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Global trends in hepatitis C-related hepatocellular carcinoma mortality:A public database analysis(1999-2019)

World Journal of Virology 2024年第1期13卷 69-83页

作者： Hassam Ali Fnu Vikash Vishali Moond Fatima Khalid Abdur Rehman Jamil Dushyant singh Dahiya Amir Humza Sohail Manesh kumar Gangwani Pratik Patel Sanjaya K Satapathy Department of Internal Medicine/Gastroenterology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Jacobi Medical Center/Albert Einstein College of MedicineBronxNY 10461United States Department of Internal Medicine Saint Peter's University Hospital/Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States Department of Internal Medicine Quaid-e-Azam Medical CollegeBahawalpur 63100PunjabPakistan Department of Internal Medicine Samaritan Medical CentreWatertownMA 13601United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Surgery New York University Winthrop HospitalNew YorkMineloaNY 11501United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Department of Gastroenterology Mather Hospital/Hofstra University Zucker School of MedicineNY 11777United States Division of Hepatology Department of MedicineNorth Shore University HospitalManhassetNY 11030United States

BACKGROUND Hepatitis C is the leading cause of chronic liver disease worldwide and it significantly contributes to the burden of hepatocellular carcinoma(HCC).However,there are marked variations in the incidence and mortality rates of HCC across different geographical *** the advent of new widely available treatment modalities,such as direct-acting antivirals,it is becoming increasingly imperative to understand the temporal and geographical trends in HCC mortality associated with Hepatitis ***,gender disparities in HCC mortality related to Hepatitis C are a crucial,yet underexplored aspect that adds to the disease's global *** some studies shed light on gender-specific trends,there is a lack of comprehensive data on global and regional mortality rates,particularly those highlighting gender *** gap in knowledge hinders the development of targeted interventions and resource allocation *** The results of our study show an overall decline in the mortality rates of patients with hepatitis C-related HCC over the last two ***,females exhibited a remarkable decrease in mortality compared to ***,East Asia and the Pacific displayed a significant decline in mortality,while Europe and Central Asia witnessed an upward *** America and the Caribbean also experienced an increase in mortality ***,no significant difference was observed in the Middle East and North *** America exhibited a notable upward *** Asia and Sub-Saharan Africa significantly declined throughout the study *** raises the hope of identifying areas for implementing more targeted *** some progress,multiple challenges remain in meeting the WHO 2030 goal of eliminating viral hepatitis[24].

关键词： Carcinoma Hepatocellular Antiviral agents Global Burden of Disease Quality indicators Health care Liver neoplasms Hepatitis C Chronic hepatitis C

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Derated Mode of Power Generation in PV System Using Modified Perturb and Observe MPPT Algorithm

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Journal of Modern Power Systems and Clean Energy 2021年第5期9卷 1183-1192页

作者： Vinit kumar Mukesh singh Thapar Institute of Engineering and Technology PatialaPunjabIndia

In a grid-integrated photovoltaic system(GIPVS),there exist issues such as surplus active power and inadequate performance of maximum power point tracking(MPPT).A surplus active power causes the overvoltage problem at the point of common coupling in low-or medium-voltage grid during the peak hours of power ***,the inadequate performance of the MPPT algorithm results in power loss due to high settling time during the sudden change of ***,to solve the surplus power problem,the curtailment of active power is suggested with improved MPPT algorithm under variable irradiance *** this paper,a derated power generation mode(DPGM)control strategy is presented for the curtailment of active ***,a drift-free(named as modified)perturb and observe(P&O)technique is also proposed to improve the performance of the MPPT ***,the DPGM control scheme with the intermediate boost converter shaves the surplus active power during the peak hours of power ***,the modified MPPT algorithm deals with the fluctuation of irradiance during non-peak ***,the proposed control scheme delivers in a more efficient system during the peak hours of power *** addition,it reduces the power loss and settling time during the change of irradiance for non-peak *** on the proposed control scheme,a 30 kW system has been simulated in MATLAB/Simulink using Simpower tools under different environmental conditions.

