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基于Dueling DQN算法的列车运行图节能优化研究

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都市快轨交通 2024年第2期37卷 39-46页

作者：刘飞唐方慧刘琳婷胡文斌哈进兵钱程苏州市轨道交通集团有限公司运营管理中心江苏苏州215101 南京理工大学南京210014

通过优化地铁时刻表可有效降低地铁牵引能耗。为解决客流波动和车辆延误对实际节能率影响的问题,提出列车牵引和供电系统实时潮流计算分析模型和基于Dueling Deep Q Network(Dueling DQN)深度强化学习算法相结合的运行图节能优化方法,... 详细信息

通过优化地铁时刻表可有效降低地铁牵引能耗。为解决客流波动和车辆延误对实际节能率影响的问题,提出列车牵引和供电系统实时潮流计算分析模型和基于Dueling Deep Q Network(Dueling DQN)深度强化学习算法相结合的运行图节能优化方法,建立基于区间动态客流概率统计的时刻表迭代优化模型,降低动态客流变化对节能率的影响。对预测Q网络和目标Q网络分别选取自适应时刻估计和均方根反向传播方法,提高模型收敛快速性,同时以时刻表优化前、后总运行时间不变、乘客换乘时间和等待时间最小为优化目标,实现节能时刻表无感切换。以苏州轨道交通4号线为例验证方法的有效性,节能对比试验结果表明:在到达换乘站时刻偏差不超过2 s和列车全周转运行时间不变的前提下,列车牵引节能率达5.27%,车公里能耗下降4.99%。

关键词：城市轨道交通时刻表优化牵引节能 Dueling DQN 动态客流

伊尔加兹山脉冰缘地貌发育和土壤形成及其气候的影响(土耳其黑海西岸)

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Journal of Geographical Sciences 2024年第3期34卷 543-570页

作者： DEDE Volkan DENGIZ Orhan DEMIraG TUraN inci TüRKES Murat SENOL Hüseyin SERIN Soner Department of Geography Ardahan UniversityArdahan75002Türkiye Department of Soil Science and Plant Nutrition Faculty of AgricultureOndokuz Mayıs UniversitySamsun55139Türkiye Department of Geography Faculty of Human and Social SciencesSamsun UniversitySamsun55080Türkiye Center for Climate Change and Policy Studies Boğaziçi Universityİstanbul34342Türkiye Faculty of Agriculture Department of Soil Science and Plant NutritionIsparta University of Applied SciencesIsparta32200Türkiye Institute of Social Sciences İstanbul Universityİstanbul34119Türkiye

The main aims of the current study are to determine the morphological features of the periglacial landforms(non-sorted step,mud circle,stony earth circle,thufur,and congeliturbation)located on the Ilgaz Mountains,examine the physicochemical and mineralogical properties with pedological processes of the soils,and assess of the effects of climatic conditions controlling the development of *** Ilgaz Mountains(2587 m a.s.l.),located in the Western Black Sea Region,within the Anatolian Mountains,are important in terms of periglacial landforms(mud circles,stony earth circles,thufurs,non-sorted steps,non-sorted stripes,congeliturbation deposits,and block currents).The descriptive statistics of 123 periglacial landforms measured by fieldworks were *** distribution of freezing and thawing in the Ilgaz Mountains throughout the year was evaluated,and it was found that freezing takes place between December and March,freezing-thawing takes place in April,May,October and November,and thawing takes place between June and *** to soil properties,organic matter content changes from 1.88%to 12.72%in non-sorted step soils,while it is between 2.03%and 12.24%in stony earth circle *** organic matter is observed to be close to congeliturbation deposits at lower ratios compared to non-sorted steps,stony earth circles and mud *** soil reactions on stony earth circles and non-sorted steps vary between slightly acidic and slightly *** the other hand,soil samples taken from the mud circles are different from those taken from the non-sorted steps and stony earth *** soil reaction is acidic,and pH changes between 4.86 and *** lime content also varies between 2.81%and 32.08%,with an average of 12.02%.The texture properties of soils are dominantly loam and clay loam,as in the non-sorted steps,stony earth circles,and mud *** their mineralogical properties,the XRD study was carried out to determine the primer mineral

关键词： periglacial landforms soil formation climate effect Ilgaz Mountains Türkiye

基于多组学技术的青少年特发性脊柱侧凸病因学研究进展

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中国脊柱脊髓杂志 2024年第5期34卷 540-547页

作者：李洺杨一卓宋哈楠徐帅史伟豪许玉雄张岩于彦丽首都体育学院体医融合创新中心北京市100191 北京大学人民医院脊柱外科北京市100044

青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)是一种以结构性侧凸、轴向旋转和矢状面畸形为特征的三维脊柱畸形,它是青少年脊柱畸形中最常见的疾病,全球患病率约为0.47%~5.2%[1]。在青春期,AIS可随患者年龄的增长逐渐加... 详细信息

