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A Neuro-Fuzzy Approach for Automatic Detection of Breast Cancer Based on Raman Spectroscopy

通讯和计算机（中英文版） 2014年第2期11卷 158-167页

作者： Francisco Javier Luna Rosas Julio Cesar Martinez Romo Ricardo Mendoza Gonzalez Valentin lopez Rivas Miguel Mora Gonzalez Gricelda Medina Veloz Computer Science Department Instituto Tecnologico de Aguascalientes Aguascalientes 20256 Mexico Centro Universitario de los Lagos Universidad de Guadalajara Jalisco 44100 Mexico Universidad Tecnologica del Norte de Aguascalientes Aguascalientes 20256 Mexico

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Open Journal of Respiratory Diseases 2012年第2期2卷 17-24页

作者： Manuel lopez-Meseguer Río Aguilar Carles Bravo Víctor Monforte Laura Dos Carmen P. Simeon Enric Domingo Antonio Roman Cardiology Department Hospital Universitari de Bellvitge Hospitalet de Llobregat Spain Cardiology Department Hospital Universitari Vall d’Hebron Institut de Recerca del Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Barcelona Spain Department of Physiology Universitat Autonòma de Barcelona Barcelona Spain Internal Medicine Department Hospital Universitari Vall d’Hebron Institut de Recerca del Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Barcelona Spain Respiratory Department Hospital Universitari Vall d’Hebron Institut de Recerca del Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Barcelona Spain

Background: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are serious diseases with similar pathophysiologic aspects. The prognosis of patients with these conditions is highly uncertain, particularly incident cases. Methods: A Cox proportional hazards model was applied to a group of 85 patients (81% women, mean age 52 (18 - 82) years) with PAH (80%) and non-surgical CTEPH (20%) to evaluate risk factors for mortality. The following variables were included in the model: age, etiology, baseline 6-minute walk test (6 mWT), cardiac index, and improvement in the 6 mWT following initiation of first medical treatment. Results: In the multivariate analysis, the response to treatment, assessed by an improvement on the 6 mWT, was the most relevant prognostic factor in these patients (RR, 4.832 (95% CI, 1.888 - 12.364);p = 0.001). The remaining variables studied in this model had less influence on the prognosis: age > 50 years (RR, 0.744 (95% CI, 0.26 - 2.133);p = 0.582);etiology of connective tissue disease-associated PAH (RR, 3.145 (95% CI, 0.995-9.946);p = 0.051) or CTEPH (RR, 0.654 (95% CI, 0.179 - 2.387);p = 0.521) with respect to idiopathic PAH;baseline 6 mWT (RR, 1.173 (95% CI, 0.599 - 4.895);p = 0.315);or cardiac index (RR, 2.295 (95% CI, 0.793 - 6.642);p = 0.125). Conclusions: There is a high degree of uncer-tainty regarding the prognosis of PAH and CTEPH at the start of appropriate treatment. Our results support the idea that the initial treatment response is of paramount importance as prognostic factor in these patients.

关键词： Pulmonary Arterial Hypertension Chronic Thromboembolic Pulmonary Hypertension Survival Risk Factors

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Prevalence of Potential Drug-Drug Interactions in Hospitalized Surgical Patients

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Journal of Pharmacy and Pharmacology 2016年第12期4卷 658-666页

作者： Virginia Aleyda Sanchez-lopez Lorena Michele Brennan-Bourdon Ana Rosa Rincon-Sanchez Maria CristinaIslas-Carbajal Andres Navarro-Ruiz Selene Guadalupe Huerta-Olvera Departamento de Fisiologia Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara 44340Jalisco Mdxico Comisi6n para la Protecci6n contra Riesgos Sanitarios del Estado de Jalisco (COPRISJAL) Guadalajara 44500 Jalisco Mdxico Departamento de Biologia Molecular y Genomica Centro Universitario de Ciencias de la Salud Universidad de GuadalajaraGuadalajara 44340 Jalisco Mexico Servicio de Farmacia Hospital General Universitario de Elche Elche (Alicante) 03203 Spain Departamento de Ciencias Medicas y de la Vida Centro Universitario de la Cienega Universidad de Guadalajara Ocotlan47820 Jalisco. Mexico

