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A Retrospective Analysis of intoxicated Patients Admitted to the intensive Care Unit: A Single-institution Assessment in the Post-Pandemic Period

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Journal of Biosciences and medicines 2024年第3期12卷 159-167页

作者： müge Arikan Abdullah Yeşilkaya Büşra Nur taşdelen ibrahim Özyiğit Department of Anesthesia and intensive Care Faculty of Medicine Karabuk University Karabuk Turkey

Background: The aim of this study was to evaluate the clinical and epidemiological characteristics of patients with acute intoxication admitted to the intensive Care Unit (iCU). material and methods: An observational retrospective study was conducted on intoxicated patients who admitted to iCU between January 2022 and January 2024. Data were collected from the patients medical records. The demographic characteristics, causes of intoxications, clinical parameters, the mean stay in the iCU, treatment modalities and prognosis were recorded. Results: A total of 2875 critically ill patients were admitted during the study period, and 109 (3.79%) of them were acute intoxications. Their mean of ages was 38.09 ± 12.29. The female-to-male ratio was 1.37/1. Drugs were found to be the primary cause (62.39%) of intoxications, and analgesics, antidepressants, and antibiotics were the most frequent agents. Suicidal attempts were present in 66 patients, most of them were female (62.13%) and between 17 - 24 years (40.91%). The other common causes of intoxications were carbon monoxide (CO) (22.02%), methyl/ethyl alcohol (8.26%) and mushroom (5.50%). The mean stay in the iCU was 2.69 ± 0.89 days. mechanical ventilation was applied to 10 of our patients. Renal replacement therapy was required in 6 patients. Despite all treatments, 6 of our patients died, and we found the mortality rate to be 5.50%. Conclusion: intoxications were more frequent in young female patients and drugs were the most common cause with suicidal intent. Unfortunately, CO poisoning continues to be a very important problem in our city. These findings provided significant information about the characteristics of intoxications in Karabuk.

关键词： intoxication intensive Care Unit Suicidal mortality

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intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease

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World Journal of Gastroenterology 2012年第25期18卷 3254-3259页

作者： Kriszta molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos mária Papp András Arató Gábor Veres First Department of Pediatrics Semmelweis UniversityH-1083 BudapestHungary Research Group for Pediatrics and Nephrology Semmelweis University and Hungarian Academy of SciencesH-1083 BudapestHungary SE-mta "Lendulet" Diabetes Research Group H-1083 BudapestHungary Second Department of Pathology Semmelweis UniversityH-1091 BudapestHungary First Department of medicine Semmelweis UniversityH-1083 BudapestHungary Second Department of medicine University of Debrecen H-4032 Debrecen Hungary

Aim： To investigate intestinal alkaline phosphatase （iAP） in the intestinal mucosa of children with inflammatory bowel disease （iBD）. mETHODS： Colonic biopsy samples were taken from 15 newly diagnosed iBD patients and from 10 healthy controls. in iBD patients, specimens were obtainedboth from inflamed and non-inflamed areas. The lAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis, respectively. Tissue localiza- tion of lAP and Toll-like receptor （TLR） 4 was investi- gated by immunofluorescent staining. RESULTS： The lAP protein level in the inflamed muco- sa of children with Crohn＇s disease （CD） and ulcerative colitis （UC） was significantly decreased when compared with controls （both P 〈 0.05）. Similarly, we found a significantly decreased level of lAP protein in the in- flamed mucosa in CD compared with non-inflamed mucosa in CD （P 〈 0.05）. in addition, the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD （P 〈 0.05）. lAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls, lAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significant- ly different from that in non-inflamed colonic mucosa with CD. Expression of lAP mRNA in patients with non- inflamed mucosa and in controls were similar. Co-local- ization of lAP with TLR4 showed intense staining with a dotted-like pattern, lAP was present in the inflamed and non-inflamed mucosa of patients with CD, UC, and in control biopsy specimens, irrespective of whether it was present in the terminal ileum or in the colon. However, the fluorescent signal of TLR4 was more pro- nounced in the colon compared with the terminal ileum in all groups studied. CONCLUSiON： Lower than normal lAP protein levels in inflamed mucosa of iBD patients may indicate a role for lAP in inflammatory lesions in iBD. Based on our r

关键词： intestinal alkaline phosphatase Toll-like recep-tor Colonic biopsy Children inflammatory bowel disease

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Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

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World Journal of Pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner mátyás Vidermann Péter Filotás Réka Szalkai-Dénes istván Szegedi Katalin Bartyik Krisztina míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss miklós Garami istván Peták Oncompass medicine Hungary Kft Retek Str.34Budapest 1024Hungary Division of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of Paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary Department of Pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHiVA01 clinical *** aim of this study was to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(involved in our precision oncology program,and samples from 100 patients were eligible for further *** or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision ***,a molecular tumor board(mTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of WES results for targeted panels missed important mutations affecting therapy *** DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support Pediatric tumors Precision oncology Tumor board

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Resource Allocation Based on SFLA Algorithm for D2D multicast Communications

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Computer Systems Science & Engineering 2023年第5期45卷 1517-1530页

作者： Wisam Hayder mahdi Necmi taşpınar University of Diyala Department of Communications EngineeringDiyalaBaquba32001Iraq Erciyes University Department of Electrical and Electronics EngineeringKayseri38039Turkey

multicast device-to-device(D2D)communication technology is considered as one of the new technologies in the fifth generation(5G)networks that directly addresses the need for content sharing among internet *** fact,when direct communication is available between devices,the spectral efficiency is improved by reusing the licensed cellular *** current studies show that D2D communication increases network capacity and reduces *** order to achieve the alternate capabilities,coordination is required to implement interference *** considered subcarrier allocation for the uplink,in addition to the power control that takes place on the underlay *** completed data rate in single multicast communication is significantly reduced and limited by nodes with lower channel *** this paper,we used Shuffled Frog Leaping Algorithm(SFLA)for resource allocation(ra)in D2D multicast *** compared the results of the SFLA algorithm with the Firefly Algorithm(FA),Ant Colony Optimization(ACO)and Particle Swarm Optimization(PSO);in terms of D2D user throughput,Cellular User(CU)throughput,network average throughput,network interference and signal interference noise ratio(SiNR)*** simulation results show that SFLA clearly outperforms other algorithms in terms of data rate under the high pressure of infeasibility.

关键词： Resource Allocation(ra) SFLA D2D 5G

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Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer

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World Journal of Gastroenterology 2016年第35期22卷 7951-7962页

作者： Kelly Cristina da Silva Oliveira taíssa maíra Thomaz Araújo Camila inagaki Albuquerque Gabriela Alcantara Bara.a.Carolina Oliveira Gigek mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel mário Rodriguez Burbano marília Cardoso Smith Danielle Queiroz Calcagno Núcleo de Pesquisas em Oncologia Universidade Federal do Pará Hospital Universitário Joao de Barros Barreto Disciplina de Genética Departamento de Morfologia e Genética Universidade Federal de Sao Paulo Laboratório de Citogenética Humana Instituto de Ciências Biológicas Universidade Federal do Pará

Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. in this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity.

关键词： Gastric cancer Epigenetic Diagnostic biomarkers miRNAs Prognostic biomarkers

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脑脊液和血清降钙素原在脑室外引流置管术后评估颅内感染风险的临床价值

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赣南医学院学报 2019年第1期39卷 42-45页

作者：胡伟康陈国永杨志勇陈学华冯伟文吴润华塔拉东莞市第五人民医院广东东莞523900

目的:分析脑脊液和血清降钙素原在脑室外引流置管术后评估颅内感染风险的临床价值。方法:选择2017年2月至2018年10月神经科接诊的110例自发性脑出血患者。患者均接受脑室引流治疗,分别于手术时、术后1 d、术后7 d、术后14 d抽取静脉血2 ... 详细信息

目的:分析脑脊液和血清降钙素原在脑室外引流置管术后评估颅内感染风险的临床价值。方法:选择2017年2月至2018年10月神经科接诊的110例自发性脑出血患者。患者均接受脑室引流治疗,分别于手术时、术后1 d、术后7 d、术后14 d抽取静脉血2 m L,且通过脑室导管收集脑脊液5 m L。对比不同时间脑脊液降钙素原(PCT)变化,并分析各指标之间的相关性。结果:随着脑室导管留置时间的延长,患者脑脊液PCT和WBC,血清PCT和WBC均呈现明显的升高趋势(P 0. 05)。结论:脑脊液和血清降钙素原对脑室导管留置时间有重要的指导价值,最大限度发挥脑脊液的引流作用,有助于提升脑室出血疾病的救治效果。

关键词：脑脊液降钙素原脑出血颅内感染 WBC

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metasomatism-induced wehrlite formation in the upper mantle beneath the Nógrád-G?m?r Volcanic Field(Northern Pannonian Basin):Evidence from xenoliths

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Geoscience Frontiers 2020年第3期11卷 943-964页

