T cells in pancreatic cancer stroma
在胰腺的癌症基质的 T 房间作者机构：Centre for Tumour Biology Barts Cancer Institute-A CRUK Centre of ExcellenceQueen Mary University of LondonLondon EC1M 6BQUnited Kingdom Barts and the London HPB CentreThe Royal London HospitalBarts Health NHS TrustLondon E11BBUnited Kingdom Centre for Experimental Medicine and RheumatologyWilliam Harvey Research InstituteQueen Mary University of LondonLondon EC1M 6BQUnited Kingdom
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2021年第27卷第46期
页 面：7956-7968页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Barts Charity Cancer Research UK, CRUK Agency for Science, Technology and Research, A*STAR Pancreatic Cancer Research Fund, PCRF Barts Health NHS Trust
主 题：Immunosuppression T cell exhaustion Tumour microenvironment Pancreatic ductal adenocarcinoma Pancreatic cancer stroma
摘 要：Pancreatic ductal adenocarcinoma(PDAC)is a highly devastating disease with a dismal 5-year survival *** has a complex tumour microenvironment;characterised by a robust desmoplastic stroma,extensive infiltration of immunesuppressive cells such as immature myeloid cells,tumour-associated macrophages,neutrophils and regulatory T cells,and the presence of exhausted and senescent T *** cross-talk between cells in this fibrotic tumour establishes an immune-privileged microenvironment that supports tumour cell escape from immune-surveillance,disease progression and spread to distant *** tumours,considered to be non-immunogenic or cold,express low mutation burden,low infiltration of CD8+cytotoxic lymphocytes that are localised along the invasive margin of the tumour border in the surrounding fibrotic tissue,and often display an exhausted ***,we review the role of T cells in pancreatic cancer,examine the complex interactions of these crucial effector units within pancreatic cancer stroma and shed light on the increasingly attractive use of T cells as therapy.
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