The objective of this study is to estimate the prevalence and describe the characteristics of pDDIs （potential drug-drug interactions） in medical prescriptions of hospitalized surgical patients. In this cross-sectional study, we analyzed 370 medical prescriptions from the surgery unit of a Mexican public teaching hospital. The identification and classification of potential drug-drug interactions were performed with the Micromedex 2.0 electronic drug information database. Results were analyzed with descriptive statistics and we estimated OR （odds ratio） to determine associated risk factors. From the study, it was found that the prevalence of potential drug-drug interactions was 45.9%. A total of 385 interactions were identified. Of these, 54.3% were classified as major and 60.5% as pharmacodynamic. Prescriptions for more than seven drugs （OR =7.33, CI （confidence interval） = 4.59-11.71） and advanced age 〉 60 years, （OR = 1.79, CI = 1.06-2.74） were positively associated with the presence of potential drug-drug interactions. We found a high prevalence of clinically relevant pDDIs in the surgery unit. In view of this outcome, the safety of drug combinations in hospitalized surgical patients should be evaluated during the prescription process in order to prevent adverse events.

关键词： Potential drug-drug interactions medical prescriptions concomitant drugs surgery.

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Early Detection of White Spot Syndrome Virus(WSSV)in Isolated Hemocytes of Litopenaeus vannamei

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CellBio 2017年第1期6卷 1-12页

作者： Ariadne Hernandez-Perez Rossanna Rodriguez-Canul Edgar Torres-Irineo Fernando Mendoza-Cano Daniel Eduardo Coronado-Molina Jesus Alejandro Zamora-Briseno Jorge Hernandez-lopez Laboratorio de Inmunología y Biología Molecular Centro de Investigación y de Estudios Avanzados del IPN(CINVESTAV-IPN)Unidad MéridaMéridaMéxico Laboratorio de Pesquerías Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional-Unidad MéridaMéridaMéxico UMDI-Sisal Facultad de CienciasUniversidad Nacional Autónoma de MéxicoSierra PapacalMéxico Centro de Investigaciones Biológicas del Noroeste HermosilloMéxico

To date, White Spot Syndrome (WSS) produced by the White Spot Syndrome Virus (WSSV) causes one of the most severe diseases infecting penaeid shrimps worldwide. Although a vast amount of studies has elucidated pathogenesis in live infection models, there is still little information about the interaction of WSSV infections using in vitro models in the whiteleg shrimp Litopenaeus vannamei (L. vannamei) hemocytes. In this study, a WSSV infection kinetics was performed using total hemocytes isolated from healthy L. vannamei organisms and maintained in in vitro conditions using isotonic solution for shrimp (ISS). The infected experimental cells received ≈ 30,000 viral copies of WSSV. The viability of the hemocytes (control and infected group) was measured during the kinetics with trypan blue exclusion method and cells were maintained up to 6 hpi (post-infection) with non-significant differences of viability between both groups. WSSV replication was assessed using RT- PCR at the RNA expression level of the early viral gene Ie1 and transcripts were detected as early as 30 min pi. Hemocytes from WSSV group showed disrupted integrity, degranulation and irregular shape. This study provides evidence of the capability of WSSV to infect and replicates in L. vannamei hemocytes using in vitro assays in short times as 30 min.

关键词： WSSV Litopenaeus vannamei Ie1 Gene Hemocytes In Vitro Infection GLS Analysis

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Fear is the Path to the Dark Side:Unsafe delivery,One of the Consequences of Fear of the SARS-CoV-2 Pandemic,A Case Report

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Maternal-Fetal Medicine 2021年第4期3卷 292-294页

作者： Albaro Jose Nieto-Calvache Ivan Padilla Mario Fernando Tabares-Blanco Maria Camila lopez-Girón Lina Maria Vergara Galliadi Placenta Accreta Spectrum Clinic Fundación Valle del LiliCali 760032Colombia Department of Neonatology Fundación Valle del LiliCali 760032Colombia Tertiary Obstetric Care Unit Fundación Valle del LiliCali 760032Colombia Clinic Research Center Fundación Vale del LiliCali 760032Colombia

Indirect effects of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic are difficult to *** of intrahospital infection has led to a decrease in the use of emergency services and the performance of elective *** low-and middle-income countries have seen the number of institutional deliveries reduced,even in the absence of a follow-up program for home *** present the case of a patient with adequate prenatal care and an institutional delivery plan who,due to the SARS-CoV-2 pandemic,chose to have a home delivery with unsafe *** lack of supervision by health personnel and the absence of an immediate consultation plan facilitated the presentation of postpartum hemorrhage and poor neonatal *** attention has been paid during the pandemic to pregnant women who decide to have their birth at home.A broad discussion is necessary in this regard,to regain the confidence of the population and strengthen institutional births,or to strengthen midwifeassisted home births ***’fear to acquiring SARS-CoV-2 infection inside hospitals is a factor that must be taken into account in prenatal care programs.

