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Frontiers of Medicine 2024年第1期18卷 180-191页

作者： Fang Wang Yuxing Liu Yi Dong Meifang Zhao Hao Huang Jieyuan Jin Liangliang Fan Rong Xiang Department of Endocrinology The Third Xiangya Hospital of Central South UniversityChangsha410013China Department of Cellular Biology School of Life SciencesKey Laboratory of Pediatric Rare DiseasesMinistry of EducationCentral South UniversityChangsha410013China

Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolase enzymes,which play crucial roles in lipid ***,little is known about the function of Lipin3 in triglyceride(TG)***,we identified a novel mutation(NM_001301860:p.1835A>T/p.D612V)of Lipin3 in a large family with hypertriglyceridemia(HTG)and obesity through whole-exome sequencing and Sanger *** studies revealed that the novel variant altered the half-life and stability of the Lipin3 ***,we generated Lipin3 heterozygous knockout(Lipin3-heKO)mice and cultured primary hepatocytes to explore the pathophysiological roles of Lipin3 in TG *** found that Lipin3-heKO mice exhibited obvious obesity,HTG,and non-alcoholic fatty liver *** study demonstrated that the haploinsufficiency of Lipin3 in primary hepatocytes may induce the overexpression and abnormal distribution of Lipin1 in cytosol and *** increased expression of Lipin1 in cytosol may contribute to TG anabolism,and the decreased Lipin1 in nucleoplasm can reduce PGC1α,further leading to mitochondrial dysfunction and reduced TG *** study suggested that Lipin3 was a novel disease-causing gene inducing obesity and *** also established a relationship between Lipin3 and mitochondrial dysfunction.

关键词： Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction

Clinical study of neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio in hypertriglyceridemia-induced acute pancreatitis and acute biliary pancreatitis with persistent organ failure

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1647-1659页

作者： Mu-Sen Xu Jia-Le Xu Xin Gao Shao-Jian Mo Jia-Yu Xing Jia-Hang Liu Yan-Zhang Tian Xi-Feng Fu The Third Hospital of Shanxi Medical University Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina Department of Environmental Health School of Public HealthShanxi Medical UniversityTaiyuan 030032Shanxi ProvinceChina

BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various *** categorize acute pancreatitis by etiology into acute biliary pancreatitis(ABP)and hypertriglyceridemia-induced acute pancreatitis(HTGP).AIM To investigate the clinical significance of NLR and PLR in assessing persistent organ failure(POF)in HTGP and *** A total of 1450 patients diagnosed with acute pancreatitis(AP)for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were *** patients were categorized into two groups according to the etiology of AP:ABP in 530 patients and HTGP in 241 *** collected and compared the clinical data of the patients,including NLR,PLR,and AP prognostic scoring systems,within 48 h of hospital *** The NLR(9.1 vs 6.9,P<0.001)and PLR(203.1 vs 160.5,P<0.001)were significantly higher in the ABP group than in the HTGP *** the HTGP group,both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score≥***,in the ABP group,NLR and PLR were significantly elevated in patients with severe AP,modified computed tomography severity index score≥4,Japanese Severity Score≥3,and modified Marshall score≥***,NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP *** NLR and PLR vary between ABP and HTGP,are strongly associated with AP prognostic scoring systems,and have predictive potential for the occurrence of POF in both ABP and HTGP.

关键词： Acute pancreatitis Gallstone hypertriglyceridemia Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Persistent organ failure

Splenic Vein Thrombosis as a Complication of hypertriglyceridemia-Induced Acute Pancreatitis

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Case Reports in Clinical Medicine 2024年第7期13卷 260-267页

作者： Qonitah Gibrata Fedaa Housen Bashar Almasri Maryam AlKhatry Emirate Health Services Ras Al-Khaimah United Arab Emirates Ibrahim Obaid Allah Hospital Ras Al-Khaimah United Arab Emirates