关键词： Derated power generation mode(DPGM) gridintegrated photovoltaic system intermediate boost converter modified perturb and observe voltage source inverter

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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit Dey Arvind K.singh Chandel Rupa Sanyal Amarnath Mishra Devendra kumar Pandey Valentina De Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

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Investigation of structural, morphological and electrochemical properties of mesoporous La2CuCoO6 rods fabricated by facile hydrothermal route

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International Journal of Minerals,Metallurgy and Materials 2020年第7期27卷 987-995页

作者： Jashandeep singh Ashok kumar Department of Physics National Institute of Technology KurukhsetraHaryana 136119India Department of Applied Sciences National Institute of Technical Teachers Training and ResearchChandigarh 160019India

This work introduces the facile hydrothermal synthesis of double perovskite La2CuCoO6.X-ray diffraction pattern confirmed the formation of a monoclinic phase with P121/c1 *** electron microscopy results revealed that the self-assembled porous rods were composed of nanocrystallite *** estimated specific surface area of these mesoporous rods with an average pore diameter of 6 nm was^41 m^2·g^–*** presence of ions with oxidation states of La^3+,Cu^2+,and Co^2+/Co^3+on the surface of the mesoporous La2CuCoO6 rods was confirmed by X-ray photoelectron spectroscopic *** cyclicvoltammetry and chronopotentiometry,the electrode fabricated from the mesoporous La2CuCoO6 rods were found to exhibit pseudocapacitive behavior with a specific capacitance of 259.4 F·g^–1 at a current density of 0.5 A·g^–***^89%retention in specific capacitance was achieved after 1000 charge/discharge cycles at a constant current density of4 A·g^–1.

关键词： rare earth double perovskites oxide materials hydrothermal electrochemical

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Multi-Objective Optimization of Fused Deposition Modeling for Mechanical Properties of Biopolymer Parts Using the Grey-Taguchi Method

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Chinese Journal of Mechanical Engineering 2023年第1期36卷 51-64页

作者： Kapil kumar Hari singh Department of Mechanical Engineering National Institute of TechnologyKurukshetra136119India

The urgent need to develop customized functional products only possible by 3D printing had realized when faced with the unavailability of medical devices like surgical instruments during the coronavirus-19 disease and the ondemand necessity to perform surgery during space *** have recently been the most appropriate option for fabricating surgical instruments via 3D printing in terms of cheaper and faster *** all 3D printing techniques,fused deposition modelling(FDM)is a low-cost and more rapid printing *** article proposes the fabrication of surgical instruments,namely,forceps and hemostat using the fused deposition modeling(FDM)*** mechanical properties are the only indicator to judge the quality of the functional *** mechanical properties of FDM-processed parts depend on various process *** parameters are layer height,infill pattern,top/bottom pattern,number of top/bottom layers,infill density,flow,number of shells,printing temperature,build plate temperature,printing speed,and fan *** strength and modulus of elasticity are chosen as evaluation indexes to ascertain the mechanical properties of polylactic acid(PLA)parts printed by *** experiments have performed through Taguchi’s L27orthogonal array(OA).Variance analysis(ANOVA)ascertains the significance of the process parameters and their percent contributions to the evaluation ***,as a multiobjective optimization technique,grey relational analysis(GRA)obtains an optimal set of FDM process parameters to fabricate the best parts with comprehensive mechanical *** electron microscopy(SEM)examines the types of defects and strong bonding between *** proposed research ensures the successful fabrication of functional surgical tools with substantial ultimate tensile strength(42.6 MPa)and modulus of elasticity(3274 MPa).

关键词： Fused deposition modeling Mechanical properties Taguchi method ANOVA Grey relational analysis SEM

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A Comprehensive Review on Preclinical Safety and Toxicity of Medicinal Plants

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 95-111页

作者： Madhav Nilakanth Mugale Kapil Dev Bhumika S.More Vaishali Sunil Mishra Kaveri R.Washimkar Kishan singh Rakesh Maurya Srikanta kumar Rath Debprasad Chattopadhyay Naibedya Chattopadhyay Division of Toxicology and Experimental Medicine CSIR-Central Drug Research Institute(CSIR-CDRI)Lucknow 226031India Division of Phytochemistry CSIR-Central Institute of Medicinal and Aromatic Plants(CSIR-CIMAP)Lucknow 226015India Medicinal and Process Chemistry Division CSIR-CDRI Lucknow 226031India Division of Endocrinology CSIR-CDRI Lucknow 226031India Division of Ethnomedicine ICMR-National Institute of Traditional MedicineNehru NagarBelagavi 590010and ICMR-Virus UnitKolkata 700010India Department of Health Research NSHM Knowledge CampusKolkata 700051India