作者： Levente Patko Nora Liptai Laszlo Elod Aradi Rita Klebesz Eszter Sendula Robert J.Bodnar istvan Janos Kovacs Karoly Hidas Bernardo Cesare Attila Novak Balazs Trasy Csaba Szabo Lithosphere Fluid Research Lab Institute of Geography and Earth SciencesEotvos Lor and UniversityBudapestHungary isotope Climatology and Environmental Research Centre Institute for Nuclear ResearchHungarian Academy of SciencesDebrecenHungary CCFS-GEmOC Department of Earth and Planetary SciencesMacquarie UniversitySydneyAustralia Geodetic and Geophysical institute Research Centre for Astronomy and Earth SciencesHungarian Academy of SciencesSopronHungary Fluids Research Laboratory Department of GeosciencesVirginia TechBlacksburgVAUnited States mta CSFK Lendület Pannon LitH2Oscope Research Group Geodetic and Geophysical InstituteResearch Centre for Astronomy and Earth SciencesHungarian Academy of SciencesSopronHungary instituto Andaluz de Ciencias de La Tierra CSIC&UGRArmillaGranadaSpain Department of Geosciences University of PaduaPaduaItaly Department of Geology Eotvos Lorand UniversityBudapestHungary

Clinopyroxene-enriched upper mantle xenoliths classified as wehrlites are common(~20% of all xenoliths) in the central part of the Nograd-G(o| ")m(o|")r Volcanic Field(NGVF),situated in the northern margin of the Pannonian Basin in northern Hungary and southern *** this study,we thoroughly investigated 12 wehrlite xenoliths,two from each wehrlite-bearing occurrence,to determine the conditions of their *** textural features,including clinopyroxene-rich patches in an olivine-rich lithology,orthopyroxene remnants in the cores of newlyformed clinopyroxenes and vermicular spinel forms all suggest that wehrlites were formed as a result of intensive interaction between a metasomatic agent and the peridotite wall *** on the major and trace element geochemistry of the rock-forming minerals,significant enrichment in basaltic(Fe,mn,Ti) and high field strength elements(Nb,ta,Hf,Zr) was observed,compared to compositions of common lherzolite *** presence of orthopyroxene remnants and geochemical trends in rock-forming minerals suggest that the metasomatic process ceased before complete wehrlitization was *** composition of the metasomatic agent is interpreted to be a mafic silicate melt,which was further confirmed by numerical modelling of trace elements using the plate *** model results also show that the melt/rock ratio played a key role in the degree of petrographic and geochemical *** lack of equilibrium and the conclusions drawn by using variable lherzolitic precursors in the model both suggest that wehrlitization was the last event that occurred shortly before xenolith entrainment in the host mafic *** suggest that the wehrlitization and the Plio-Pleistocene basaltic volcanism are related to the same magmatic event.

关键词： Wehrlite xenoliths Upper mantle metasomatism mafic silicate melt Trace element modelling

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Rotational and translational domains of beta precipitate in aged binary mg-Ce alloys

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Journal of magnesium and Alloys 2021年第3期9卷 1039-1056页

作者： B.Z.Sun H.X.Zhang Y.Dong J.X.Ren Y.Tian G.m.Xie J.tan Y.H.Sun Na Xiao School of materials Science and Engineering Northeastern UniversityShenyang 110819China State Key Lab Rolling&Automat Northeastern UniversityShenyang 110819China Key Laboratory for Anisotropy and Texture of materials Ministry of EducationNortheastern UniversityShenyang 110819China Analytical and Testing Center Northeastern UniversityShenyang 110819China

The structural evolution fromβ_(1)(mg_(3)Ce)toβ(mg_(12)Ce)precipitates,which takes place at the over-aged stage of binary mg-Ce alloys,are investigated by high-angle annular dark-field scanning transmission electron *** structural transformation mainly occurs in the{111}_(β1)crystallographic planes,where the newly formedβlattices exhibit two categories of domain structures,namely rotational and translational *** rotational domain is composed of threeβdomains(β_(ra),β_(RB)andβ_(RC)),which are related by a 120°rotation with respect to each other around the 111_(β1)axis of theirβ_(1)parent ***{111}_(β1)crystallographic planes can provide four sets of sublattices with the same orientation for an initial nucleation ofβ*** leads to the formation of four translationalβdomains(β_(ta),β_(TB),β_(TC)andβ_(TD)),among which any two differ by a vector of 1/6112_(β1).We deduce theoretically that there exist twenty-fourβdomains during this ***,considering the interfacial misfit,only one-third of domains can grow up and eventually formsβ***,a majority ofβribbons overlap partiallyβ_(1)plate,which is beneficial to relax interfacial strain amongβ,β_(1)andα-mg matrix(α/β/β_(1)).The configuration of multipleβdomains can effectively regulate interfacial misfit ofα/βandβ/β_(1),which are responsible for enhancing the hardness and strength of mg-Ce ***,this study aims to provide some clues to improve the over-aged performance of magnesium alloys by constructingβdomains and optimizing theα/β/β_(1)interface.