Background: Acute pancreatitis (AP) is an extensive inflammation condition that may lead to local and systemic complications, ranging from mild edematous peripancreatic fluid collection to multiorgan failure and death. Aim: To report the case of the patient with the complications that happened and the presented management. Case presentation: A 37-year-old female patient presented with acute necrotizing pancreatitis secondary to hypertriglyceridemia. During hospitalization, the patient developed severe ileus with splenic vein thrombosis. She was treated conservatively with Intravenous (IV) fluids, insulin infusion, anticoagulant, pain relief medication and antibiotics. Discussion: This case of pancreatitis induced splenic vein thrombosis (PIVST) was treated supportively with outstanding improvement of the patient’s symptoms. Conclusion: Acute pancreatitis can be complicated by splenic vein thrombosis that can be self-limited and treated with conservative measures.

关键词： hypertriglyceridemia Acute Pancreatitis

Eruptive xanthomas in a patient with severe hypertriglyceridemia:A case report

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World Journal of Clinical Cases 2024年第16期12卷 2842-2846页

作者： Ci Ren Ling Zhu Yan-Chao Niu Lian-Yu Tu Zhou-Feng Jin Jian Zhang Department of Dermatological Surgery Shenyang Seventh People’s HospitalShenyang 110003Liaoning ProvinceChina Department of Medical Technology Sichuan Nursing Vocational CollegeChengdu 610100Sichuan ProvinceChina Department of Dermatovenereology Chengdu Second People’s HospitaChengdu 610021Sichuan ProvinceChina Department of Plastic Surgery Shenyang Mingliu Plastic Surgery and Aesthetics HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND Xanthomatosis,a metabolic disorder causing yellow growths(xanthomas),poses challenges in lipid *** case study introduces the first documented instance within China's Yi population,emphasizing the need to explore dietary habits and treatment strategies tailored to this specific *** SUMMARY Xanthomatosis is a metabolic disorder where lipid metabolism goes awry,resulting in the development of yellowish growths called xanthomas.A male patient,47 years of age,from China's Yi population,who is obese,visited our dermatology clinic complaining of widespread,non-painful rashes that have been present for two *** patient works as a chef and has a diet that frequently includes oily and greasy *** case represents the initial documentation of xanthomatosis within the Yi population in China,offering a theoretical foundation for understanding dietary patterns and treatment options specific to the Yi *** The first report of xanthomatosis in the Yi population in China lays a theoretical foundation for understanding Yi dietary patterns and treatment.

关键词： Eruptive xanthomas hypertriglyceridemia Yi ethnicity Dermatology Chef Case report

Association of obesity anthropometric indices with hypertension,diabetes mellitus and hypertriglyceridemia in apparently healthy adult Nigerian population

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World Journal of Cardiology 2022年第6期14卷 363-371页

作者： Anil Sirisena Basil Okeahialam Department of Radiology Jos University Teaching HospitalJos 930001Nigeria Department of Medicine Jos University Teaching HospitalJos 930001Nigeria

BACKGROUND Hypertension,hyperglycemia and hypertriglyceridemia are chronic conditions associated with cardiometabolic *** anthropometric indices are known to predict *** To investigate the association of anthropometric indices with these chronic diseases and which anthropometric index predicts them *** In this study,221 apparently healthy individuals who never received treatments for cardiovascular disease(CVD),diabetes or other chronic diseases *** age of the participants ranged from 20-75 years with mean age of 36.9±11.4 *** risk factors of these diseases namely systolic blood pressures(SBP)and diastolic blood pressures(DBP),fasting blood glucose(FBG)and triglycerides(TG)were determined for all the participants using standard clinical *** obesity anthropometric indices,waist circumference,waist-to-height ratio,waist-to-hip ratio and body mass index as well as abdominal height(AH)and body surface index were *** association between each of them with the risk factors were determined by the Pearson correlation *** From the results,it was found that AH showed superiority over the rest for SBP(r=0.301,P<0.01),DBP(r=0.370,P<0.01),FBG(r=0.297,P<0.01)and TG(r=0.380,P<0.01).Using the receiver operating characteristic curves,cut-off values of AH for SBP,DBP,FBG and TG were determined to be 24.75 cm,24.75 cm,25.25 cm and 24.75 cm *** The indices of anthropometry used in this study correlated significantly with the studied CVD risk factors,with AH emerging as the most predictive.