Background:Globally,80%people use plant-derived products for treating or preventing *** prevalent perception about medicinal plants is that they are safe and devoid of adverse ***,approximately 1,50,000 plants contain toxic ***:The present review focuses on medicinal plant extracts/fractions toxicity assessments made in preclin-ical models by oral ***:Detail studies were searched from databases including PubMed and Google Scholar.A manual reference screening of the selected studies was done to identify relevant articles,with no language restriction being imposed at the time of ***:The studies included were performed in rodents,and the test substances were administered *** search revealed 33 widely used plants or products with significant toxicity,and phytochemicals from these plants have been *** a systematic review,we identified a plethora of medicinal plant extracts reporting safety and toxicity ***:In the future,preclinical toxicokinetic studies of herbs and the determination of their no-observed-adverse-effect levels are required for a complete safety ***,the interaction of herbs with com-monly used/over-the-counter drugs in terms of the latter’s metabolic profile should be undertaken.

关键词： Extract Herbal medicine Toxicity Rodent Secondary metabolite

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Optical anisotropy and the direction of polarization of exciton emissions in a semiconductor quantum dot:Effect of heavy-and light-hole mixing

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Chinese Physics B 2017年第8期26卷 400-406页

作者： Ranber singh Rajiv kumar Vikramjeet singh Department of Physics Sri Guru Gobind Singh CollegeSector 26Chandigarh 160019India Department of Physics DAV University JalandharPunjab 144012India IKGPTU Campus HoshiarpurPunjab 146001India

The dependence of the directions of polarization of exciton emissions, fine structure splittings （FSS）, and polarization anisotropy on the light- and heavy-hole （LH-HH） mixing in semiconductor quantum dots （QDs） is investigated using a mesoscopic model. In general, all QDs have a four-fold exciton ground state. Two exciton states have directions of polarization in the growth-plane, while the other two are along the growth direction of the QD. The LH-HH mixing does affect the FSS and polarization anisotropy of bright exciton states in the growth-plane in the low symmetry QDs （e.g., C2v, CS, C1 ）, while it has no effect on the FSS and polarization anisotropy in high symmetry QDs （e.g., C3V, D2d）. When the hole ground state is pure HH or LH, the bright exciton states in the growth-plane are normal to each other. The LH-HH mixing affects the relative intensities and directions of bright exciton states in the growth-plane of the QD. The polarization anisotropy of exciton emissions in the growth-plane of the QD is independent of the phase angle of LH-HH mixing but strongly depends on the magnitude of LH-HH mixing in low symmetry QDs.

关键词： light-heavy hole mixing excitons quantum dots

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Investigation of 58Ni(n, p)58Co reaction cross-section with covariance analysis

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Chinese Physics C 2024年第2期48卷 78-90页

作者： Akash Hingu S.Mukherjee Siddharth Parashari Arora Sangeeta A.Gandhi Mahima Upadhyay Mahesh Choudhary Sumit Bamal Namrata singh G.Mishra Sukanya De Saurav Sood Sajin Prasad G.Saxena Ajay kumar R.G.Thomas B.K.Agrawal K.Katovsky A.kumar Department of Physics Faculty of ScienceThe M.S.University of BarodaVadodara 390002India Faculty of Electrical Engineering and Communication Brno University of TechnologyBrnoCzech Republic Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.32Zagreb 10000Croatia Department of Physics University Institute of SciencesChandigarh UniversityGharuanMohali 140413PunjabIndia Department of Physics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei National Institute for Physics and Nuclear Engineering Măgurele 077125Romania Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Health Physics Division Bhabha Atomic Research CentreMumbai 400085India Department of Physics(H&S) Government Women Engineering CollegeAjmer 305002India Saha Institute of Nuclear Physics Kolkata 700064India Homi Bhabha National Institute Anushakti NagarMumbai 400094India

