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Performance of inclined pillars with a major discontinuity

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International journal of Mining Science and Technology 2019年第3期29卷 437-443页

作者： K.v.jessu A.j.S.Spearing Western Australia School of Mines Kalgoorlie Curtin University

Discontinuities are an inherent part of the rock mass and majorly affect the stability of the excavation skin and *** dip of the discontinuities and their properties also have a significant effect on the strength of the *** approaches are commonly used to determine the pillar strength but can overestimate the strength and don’t consider the inclination of the pillars and the strength reduction caused by *** modeling is a powerful tool and if calibrated can be used to evaluate the strength of the pillars with discontinuities having a range of *** effect of a discontinuity on inclined pillars was conducted which has been seldom considered in evaluating the pillar ***-dimensional vertical pillars were simulated,and the pillar strength was calibrated to accepted theoretical results and then the discontinuities were introduced in different pillar inclinations with distinct width to height ratios to gain an insight into the effective pillar strength *** upon the results,it was found that the discontinuities have a significant effect with the increase in the inclination of the pillars even at a higher width to height ratios.

关键词： Numerical modelling Pillar Discontinuities Inclination Width to height ratios

Spectroscopic investigations on Yb^3+ doped and Pr^3+/Yb^3+ codoped tellurite glasses for photonic applications

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journal of Rare Earths 2021年第1期39卷 33-42,I0002页

作者： M.Seshadri M.j.v.Bell v.Anjos Y.Messaddeq Grupo de Engenharia e Espectroscopia de Materiais Departamento de Fisica-ICEUniversidade Federal de Juiz de ForaJuiz de ForaMG36036-900Brazil Centre d'Optique Photonique et Laser2375 Rue de la TerrasseUniversite LavalQuebecQCG1V 0A6Canada

In this work we repo rt on structural and spect roscopic properties of Yb^3+doped and Pr^3+/Yb^3+co-doped TeO2-Bi2 O3-ZnO-Li2 O-Nb2 O5(TBZLN)tellurite *** and stretching modes of TeO2 and Te-OH bond(strong and weak)were analysed from the deconvolution of observed Raman and FT-IR *** on the absorption measurements,the energy bands of Yb^3+and Pr^3+ions are *** spectroscopic properties for the radiative transitions of Yb^3+and Pr^3+ions were reported using McCumber and judd-Ofelt *** emission bands originating from 3 P1 and 3 P0 to lower lying levels of Pr^3+were registered under 447 nm *** emission band around 1334 nm assigned to the Pr3:1 G4→3 H5 was observed when excited at 980 *** stimulated emission cross-section(σemi(λ))and effective linewidth(Δλeff)for the 3 P1→3 H6,3 P1→3 H5,3 P0→3 H6,3 P0→3 F2,3 P1→3 F3,3 P1→3 F4,3 P0→3 F4 and 1 G4→3 H5 transitions of Pr^3+are *** luminescence in Pr^3+/Yb^3+codoped glass upon 980 nm excitation was *** resonant transfer processes between Yb^3+and Pr^3+ions are presented and *** chromaticity co-ordinates were also evaluated from the visible emission spectra showing that Pr^3+/Yb^3+co-doped glass may be suitable for the development of yellow-orange(λexc=447 nm)and near white light(λexc=980 nm)emitting devices in photonics.

关键词： Rare earth ions Tellurite glass Spectroscopic properties Upconversion luminescence

Simplicial Indicator Kriging

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journal of China University of Geosciences 2008年第1期19卷 65-71页

作者： R Tolosana-Delgado v Pawlowsky-Glahn j j Egozcue department of Sedimentology and Environmental Geology Georg-August-Universitt Gttingen D-37077 Gttingen Germany department of Computer Science and Applied Mathematics University of Girona Girona Spain department of Applied Mathematics III Universidad Politécnica de Catalunya Barcelona Spain

Indicator kriging （IK） is a spatial interpolation technique devised for estimating a conditional cumulative distribution function at an unsampled location. The result is a discrete approximation, and its corresponding estimated probability density function can be viewed as a composition in the simplex. This fact suggested a compositional approach to IK which, by construction, avoids all its standard drawbacks （negative predictions, not-ordered or larger than one）. Here, a simple algorithm to develop the procedure is presented.

