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Broccoli products supplemented beers provide a sustainable source of dietary sulforaphane

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Food Bioscience 2023年第1期51卷 413-419页

作者： Paola Sanchez-Bravo Angel Abellan Pedro JZapata Cristina García-Viguera raúl Domínguez-Perles María Jose Gimenez lab.Fitoquímica y Alimentos saludables(labFAS) Centro de Edafología y Biología Apliada del Segura(CEBAS)-CSICUniversity Campus-2530100EspinardoMurciaSpain Department of Food Technology EPSOUniveristy Miguel HernandezCtra Beniel km 3.203312OrihuelaAlicanteSpain

Broccoli is a highly consumed vegetable due to its content of bioactive nutrients and non-nutrients,including glucosinolates and ***,the consumption of craft beer has been boosted by the seek for enhanced sensory and functional *** this frame,broccoli have been proven as an ingredient to develop healthy *** objective of the work was to evaluate alternative broccoli materials(sprouts and byproducts powder)to go further from previous results,in a way contributing to the sustainability and circularity of the agro-food chain using underexploited material to supplement beers,which could be a sustainable dietary source of bioactive sulforaphane(SFN).The results showed high concentrations of SFN in beers supplemented with broccoli sprouts and powder(5.00 and 2.54 mg/l,respectively,previous to bottling).These concentrations remained stable until bottling,where they were reduced by>50%.After 150 storage days,the concentrations of SFN were 1.08 and 0.30 mg/l in beers supplemented with sprouts and powder,*** sensory analysis revealed the positive attributes(colour,floral,fruity,and aftertaste as a result of the profile of volatile compounds)of beers developed using sprouts,and significant values of cooked vegetables,alcoholic,and earthy leather,which could be considered negative in *** latter negative tips are the ones offering sensory traits associated to ITC to broccoli-based ***,the addition of broccoli in the format of fresh sprouts is more appropriate according to the SFN content and sensory features,providing a functional alternative that could be appreciated by consumers.

关键词： Healthy foods Beverages Brassica Isothiocyanates UHPlC-ESI-MS/MS Sensory properties

SMEFT is falsifiable through multi-Higgs measurements(even in the absence of new light particles)

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Communications in Theoretical Physics 2023年第9期75卷 69-74页

作者： raquel Gómez-Ambrosio Felipe J llanes-Estrada Alexandre Salas-Bernárdez Juan J sanz-Cillero Dipartimento di Fisica Univ.di Torinoand INFNSezione di TorinoVia P.Giuria 1Torino10125Italy 2Univ.Complutense de MadridDept.Fisica Teorica and IPARCOSPlaza de las Ciencias 1Madrid28040Spain

By embedding the Standard Model effective field theory(SMEFT) in the more general Higgs effective field theory(HEFT), we expose correlations among the coefficients of the latter that, if found to be violated in future data, would lead to the experimental falsification of the SMEFT framework. These are derived from the necessary symmetric point of HEFT and analyticity of the SMEFT lagrangian that allows the construction of the SMEFT expansion, as laid out by other groups, and properties at that point of the Higgs-flare function F(h) coupling Goldstone and Higgs bosons, of the Higgs potential V(h) and of the Higgs-top quark coupling function G(h).

关键词： SMEFT HEFT EFT effective field theories electroweak lHC quantum field theories

Interplay between mesenchymal stromal cells and the immune system after transplantation: implications for advanced cell therapy in the retina

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Neural Regeneration Research 2024年第3期19卷 542-547页

作者： María Norte-Muñoz David García-Bernal Diego García-Ayuso Manuel Vidal-sanz Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain Grupo de Investigación Trasplante Hematopoyético y Terapia celular Departamento de Bioquímica e Inmunología.Facultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain

Advanced mesenchymal stromal cell-based therapies for neurodegenerative diseases are widely investigated in preclinical *** stromal cells are well positioned as therapeutics because they address the underlying mechanisms of neurodegeneration,namely trophic factor deprivation and *** studies have focused on the beneficial effects of mesenchymal stromal cell transplantation on neuronal survival or functional ***,little attention has been paid to the interaction between mesenchymal stromal cells and the host immune system due to the immunomodulatory properties of mesenchymal stromal cells and the long-held belief of the immunoprivileged status of the central nervous ***,we review the crosstalk between mesenchymal stromal cells and the immune system in general and in the context of the central nervous system,focusing on recent work in the retina and the importance of the type of transplantation.

