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Mitochondrial GPX1 sile.cing trigge.s diffe.e.tial photosynthe.is impairme.t in re.ponse.to salinity in rice.plants

Journal of Inte.rative.Plant Biology 2016年第8期58卷 737-748页

作者： Yugo Lima-Me.o Fabricio e.L.Carvalho Márcio O.Martins Gise.e.Passaia rachel H.V.Sousa Milton C.Lima Ne.o Márcia Margis-Pinhe.ro Joaquim A.G.Silve.ra De.artme.t of Bioche.istry and Mole.ular Biology Federal University of Ceará De.artme.t of Ge.e.ics Federal University of Rio Grande do Sul

The.physiological role.of plant mitochondrial glutathione.pe.oxidase. is scarce.y known. This study atte.pte. to e.ucidate.the.role.of a rice.mitochondrial isoform（GPX1） in photosynthe.is unde. normal growth and salinity conditions. GPX1 knockdown rice.line.（GPX1s） we.e.te.te. in abse.ce.and pre.e.ce.of 100 mM NaCl for 6 *** re.uction of GPX1 s line.unde. non-stre.sful conditions, compare. with non-transforme.（NT） plants occurre. in paralle. to incre.se. H_2O_2 and de.re.se. GSH conte.ts. The.e.change. occurre. concurre.tly with photosynthe.is impairme.t, particularly in Calvin cycle.s re.ctions, since.photoche.ical e.ficie.cy did not ***, GPX1 sile.cing and downstre.m mole.ular/me.abolic change. modulate. photosynthe.is diffe.e.tially. In contrast, salinity induce. re.uction in both phase. of photosynthe.is, which we.e.more.impaire. in sile.ce. *** change. we.e.associate. with root morphology alte.ations but not shoot growth. Both studie. line. displaye. incre.se. GPX activity but H_2O_2 conte.t did not change.in re.ponse.to salinity. Transforme. plants e.hibite. lowe. photore.piration, wate. use.e.ficie.cy and root growth, indicating that GPX1 could be.important to salt tole.ance. Growth re.uction of GPX1 s line.might be.re.ate. to photosynthe.is impairme.t, which in turn could have.involve. a cross talk me.hanism be.we.n mitochondria and chloroplast originate. from re.ox change. due.to GPX1 de.icie.cy.

关键词： CO2 assimilation glutathione.pe.oxidase Oryza sativa photoche.istry re.ox home.stasis

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B ce.ls in pancre.tic cance. stroma

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World Journal of Gastroe.te.ology 2022年第11期28卷 1088-1101页

作者： France.ca Romana De.ve.chio Miche.le.R Goulart rachel e.izabe.h Ann Fincham Miche.e.Bombadie.i He.ant M Koche. William Harve. Re.e.rch Institute Queen Mary University of LondonLondon EC1M 6BQUnited Kingdom Barts Cance. Institute Queen Mary University of LondonLondon EC1M 6BQUnited Kingdom Barts and the.London HPB Ce.tre Barts Health NHS TrustLondon E11BBUnited Kingdom

Pancre.tic cance. is a dise.se.with high unme. clinical *** cance. is also characte.ise. by an inte.se.fibrotic stroma,which harbours many immune.*** in both human and animal mode.s have.de.onstrate. that the.immune.syste. plays a crucial role.in modulating tumour onse. and *** human pancre.tic ductal ade.ocarcinoma,high B-ce.l infiltration corre.ate. with be.te. patie.t ***,B ce.ls have.re.e.ve. re.e.t inte.e.t in pancre.tic cance. as pote.tial the.ape.tic ***,the.data on the.role.of B ce.ls in murine.mode.s is uncle.r as it is de.e.de.t on the.pancre.tic cance. mode. use. to ***,it appe.rs that B ce.ls do organise.along with othe. immune.ce.ls such as a ne.work of follicular de.dritic ce.ls(DCs),surrounde. by T ce.ls and DCs to form te.tiary lymphoid structure.(TLS).TLS are.incre.singly re.ognise. as site. for antige. pre.e.tation,T-ce.l activation,Bce.l maturation and diffe.e.tiation in plasma *** this re.ie. we.disse.t the.role.of B ce.ls and provide.dire.tions for future.studie. to harne.s the.role.of B ce.ls in tre.tme.t of human pancre.tic cance..

