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Testicular sperm extraction(TESE)outcomes in the context of malignant disease:a systematic review

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Asian Journal of Andrology 2022年第6期24卷 584-590页

作者： Ludmilla Ogouma Isabelle Berthaut rachel Lévy Rahaf Haj Hamid marie Prades marie Audouin Nathalie Sermondade Charlotte Dupont Fertility Center(Service de Biologie de la Reproduction CECOS) Tenon Hospital(AP-HPSorbonne-Universite)Paris F-75020France Sorbonne University Saint Antoine Research CenterInserm Us938Paris F-75012France Fertility Center Diaconesses HospitalParis F-75012France

Advances in the oncology field have led to improved survival ***,quality of life after remission is anticipated,which includes the possibility to conceive *** cancer treatments are potentially gonadotoxic,fertility preservation must be *** fertility preservation is mainly based on ejaculated sperm *** this is not possible,testicular sperm extraction(TESE)may be *** identify situations in which TESE has been beneficial,a systematic review was *** search was carried out on the PubMed,Scopus,Google Scholar,and CISMeF databases from 1 January 2000 to 19 March *** Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)recommendations were followed in selecting items of ***-four articles were included in the systematic review,including 15 articles on oncological testicular sperm extraction(oncoTESE),18 articles on postgonadotoxic treatment TESE and 1 article on both oncoTESE and postgonadotoxic treatment *** sperm freezing was possible for 42.9%to 57.7%of patients before gonadotoxic treatment and for 32.4%to 75.5%of patients after gonadotoxic treatment,depending on the type of malignant *** no formal conclusion could be drawn about the chances to obtain sperm in specific situations,our results suggest that TESE can be proposed before and after gonadotoxic *** treatment,TESE is more often proposed for men with testicular cancer presenting with azoospermia since TESE can be performed simultaneously with tumor removal or *** chemotherapy,TESE may be planned if the patient presents with persistent azoospermia.

关键词： cancer fertility preservation oncological testicular sperm extraction spermatozoa testicular sperm extraction

Nicotine-induced adrenal beta-arrestin1 upregulation mediates tobacco-related hyperaldosteronism leading to cardiac dysfunction

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World Journal of Cardiology 2020年第5期12卷 192-202页

作者： Natalie Cora Jennifer Ghandour Celina marie Pollard Victoria Lynn Desimine Krysten Elaine Ferraino Janelle marie Pereyra rachel Valiente Anastasios Lymperopoulos Laboratory for the Study of Neurohormonal Control of the Circulation Department of Pharmaceutical Sciences(Pharmacology)College of PharmacyNova Southeastern UniversityFort LauderdaleFL 33328-2018United States

BACKGROUND Tobacco-related products,containing the highly addictive nicotine together with numerous other harmful toxicants and carcinogens,have been clearly associated with coronary artery disease,heart failure,stroke,and other heart *** the mechanisms by which nicotine contributes to heart disease is elevation of the renin-angiotensin-aldosterone system(RAAS)***,and its major metabolite in humans cotinine,have been reported to induce RAAS activation,resulting in aldosterone elevation in *** has various direct and indirect adverse cardiac *** is produced by the adrenal cortex in response to angiotensin II(AngII)activating AngII type 1 *** activity increases in chronic smokers,causing raised aldosterone levels(nicotine exposure causes the same in rats).AngII receptors exert their cellular effects via either G proteins or the twoβarrestins(βarrestin1 and-2).AIM Since adrenal?arrestin1 is essential for adrenal aldosterone production and nicotine/cotinine elevate circulating aldosterone levels in humans,we hypothesized that nicotine activates adrenal?arrestin1,which contributes to RAAS activation and heart disease *** We studied human adrenocortical zona glomerulosa H295R cells and found that nicotine and cotinine upregulateβarrestin1 mRNA and protein levels,thereby enhancing AngII-dependent aldosterone synthesis and *** In contrast,siRNA-mediatedβarrestin1 knockdown reversed the effects of nicotine on AngII-induced aldosterone production in H295 R ***,nicotine promotes hyperaldosteronism via adrenalβarrestin1,thereby precipitating cardiac dysfunction,also in vivo,since nicotine-exposed experimental rats with adrenal-specificβarrestin1 knockdown display lower circulating aldosterone levels and better cardiac function than nicotine-exposed control animals with normal adrenalβarrestin1 *** Adrenalβarrestin1 upregulation is one of the mechanisms by whic

关键词： Adrenocortical zona glomerulosa cell Aldosterone βarrestin Nicotine Signal transduction Tobacco-related heart disease

Successful testicular sperm extraction after hematopoietic stem cell transplantation

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Asian Journal of Andrology 2023年第4期25卷 539-540页

