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Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

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Translational Neurodegeneration 2021年第4期10卷 666-677页

作者： Nuole Zhu miguel Santos-Santos Ignacio lllán-Gala Victor montal Teresa Estellés Isabel Barroeta miren Altuna Javier Arranz Laia muñoz Olivia Belbin Isabel Sala maria Belén Sánchez-Saudinós Andrea Subirana Laura Videla Jordi Pegueroles rafael Blesa Jordi Clarimón maria Carmona-Iragui Juan Fortea Alberto Lleó Daniel Alcolea Sant Pau memory Unit Department of NeurologyInstitut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant PauUniversitat Autònoma de Barcelona08041 BarcelonaSpain Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas(CIBERNED) 28031 MadridSpain Autonomous University of Barcelona 08913 BarcelonaSpain Fundación Catalana Sindrome de Down Centre Mèdic Down08029 BarcelonaSpain

Background:Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative *** of glial fibrillary acidic protein(GFAP),an astrocytic damage marker,may help advance our understanding of different neurodegenerative *** this study,we investigated the diagnostic performance of plasma GFAP(pGFAP),plasma neurofilament light chain(pNfL)and their combination for frontotemporal dementia(FTD)and Alzheimer's disease(AD)and their clinical utility in predicting disease ***:pGFAP and pNfL concentrations were measured in 72 FTD,56 AD and 83 cognitively normal(CN)participants using the Single molecule Array *** the 211 participants,199 underwent cerebrospinal(CSF)analysis and 122 had magnetic resonance *** compared cross-sectional biomarker levels between groups,studied their diagnostic performance and assessed correlation between CSF biomarkers,cognitive performance and cortical *** prognostic performance was investigated,analyzing cognitive decline through group comparisons by ***:Unlike pNfL,which was increased similarly in both clinical groups,pGFAP was increased in FTD but lower than in AD(all Pmbination of both plasma markers improved the diagnostic performance to discriminate FTD from AD(area under the curve[AUC]:combination 0.78;pGFAP 0.7;pNfL 0.61,all Pma NfL,and cortical thickness(all PmmSE score and poor cognitive outcome during follow-up both in FTD(1.40 points annually,hazard ratio[HR]3.82,Pmbination is useful for distinguishing between the two *** could also be used to track disease severity and predict greater cognitive decline during follow-up in patients with FTD.

关键词： Glial fibrillary acidic protein Neurofilament Frontotemporal dementia Plasma biomarkers

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Identification of life habits factors as risk for gastritis and colitis occurrence in a mestizo population of Chabeklumil, Chiapas, méxico

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Open Journal of Nursing 2012年第2期2卷 67-71页

作者： Diana Cecilia Tapia-Pancardo Ramiro Jesús-Sandoval myrna miriam Valera-mota José Luis Cadena-Anguiano miguel murguía-Romero rafael Villalobos-molina Carrera de Cirujano Dentista FES Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Carrera de médico Cirujano FES Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Carrera de Optometría FES Iztacala Universidad Nacional Autónoma de México Tlalnepantla México División de Investigación y Posgrado FES Iztacala Universidad Nacional Autónoma de México Tlalnepantla México

Aim: Gastric diseases are a recent trend in morbidity in méxico. We aimed to identify most frequent life habits factors as risk for gastritis and colitis occurrence, in a mexican mestizo population in Chabeklumil, Chiapas. Population: This study was observational, descriptive, transversal and prospective;346 questionnaires were applied to individuals of both genders from 11 years of age, with low income and socio-economic status, after they signed the informed consent. An individual file was created by the nurses in Chabeklumil. The predominant gender in the population was female (56.1%), with a distribution of 166 among adulthood (19 - 59 years of age);among males (43.9%), 133 included adults. Results: We identified the following environmental risk factors to develop gastritis and colitis: long periods of daily fasting > consumption of irritant food and drink > stress, in females;in contrast, males reported alcohol and tobacco consumption > irritant food and drink > long periods of daily fasting > stress. We found statistical differences (P males and males, in drugs and alcohol consumption, fasting, and stress, but not in consumption of irritant foods, nor in colitis and gastritis prevalence. Conclusions: Females are most affected by life habits risk factors for gastritis/colitis, which occurs mainly due to lifestyle and “macho” culture, since women are precluded of a better living standard, they work hard in the field, and start early in the day without consuming a meal, which they eat late in the day once arriving home. People in Chabeklumil eat/drink a lot of irritant food like hot pepper and coffee, which damage the gastrointestinal system leading to gastritis and colitis. Furthermore, men started to consume drugs at early ages, a condition also involved in developing gastritis.