关键词： B ce.ls Pancre.tic cance. Cance. immunology Te.tiary lymphoid structure. Anti-tumour immunoglobulins Plasma ce.ls

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T ce.ls in pancre.tic cance. stroma

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World Journal of Gastroe.te.ology 2021年第46期27卷 7956-7968页

作者： Miche.le.R Goulart Konstantinos Stasinos rachel e.izabe.h Ann Fincham France.ca R De.ve.chio He.ant M Koche. Ce.tre.for Tumour Biology Barts Cance. Institute.A CRUK Ce.tre.of e.ce.le.ce Queen Mary University of LondonLondon EC1M 6BQUnited Kingdom Barts and the.London HPB Ce.tre The Royal London HospitalBarts Health NHS TrustLondon E11BBUnited Kingdom Ce.tre.for e.pe.ime.tal Me.icine.and Rhe.matology William Harvey Research InstituteQueen Mary University of LondonLondon EC1M 6BQUnited Kingdom

Pancre.tic ductal ade.ocarcinoma(PDAC)is a highly de.astating dise.se.with a dismal 5-ye.r survival *** has a comple. tumour microe.vironme.t;characte.ise. by a robust de.moplastic stroma,e.te.sive.infiltration of immune.uppre.sive.ce.ls such as immature.mye.oid ce.ls,tumour-associate. macrophage.,ne.trophils and re.ulatory T ce.ls,and the.pre.e.ce.of e.hauste. and se.e.ce.t T *** cross-talk be.we.n ce.ls in this fibrotic tumour e.tablishe. an immune.privile.e. microe.vironme.t that supports tumour ce.l e.cape.from immune.surve.llance.dise.se.progre.sion and spre.d to distant *** tumours,conside.e. to be.non-immunoge.ic or cold,e.pre.s low mutation burde.,low infiltration of CD8+cytotoxic lymphocyte. that are.localise. along the.invasive.margin of the.tumour borde. in the.surrounding fibrotic tissue.and ofte. display an e.hauste. ***,we.re.ie. the.role.of T ce.ls in pancre.tic cance.,e.amine.the.comple. inte.actions of the.e.crucial e.fe.tor units within pancre.tic cance. stroma and she. light on the.incre.singly attractive.use.of T ce.ls as the.apy.

关键词： Immunosuppre.sion T ce.l e.haustion Tumour microe.vironme.t Pancre.tic ductal ade.ocarcinoma Pancre.tic cance. stroma

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HDAC inhibitors ove.come.immunothe.apy re.istance.in B-ce.l lymphoma

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Prote.n & Ce.l 2020年第7期11卷 472-482页

作者： Xiaoguang Wang Brittany C.Waschke.rachel A Woolave. Samantha M.Y.Che. Zhangguo Che. Jing H.Wang De.artme.t of Immunology and Microbiology University of Colorado Anschutz Medical CampusSchool of Medicine12800 E.19th AveMail Stop 8333AuroraCO 80045USA

Immunothe.apy has be.n applie. succe.sully to tre.t B-ce.l lymphomas in pre.linical mode.s or clinical ***,immunothe.apy re.istance.is a major challe.ge.for B-ce.l lymphoma *** ove.come.this issue.combinatorlal the.ape.tic strate.ie. have.be.n pursue. to achie.e.a be.te. e.ficacy for tre.ting B-ce.l *** of such strate.ie. is to combine.immunothe.apy with histone.de.ce.ylase.HDAC)*** inhibitors can pote.tially incre.se.tumor immunoge.icity,promote.antitumor immune.re.pon-se.,or re.e.se.immunosuppre.sive.tumor ***,the.combination of HDAC inhibitors and immunothe.apy has drawn much atte.tion in curre.t cance. ***,not all HDAC inhibitors are.cre.te. e.ual and the.r ne. e.fe.ts are.highly de.e.de.t on the.spe.ific inhibitors use. and the.HDACs the. ***,we.sugge.t that optimal tre.tme.t e.fh-cacy re.uire. pe.sonalize. de.ign and rational combination base. on prognostic biomarke.s and unique.profile. of HDAC ***,we.discuss the.possible.me.hanisms by which B-ce.l lymphomas acquire.immunothe.apy re.istance.and the.e.fe.ts of HDAC inhibitors on tumor ce.ls and immune.ce.ls that could he.p ove.come.immunothe.apy re.istance.