关键词： Hypertension Hyperglycemia hypertriglyceridemia Abdominal height Anthropometric indices

Insulin Management for hypertriglyceridemia in Pregnancy

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Maternal-Fetal Medicine 2023年第1期5卷 47-50页

作者： Decui Cheng Jie Ma Menghua Kuang Cong Lu Jianrong Weng Yuemin Yang Xianming Xu Department of Obstetrics and Gynecology Shanghai General HospitalShanghai 201600China

To editor:hypertriglyceridemia is a major risk factor for cardiovascu-lar disease and acute pancreatitis.1Accordingly,during preg-nancy,the growing serum lipid levels have potentially critical implications.2,3However,the management of gestational hypertriglyceridemia is further complicated because of the lackof safety data for most of the lipid-lowering agents.

关键词： Insulin hypertriglyceridemia Metabolism

hypertriglyceridemia:a case report from diagnostic laboratory,Barasat,West Bengal,India

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Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 328-329页

作者： Utpal Kumar Biswas Arun Kumar Medicave Diagnostic Center Private Limited Barasa

hypertriglyceridemia is defined as an abnormal concentration of triglyceride in the blood and has been associated with atherosclerosis,even in the absence of *** case report is of 40-year-old man diagnosed to have hypertriglyceridemia who attended for routine screening in our diagnostic laboratory at *** was nonsmoker,non-alcoholic,had a reasonable diet with abundant fruits and vegetables,and was on regular *** was not taking any lipid lowering *** hailed from Barasat,and was employed in Government sector in Barasat and policeman by *** father died at the age of 57 years in a heart attack;but his mother is healthy and now almost 62 years of age,and he has two brothers one elder and another younger to him,both are *** blood pressure was normal,his body-mass index was 27,and his waist circumference was 96 cm and hip circumference was *** waist/hip ratio was *** Biochemical analyses were as follows- Fasting Glucose:186 mg/dL,Total Cholesterol:90 mg/dL,Triglycerides:372 mg/dL,High-density cholesterol:3.80 mg/dL,Low-density cholesterol:2.90 mg/dL,VLDL:83.20 mg/dL,Cholesterol/HDL-C ratio:23.6:1,LDL-C/HDL-C:0.07:*** study revealed the increased prevalence of dyslipidemia to be more prevalent in 31-40 year males,suggesting that this group is at an increased risk of developing CAD leading to young *** lifestyle therapies i.e.,enhanced physical activity and dietary modification and therapeutic intervention would help us in the treatment and management of dyslipidemia.

关键词： hypertriglyceridemia Diabetes Hypo LDL-C Hypo HDL-C Barasat Triglyceride dyslipidemia Fasting glucose Total cholesterol

Clinical Study of 224 Patients with hypertriglyceridemia Pancreatitis

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Chinese Medical Journal 2015年第15期128卷 2045-2049页

作者： Xiao-Li Zhang Fei Li Ya-Min Zhen Ang Li Yu Fang Department of General Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China