The excitation function of the 58Ni(n,p)58Co reaction was measured using the well-established neutron activation technique andγ-ray *** in the energy range of 1.7 to 2.7 MeV were generated using the 7Li(p,n)*** neutron flux was measured using the standard 115In(n,n’)115mIn monitor *** results of the neutron spectrum averaged cross-section of 58Ni(n,p)58Co reactions were compared with existing cross-section data available in the EXFOR data library as well as with various evaluated data libraries such as ENDF/B-VIII.0,JEFF-3.3,JENDL-4.0,and *** calculations were performed using the nuclear reaction code *** nuclear level density(NLD)models were tested,and their results were compared with the present *** NLDs were also obtained through the spectral distribution method(SDM).The cross-section results,along with the absolute errors,were obtained by investigating the uncertainty propagation and using the covariance *** forγ-ray true coincidence summing,low-energy background neutrons,andγ-ray self attenuation were *** experimental cross-section obtained in the present study is consistent with previously published experimental data,evaluated libraries,and theoretical calculations carried out using the TALYS code.

关键词： nuclear reactions (n,p)reaction cross-section measurement covariance analysis nuclear level density

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Information hiding with adaptive steganography based on novel fuzzy edge identification

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Defence Technology（防务技术） 2019年第2期15卷 162-169页

作者： Sanjeev kumar Amarpal singh Manoj kumar I.K.G Punjab Technical University Department of ECE Beant College of Engineering & Technology DAV Institute of Engineering & Technology

The evolution in communication techniques has created wide threats for crucial information transfer through a communication channel. Covert communication with steganography is a skill of concealing secret information within cover object and hence shields the data theft over rapidly growing ***, diverse steganography techniques using edge identification have been proposed in *** methods however utilize certain pixels in the cover image for inserting edge information,resulting in significant deformation. The conventional edge detection method limits the deployment of edge detection in steganography as concealing the information would introduce some variations to the cover image. Hence inserting data in pixel areas recognized by existing conventional edge detection techniques like canny cannot ensure the recognition of the exact edge locations for the cover and stego images. In this paper, an Adaptive steganography method based on novel fuzzy edge identification is proposed. The method proposed is proficient of estimating the precise edge areas of a cover image and also ensures the exact edge location after embedding the secret message. Experimental results reveal that the technique has attained good imperceptibility compared to the Hayat AI-Dmour and Ahmed AIAni Edge XOR method in spatial domain.

关键词： Information security Adaptive steganography Fuzzy edge detection Pattern recognition

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Grid Tied Solar PV System with Power Quality Enhancement Using Adaptive Generalized Maximum Versoria Criterion

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CSEE Journal of Power and Energy Systems 2023年第2期9卷 722-732页

作者： Manoj Badoni Alka singh Ankit kumar singh Hemant Saxena Rajeev kumar Delhi Technological University Delhi 110042India.A.K.Singh is with Netaji Subhas University of TechnologyDelhi 110078India Netaji Subhas University of Technology Delhi 110078India Electrical and Electronics Engineering Department KIET Group of InstitutionsGhaziabadIndia Electrical Engineering Department Jamia Millia IslamiaNew DelhiIndia

A three phase grid tied solar photovoltaic(PV)system with power quality compensation features is presented in this *** system is used to transfer power generated from a solar PV array to feed linear and nonlinear loads along with compensation for several power quality(PQ)issues,such as harmonics,redundant reactive power and load *** generated DC power from the PV array is converted into AC by implementing a three-phase voltage source converter(VSC).In order to transfer active power and mitigate PQ problems,an efficient control technique is required for the grid tied solar PV *** study presents the use of an adaptive generalized maximum Versoria criterion(AGMVC)controller for VSC used in a solar PV energy conversion *** utilization of the solar PV array is accomplished by using the Perturb and Observe based maximum power point tracking(MPPT)*** experimental setup of the grid integrated PV system is implemented in the laboratory using an IGBT based VSC and DSP(dSPACE DS-1202).The performance of the AGMVC control technique is verified experimentally using laboratory *** control technique is compared with different conventional controllers,such as synchronous reference frame theory(SRFT)and instantaneous reactive power theory(IRPT)along with recently developed weight-based controllers viz.,least mean square(LMS),least mean mixed norm(LMMN)and normalized kernel least mean fourth-neural network(NKLMFNN).Numerous terms,such as fundamental weight convergence,steady state error,computational complexity,phase lock loop(PLL)requirement and harmonic compensation capability,are considered for comparison purposes of AGMVC with the above listed control *** system performance is verified according to the IEEE-519 standard.

关键词： Harmonics maximum versoria criterion power factor corection(PFC) solar photovoltaic

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