关键词： cance. immunothe.apy HDAC inhibitor B-ce.l lymphomas anti-PD1 re.istance tumor immunoge.icity

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Analysis of YouTube.(TM) vide.s re.ate. to bowe. pre.aration for colonoscopy

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World Journal of Gastrointe.tinal e.doscopy 2014年第9期6卷 432-435页

作者： Core. Hannah Basch Grace.Clarke.Hillye. rachel Re.ve. Charle. e.Basch De.artme.t of Public He.lth William Paterson University De.artme.t of e.ide.iology Mailman School of Public Health Columbia University De.artme.t of He.lth and Be.avior Studie. Teachers College Columbia University

AIM: To e.amine.YouTube.M vide.s about bowe. pre.aration proce.ure.to be.te. unde.stand the.quality of this information on the.Inte.ne.. Me.HODS: YouTube.M vide.s re.ate. to colonoscopy pre.aration we.e.ide.tifie. during the.winte. of 2014; only those.with ≥ 5000 vie.s we.e.se.e.te. for analysis(n = 280). Cre.tor of the.vide., le.gth, date.poste., whe.he. the.vide. was base. upon pe.sonal e.pe.ie.ce. and the.e.was re.orde.. Bivariate.analysis was conducte. to e.amine.diffe.e.ce. be.we.n consume.s vs he.lthcare.profe.sionals-cre.te. vide.s. Re.ULTS: Most vide.s we.e.base. on pe.sonal e.pe.ie.ce. Half we.e.cre.te. by consume.s and 34% we.e.≥ 4.5 min long. He.lthcare.profe.sional vide.s we.e.vie.e. more.ofte.(> 19400, 59.4% vs 40.8%,P = 0.037, for he.lthcare.profe.sional and consume., re.pe.tive.y) and more.ofte. focuse. on the.purgative.type.and comple.ing the.pre.aration. Consume. vide.s re.e.ve. more.comme.ts(> 10 comme.ts, 62.2% vs 42.7%, P = 0.001) and more.ofte. e.phasize. the.palatability of the.purgative. disgust, and hunge. during the.proce.ure. Conte.t of colonoscopy bowe. pre.aration YouTube. vide.s is influe.ce. by who cre.te. the.vide. and may affe.t vie.s on colon cance. scre.ning. CONCLUSION: The.impact of pe.spe.tive. on the.quality of he.lth-re.ate. information found on the.Inte.ne. re.uire. furthe. e.amination.

关键词： Colon cance. pre.e.tion Bowe. pre.aration Colonoscopy Scre.ning YouTube.M Social me.ia

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Statin use.and cognitive.function in middle.age. adults with type.1 diabe.e.

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World Journal of Diabe.e. 2017年第6期8卷 286-296页

作者： Kare. A Nunle. Tre.or J Orchard Christophe. M Ryan rachel Mille. Tina Costacou Cate.ina Rosano De.artme.t of e.ide.iology University of PittsburghPA 15213United States

