检索结果-南通市图书馆

Intracerebral Microdialysis in Neurosurgery for Obsessive-Compulsive Disorder: Report of 2 Preliminary Cases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Modern Neurosurgery 2020年第3期10卷 371-381页

作者： Sergio A. Sacchettoni rafael Galera Juan f. Del Corral Juan P. Abud Aníbal Pinero Luis Teneud Napoleón Torres rafael Rojas Pedro Rada félix Guerrero Edgar González Mónica Bifano Dely Yazawa Luis Hernández Hospital and School of Medicine JM Vargas Universidad Central de Venezuela Caracas Venezuela Centro Medico-Docente La Trinidad Caracas Venezuela Neurology Mobile System Associates Miami FL USA Laboratory of Physiology of Behavior Universidad de Los Andes Mérida Venezuela University of Grenoble-Alpes CEA LETI Clinatec France

Neurosurgery for psychiatric disorders, notably for obsessive-compulsive disorder (OCD), was initiated in Venezuela in the decade of 1970, and consisted since that time in the classic stereotactic anterior cingulotomy. In order to know further about the physiopathology of this disorder, we performed intracerebral microdialysis in 2 patients who were operated on. The aim was to measure changes in extracellular neurotransmitters within the basal ganglia. The microdialysis probes were stereotactically placed in the right caudate nucleus and in the dorsomedial nucleus of the right thalamus. The microdialysis was done before the left cingulotomy, during the pause and after the right cingulotomy. Glutamate and gamma-aminobutyric acid (GABA) changes were similar in the caudate nucleus of both patients, whereas in the dorsomedial nucleus the changes were opposite among the 2 patients. Although this study does not bring enough data to explain such differences yet, the existence of dynamic changes in the neurochemistry of the basal ganglia during cingulotomy shows that intracerebral microdialysis can help in the understanding of the pathophysiology of OCD and eventually in the design of new surgeries with better results.

关键词： Psychiatric Neurosurgery Psychosurgery Obsessive-Compulsive Disorder Intracerebral Microdialysis

forecasting the number of species of asexually reproducing fungi(Ascomycota and Basidiomycota)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

fungal Diversity 2022年第3期114卷 463-490页

作者： Nalin N.Wijayawardene Alan J.L.Phillips Diana Santos Pereira Dong-Qin Dai AndréAptroot Josiane S.Monteiro Irina S.Druzhinina feng Cai Xinlei fan Laura Selbmann Claudia Coleine rafael f.Castañeda-ruiz Martin Kukwa Adam flakus Patricia Oliveira fiuza Paul M.Kirk Kunhiraman C.Rajesh Kumar Ilesha S.leperuma Arachchi Nakarin Suwannarach Li-Zhou Tang Teun Boekhout Chen Shuhui Tan R.P.Prabath K.Jayasinghe Marco Thines Centre for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanPeople’s Republic of China Section of Genetics Institute for Research and Development in Health and Social CareNo:393/3Lily AvenueOff Robert Gunawardane MawathaBattaramulla 10120Sri Lanka faculdade de Ciências Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal Laboratório de Botânica/Liquenologia Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva S/NBairro UniversitárioCampo GrandeMS CEP 79070-900Brazil Coordination of Botany Museu Paraense Emílio GoeldiBelémPA 66077830Brazil fungal Genomics Laboratory(fungiG) College of Resources and Environmental SciencesNanjing Agricultural UniversityWeigang 1Nanjing 210095JiangsuPeople’s Republic of China The Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing 100083People’s Republic of China Department of Ecological and Biological Sciences University of TusciaViterboItaly Italian National Antarctic Museum(MNA) Mycological SectionGenoaItaly Alejandro de Humboldt’(INIfAT) Instituto de Investigaciones Fundamentales en AgriculturaTropicalSantiago de Las VegasHavanaCuba Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of GdańskWita Stwosza 5980-308 GdańskPoland W.Szafer Institute of Botany Polish Academy of SciencesLubicz 4631-512 KrakowPoland Universidade federal do Rio Grande do Norte(UfRN) Programa de Pós-Graduação em Sistemática e EvoluçãoCentro de BiociênciasCampus UniversitárioAv.Senador Salgado Filho3000Lagoa NovaNatalRN 59078-970Brazil Biodiversity Informatics and Spatial Analysis Jodrell LaboratoryRoyal Botanic GardensKewRichmond TW93DSSurreyUK National fungal Culture Collection of India(NfCCI) Biodiversity and Palaeobiology GroupMACS Agharkar Research InstituteG.G.