青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)是一种以结构性侧凸、轴向旋转和矢状面畸形为特征的三维脊柱畸形,它是青少年脊柱畸形中最常见的疾病,全球患病率约为0.47%~5.2%[1]。在青春期,AIS可随患者年龄的增长逐渐加重,导致生活质量下降,并给家庭和社会带来巨大的经济负担。因此,确定AIS的病因和病理生理机制是进一步认识本病、及时诊断治疗和科学预防的关键。

关键词：病理生理机制脊柱畸形青少年特发性脊柱侧凸病因学研究组学技术科学预防及时诊断矢状面

肠道菌群代谢产物氧化三甲胺对肾小球系膜细胞和肾小管上皮细胞NF-κB/MAPK信号通路的影响

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中国生物制品学杂志 2024年第8期37卷 932-937页

作者：宋月娟杨波冯强生哈小琴联勤保障部队第九四○医院检验科甘肃兰州730050

目的探讨肠道菌群代谢产物氧化三甲胺(trimethylamine oxide,TMAO)对人肾小球系膜细胞HMC和肾小管上皮细胞HK-2核因子-κB(nuclear factor-kappa B,NF-κB)/丝裂原活化蛋白激酶(mitogen activated protein kinase,MAPK)信号通路的影响,为通过肠道菌群治疗和预防肾损伤提供理论依据。方法用TMAO处理HMC和HK-2细胞,并设未处理或TMAO处理0 h对照组,Real-time PCR法检测炎性反应因子MCP-1、IL-6、TNF-α和IL-1β基因mRNA的转录水平,Western blot法检测NF-κB和MAPK信号通路相关蛋白的表达。并用NF-κB抑制剂BAY11-7082处理HMC和HK-2细胞,验证TMAO的促炎作用。结果与对照组相比,HMC和HK-2细胞TMAO处理组炎性反应因子MCP-1、IL-6、TNF-α和IL-1βmRNA转录水平均明显上升(t=33.349,P=0.001),TMAO对两种细胞有明显的促炎作用;TMAO可激活HMC和HK-2细胞的NF-κB及MAPK信号通路,引起炎性反应,造成对肾脏的损伤。结论TMAO含量的增高可激活HMC和HK-2细胞NF-κB/MAPK信号通路,刺激两种细胞释放炎性反应因子,从而导致肾损伤的发生和发展。

关键词：氧化三甲胺肾损伤信号通路人肾小球系膜细胞人肾小管上皮细胞

Planar dual-polarized millimeter-wave shared-aperture array antenna with high band isolation

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Frontiers of Information Technology & Electronic Engineering 2022年第10期23卷 1568-1578页

作者： Yuyan CAO Zijun GUO Zhangcheng ha State Key Lab of Millimeter Waves School of Information Science and EngineeringSoutheast UniversityNanjing 210096China Frontiers Science Center for Mobile Information Communication and Security Southeast UniversityNanjing 210096China Purple Mountain Laboratories Nanjing 211111

A planar millimeter-wave shared-aperture array antenna is proposed and designed in this *** composing the substrate integrated waveguide(SIW)and the stripline,the K-band antenna is embedded inside the Ka-band antenna to achieve a smaller size and a low profile by sharing an *** Ka-band antenna radiates through the parallel slot pairs on the surface of the SIW cavities with horizontal polar‐ization,while the K-band antenna radiates through the butterfly-shaped slots with vertical polarization,which are also designed on the *** the two array antennas can radiate by sharing a common ap‐erture with high *** verify this idea,a proto‐type of an 8×8 shared-aperture array antenna has been designed with center frequencies of 19 and 30 GHz and fabricated using multilayer printed circuit board(PCB)technology.

关键词： antenna millimeter polarization

Vertically aligned nanocomposite films by self-assembled epitaxial nucleation for super-broadband transparent conductors

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InfoMat 2023年第4期5卷 14-24页

作者： Youngkyoung ha Judith L.MacManus-Driscoll Shinbuhm Lee Department of Physics and Chemistry DGISTDaeguRepublic of Korea Department of Emerging Materials Science DGISTDaeguRepublic of Korea Department of Materials Science and Metallurgy University of CambridgeCambridgeUK

Designing super-broadband transparent conductors is challenging because of the exclusive nature of conductivity and infrared ***,using a one-step process,we created vertically aligned nanocomposite conducting films with high transparency across a super-broad wavelength *** aligned transparent Ba_(3)V_(2)O_(8)nanocolumns with lateral-100-nm widths enable high transmittance(>50%,even at a 4-μm wavelength)for all incident light and outperform that of Sn-doped In_(2)O_(3),while the conducting SrVO_(3)matrix retains low resistivity(rature).A combined study of scanning transmission electron microscopy,scattering scanning nearfield infrared microscopy,and X-ray diffraction revealed that spontaneous phase separation of Ba_(3)V_(2)O_(8)nanocolumns in a SrVO_(3)matrix film occurs via self-assembled epitaxial *** vertically aligned nanocomposite films provide a fertile platform for next-generation optoelectronics.