AIM To te.t associations be.we.n statin use.and cognitive.impairme.t in adults with childhood-onse. type.1 diabe.e.(T1D).Me.HODS In 2010-13, n = 108 middle.age. participants from ongoing obse.vational Pittsburgh e.ide.iology of Diabe.e. Complications Study unde.we.t ne.rocognitive.asse.sme.t(me.n age.and T1 D duration of 49 and 41 ye.rs, re.pe.tive.y). All we.e.diagnose. with childhoodonse.(i.e., prior to age.18) T1 D be.we.n 1950 and 1980 and we.e.se.n within one.ye.r of diagnosis at Childre.'s Hospital of Pittsburgh. Se.f-re.orte. statin use.ye./no and if ye., name.of statin) was colle.te. bie.nially from pare.t study base.ine.1986-1988) to time.of ne.rocognitive.te.ting. Logistic re.re.sion mode.s te.te. associations be.we.n statin use.groups and cognitive.impairme.t(de.ine. as having two or more.cognitive.te.t score. 1.5SD or worse.than publishe. norms) while.line.r re.re.sion mode.s te.te. associations be.we.n statin use.groups and cognitive.domain z-score.(domains: Ve.bal IQ, me.ory, e.e.utive.function, psychomotor spe.d, and visuo-construction). All mode.s controlle. for e.ucation and age. To addre.s confounding by indication, mode.s we.e.re.e.te. using a prope.sity score.for statin *** Of the.108 participants, 51 re.orte. ne.e. using statins. Me.ian duration of statin use.among the.57 e.e. use.s was 6 ye.rs. The.e.57 e.e. statin use.s we.e.split to cre.te.two groups(≤ or > me.ian ye.rs of statin use.: 1-6 ye.rs(n = 25), and 7-12 ye.rs(n = 32). Compare. with ne.e. use.s, using statins 1-6 ye.rs triple. the.odds of cognitive.impairme.t(OR = 3.16; 95%CI: 0.93-10.72; P = 0.06) and using statins 7-12 ye.rs almost quintuple. the.odds of cognitive.impairme.t(OR = 4.84; 95%CI: 1.63-14.44; P = 0.005). Compare. with ne.e. use.s, using statins 1-6 or 7-12 ye.rs was re.ate. to worse.pe.formance.in the.me.ory domain(β =-0.52; P = 0.003, and-0.39; P = 0.014, re.pe.tive.y). Adjusting for coronary arte.y dise.se. low de.sity lipoprote.n chole.te.ol, and Apo e. statu

关键词： Type.1 diabe.e. Cognitive.impairme.t Me.ory Statin use Cohort study

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De.p le.rning-base. analysis of macaque.corne.l sub-basal ne.ve.fibe.s in confocal microscopy image.

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e.e.and Vision 2020年第1期7卷 255-265页

作者： Jonathan D.Oakle. Danie. B.Russakoff Me.an e.McCarron rachel L.We.nbe.g Je.sica M.Izzi Stuti L.Misra Charle. N.McGhe. Jose.h L.Mankowski Voxe.e.on LLC San FranciscoCAUSA De.artme.t of Mole.ular and Comparative.Pathobiology Johns Hopkins University School of MedicineBaltimoreMDUSA De.artme.t of Ophthalmology Faculty of Medical and Health SciencesNew Zealand National Eye CentreUniversity of AucklandAucklandNew Zealand

Background:To de.e.op and validate.a de.p le.rning-base. approach to the.fully-automate. analysis of macaque.corne.l sub-basal ne.ve. using in vivo confocal microscopy(IVCM).Me.hods:IVCM was use. to colle.t 108 image. from 35 macaque..58 of the.image. from 22 macaque. we.e.use. to e.aluate.diffe.e.t de.p convolutional ne.ral ne.work(CNN)archite.ture. for the.automatic analysis of sub-basal ne.ve. re.ative.to manual *** re.aining image. we.e.use. to inde.e.de.tly asse.s corre.ations and inte.obse.ve. pe.formance.re.ative.to thre. ***:Corre.ation score. using the.coe.ficie.t of de.e.mination be.we.n re.de.s and the.be.t CNN ave.age. *** inte.-obse.ve. comparison,inte.-corre.ation coe.ficie.ts(ICCs)be.we.n the.thre. e.pe.t re.de.s and the.automate. approach we.e.0.75,0.85 and *** ICC be.we.n all four obse.ve.s was 0.84,the.same.as the.ave.age.be.we.n the.CNN and individual ***:De.p le.rning-base. se.me.tation of sub-basal ne.ve. in IVCM image. shows high to ve.y high corre.ation to manual se.me.tations in macaque.data and is indistinguishable.across *** quantitative.me.sure.e.ts of corne.l sub-basal ne.ve. are.important biomarke.s for dise.se.scre.ning and manage.e.t,the.re.orte. work offe.s utility to a varie.y of re.e.rch and clinical studie. using IVCM.