Asexually reproducing fungi play a significant role in essential processes in managed and wild ecosystems such as nutrients cycling and multitrophic interactions.A large number of such taxa are among the most notorious plant and animal *** addition,they have a key role in food production,biotechnology and *** without or rare sexual reproduction are distinguished based on their sporulating structures and conidiomata in traditional morphology-based *** number,variation and diversity of asexually reproducing taxa are insufficiently known,even though fungi capable of asexual reproduction may provide an untapped,rich biological resource for future ***,ca.30,000 asexual species belonging to ca.3800 genera have been reported(including 1388 coelomycetous and 2265 hyphomycetous genera).Recent reports(2017–2020)reiterate that the number of asexually producing fungi is higher than the number of frequently sexually-reproducing *** the advent of molecular tools and the abandonment of the dual nomenclature system for pleomorphic fungi,priority criteria were established and revisited in the latest outline of fungi and fungus-like ***,species numbers and taxonomic boundaries of pleomorphic taxa and their synanamorphs or synasexual morphs have yet to be *** number of species of speciose genera(***,Aspergillus,Cercospora,fusarium,Phoma and Pseudocercospora),cryptic species,species of pleomorphic genera,less studied life modes(such as lichenicolous taxa,taxa from extreme environments)and species from biodiversity-rich areas still need evaluation to achieve more reliable estimates of their *** paper discusses the current knowledge on the matter,with diversity estimates,and potential obstacles in several chapters on(1)speciose genera;(2)pleomorphic genera;(3)cryptic species;(4)well-studied but insufficiently resolved taxa,*** inhabiting species,marine fungi,(5)less studied life modes,e.g.

关键词： Cryptic species DNA sequences Morphology Pleomorphism Speciose genera Species identificat

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

猪呼吸道疾病综合征

国外畜牧学（猪与禽） 2000年第6期20卷 43-45页

作者： rafael Luis f.Morillo 菲律宾综合兽医顾问服务部

Association between urinary concentrations of bisphenol A substitutes and diabetes in adults

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2022年第7期13卷 521-531页

作者： rafael Moreno-Gómez-Toledano Esperanza Vélez-Vélez María I Arenas Marta Saura Ricardo J Bosch Universidad de Alcalá Department of Biological Systems/Physiology UnitAlcaláde Henares 28871Spain fundación Jiménez Díaz School of Nursing Jiménez Díaz FoundationAutonomous University of MadridMadrid 28040Spain Universidad de Alcalá Department of Biomedicine and BiotechnologyAlcaláde Henares 28871Spain Centro de Investigación en Red de Enfermedades Cardiovasculares Instituto Ramón y Cajal de Investigación SanitariaMadrid 28034Spain

BACKGROUND Due to new restrictions on the use of bisphenol A(BPA),industries are beginning to replace it with derived molecules such as bisphenol S and f(BPS and BPf).There is extensive evidence in the academic literature on the potential health effects of BPA,which is known to be a diabetogenic ***,there are few publications related to new compounds derived from *** To perform an epidemiological study of urinary BPS and BPf in the American National Health and Nutrition Examination Survey(NHANES)cohort,and analyze their possible relationship with diabetes *** NHANES datasets from 2013 to 2016 were used due to the urinary BPf and BPS *** from 3658 adults were analyzed to perform regression analysis exploring the possible relationship between BPA-derived compounds and *** Descriptive statistics,linear regression modeling,and logistic regression analysis revealed a significant relationship between urinary BPS,but not BPf,and diabetes ***,a relationship was observed between both compounds and hypertension and a slight relationship between BPf and *** In the present study,a strong relationship between urinary BPS,not BPf,and diabetes risk has been *** substitute molecules do not exempt the population from potential health risks.