关键词： magnesium alloys HAADF-STEm Rotational domain Translational domain Phase transition interfacial misfit

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祁连山大野口流域青海云杉种群空间格局及其关联性

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植物生态学报 2020年第11期44卷 1172-1183页

作者：拓锋刘贤德刘润红赵维俊敬文茂马剑武秀荣赵晶忠马雪娥甘肃农业大学林学院兰州730070 甘肃省祁连山水源涵养林研究院(甘肃祁连山森林生态系统国家定位观测研究站甘肃祁连山森林生态监测与评估国际科技合作基地甘肃省森林生态与冻土水文水资源重点实验室甘肃省祁连山森林生态系统野外科学观测研究站)甘肃张掖734000 兰州大学生命科学学院兰州730000

研究青海云杉(Piceacrassifolia)种群不同发育阶段的空间分布格局及其关联性,能揭示其种群的发展规律,推断其潜在的生态学过程或影响机制,进而为该种群的配置、种植和森林的经营与管理等提供指导。该研究基于祁连山大野口流域10.2hm2青... 详细信息

研究青海云杉(Piceacrassifolia)种群不同发育阶段的空间分布格局及其关联性,能揭示其种群的发展规律,推断其潜在的生态学过程或影响机制,进而为该种群的配置、种植和森林的经营与管理等提供指导。该研究基于祁连山大野口流域10.2hm2青海云杉动态监测样地调查资料,分析了青海云杉群落的物种组成和径级结构,并采用点格局方法,通过单变量成对相关函数和双变量成对相关函数对不同年龄阶段青海云杉种群的空间分布格局及其空间关联性进行分析。结果表明:(1)青海云杉种群的径级结构呈倒"J"型分布,属增长型种群,种群自然更新状况良好。(2)青海云杉种群4个径级的个体在小尺度上呈聚集分布,但随着空间尺度的增大,聚集强度逐渐减弱,趋向随机分布;较小径级的个体常呈聚集分布,而随着径级增大,也趋向于随机分布。(3)青海云杉大树个体在小尺度(m)范围内与其他径级个体都呈负关联,随着尺度的增加,大树与幼树表现出正关联且关联性随尺度的增加而减弱,而与小树、中树则表现为无关联或者微弱的负关联;径级相近的个体空间关联性为正关联或无关联,随着个体径级间差距增大,空间关联性转变为无关联或负关联。研究表明,祁连山大野口流域青海云杉种群的分布格局及其关联性随空间尺度和发育阶段而变化,这是由种群自身的生物生态学特性、种内种间关系以及环境条件共同作用的结果。

关键词：祁连山青海云杉种群成对相关函数径级结构空间分布格局空间关联

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1050例腹膜后占位的病理诊断单中心分析

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海军军医大学学报 2023年第3期44卷 272-277页

作者：武宇轩塔娜杜甑衎屈小翔庚广烨王沈凡施挺冯翔陈锐海军军医大学(第二军医大学)基础医学院上海200433 海军军医大学(第二军医大学)第一附属医院病理科上海200433 海军军医大学(第二军医大学)第一附属医院泌尿外科上海200433 海军军医大学(第二军医大学)卫生勤务学系卫生统计学教研室上海200433

目的总结腹膜后肿瘤的疾病谱和病理特点。方法回顾性收集2012年1月至2021年12月海军军医大学(第二军医大学)第一附属医院冯翔医师牵头的外科团队收治的1050例诊断为腹膜后占位/肿瘤患者的病理信息,分析各类肿瘤占比及临床和病理特征。... 详细信息

目的总结腹膜后肿瘤的疾病谱和病理特点。方法回顾性收集2012年1月至2021年12月海军军医大学(第二军医大学)第一附属医院冯翔医师牵头的外科团队收治的1050例诊断为腹膜后占位/肿瘤患者的病理信息,分析各类肿瘤占比及临床和病理特征。结果共纳入1050例病理标本,间叶源性肿瘤407例(38.76%),其中恶性肿瘤348例(33.14%),良性肿瘤59例(5.62%);神经源性肿瘤211例(20.10%),其中恶性肿瘤18例(1.71%),良性肿瘤193例(18.38%);淋巴造血组织来源肿瘤127例(12.10%),其中恶性肿瘤88例(8.38%),良性肿瘤39例(3.71%);其他原发性腹膜后肿瘤19例(1.81%);未知来源恶性肿瘤42例(4.00%);转移性肿瘤244例(23.24%)。在间叶源性肿瘤恶性肿瘤中,最常见的病理类型为脂肪肉瘤(178例,16.95%)、平滑肌肉瘤(54例,5.14%)。结论在腹膜后肿瘤中,间叶源性肿瘤最为常见,同时存在较高比例的神经源性肿瘤、淋巴造血组织来源肿瘤、转移性肿瘤。

关键词：腹膜后肿瘤肉瘤神经组织肿瘤淋巴瘤病理诊断

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