作者： Ludmilla Ogouma Aworet Rahaf Haj Hamid Diane Rivet Danon Isabelle Berthaut Anna Ly Guillaume Bachelot marie Prades Kamila Kolanska Valentine Frydman rachel Lévy Nathalie Sermondade Charlotte Dupont Reproductive Biology and CECOS Tenon Hospital(AP-HP)Sorbonne-UniversitéParis 75020France Reproductive Biology and CECOS Cochin Hospital(AP-HP)UniversitéParis CentreParis 75014France Sorbonne University Research Center Saint-AntoineInserm US938Paris 7501France Department of Urology Hôpital Tenon(AP-HP)Sorbonne-UniversitéParis 75020France

Dear Editor,Allogeneic or autologous hematopoietic stem cell transplantation(HSCT)concerns an increasing number of ***,89070 allogeneic and autologous HSCT procedures were reported in 2016,representing a 7%increase per year since 1991.1 Improved transplant strategies and therapeutic efficacy have made HSCT a curative option for various indications,mostly comprising malignant blood cell pathologies but also including solid tumors or benign conditions.2 The conditioning regimen for transplantation often includes alkylating agents and/or total body irradiation(TBI).2 These treatments usually lead to permanent infertility.3 In men,the consequences include the impairment and reduction of Sertoli and Leydig cells,leading to the suppression of the spermatogonia pool and increased release of gonadotrophin.3 Although sperm banking can mitigate the risk of infertility.

关键词： hematopoietic consequences mostly

A practical reference for studying meiosis in the model ciliate Tetrahymena thermophila

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Marine Life Science & Technology 2022年第4期4卷 595-608页

作者： Miao Tian Xia Cai Yujie Liu Mingmei Liucong rachel Howard-Till Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdao266003China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266237China Department of Molecular and Cellular Biology University of California DavisDavisCAUSA Institute of Human Genetics CNRSUniversity of Montpellier34090MontpellierFrance

Meiosis is a critical cell division program that produces haploid gametes for sexual *** in meiosis are often causes of infertility and birth defects(e.g.,Down syndrome).Most organisms use a highly specialized zipper-like protein complex,the synaptonemal complex(SC),to guide and stabilize pairing of homologous chromosomes in *** the SC is critical for meiosis in many eukaryotes,there are organisms that perform meiosis without a functional ***,such SC-less meiosis is poorly *** understand the features of SC-less meiosis and its adaptive significance,the ciliated protozoan Tetrahymena was selected as a *** research in Tetrahymena has revealed intriguing aspects of the regulatory programs utilized in its SC-less meiosis,yet additional efforts are needed for obtaining an in-depth comprehension of mechanisms that are associated with the absence of ***,aiming at promoting a wider application of Tetrahymena for meiosis research,we introduce basic concepts and core techniques for studying meiosis in Tetrahymena and then suggest future directions for expanding the current Tetrahymena meiosis research *** methodologies could be adopted for dissecting meiosis in poorly characterized ciliates that might reveal novel *** data will hopefully provide insights into the function of the SC and the evolution of meiosis from a unique perspective.

关键词： Meiosis Ciliate Tetrahymena Synaptonemal complex Cytogenetics

Minor Gynecologic Surgery: A Review of the Training Experience and Skill Building Opportunities for Providers in Low and Middle Income Countries

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Open Journal of Obstetrics and Gynecology 2014年第7期4卷 432-444页

作者： rachel marie Clark Leslie Siriya Bradford Jessica Opoku-Anane Joseph Ngonzi Ferdous Islam Mithila Faruque Annekathryn Goodman Department of Obstetrics and Gynecology Birdem Hospital Dhaka Bangladesh Department of Obstetrics and Gynecology Dhaka Medical College Hospital Dhaka Bangladesh Department of Obstetrics and Gynecology Division of Gynecology Oncology Massachusetts General Hospital Boston USA Department of Obstetrics and Gynecology Division of Gynecology Oncology University of Massachusetts Worcester USA Department of Obstetrics and Gynecology George Washington University Hospital Washington D.C. USA Department of Obstetrics and Gynecology Mbarara University Teaching Hospital Mbarara Uganda