关键词： Bisphenol S Bisphenol f Diabetes mellitus National Health and Nutrition Examination Survey Urine

A Technical Review of Hydro-Project Development in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2016年第3期2卷 302-312页

作者： rafael Duarte António Pinheiro Anton J. Schleiss Laboratory of Hydraulic Constructions (LCH) école polytechnique fédérale de Lausanne (EPFL) Civil Engineering Research and Innovation for Sustainability (CERIS) Instituto Superior Técnico Universidade de Lisboa

This paper summarizes the development of hydro-projects in China,blended with an international *** expounds major technical progress toward ensuring the safe construction of high dams and river harnessing,and covers the theorization of uneven non-equilibrium sediment transport,inter-basin water diversion,giant hydro-generator units,pumped storage power stations,underground caverns,ecological protection,and so on.

关键词： DamRiver harnessingWater diversionPumped storage power stationUnderground cavernEcological protection

Snai-1 and Epithelial-Mesenchymal Transition-Related Protein Immunoexpression in Canine Mammary Carcinomas

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in Breast Cancer Research 2014年第4期3卷 111-117页

作者： Breno S.Salgado rafael M.Rocha fernando A.Soares fátima Gartner Noeme S.Rocha Departamento de Patologia Faculdade de Medicina de BotucatuUniversidade Estadual Paulista(UNESP)BotucatuBrazil Laboratório de Patologia Investigativa e Comparada Departamento de Clínica VeterináriaFaculdade de Medicina Veterinária e ZootecniaUniversidade Estadual Paulista(UNESP)BotucatuBrazil Departamento de Anatomia Patológica Hospital A.C.CamargoFundacao Antonio PrudenteSao PauloBrazil Institute of Pathology and Molecular Immunology(IPATIMUP) OportoPortugal

Epithelial-mesenchymal transition (EMT) is defined as switching of polarized epithelial cells to a migratory fibroblastoid phenotype. EMT is known to be involved in the progression and metastasis of various cancers in humans, but this specific process is still little explored in the veterinary literature. The aim of this research was to evaluate the expression of EMT-related proteins in canine mammary carcinomas (CMCs). The expression of six EMT-related proteins in 94 CMCs of female dogs was evaluated by immunohistochemistry using a tissue array method. Additionally, clinicopathological characteristics were compared with the expression of EMT-related proteins. Loss of epithelial protein and/or acquisition of the expression of mesenchymal proteins were observed in CMCs. Loss of epithelial protein and/or acquisition of the expression of mesenchymal proteins were observed, particularly in tumors with evidence of stromal invasion;however, significance was only observed between the S100A4 and vascular invasion. In addition, Snai-1 nuclear immunoexpression was significantly related to E-cadherin loss. In conclusion, loss of epithelial proteins and/or the acquisition of mesenchymal proteins are associated with EMT and may have an important role in the evaluation of CMC patients. The unique immunoexpression pattern of Snai-1 could help to distinguish between an adenoma and a non-metastatic carcinoma and seems to be related to conversion of myoepithelial cells to a complete mesenchymal-like phenotype. Loss of E-cadherin and cytokeratin and change of immunoexpression pattern of Snai-1, N-cadherin, S100A4 and MMP-2 indicate the occurrence of EMT in canine mammary carcinomas and should result in an en bloc resection or a close follow-up.