关键词： epitaxial nucleation spontaneous phase separation SrVO_(3)-Ba_(3)V_(2)O_(8) super-broadband transparent conductors vertically aligned nanocomposite films

Convolutional Neural Network-Based Regression for Predicting the Chloride Ion Diffusion Coefficient of Concrete

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Computers, Materials & Continua 2022年第3期70卷 5059-5071页

作者： Hyun Kyu Shin ha Young Kim Sang Hyo Lee Architectural Engineering Hanyang University ERICAAnsan15588Korea Graduate School of Information Yonsei UniversitySeoul03722Korea Division of Smart Convergence Engineering Hanyang University ERICAAnsan15588Korea

The durability performance of reinforced concrete(RC)building structures is significantly affected by the corrosion of the steel reinforcement due to chloride penetration,thus,the chloride ion diffusion coefficient should be investigated through experiments or theoretical equations to assess the durability of an RC *** study aims to predict the chloride ion diffusion coefficient of concrete,a heterogeneous material.A convolutional neural network(CNN)-based regression model that learns the condition of the concrete surface through deep learning,is developed to efficiently obtain the chloride ion diffusion *** the model implementation to determine the chloride ion diffusion coefficient,concrete mixes with w/c ratios of 0.33,0.40,0.46,0.50,0.62,and 0.68,are cured for 28 days;subsequently,the surface image data of the specimens are ***,the proposed model predicts the chloride ion diffusion coefficient using the concrete surface image data and exhibits an error of approximately 1.5E−12 m^(2)/*** results suggest the applicability of proposed model to the field of facility maintenance for estimating the chloride ion diffusion coefficient of concrete using images.

关键词： Chloride ion diffusion coefficient convolutional neural network deep learning

电针治疗结直肠癌腹腔镜术后肠麻痹患者疗效研究

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湖北中医药大学学报 2024年第3期26卷 88-91页

作者：吉怕伍哈子魏寿江川北医学院附属医院胃肠外一科四川南充637100

目的观察电针治疗结直肠癌腹腔镜术后肠麻痹患者的效果。方法将我院结直肠癌腹腔镜术后肠麻痹患者251例随机分为对照组126例与治疗组125例。对照组行单孔+1腹腔镜结直肠癌根治术,治疗组在单孔+1腹腔镜结直肠癌根治术后应用电针。比较两... 详细信息

目的观察电针治疗结直肠癌腹腔镜术后肠麻痹患者的效果。方法将我院结直肠癌腹腔镜术后肠麻痹患者251例随机分为对照组126例与治疗组125例。对照组行单孔+1腹腔镜结直肠癌根治术,治疗组在单孔+1腹腔镜结直肠癌根治术后应用电针。比较两组临床疗效,记录首次排便、排气、进食时间,检测白细胞计数(WBC)、淀粉样蛋白A(SAA)、C反应蛋白(CRP)水平,比较Prince-Henry疼痛评分、胃肠道症状分级量表(GSRS)评分。结果治疗后,治疗组总有效率高于对照组(P0.05),术后第3天两组WBC、SAA、CRP水平低于术后第1天,治疗组WBC、SAA、CRP水平低于对照组(P0.05);术后第3天两组Prince-Henry、GSRS评分低于术后第1天,治疗组Prince-Henry、GSRS评分低于对照组(P<0.05)。结论电针治疗结直肠癌腹腔镜术后肠麻痹能够促进胃肠功能恢复,降低炎性因子,减轻疼痛,改善胃肠道症状。

关键词：结直肠癌腹腔镜肠麻痹电针

依托咪酯中/长链脂肪乳注射液生物等效性研究设计的一般考虑

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中国临床药理学杂志 2024年第10期40卷 1541-1544页

作者：安娜李栋刘力力李芳哈莉莉任曼茹周誉国家药品监督管理局药品审评中心北京100076

依托咪酯通过可逆性地阻断11-β-羟化类固醇脱氢酶,从而抑制肾上腺细胞合成皮质醇。本品为特殊注射剂,在评估仿制药与参比制剂质量和疗效一致时,应在药学及非临床一致性的基础上,用逐步递进研究策略,首先进行人体生物等效性(BE)研究。... 详细信息

依托咪酯通过可逆性地阻断11-β-羟化类固醇脱氢酶,从而抑制肾上腺细胞合成皮质醇。本品为特殊注射剂,在评估仿制药与参比制剂质量和疗效一致时,应在药学及非临床一致性的基础上,用逐步递进研究策略,首先进行人体生物等效性(BE)研究。在BE研究中需对研究类型、给药剂量和方法、BE评价、安全性监测、药效学(PD)评价等方面进行充分考虑与合理设计。本文结合依托咪酯中/长链脂肪乳注射液的药代动力学(PK)特征,并基于其仿制药在国内上市前所开展的BE研究实例,系统探讨了本品BE研究的一般设计要求及相关考虑,旨在为国内仿制药的研发工作提供有益的参考和指导。

关键词：依托咪酯仿制药生物等效性研究安全性