关键词： Gastritis Colitis Life Habits Risk Factors Poverty mexican mestizo Population

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Prevalence of refractive errors in Villa maria,Córdoba,Argentina

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Eye Science 2016年第2期31卷 68-77页

作者： Victoria m.Sainchez rafael Iribarren Santiago G.Latino Victor E.Torres Anal L.Gramajo maria N.Artal maria B.Yadarola Patricia R.Garay Jose D.Luna Claudio P.Juarez Fundacion VER Centro Privado de Ojos RomagosaCordobaArgentina Department of Ophthalmology Centro Medico San LuisBuenos AiresArgentina CIES(Conicet y UNC) Facultad de Ciencias EconornicasUNCCordobaArgentina

Background:Refractive errors are among the most frequent reasons for demand of eye-care *** on refractive errors prevalence in our country are *** study has the purpose to assess the prevalence of refractive errors in an adult population of Villa maria,Córdoba,***:The Villa maria Eye Study is a population-based cross-sectional study conducted in the city of Villa maria,Córdoba,Argentina from may 2008 to November ***’s aged 40+received a demographic interview and complete ophthalmological *** acuity was obtained with an ETDRS *** auto refraction was *** spherical equivalent was highly correlated between right and left eyes,so only data of right eyes are *** and hyperopia were defined with a±0.50 diopters(D)criterion and astigmatism>1 ***:This study included 646 subjects,aged 40 to 90(mean age:59.6±10.3 years old).Four hundred and sixty two(71.5%)were *** mean spherical equivalent was+0.714±2.41 D(range,-22.00 to+8.25 D)and the power of the cylinder was,on average,-0.869±0.91 D(range,0 to-6.50 D).In this sample,61.6%subjects were hyperopic,and 13.5%were *** prevalence was lower in men(9.8%versus14.9%)but this difference among genders was not statistically *** were 141 subjects(21.8%)with anisometropia greater than 1 D,and 168 subjects(26.0%)with astigmatism greater than 1 ***:The present study shows the prevalence of cycloplegic refractive errors in an adult population of *** prevalence of hyperopia was high,while myopia prevalence was very low.

关键词：屈光不正患病率玛丽亚阿根廷别墅平均年龄近视眼屈光度

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萨拉戈萨的白色日光

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现代装饰（家居） 2012年第1期 94-103页

作者： Joaquín Torres rafael Llamazares Luis H.Segovia 肖俊 A-cero A-cero合

项目地址西班牙萨拉戈萨项目面积250m^2设计单位A-cero本案是对一套双层公寓进行全面改造,公寓占据了一栋四层楼建筑的最高两层,建筑始建于上世纪80年代初。从第一任屋主开始,这套现已被完全废弃的公寓几乎从未被翻新或改造过,所以在本... 详细信息

项目地址西班牙萨拉戈萨项目面积250m^2设计单位A-cero本案是对一套双层公寓进行全面改造,公寓占据了一栋四层楼建筑的最高两层,建筑始建于上世纪80年代初。从第一任屋主开始,这套现已被完全废弃的公寓几乎从未被翻新或改造过,所以在本次改造前,公寓内所有的材料和涂饰均保留着当时的经典式样,老旧过时的家具也从未更新过。在改造过程中,根据当地的建筑规章,只有窗边陈旧的百叶窗仍需被保留,然而这样却影响了房屋的采光。基于对房屋进行完整改造的目的,设计师需要对房屋内的所有元素进行改善:布局、灯光、装饰以及各类设施等等。

关键词：萨拉戈萨项目地址项目面积主卧设计单位室内采光公共空间地面铺装纯白 floor

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Antioxidant and Antifungal Activity of Naphthoquinones Dimeric Derived from Lawsone

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Journal of Biosciences and medicines 2017年第2期5卷 39-48页