关键词： EMT S100A4 Keratin Mammary Tumors Dog

Optimal laser intensity profiles for a uniform target illumination in direct-drive inertial confinement fusion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2014年第4期2卷 62-67页

作者： Mauro Temporal Benoit Canaud Warren J.Garbett rafael Ramis Centre de Mathématiques et de Leurs Applications ENS Cachan and CNRS 61 Av.du President WilsonF-94235 Cachan Cedex France CEA DIF F-91297 Arpajon Cedex France AWE plc Aldermaston ReadingBerkshire RG7 4PR United Kingdom ETSI Aeronuticos Universidad Polit'ecnica de Madrid28040 Madrid Spain

A numerical method providing the optimal laser intensity profiles for a direct-drive inertial confinement fusion scheme has been developed. The method provides an alternative approach to phase-space optimization studies, which can prove computationally expensive. The method applies to a generic irradiation configuration characterized by an arbitrary number NBof laser beams provided that they irradiate the whole target surface, and thus goes beyond previous analyses limited to symmetric configurations. The calculated laser intensity profiles optimize the illumination of a spherical *** paper focuses on description of the method, which uses two steps: first, the target irradiation is calculated for initial trial laser intensities, and then in a second step the optimal laser intensities are obtained by correcting the trial intensities using the calculated illumination. A limited number of example applications to direct drive on the Laser Mega Joule(LMJ) are described.

关键词： direct drive inertial confinement fusion laser system

An Educational GUI-Based Software for Dynamic Analysis of framed Structural Models

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Software Engineering and Applications 2023年第7期16卷 265-286页

作者： Claudio H. B. Resende Pedro C. Lopes rafael L. Rangel Luis f. Paullo Muñoz Luiz f. Martha Department of Civil and Environmental Engineering Pontifical Catholic University of Rio de Janeiro Rio de Janeiro Brazil Institute of Computing Fluminense Federal University Niter&#243i Brazil International Centre for Numerical Methods in Engineering (CIMNE) Universitat Politècnica de Catalunya Barcelona Spain

This paper introduces a new version of the open-source educational software, LESM (Linear Elements Structure Model), developed in MATLAB for structural analysis of one-dimensional models such as frames, trusses, and grillages. The updated program includes dynamic analysis, which incorporates inertial and damping effects, time-dependent load conditions, and a transient solver with multiple time integration schemes. The software assumes small displacements and linear-elastic material behavior. The paper briefly explains the theoretical basis for these developments and the reorganization of the source code using Object-Oriented Programming (OOP). The updated Graphical User Interface (GUI) allows interactive use of dynamic analysis features and displays new results such as animations, envelope diagrams of internal forces, phase portraits, and the response of degrees-of-freedom in time and frequency domain. The new version was used in a structural dynamics course, and new assignments were elaborated to improve students’ understanding of the subject.

关键词： Structural Analysis Structural Dynamics Educational Software MATLAB Graphical User Interface

Studying Group Dynamics through Social Networks Analysis in a Medical Community

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Social Networking 2014年第2期3卷 134-141页

作者： Ruben P. Albuquerque Jonice Oliveira fabrício f. faria rafael Monclar Jano M. de Souza Graduate School in Computing Science (PPGI) Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brasil Systems and Computing Engineering Graduate School (COPPE) Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brasil Systems and Computing Engineering Graduate School (COPPE) Universidade Federal do Rio de Janeiro (UFRJ)Rio de Janeiro Brasil

In 2008, the Brazilian Department of Science and Technology created the INCTs (Brazilian Science and Technology Institutes). One of them was the Cancer Control INCT. Due to its importance and considering that there are different groups working together in the same area, it is important that they collaborate intensely. Envisioning an empowerment of scientific collaboration, the BRINCA project was created to support a set of analyses of the social networks from this particular INCT. These analyses were created by mining curricular and publications bases, and identifying different types of scientific relationships and areas. We were able to observe, for instance, how the interaction is amongst researchers from related areas, which researchers were more collaborative and which ones were isolated from the network. These analyzes were used by the INCT coordination to understand and act to improve scientific collaboration.

关键词： Social Networks Scientific Collaborations Data Mining