Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis

作     者：Radka Ivanova Susana Puerta Alfonso Garrido Ignacio Cueto Ana Ferro María José Ariza Andrés Cobos Pedro González-Santos Pedro Valdivielso 

作者机构：Division of Internal MedicineHospital Universitario "Virgen de la Victoria" Division of GastroenterologyHospital Universitario "Virgen de la Victoria" CIMESDepartment of Medicine & Dermatology University of Malaga Division of Laboratory Hospital Universitario "Virgen de la Victoria" 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2012年第11卷第1期

页      面：96-101页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by a grant from Grupos de Investigacion y Desarrollo Tecnologico de la Junta de Andalucía(Grupo consolidado CTS-159) 

主　　题：acute pancreatitis hypertriglyceridemia apolipoprotein E alcohol biliary lithiasis 

摘      要：BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an *** study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe ***:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum *** APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being *** patients’ progression,etiological diagnosis,hospital stay and clinical and radiological severity were all ***:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) *** with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes *** usually consumed alcohol or consumed it excessively on the days before ***,the ε4 allele of the APOE gene was more common in this group (P0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption.