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Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis

Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 96-101页

作者： radka ivanova Susana Puerta Alfonso Garrido Ignacio Cueto Ana Ferro María José Ariza Andrés Cobos Pedro González-Santos Pedro Valdivielso Division of Internal Medicine Hospital Universitario "Virgen de la Victoria" Division of Gastroenterology Hospital Universitario "Virgen de la Victoria" CIMES Department of Medicine & Dermatology University of Malaga Division of Laboratory Hospital Universitario "Virgen de la Victoria"

BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an *** study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe ***:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum *** APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being *** patients’ progression,etiological diagnosis,hospital stay and clinical and radiological severity were all ***:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) *** with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes *** usually consumed alcohol or consumed it excessively on the days before ***,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption.

关键词： acute pancreatitis hypertriglyceridemia apolipoprotein E alcohol biliary lithiasis

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Physicochemical Characterization and Antimicrobial Properties of Inulin Acetate Obtained by Microwave-Assisted Synthesis

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Journal of Renewable Materials 2020年第4期8卷 365-381页

作者： Nadezhda Petkova radka Arabadzhieva Dragomir Vassilev Gergana Gencheva Yulian Tumbarski Tsveteslava Ignatova-ivanova Sevginar Ibryamova Mina Todorova Milena Koleva Panteley Denev Department of Organic Chemistry and Inorganic Chemistry University of Food TechnologiesPlovdiv4002Bulgaria Department of Physics Chemistry and EcologyTechnical University of GabrovoGabrovo5300Bulgaria Department of Microbiology University of Food TechnologiesPlovdiv4002Bulgaria Department of Biology Konstantin Preslavsky University of ShumenShumenBulgaria

Microwave-assisted irradiation was performed for esterification of chicory inulin with high degree of polymerization with acetic anhydride without a solvent only with a *** resulting esters were characterized by melting point,hydrophilic-lipophilic balance,thin-layer chromatography,ultraviolet spectroscopy,Fourier transform infrared spectroscopy(FTIR)and nuclear magnetic resonance(NMR)*** acetate demonstrated a high degree of acetylation(2.5-3.0)and presented a white,water-insoluble substance with bitter *** FTIR and NMR spectra confirmed esterification and demonstrated the incorporation of hydrophobic residue to the water soluble inulin *** capacity,water holding,oil-holding capacities,the foamability,foam stability and emulsifying properties were also *** acetate showed promising foam stability 52%for 60 min and formed stable emulsions at concentration 0.2 g/L with 50 and 80%oil *** water holding capacity was lower than the oil holding *** addition to this,for the first time,the antimicrobial potential of inulin acetate was tested against seventeen microorganisms(Gram-positive and Gram-negative bacteria,yeasts and fungi).Inulin acetate(10 mg/ml)inhibited the growth of Bacillus cereus,Escherichia coli ATCC 8739,Salmonella abony,Candida albicans and Penicillium ***,inulin acetate demonstrated antimicrobial activity at concentration 1 mg/ml against Listeria monocytogenes 863,Escherichia coli 3398,Candida albicans 8673,Fusarium oxysporum and Aspergillus *** current study demonstrated the applications of“green”synthesized inulin acetate as a foaming agent,oil-in-water emulsion stabilizer and antimicrobial substance in pharmaceutical,agricultural and cosmetic preparations.

关键词： Inulin acetates microwave irradiation FTIR and NMR spectroscopy foams emulsions antimicrobial activity

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