作者： Aldo S. de Oliveira Inês m. C. Brighente rafael G. Lund Luana C. Llanes Ricardo J. Nunes Lizandra C. Bretanha Rosendo Augusto Yunes Pedro H. A. Carvalho Juliana S. Ribeiro Department of Chemistry Center of Physical and Mathematical Sciences Federal University of Santa Catarina Florian&oacute polis SC Brazil Oral microbiology Laboratory Faculty of Dentistry Federal University of Pelotas Pelotas Brazil

This article reports the evaluation of antioxidant and antifungal activity from synthetic naphthoquinones derived from lawsone. The antifungal activity was carried out through the inhibition of exoenzymes produced by Candida albicans. The inhibition of phospholipase and the proteinase production by Candida was similar in all derivatives tested;however, the difference between the enzyme production of the control and test does not show statistical difference in any of the studied strains. Furthermore, the antioxidant activity using DPPH radical-scavenging assay showed an important activity for all naphtoquinone derivatives.

关键词： Napthoquinones Antifungal Candida albicans Antioxidant

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Commercially Important marine mollusks for Human Consumption in Acapulco,mexico

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Natural Resources 2012年第1期3卷 11-17页

作者： rafael Flores-Garza Sergio Garcia-Ibanez Pedro Flores-Rodriguez Carmina Torreblanca-Ramirez Lizeth Galeana-Rebolledo Arcadio Valdes-Gonzalez Arquimedes Suastegui-Zarate Juan Violante-Gonzalez Unidad Academica de Ecologia marina Universidad Autonoma de GuerreroAcapulcoMexico Facultad de Ciencias Biologicas Universidad Autonoma de Nuevo LeonCiudad UniversitariaSan Nicolas de los GarzaMexico

Acapulco, offers for international tourism a variety of mollusks that are delightful to the palate and a source of economic revenue for its residents;however there are no studies on the species consumed. Furthermore, data from the State agencies responsible for registration of these products are unclear. This work is aimed to develop an inventory of Gastropoda, Bivalvia and Polyplacophora marketed as food, to gain knowledge on the species native to Acapulco and the introduced ones. The places that sell shellfish were interviewed from 2008 to 2011 in order to determine the geographical origin of their products being offered. We identified 42 species: 15 species of gastropods are captured locally and three are introduced. On Bivalvia, seven species are caught locally and 16 are introduced. There are Bivalvia species caught locally;however, their capture is now unaffordable. It is likely that this situation is due to overfishing and/or the transmission of diseases or parasites caused by the introduction of foreign living organisms to Acapulco. Within the list of species caught locally, there are some listed as of subject protection;all of these organisms are exploited in Acapulco without control. The wealth of marine mollusks for human consumption in Acapulco is very high. The capture does not satisfy local market demand and the amount of introduced species is very high. It is necessary to make a diagnostic analysis of mollusk fishing industry in the state of Guerrero, also implement a management program, including the sanitary measures and control of introduced species, as they arrive alive and stay alive in the waters of Acapulco. A significant number of native species that have aquaculture potential should be studied for commercial culture practice as well as to conduct studies on their biology on those species that are considered over-exploited and allow recovery of the species in its habitat.

关键词： mollusks Commercial Consumption Human Acapulco méxico

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Production, Detection and Cross-Reactivity of Anti-Polysaccharide Antibodies from Environmental Fungi

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Advances in Bioscience and Biotechnology 2014年第10期5卷 815-822页

作者： rafael Andrade menolli Thais Soprani Ayala Pablo Rodrigo da Rosa Claudia Rejane Lima de macedo Costa Erica Fernanda Osaku Rosiane G. mello Zibetti Centro de Ciências médicas e Farmacêuticas Universidade Estadual do Oeste do Paraná Cascavel Brasil Centro de Ciências Biológicas e da Saúde Universidade Estadual do Oeste do Paraná Cascavel Brasil Faculdades Pequeno Príncipe Curitiba Brasil