关键词： Aitchison geometry compositional data disjunctive kriging log-ratio approach simplex.

decoupling the role of chemistry and microstructure in hMSCs response to an osteoinductive calcium phosphate ceramic

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Bioactive Materials 2023年第1期19卷 127-138页

作者： v.P.Galván-Chacon D.de Melo Pereira S.vermeulen H.Yuan j.Li P.Habibovic MERLN Institute for Technology Inspired Regenerative Medicine Maastricht Universitythe Netherlands Kuros Biosciences Bv 3723 MBBilthoventhe Netherlands

Calcium phosphates(CaP)are widely used synthetic bone graft substitutes,having bioactivity that is regulated by a set of intertwined physico-chemical and structural *** some CaPs have shown to be as effective in regenerating large bone defects as autologous bone,there is still the need to understand the role of individual material properties in CaP ***,we aimed to decouple the effects of chemical composition and surface-microstructure of a beta-tricalcium phosphate(TCP)ceramic,with proven osteoinductive potential,on human mesenchymal stromal cells(hMSCs)*** this end,we replicated the surface structure of the TCP ceramic into polylactic acid without inorganic additives,or containing the chemical constituents of the ceramic,i.e.,a calcium salt,a phosphate salt,or TCP *** microstructure of the different materials was characterized by confocal laser *** were cultured on the materials,and the expression of a set of osteogenic genes was *** cell culture medium was collected and the levels of calcium and phosphate ions were quantified by inductively-coupled plasma mass *** results revealed that none of the tested combinations of properties in polymer/composite replicas was as potent in supporting the osteogenic differentiation of hMSCs as the original ***,we observed some effects of the surface structure in the absence of inorganics,as well as combined effects of surface structure and the added salts,in particular calcium,on osteogenic *** approach presented here can be used to study the role of independent properties in other CaP-based biomaterials.

关键词： Calcium phosphate Microstructure Chemical composition Mesenchymal stromal cells Osteogenic differentiation

用于诊断肝细胞癌的肝脏影像报告及数据系统2018版5类：一项最新Meta分析

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国际医学放射学杂志 2024年第3期 373-374页

作者： S.Lee Y.Y.Kim j.Shin Y.H.Roh j.Y.Choi v.Chernyak 吴玉平

摘要目的该项更新的Meta分析旨在确定使用肝脏影像报告和数据系统（LI-RADS）2018版本（v2018）的LI-RADS LR-5类对肝细胞癌（HCC）的诊断能力，并通过评估成像方

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Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome

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World journal of Gastroenterology 2021年第18期27卷 2219-2237页

作者： Magdy el-Salhy Christina Casen jørgen valeur Trygve Hausken jan Gunnar Hatlebakk department of Medicine Stord Helse-Fonna HospitalStord 5416Norway department of Clinical Medicine University of BergenBergen 5020Norway National Centre for Functional Gastrointestinal Disorders Department of MedicineHaukeland University HospitalBergen 5020Norway Genetic Analysis AS Oslo 0485Norway Unger-vetlesen Institute Lovisenberg Diaconal HospitalOslo 0440Norway

BACKGROUND Faecal microbiota transplantation(FMT)seems to be a promising treatment for irritable bowel syndrome(IBS)*** Western countries(United States and Europe),there is a female predominance in IBS.A sex difference in the response to FMT has been reported recently in IBS *** To investigate whether there was a sex difference in the response to FMT in the IBS patients who were included in our previous randomized controlled trial of the efficacy of *** The study included 164 IBS patients who participated in our previous randomized controlled *** patients had moderate-to-severe IBS symptoms belonging to the IBS-D(diarrhoea-predominant),IBS-C(constipation-predominant)and IBSM(mixed)subtypes,and had not responded to the National Institute for Health and Care Excellence(NICE)-modified *** belonged in three groups:placebo(own faeces),and active treated group(30-g or 60-g superdonor faeces).The patients completed the IBS severity scoring system(IBS-SSS),Fatigue Assessment Scale(FAS)and the IBS quality of life scale(IBS-Qol)questionnaires at the baseline and 2 wk,1 mo and 3 mo after *** also provided faecal samples at the baseline and 1 mo after *** faecal bacteria profile and dysbiosis were determined using the 16S rRNA gene polymerase chain reaction DNA amplification covering v3-v9;probe labelling by single nucleotide extension and signal *** levels of short-chain fatty acids(SCFAs)were determined by gas chromatography and flame *** There was no sex difference in the response to FMT either in the placebo group or active treated *** was no difference between females and males in either the placebo group or actively treated groups in the total score on the IBS-SSS,FAS or IBS-Qol,in dysbiosis,or in the faecal bacteria or SCFA ***,the response rate was significantly higher in females with diarrhoea-predominant(IBS-D)than that of males at 1 mo,and 3 mo after ***,IBS-SSS total