Purpose: Minor gynecologic surgery is the cornerstone of gynecologic evaluation and intervention in countries with a well-established medical infrastructure. Surgical training and exposure to minor procedures are not available in low and middle-income countries due to the complex challenges of patient delay and lack of access to healthcare, physician shortages, and the lack of ancillary services such as pathology and radiology. This paper reviews current training statistics, the international literature on minor gynecologic surgery and training strategies. Methods: PubMed searches using MESH terms cone biopsy, dilation and curettage, and loop electrosurgical excision procedure were performed. Statistics of minor surgical procedures among US Obstetrics and Gynecology Residency programs were tabulated. We then searched for data of training programs and surgical statistics in low resource countries. Results:Dilation and curettage is the most common minor gynecologic procedure in the United States but is performed with significantly lower frequency in low and middle-income countries. The most common procedure for the treatment of preinvasive disease was cryotherapy followed by loop electrosurgical excision procedure. There was no information about minor surgical procedures performed in hospitals in low and middle-income countries. Statistics from four-year American training programs showed an average of 209 minor cervical procedures performed annually. Conclusion: Expertise in minor gynecologic procedures is vital and requires the development of both adequate training programs and local medical infrastructure. Strategies for training in minor surgery for providers in low and middle-income countries include online curriculums, mentored relationships with senior physicians, and simulation models.

关键词： Minor Surgery Gynecology Dilation and Curettage Hysteroscopy Cone Biopsy Residency Training LMICs

The Glucosinolate Biosynthetic Gene A OP2 Mediates Feed-back Regulation of Jasmonic Acid Signaling in Arabidopsis

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Molecular Plant 2015年第8期8卷 1201-1212页

作者： Meike Burow Susanna Atwell Marta Francisco rachel E. Kerwin Barbara A. Halkier Daniel J. Kliebenstein DynaMo Center of Excellence Department of Plant and Environmental Sciences Faculty of Science University of Copenhagen Thorvaldsensvej 40 1871Frederiksberg C Denmark Copenhagen Plant Science Centre Department of Plant and Environmental Sciences Faculty of Science University of Copenhagen Thorvaldsensvej 40 1871Frederiksberg C Denmark Department of Plant Sciences University of California at Davis Davis CA 95616 USA Mision Biologica de Galicia (MBG-CSIC) PO Box 28 36080 Pontevedra Spain

Survival in changing and challenging environments requires an organism to efficiently obtain and use its resources. Due to their sessile nature, it is particularly critical for plants to dynamically optimize their meta- bolism. In plant primary metabolism, metabolic fine-tuning involves feed-back mechanisms whereby the output of a pathway controls its input to generate a precise and robust response to environmental changes. By contrast, few studies have addressed the potential for feed-back regulation of secondary metabolism. In Arabidopsis, accumulation of the defense compounds glucosinolates has previously been linked to genetic variation in the glucosinolate biosynthetic gene AOP2. AOP2 expression can increase the transcript levels of two known regulators （MYB28 and MYB29） of the pathway, suggesting thatAOP2 plays a role in positive feed-back regulation controlling glucosinolate biosynthesis. We generated mutants affecting AOP2, MYB28/29, or both. Transcriptome analysis of these mutants identified a so far unrecognized link between AOP2 and jasmonic acid （JA） signaling independent of MYB28 and MYB29. Thus, AOP2 is part of a regulatory feed-back loop linking glucosinolate biosynthesis and JA signaling and thereby allows the glucosinolate pathway to influence JA sensitivity. The discovery of this regulatory feed-back loop provides insight into how plants optimize the use of resources for defensive metabolites.

关键词： feed-back regulation jasmonates JA signaling glucosinolates Arabidopsis

Potential impacts of UV exposure on lichen communities:a pilot study of Nothofagus dombeyi trunks in southernmost Chile

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Ecosystem Health and Sustainability 2015年第4期1卷 40-52页

作者： marie T.Trest Susan Will-Wolf rachel Keuler Nathaniel Shay Karen Hill Alyssa Studer Andy Muench Zachary Alexander Axel Adams Leah Dittberner Martin Feehan Hannah Lee Nicholas Galleguillos-Katz Joy B.Zedler Linda Graham Patricia Arancibia-Avila Department of Botany University of WisconsinMadisonWisconsin 53706 USA Department of Basic Sciences University of Bio-BioChillan 3800708 Chile

High-latitude terrestrial ecosystems face the triple threats of climate warming,increased exposure to UV arising from polar ozone depletion,and *** communities of southernmost Chile are recognized for their high diversity,which includes nitrogen-fixing *** lichens are common on forest trees,contribute nitrogen to forests,and are sensitive to exposure following deforestation(widespread in this region).In a pilot study of exposure effects on tree lichens,using nondestructive imaging methods,we compared lichen communities on trunks of isolated *** tree trunks of southern Chilean beech(Nothofagus dombeyi,Nothofagaceae).We chose trees of similar diameter and trunk lean angle in conserved forest and nearby logged meadow on Navarino Island,XII Region Magallanes and Chilean Antarctica,Chile,within the annual southern ozone ***-five percent of cyanolichen records,including Nephroma antarcticum,and 66%of records for other foliose lichens were from the forest,whereas pendulous usneoid lichens dominated *** bark at the meadow *** of cyanolichen growth on isolated trees could affect ecosystem function in this poorly studied *** factors contributing to strong community differences were increased light intensity,UV radiation,and wind stress,plus limited ability of lichens to colonize isolated trees in the logged *** radiation was likely an important stressor for some lichen species but not *** recommend more extensive monitoring to pinpoint causes of differing lichen communities,and we encourage better protection of bark-dwelling lichens in southern hemisphere regions facing multiple threats.