The diagnosis of Invasive Fungal Disease (IFD) is difficult because the sensitivity of conventional culture and cytology methods for the detection of Aspergillus is poor, and because serological methods exhibit cross-reactivity with environmental fungi. Fungal polysaccharides are of particular interest in the serologic diagnosis of IFD, especially galactomannan (Gm) and glucan, which have been recognized as useful tools for the diagnosis of fungal infections. Further investigation into polysaccharide antibody cross-reactivity is important in improving diagnostic tests. Our aim was to verify the production of antibodies against fungal antigens in mice immunized with exopolysaccharides (EPS) obtained from three fungal species (Aspergillus terreus, Paecilomyces variotii and Curvularia brachyspora). ELISA assays were performed to evaluate homologous and heterologous reactions and showed anti-polysaccharide antibodies production. EPS from A. terreus was immunogenic enough to immunize the animal and lead to antibody production against this EPS. In addition, no cross-reactivity was observed with EPS obtained from P. variotii and C. brachyspora. The EPS from P. variotii did not exhibit good immunogenicity, whereas EPS from C. brachyspora showed good immunogenicity, and heterologous reactions were detected on the ELISA assays performed using the EPS from this species. The results indicate that immunization can occur for environmental fungal polysaccharides, generating antibodies may be interfere in serological diagnosis that are based on detection of fungal polysaccharides, mainly glucans and galactomannans.

关键词： Exopolysaccharides Environmental Fungi Immunization

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Electrochemical nucleation and growth of aluminum nanoparticles and leaf-like flat microstructures from reline deep eutectic solvent: Effect of temperature and angular speed of working electrode

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Transactions of Nonferrous metals Society of China 2022年第3期32卷 1050-1060页

作者： G.VIDAL-GARCÍA C.E.GUINTO-PANO I.GARCÍA-HERNÁNDEZ E.RODRÍGUEZ-CLEmENTE P.mORALES-GIL m.T.RAmÍREZ-SILVA m.ROmERO-ROmO m.PALOmAR-PARDAVÉ Universidad Autónoma metropolitana-Azcapotzalco Departamento de MaterialesAv.San Pablo 180 Col.Reynosa-TamaulipasCDMXC.P.02200México Instituto mexicano del Petróleo Laboratorio de Caracterización de Materiales Sintéticos y NaturalesEje Central Lázaro Cárdenas 152CDMXC.P.07730México Universidad Autónoma metropolitana-Iztapalapa Departamento de QuímicaAv.San Rafael Atlixco#186Col.VicentinaCDMX.C.P.09340México

The main objective of this work was to use reline deep eutectic solvent,containing Al(III)ions,for the electrochemical study of the nucleation and growth of aluminum onto a glassy carbon electrode at different temperatures and angular speeds(ω)of the working *** order to fulfill this,electrochemical and surface characterization techniques were *** was found that as temperature increased,the onset of the Al(III)DES reduction occurred at less negative potentials while the current peak of the voltammograms *** indicate that Al deposition thermodynamics and kinetics were ***,no anodic current was detected due to Al passivation by Al(OH)_(3)(s)andγ-Al_(2)O_(3)(s).Atω=0 r/min,the Al deposition chronoamperograms were analyzed by a theoretical model comprising Al 3D diffusion-controlled nucleation and growth and residual water ***,those recorded at different angular speeds were analyzed with a theoretical model where adsorption−desorption and diffusion-controlled nucleation−growth occurred *** deposits were characterized by SEm,EDX,XPS and ***ω=0 r/min,formation of well distributed nanoparticles((78.1±9.5)nm)was observed,while atω=900 r/min the deposit was formed by multiple 10μm diameter leaf-like flat microstructures,composed by Al,Al(OH)_(3)(s)andγ-A2O3(s).

关键词： aluminum electrochemical nucleation deep eutectic solvent angular speed of working electrode temperature

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Forecasting the number of species of asexually reproducing fungi(Ascomycota and Basidiomycota)

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Fungal Diversity 2022年第3期114卷 463-490页