关键词： Dysbiosis Fatigue Microbiome Quality of life Short-chain fatty acids Superdonor

Mechanical Properties of Living Adherent Cells :Relationship with Structure and Function

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生物医学工程学杂志 2005年第S1期22卷 9-10页

作者： R. FODIL S. Féréol E. PLANUS v.M. LAURENT B. LOUIS D. ISABEY Inserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 FranceInserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 FranceInserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 FranceInserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 FranceInserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 FranceInserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 France

The influence of monomer concentration on the optical properties of electrochemically synthesized polypyrrole thin films

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journal of Semiconductors 2013年第10期34卷 13-18页

作者： j.v.Thombare M.C.Rath S.H.Han v.j.Fulari Holography and Material Research Laboratory Department of PhysicsShivaji UniversityKolhapur-416 004India Radiation and Photochemistry Division BARCMumbaiIndia department of Chemistry Hanyang UniversitySeoulSouth Korea

Polypyrrole （PPy） thin films were deposited on stainless steel and ITO coated glass substrate at a constant deposition potential of 0.8 v versus saturated calomel electrode （SCE） by using the electrochemical polymerization method. The PPy thin films were deposited at room temperature at various monomer concentrations ranging from 0.1 M to 0.3 M pyrrole. The structural and optical properties of the polypyrrole thin films were investigated using an X-ray diffractometer （XRD）, FTIR spectroscopy, scanning electron microscopy （SEM）, and ultravioletvisible （Uv-vis） spectroscopy. The XRD results show that polypyrrole thin films have a semi crystalline structure. Higher monomer concentration results in a slight increase of crystallinity. The polypyrrole thin films deposited at higher monomer concentration exhibit high visible absorbance. The refractive indexes of the polypyrrole thin films are found to be in the range of 1 to 1.3 and vary with monomer concentration as well as wavelength. The extinction coefficient decreases slightly with monomer concentration. The electrochemically synthesized polypyrrole thin film shows optical band gap energy of 2.14 ev.

关键词： polypyrrole electrochemical polymerization method structure optical properties

Hydroxychloroquine in SARS-Cov-2 infection:Understanding the misadventure

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journal of Acute Disease 2024年第2期13卷 45-52页

作者： David Banji Otilia j F Banji department of Pharmacology&Toxicology College of PharmacyJazan UniversitySaudi Arabia department of Clinical Pharmacy College of PharmacyJazan UniversitySaudi Arabia

The widespread outbreak of SARS-Cov-2 was declared a public health emergency by the World Health Organization and various governments *** prompted the implementation of stringent infection control measures to curb the spread of the *** this,the medical community faced the challenge of treating the virus without specific therapies or a vaccine,leading to reliance on empirical treatment *** this context,hydroxychloroquine,an antimalarial and antirheumatic drug,gained attention as a potential treatment *** its theoretical benefits,such as inhibiting viral entry,reducing inflammation,and modulating immune responses,empirical studies yielded inconsistent *** indicated a potential for symptom relief,while others showed no significant improvement in patient *** initial enthusiasm waned as the lack of substantial evidence led to revoking its Emergency Use Authorization,and several clinical trials were prematurely *** review in question critically examines the factors contributing to the ineffectiveness of hydroxychloroquine in treating SARS-Cov-2 infection,highlighting the complexities of drug repurposing during a rapidly evolving pandemic.

关键词： SARS-Cov-2 Hydroxychloroquine Pharmacogenomics TLR signaling Cardiotoxicity