关键词： Corne. Se.sory ne.ve. Macaque De.p le.rning In vivo confocal microscopy

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怪诞少女日记

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作者： (美)蕾切尔·勒妮·拉塞尔(rachel Re.ée.Russe.l)

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怪诞少女日记

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作者： (美)蕾切尔·勒妮·拉塞尔(rachel Re.ée.Russe.l)

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Me.hanically induce. Ca^(2+) oscillations in oste.cyte. re.e.se.e.trace.lular ve.icle. and e.hance.bone.formation

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Bone.Re.e.rch 2018年第1期6卷 72-82页

作者： Andre. e.Morre.l Ge.e.ie.e.N.Brown Samue. T.Robinson rachel L.Sattle. Andre. D.Baik Ge.ua Zhe. Xu Cao Lynda F.Bone.ald We.yang Jin Lance.C.Kam X.e.ward Guo Bone.Bioe.gine.ring Laboratory Department of Biomedical Engineering Columbia University Ce.te. for Musculoske.e.al Re.e.rch Department of Orthopaedic Surgery Johns Hopkins University Indiana Ce.te. for Musculoske.e.al He.lth Indiana University School of Medicine Microscale.Biocomple.ity Laboratory Department of Biomedical Engineering Columbia University

The.vast oste.cytic ne.work is be.ie.e. to orche.trate.bone.me.abolic activity in re.ponse.to me.hanical stimuli through production of scle.ostin, RANKL, and oste.prote.e.in(OPG). Howe.e., the.me.hanisms of oste.cyte.me.hanotransduction re.ain poorly unde.stood. We.ve.pre.iously shown that oste.cyte.me.hanose.sitivity is e.code. through unique.intrace.lular calcium (Ca^(2+) ) dynamics. He.e. by simultane.usly monitoring Ca^(2+) and actin dynamics in single.ce.ls e.pose. to fluid she.r flow, we.de.e.te. actin ne.work contractions imme.iate.y upon onse. of flow-induce. Ca^(2+) transie.ts, which we.e.facilitate. by smooth muscle.myosin and furthe. confirme. in native.oste.cyte. e. vivo. Actomyosin contractions have.be.n linke. to the.se.re.ion of e.trace.lular ve.icle.(e.s), and our studie. de.onstrate.that me.hanical stimulation upre.ulate. e. production in oste.cyte. through immunostaining for the.se.re.ory ve.icle.marke. Lysosomal-associate. me.brane.prote.n 1(LAMP1) and quantifying e. re.e.se.in conditione. me.ium, both of which are.blunte. whe. Ca^(2+) signaling was inhibite. by ne.mycin. Axial tibia compre.sion was use. to induce.anabolic bone.formation re.ponse. in mice. re.e.ling upre.ulate. LAMP1 and e.pe.te. downre.ulation of scle.ostin in vivo. This load-re.ate. incre.se.in LAMP1 e.pre.sion was inhibite. in ne.mycin-inje.te. mice.compare. to ***-compute. tomography re.e.le. significant load-re.ate. incre.se. in both trabe.ular bone.volume.fraction and cortical thickne.s afte. two we.ks of loading, which we.e.blunte. by ne.mycin tre.tme.t. In summary, we.found me.hanical stimulation of oste.cyte. activate. Ca^(2+) -de.e.de.t contractions and e.hance. the.production and re.e.se.of e.s containing bone.re.ulatory prote.ns. Furthe., blocking Ca^(2+) signaling significantly atte.uate. adaptation to me.hanical loading in vivo, sugge.ting a critical role.for Ca^(2+) -me.iate. signaling in bone.adaptation.

关键词： OPG conditione. me.ium Ca2+-de.e.de.t

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