作者： Nalin N.Wijayawardene Alan J.L.Phillips Diana Santos Pereira Dong-Qin Dai AndréAptroot Josiane S.monteiro Irina S.Druzhinina Feng Cai Xinlei Fan Laura Selbmann Claudia Coleine rafael F.Castañeda-Ruiz martin Kukwa Adam Flakus Patricia Oliveira Fiuza Paul m.Kirk Kunhiraman C.Rajesh Kumar Ilesha S.leperuma Arachchi Nakarin Suwannarach Li-Zhou Tang Teun Boekhout Chen Shuhui Tan R.P.Prabath K.Jayasinghe marco Thines Centre for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanPeople’s Republic of China Section of Genetics Institute for Research and Development in Health and Social CareNo:393/3Lily AvenueOff Robert Gunawardane MawathaBattaramulla 10120Sri Lanka Faculdade de Ciências Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal Laboratório de Botânica/Liquenologia Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva S/NBairro UniversitárioCampo GrandeMS CEP 79070-900Brazil Coordination of Botany Museu Paraense Emílio GoeldiBelémPA 66077830Brazil Fungal Genomics Laboratory(FungiG) College of Resources and Environmental SciencesNanjing Agricultural UniversityWeigang 1Nanjing 210095JiangsuPeople’s Republic of China The Key Laboratory for Silviculture and Conservation of ministry of Education Beijing Forestry UniversityBeijing 100083People’s Republic of China Department of Ecological and Biological Sciences University of TusciaViterboItaly Italian National Antarctic museum(mNA) Mycological SectionGenoaItaly Alejandro de Humboldt’(INIFAT) Instituto de Investigaciones Fundamentales en AgriculturaTropicalSantiago de Las VegasHavanaCuba Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of GdańskWita Stwosza 5980-308 GdańskPoland W.Szafer Institute of Botany Polish Academy of SciencesLubicz 4631-512 KrakowPoland Universidade Federal do Rio Grande do Norte(UFRN) Programa de Pós-Graduação em Sistemática e EvoluçãoCentro de BiociênciasCampus UniversitárioAv.Senador Salgado Filho3000Lagoa NovaNatalRN 59078-970Brazil Biodiversity Informatics and Spatial Analysis Jodrell LaboratoryRoyal Botanic GardensKewRichmond TW93DSSurreyUK National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS Agharkar Research InstituteG.G.

Asexually reproducing fungi play a significant role in essential processes in managed and wild ecosystems such as nutrients cycling and multitrophic interactions.A large number of such taxa are among the most notorious plant and animal *** addition,they have a key role in food production,biotechnology and *** without or rare sexual reproduction are distinguished based on their sporulating structures and conidiomata in traditional morphology-based *** number,variation and diversity of asexually reproducing taxa are insufficiently known,even though fungi capable of asexual reproduction may provide an untapped,rich biological resource for future ***,ca.30,000 asexual species belonging to ca.3800 genera have been reported(including 1388 coelomycetous and 2265 hyphomycetous genera).Recent reports(2017–2020)reiterate that the number of asexually producing fungi is higher than the number of frequently sexually-reproducing *** the advent of molecular tools and the abandonment of the dual nomenclature system for pleomorphic fungi,priority criteria were established and revisited in the latest outline of fungi and fungus-like ***,species numbers and taxonomic boundaries of pleomorphic taxa and their synanamorphs or synasexual morphs have yet to be *** number of species of speciose genera(***,Aspergillus,Cercospora,Fusarium,Phoma and Pseudocercospora),cryptic species,species of pleomorphic genera,less studied life modes(such as lichenicolous taxa,taxa from extreme environments)and species from biodiversity-rich areas still need evaluation to achieve more reliable estimates of their *** paper discusses the current knowledge on the matter,with diversity estimates,and potential obstacles in several chapters on(1)speciose genera;(2)pleomorphic genera;(3)cryptic species;(4)well-studied but insufficiently resolved taxa,*** inhabiting species,marine fungi,(5)less studied life modes,e.g.

关键词： Cryptic species DNA sequences morphology Pleomorphism Speciose genera Species identificat

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Structural genomics and chemical profiling of the human cytosolic sulfotransferases

Structural genomics and chemical profiling of the human cyto...

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The 4th ISGO International Conference on Structural Genomics

作者： Patricia W.Pan Abdellah Al Hassani Ludmila Dombrovski rafael Najmanovich Peter Loppnau Wolfram Tempel Fernando martin Janet Thornto Aled m.Edwards Alexei Botchkarev Alexander Plotnikov masoud Vedadi Cheryl H.Arrowsmith Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada Structural Genomics Consortium 100 College St.Toronto ON Canada

＜正＞The human cytosolic sulfotransfases （SULTs） comprise a family of phase II detoxification enzymes that catalyze the transfer of a sulfonate group from 3’-phosphoadenosine 5’-phosphosulfate （PAPS） to an acceptor group of substrates. In doing so, they modulate the activities of a large array of small endogenous and foreign chemicals including drugs, toxic compounds, steroid hormones, and

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