Background：Hypertriglyceridenia （HTG） is the most common etiology of acute pancreatitis （AP） after alcohol and gallstone-induced *** of serum triglyceride （TG） levels to ≥ 1000 mg/dl in a patient with AP strongly indicates HTG as the *** absolute risk of pancreatitis based on serum TG ≤1000 mg/dl has not been clearly *** aims of this study were to address the role of elevated TG levels between 500 and 1000 mg/dl in the clinical course of HTG pancreatitis （HTGP）;and assess the relationship between the level of serum TG and disease ***：A total of 224 HTGP patients between 2007 and 2011 were divided into two ***,122 patients in Group A had serum TG 〉1000 mg/dl;102 patients in Group B had maximal TG levels between 500 and 1000 mg/dl accompanied by lactescent serum;100 patients with biliary AP and 99 patients with alcoholic AP hospitalized during the study period were enrolled as *** clinical and biochemical data were ***：The clinical presentation ofHTG-induced pancreatitis was similar to other *** form of AP in Group A was higher than Group B （Х^2 =4.002,P =0.045）.The severity with HTGP was significantly higher as compared to biliaryAP （Х^2 =33.533,P =0.000） and alcoholic AP （Х^2 =7.179,P =0.007）.Systemic complications with HTGP were significantly higher than biliary AP （Х^2 =58.763,P =0.000）.Conclusions：The study demonstrated that TG level ≥500 mg/dl should raise a high degree of suspicion,especially if no other etiology of AP is *** severity of HTGP seems to correlate directly with TG *** seems be more severe than other causes of AP.

关键词： Acute Pancreatitis Clinical Features hypertriglyceridemia

Severe acute pancreatitis due to tamoxifen-induced hypertriglyceridemia with diabetes mellitus

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Chinese Journal of Cancer Research 2014年第3期26卷 341-344页

作者： Young Ae Kim Sol Lee Ji Woong Jung Yu Jin Kwon Gyeong Bok Lee Dong Gue Shin Sang Su Park Jin Yun Yong-Seog Jang Dong Hui Cho Department of Surgery Seoul Medical CenterSeoulKorea Department of Surgery Red Cross HospitalSeoulKorea

The side effects of tamoxifen are generally mild, including the effect on lipoprotein metabolism. However, there are few cases of severe tamoxifen induced hypertriglyceridemia. hypertriglyceridemia is a marked risk factor for acute pancreatitis and approximately 2% to 5% of cases of acute pancreatitis are related to drugs. We report on tamoxifen-induced hypertriglyceridemia and acute pancreatitis in a 40 years old woman with type 2 diabetes mellitus occurred by dexamethasone. She was treated with insulin infusion and fenofibrate, and goserelin acetate was started instead of tamoxifen after discharge from the hospital. Also, probable pathogenic hypotheses about the correlation between tamoxifen and dexamethasone induced type 2 diabetes mellitus on severe acute pancreatitis are provided. Clinicians should take care of risks of severe acute pancreatitis on using tamoxifen, especially for patients with dexamethasone induced diabetes mellitus. These individuals should undergo pre-post tamoxifen lipid screening and careful history taking of drugs, including dexamethasone.

关键词： Tamoxifen acute pancreatitis hypertriglyceridemia type 2 diabetes mellitus dexamethasone

Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes

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The Journal of Biomedical Research 2019年第1期33卷 1-16页

作者： Toru Hiyoshi Mutsunori Fujiwara Zemin Yao Division of Diabetes and Endocrinology Department of Internal Medicine Japanese Red Cross Medical Center Department of Laboratory Medicine Japanese Red Cross Medical Center Department of Biochemistry Microbiology and Immunology Ottawa Institute of Systems BiologyUniversity of Ottawa

Postprandial glucose level is an independent risk factor for cardiovascular disease that exerts effects greater than glucose levels at fasting state, whereas increase in serum triglyceride level, under both fasting and postprandial conditions, contributes to the development of arteriosclerosis. Insulin resistance is a prevailing cause of abnormalities in postabsorptive excursion of blood glucose and postprandial lipid profile. Excess fat deposition renders a vicious cycle of hyperglycemia and hypertriglyceridemia in the postprandial state, and both of which are contributors to atherosclerotic change of vessels especially in patients with type 2 diabetes mellitus. Several therapeutic approaches for ameliorating each of these abnormalities have been attempted, including various antidiabetic agents or new compounds targeting lipid metabolism.

关键词： postprandial hyperglycemia postprandial hypertriglyceridemia Type 2 diabetes mellitus atherosclerosis