Computational Materials 2018年第1期4卷 591-596页

作者： Yubo Zhang Daniil A.Kitchaev Julia Yang Tina Chen Stephen T.Dacek rafael A.Sarmiento-Pérez Maguel A.L.marques Haowei Peng Gerbrand Ceder John P.Perdew Jianwei Sun Department of Physics and Engineering Physics Tulane UniversityNew OrleansLA 70118USA Department of Materials Science and Engineering MITCambridgeMA 02139USA Materials Science Division LBNLBerkeleyCA 94720USA Department of Materials Science and Engineering UC BerkeleyBerkeleyCA 94720USA Institute of Physical Chemistry and National Center for Computational Design and Discovery of Novel Materials Department of ChemistryUniversity of BaselKlingelbergstrBasel 804056Switzerland Institut für Physik Martin-Luther-Universität Halle-WittenbergHalle D-06099Germany Department of Physics Temple UniversityPhiladelphiaPA 19122USA Department of Chemistry Temple UniversityPhiladelphiaPA 19122USA

The question of material stability is of fundamental importance to any analysis of system properties in condensed matter physics and materials *** ability to evaluate chemical stability,i.e.,whether a stoichiometry will persist in some chemical environment,and structure selection,*** crystal structure a stoichiometry will adopt,is critical to the prediction of materials synthesis,reactivity and ***,we demonstrate that density functional theory,with the recently developed strongly constrained and appropriately normed(SCAN)functional,has advanced to a point where both facets of the stability problem can be reliably and efficiently predicted for main group compounds,while transition metal compounds are improved but remain a *** therefore offers a robust model for a significant portion of the periodic table,presenting an opportunity for the development of novel materials and the study of fine phase transformations even in largely unexplored systems with little to no experimental data.

关键词： properties stability chemical

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Electronic structure, optical properties, and lattice dynamics in atomically thin indium selenide flakes

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Nano Research 2014年第10期7卷 1556-1568页

作者： Juan F. Sanchez-Royo Suillermo Munoz-Matutano Mauro Brotons-Gisbert Juan P. Martinez-Pastor Alfredo Segura Andres Cantarero rafael Mata Josep Canet-Ferrer Gerard Tobias Enric Canadell Jose marques-Hueso Brian D. Gerardot ICMUV Instituto de Oencia de Materiales Universidad de Valencia P.O. Box 22085 46071 Valencia Spain MALTA-Consolider Team Institut de Ciencia dels Materials-Dpto. de Fisica Apficada Universitat de Valencia E-46100 Burjassot (Valencia) Spain Institut de Ciencia de Materials de Barcelona (ICMAB-CSIC) Campus de la UAB 08193 Bellaterra Barcelona Spain Institute of Photonics and Quantum Science SUPA Hefiot-Watt University Edinburgh EH14 4AS UK

The progressive stacking of chalcogenide single layers gives rise to two- dimensional semiconducting materials with tunable properties that can be exploited for new field-effect transistors and photonic devices. Yet the properties of some members of the chalcogenide family remain unexplored. Indium selenide （InSe） is attractive for applications due to its direct bandgap in the near infrared, controllable p- and n-type doping and high chemical stability. Here, we reveal the lattice dynamics, optical and electronic properties of atomically thin InSe flakes prepared by micromechanical cleavage. Raman active modes stiffen or soften in the flakes depending on which electronic bonds are excited. A progressive blue-shift of the photoluminescence peaks is observed for decreasing flake thickness （as large as 0.2 eV for three single layers）. First-principles calculations predict an even larger increase in the bandgap, 0.40 eV, for three single layers, and as much as 1.1 eV for a single layer. These results are promising from the point of view of the versatility of this material for optoelectronic applications at the nanometer scale and compatible with Si and III-V technologies.

关键词： indium selenide two-dimensional flakes micro-Raman spectroscopy micro-photoluminescence electronic structure

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Optimizing Hot Forging Process Parameters of Hollow Parts Using Tubular and Cylindrical Workpiece： Numerical Analysis and Experimental Validation

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Journal of Mechanics Engineering and Automation 2018年第2期8卷 60-70页

作者： Angela Selau marques Luana DeLuccade Costa rafael Luciano Dalcin Alberto Moreira Guerreiro Brito Lirio Schaeffer Alexandre da Silva Rocha Faculty of Engineering Metallurgical Department Federal Universityof Rio Grande do Sul (UFRGS) Avenue Bento Goncalves 9500 Porto Alegre CEP 91509-900 Brazil

CAE （computer aided engineering） evaluates the forging process virtually to optimize the industrial production. The numerical and experimental investigations of forging process of a hollow part are important in industrial point of view. This study has been focused on the development of a 3D elastic-plastic FEM （finite element model） of hot forging to evaluate the forming process of hollow parts. The validity of this method was verified through a laboratory experiment using aluminum alloy （AA6351） with medium geometric complexity. The distributions of effective strain, temperature, metal flow and strength were analyzed for two different initial workpieces （tubular and cylindrical）. It was observed that both initial workpieces can be used to produce the final hollow part using the numerical simulation model. The results showed that the numerical analyses predict, filling cavity, calculated strength, work temperature and material flow were in agreement with the experimental results. However, some problems such as air trapping in the die causing incomplete filling could not be predicted and this problem was resolved experimentally by drilling small holes for air release in the dies.

关键词： Hot forging FEM hollow parts AA6351.

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Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital

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World Journal of Clinical Cases 2023年第8期11卷 1761-1770页

作者： Fillipe Dantas Pinheiro Luana Weber Lopes rafael Santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior Maria Teresa Araújo de Lorenzo Barcia Renata de Amorim marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas Miranda marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Hospital Geral de Vitória da Conquista Vitória da Conquista 45030-160BahiaBrazil Departamento de Ciências da Saúde Universidade Estadual do Sudoeste da Bahia(UESB)Vitória da Conquista 45083-900BahiaBrazil Faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern *** that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and *** To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease *** This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian *** The patients had a median age of 65.60±15.78 *** was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the *** least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with *** and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective *** This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected *** associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features.

关键词： COVID-19 Epidemiology Symptoms Comorbidities Laboratory parameters

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Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in Brazil

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World Journal of Experimental Medicine 2022年第5期12卷 100-103页

作者： Fabrício Freire de Melo Lilian Martins Oliveira Diniz JoséNélio Januário João Fernando Gonçalves Ferreira rafael Santos Dantas Miranda Dórea Breno Bittencourt de Brito Hanna Santos marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Dulciene Maria de Magalhães Queiroz Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Departamento de Pediatria Universidade Federal de Minas GeraisBelo Horizonte 31270-901Brazil Núcleo de Ações e Pesquisa em Apoio Diagnóstico Universidade Federal de Minas GeraisBelo Horizonte 31270-901Brazil Laboratory of Research in Bacteriology Universidade Federal de Minas GeraisBelo Horizonte 31270-901Brazil Laboratory of Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 31270-901Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094Brazil

Qualitative antibody tests are an easy,point-of-care diagnostic method that is useful in diagnosing coronavirus disease 2019,especially in situations where reverse transcription-polymerase chain reaction is ***,some factors are able to affect its sensitivity and accuracy,which may contribute to these tests not being used as a first-line diagnostic tool.

关键词： Serological test IgM IgG COVID-19 Diagnosis Antibody

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Metabolic Syndrome: Consensus and Controversy: State of the Art

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Open Journal of Endocrine and Metabolic Diseases 2015年第9期5卷 124-130页

作者： Hamilton dos Prazeres Tavares rafael Bottaro Gelaleti Fernanda Picolo Suelma Beatriz marques Prata Tavares Gabriela Marini Joelcio Francisco Abbade Debora Cristina Damasceno Meirelles dos Santos Paulo Adao de Campos Iracema de matos Paranhos Calderon Marilza Vieira Cunha Rudge Department of Gynecology and Obstetrics Botucatu Medical School UNESP—Universidade Estadual Paulista Botucatu Brazil Department of Gynecology and Obstetrics of the Municipal Hospital of Huambo Huambo Angola University of Sacred Heart (USC) Bauru Brazil Departament of Gynecology and Obstetric in Medical School Agostinho Neto University Luanda Angola

Metabolic syndrome is an epidemic that affects more and more people, increasing the probability of suffering metabolic and cardiovascular diseases in the short, medium or long term depending on the severity. The purpose of this article is to review the metabolic syndrome, assessing consensus, controversy and prevalence. The methodology was the preparation of a literature review on various health care databases, which were from 43 articles published from 2010 to 2015, in the general population. SM rate ranges from 0% to 90% depending on genders, ages and regions. There is still lack of consensus on cutoffs of diagnostic criteria. Thus, it is concluded that the prevalence of metabolic syndrome is being increased, urging the need for early diagnosis and treatment to promote the health of the global population.

关键词： Metabolic Syndrome X Prevalence Consensus

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Correction to“Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in Brazil”

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World Journal of Experimental Medicine 2023年第3期13卷 47-49页

作者： Fabrício Freire de Melo Lilian Martins Oliveira Diniz JoséNélio Januário João Fernando Gonçalves Ferreira rafael Santos Dantas Miranda Dórea Breno Bittencourt de Brito Hanna Santos marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Gifone Aguiar Rocha Dulciene Maria de Magalhães Queiroz Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Departamento de Pediatria Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Departamento de Clínica Médica Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Research in Bacteriology Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

Correction to“Freire de Melo F,Martins Oliveira Diniz L,Nélio Januário J,Fernando Gonçalves Ferreira J,Dórea RSDM,de Brito BB,marques HS,Lemos FFB,Silva Luz M,Rocha Pinheiro SL,de Magalhães Queiroz *** of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in *** J Exp Med 2022;12(5):100-103[PMID:36196438 DOI:10.5493/wjem.v12.i5.100]”.In this article,we identified an issue with the“Acknowledgments”***,we then provide a recognition section for our supporting institutions.

关键词： Correction COVID-19 serological testing Serologic tests Rapid diagnostic

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Relationship between Th17 immune response and cancer

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World Journal of Clinical Oncology 2021年第10期12卷 845-867页

作者： Hanna Santos marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next *** has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer *** Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin *** type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor *** other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 ***(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in ***,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical *** understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets.

关键词： Cancer Immune response Th17 cells Interleukin-17 Tumor microenvironment Pathophysiology

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