关键词： SARS-CoV-2 Case report delivery Safety

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Plasma-Induced γ-Fe Phase on S3A Alloy Ribbons

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材料科学与工程（中英文A版） 2011年第5X期1卷 632-638页

作者： A. Cabral-Prieto N. Nava I. Garcia-Sosa E. Camps Luis Escobar R. lopez-Castafiarez O. Olea-Cardoso Departamento de Quimica Instituto Nacional de Investigaciones Nucleares DeL Miguel Hidalgo 11801 Mexico D.F. Mexico Instituto Mexicano del Petroleo Eje Central Lazaro Cardenas 152 Col. San Bartolo Atepehuacan Del. Gustavo A. Madero C.P 07730 Mexico D.F. Mexico Facultad de Quimica Universidad Autonoma del Edo. de Mexico Toluca Edo. de Mexico Mexico

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Use of antiepileptic drugs in children with brain tumors: A review for acute management

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Journal of Acute Disease 2018年第5期7卷 181-185页

作者： Jennifer Herrera-Bejarano Amit Agrawal Claudia Marcela Navas Valbuena Guru Dutta Satyarthee Chandramouli Balasubramanian Andrei F.Joaquim George Chater Cure Luis rafael Moscote-Salazar Physician Universidad del RosarioBogotaColombia Professor of Neurosurgery MM Institute of Medical Sciences&ResearchMaharishi Markandesh(w)ar UniversityMullana-Ambala133-207.HaryanaIndia Physician Universidad Industrial de SantanderUISBucaramangaColombia Assistant Professor of Neurosurgery All India Institute of Medical SciencesNew DelhiIndia Department of Neurosurgery Birmingham Children's HospitalBirminghamUK Department of Neurology Neurosurgery DivisionUniversity of Campinas(UNICAMP)Campinas-SPBrazil Neurosurgeon Clinica General del NorteBarranquillaColombia Neurosurgeon-Critical Care University of CartagenaCartagena de IndiasColombia

Patients with primary or secondary tumors in the central nervous system may have seizures resulting from direct tissue damage,metabolic abnormalities,infection,or toxic side effects of *** pediatric patients,it is more frequent to use drugs to control secondary *** this article,we discuss the main nuances of antiepileptic drugs for the proper management of children with central nervous system tumors.

关键词： Antiepileptic drugs Brain tumors Neuro oncology Seizures

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A novel motion tracking system for evaluation of functional rehabilitation of the upper limbs

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Neural Regeneration Research 2013年第19期8卷 1773-1782页

作者： ngel Gil-Agudo Ana de los Reyes-Guzmán Iris Dimbwadyo-Terrer Benito Peasco-Martín Alberto Bernal-Sahún Patricia López-Monteagudo Antonio del Ama-Espinosa José Luis Pons Department of Biomechanics and Technical Aids National Hospital for Spinal Cord Injury Health Department Indra SystemsAlcobendas Madrid Spain Bioengineering Group Spanish National Research Council (CSIC) Arganda del ReyMadrid Spain

Upper limb function impairment is one of the most common sequelae of central nervous system in jury, especially in stroke patients and when spinal cord injury produces tetraplegia. Conventional assessment methods cannot provide objective evaluation of patient performance and the effec tiveness of therapies. The most common assessment tools are based on rating scales, which are inefficient when measuring small changes and can yield subjective bias. In this study, we designed an inertial sensorbased monitoring system composed of five sensors to measure and analyze the complex movements of the upper limbs, which are common in activities of daily living. We devel oped a kinematic model with nine degrees of freedom to analyze upper limb and head movements in three dimensions. This system was then validated using a commercial optoelectronic system. These findings suggest that an inertial sensorbased motion tracking system can be used in patients who have upper limb impairment through data integration with a virtual realitybased neurorehabili tation system.

