A practical reference for studying meiosis in the model ciliate Tetrahymena thermophila

作     者：Miao Tian Xia Cai Yujie Liu Mingmei Liucong Rachel Howard-Till 

作者机构：Institute of Evolution&Marine BiodiversityOcean University of ChinaQingdao266003China Laboratory for Marine Biology and BiotechnologyQingdao National Laboratory for Marine Science and TechnologyQingdao266237China Department of Molecular and Cellular BiologyUniversity of California DavisDavisCAUSA Institute of Human GeneticsCNRSUniversity of Montpellier34090MontpellierFrance 

出 版 物：《Marine Life Science & Technology》 (海洋生命科学与技术（英文）)

年 卷 期：2022年第4卷第4期

页      面：595-608页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：Funds for the Central Universities(No.202241003,to Dr.Miao Tian) the Natural Science Foundation of Shandong Province(ZR2022JQ13,to Dr.Miao Tian) by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement(No.101024333) Dr.Rachel Howard-Till is supported by NIH RO1GM127571 

主　　题：Meiosis Ciliate Tetrahymena Synaptonemal complex Cytogenetics 

摘      要：Meiosis is a critical cell division program that produces haploid gametes for sexual *** in meiosis are often causes of infertility and birth defects(e.g.,Down syndrome).Most organisms use a highly specialized zipper-like protein complex,the synaptonemal complex(SC),to guide and stabilize pairing of homologous chromosomes in *** the SC is critical for meiosis in many eukaryotes,there are organisms that perform meiosis without a functional ***,such SC-less meiosis is poorly *** understand the features of SC-less meiosis and its adaptive significance,the ciliated protozoan Tetrahymena was selected as a *** research in Tetrahymena has revealed intriguing aspects of the regulatory programs utilized in its SC-less meiosis,yet additional efforts are needed for obtaining an in-depth comprehension of mechanisms that are associated with the absence of ***,aiming at promoting a wider application of Tetrahymena for meiosis research,we introduce basic concepts and core techniques for studying meiosis in Tetrahymena and then suggest future directions for expanding the current Tetrahymena meiosis research *** methodologies could be adopted for dissecting meiosis in poorly characterized ciliates that might reveal novel *** data will hopefully provide insights into the function of the SC and the evolution of meiosis from a unique perspective.