关键词： bark lichens Chile cyanolichens deforestation forest fragmentation lichen diversity Nothofagus dombeyi southern ozone hole UV radiation

Prediction of delayed graft function using different scoring algorithms: A single-center experience

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World Journal of Transplantation 2017年第5期7卷 260-268页

作者： Magda Michalak Kristien Wouters Erik Fransen rachel Hellemans Amaryllis H Van Craenenbroeck marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans Department of Nephrology-Hypertension Antwerp University Hospital Department of Medical Statistics Antwerp University Hospital StatUa Center for Statistics University of Antwerp Department of Hepatobiliary Endocrine and Transplantation SurgeryAntwerp University Hospital Histocompatibility and Immunogenetic Laboratory

AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each *** This single-center,retrospective study included 247 consecutive kidney transplants from a deceased *** kidney transplantations were performed at our institution between January 2003 and December *** compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under *** c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without *** sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations.

关键词： Delayed graft function Kidney transplantation Nomogram Receiver operating characteristic curve Risk calculation

Sodium Diffuses from Glass Substrates through P1 Lines and Passivates Defects in Perovskite Solar Modules

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Energy & Environmental Materials 2023年第6期6卷 393-401页

作者： Felix Utama Kosasih Francesco Di Giacomo Jordi Ferrer Orri Kexue Li Elizabeth M.Tennyson Weiwei Li Fabio Matteocci Gunnar Kusch Narges Yaghoobi Nia rachel A.Oliver Judith L.MacManus-Driscoll Katie L.Moore Samuel D.Stranks Aldo Di Carlo Giorgio Divitini Caterina Ducati Department of Materials Science and Metallurgy University of Cambridge27 Charles Babbage RoadCambridge CB30FSUK Centre for Hybrid and Organic Solar Energy(CHOSE) Department of Electronic EngineeringUniversity of Rome Tor VergataRome 00133Italy Cavendish Laboratory University of CambridgeJJ Thomson AvenueCambridge CB30HEUK Department of Materials and Photon Science Institute University of ManchesterOxford RoadManchester M139PLUK Department of Chemical Engineering and Biotechnology University of CambridgePhilippa Fawcett DriveCambridge CB30ASUK Laboratory for Advanced Solar Energy(LASE) National University of Science and Technology MISiSLeninskiy Prospekt 4Moscow 119049Russia Energy Research Institute@NTU Nanyang Technological University50 Nanyang DriveSingapore 637553Singapore MIIT Key Laboratory of Aerospace Information Materials and Physics College of PhysicsNanjing University of Aeronautics and AstronauticsNanjing 211106China Istituto di Struttura della Materia-CNR(ISM-CNR) Via del Fosso del Cavaliere 100Rome 00133Italy Electron Spectroscopy and Nanoscopy Istituto Italiano di TecnologiaVia Morego 30Genova 16163Italy

Most thin-film photovoltaic modules are constructed on soda-lime glass(SLG)substrates containing alkali oxides,such as Na_(2)*** may diffuse from SLG into a module's active layers through P1 lines,an area between a module's constituent cells where the substrate-side charge transport layer(CTL)is in direct contact with *** diffusion from SLG is known to cause several important effects inⅡ-Ⅵand chalcogenide solar modules,but it has not been studied in perovskite solar modules(PSMs).In this work,we use complementary microscopy and spectroscopy techniques to show that Na diffusion occurs in the fabrication process of *** diffuses vertically inside P1 lines and then laterally from P1 lines into the active area for up to 360 *** propose that this process is driven by the high temperatures the devices are exposed to during CTL and perovskite *** diffused Na preferentially binds with Br,forming Br-poor,l-rich perovskite and a species rich in Na and Br(Na-Br)close to P1 ***-Br passivates defect sites,reducing non-radiative recombination in the perovskite and boosting its luminescence by up to 5×.Na-Br is observed to be stable after 12 weeks of device storage,suggesting long-lasting effects of Na *** results not only point to a potential avenue to increase PSM performance but also highlight the possibility of unabated Na diffusion throughout a module's lifetime,especially if accelerated by the electric field and elevated temperatures achievable during device operation.

关键词： defect passivation monolithic interconnection perovskite solar modules soda-lime glass sodium diffusion solar cells thin-film photovoltaics