关键词： neural regenerationtion tracking upperroregenerationbrain injury spinal cordmb: neurorehabilitationnjury kinematic analysis inertial measurement mo-virtual reality sensors grants-supported paper neu-

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Effect of Chia Seed on Physicochemical and Sensory Characteristics of Common Carp Restructured as Functional Food

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Journal of Food Science and Engineering 2017年第3期7卷 115-126页

作者： Angel Santillan-Alvarez Octavio Dublain-Garcia Leticia Xochitl lopez-Martinez Baciliza Quintero-Salazar Leobardo Manuel Gomez-Olivan Daniel Diaz-Bandera Maria Dolores Hemandez-Navarro Department of Food Science and Toxicology Facultad de Quimica Universidad Autonoma del Estado de Mexieo Estado deMexico Mexico Centro de Investigacion en Alimentaciony Desarrollo A. C. Culiacon Sinaloa Mexico Department of Food Science Facultad de Turismo y Gastronomia Universidad Autonoma del Estado de Mexico Estado deMexico Mexico

Physicochemical and sensory characteristics of restructured meat of common carp （Cyprinus carpio） fortified with 0-8 g/100 g of chia seed flour （CSF） was evaluated. It had a higher nutritional value （higher fibre content and protein retention] （p 〈 0.05） and better cooking characteristics （higher cooking yield and moisture retention）（p 〈 0.05） than the control. The colour （a＊, b＊） increased; lightness and whiteness index decrease （p 〈 0.05）. Hardness increase （p 〈 0.05） occurred because of CSF addition. Differential scanning calorimetry showed that fibre fortification did not interfere with the thermal transitions of the restructured meat. No significant differences were detected with the preference test scores of 4% or 8% CSF compared with the control. Restructured （4%-8% CSF） had a higher content of fibre and fat, which could be linoleic and linolenic acid, and an increase in the content of protein compared with those of commercial products, among had 1.62 and 2.25 mg AGE/g. Therefore, the restructured properties of common carp were governed by CSF addition.

关键词： Protein gel common carp chia seeds restructured meat physicochemical properties.

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Analysis of the therapeutic evolution in the management of airway infantile hemangioma

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World Journal of Clinical Pediatrics 2016年第1期5卷 95-101页

作者： Grecia V Vivas-Colmenares Israel Fernandez-Pineda Juan Carlos lopez-Gutierrez Miguel Angel Fernandez-Hurtado Maria Antonia Garcia-Casillas Jose Antonio Matute de Cardenas Department of Pediatric Surgery Virgen del Rocio Children’s Hospital Department of Pediatric Surgery La Paz’s Children’s Hospital Department of Pediatric Surgery Gregorio Mara?on Children’s Hospital

AIM: To analyze the evolution in the management of airway infantile hemangioma(AIH) and to report the results from 3 pediatric tertiary care ***: A retrospective study of patients with diagnosis of AIH and treated in 3 pediatric tertiary care institutions from 1996 to 2014 was performed. RESULTS: Twenty-three patients with diagnosis of AIH were identified. Mean age at diagnosis was 6 mo(range, 1-27). Single therapy was indicated in 16 patients and 7 patients received combined therapy. Two therapeutic groups were identified: Group A included 14 patients who were treated with steroids, interferon, laser therapy and/or surgery; group B included 9 patients treated with oral propranolol. In group A, oral corticosteroids were used in 9 patients with a good response in 3 cases(no requiring other therapeutic option), the other patients required additional treatment options. Cushing syndrome was observed in 3 patients. One patient died of a fulminant sepsis. Open surgical excision and endoscopic therapy were performed in 11 patients(in 5 of them as a single treatment) with a response rateof 54.5%. Stridor persisted in 2 cases, and one patient died during the clinical course of bronchial aspiration. In group B, oral propranolol was used in 9 patients(in 8 of them as a single treatment) with a response rate of 100%, with an mean treatment duration of 7 mo(range, 5-10); complications were not observed. CONCLUSION: Our experience and the medical literature support the use of propranolol as a first line of treatment in AIH.

关键词： Infantile hemangioma Propranolol Surgery Airway Fibrobronchoscopy

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