关键词： adaptive immunity cell therapy central nervous system immune system innate immunity mesenchymal stromal cells neuroregeneration preclinical studies retina transplantation

Cutaneous Dengue Virus Inoculation Triggers Strong B Cell Reactions but Contrastingly Poor T Cell Responses

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Virologica Sinica 2020年第5期35卷 575-587页

作者： Edith Marcial-Juárez Julio García-Cordero raúl Antonio Maqueda-Alfaro rafael Eduardo Saucedo-lópez luvia Enid Sánchez-Torres leticia Cedillo-Barrón leopoldo Flores-Romo Department of Cell Biology Center for Advanced Research(CINVESTAV-IPN)The National Polytechnic Institute07360 Mexico CityMexico Department of Molecular Biomedicine Center for Advanced Research(CINVESTAV-IPN)The National Polytechnic Institute07360 Mexico CityMexico Immunology Department The National School of Biological Sciences(ENCB-IPN)The National Polytechnic Institute11340 Mexico CityMexico

Dengue is a global health problem without current specific treatment nor safe vaccines *** severe dengue is related to pre-existing non-neutralizing dengue virus(DENV)antibodies,the role of T cells in protection or pathology is *** cutaneous DENV infection in immunocompetent mice we previously showed the generation of PNA+germinal centers(GCs),now we assessed the activation and proliferation of B and T cells in draining lymph nodes(DlNs).We found a drastic remodelling of DlN compartments from 7 to 14 days post-infection(dpi)with greatly enlarged B cell follicles,occupying almost half of the DlN area compared to*24%in na?ve *** clusters of proliferating(Ki-67+)cells inside B follicles were found 14 dpi,representing*33%of B cells in DlNs but only*2%in noninfected *** GCs,we noticed an important recruitment of tingle body macrophages removing apoptotic *** contrast,the percentage of paracortex area and total T cells decreased by 14–16 dpi,compared to *** randomly distributed Ki-67+T cells were found,similar to non-infected ***69 expression by CD4+and CD8+T cells was minor,while it was remarkable in B cells,representing 1764.7%of change from basal levels 3 *** apparent lack of T cell responses cannot be attributed to apoptosis since no significant differences were observed compared to noninfected *** study shows massive B cell activation and proliferation in DlNs upon DENV *** contrast,we found very poor,almost absent CD4+and CD8+T cell responses.

关键词： Dengue virus(DENV) B and T cells proliferation lymphocyte activation lymph nodes In vivo cutaneous infection Immunocompetent mice

Dependence of dynamic contour and Goldmann applanation tonometries on peripheral corneal thickness

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1521-1527页

作者： Federico Saenz-Frances Claudia sanz-Pozo lara Borrego-sanz luis Ja?ez laura MoralesFernandez Jose Maria Martinez-de-la-Casa Julian Garcia-Sanchez Julian Garcia-Feijoo Enrique Santos-Bueso Ophthalmology Department Clinico Universitario San Carlos HospitalComplutense University Institute of Knowledge Technology Complutense University

AIM：To determine the effects of peripheral corneal thickness（PCT）on dynamic contour tonometry（DCT）and Goldmann applanation tonometry（GAT）.METHODS：A cross-sectional *** created a software which calculates the corneal contour（CC）as a function of the radius from the corneal apex to each pixel of the *** software generates a central circumference with a radius of 1 mm and the remainder of the cornea is segmented in 5 rings concentric with corneal apex being its diameter not constant around the corneal circumference as a consequence of the irregular CC but keeping constant the diameter of each ring in each direction of the *** was determined as the mean thickness of the most eccentric *** weighted scatterplot smoothing（lOWESS）regression was used to determine the pattern of the relationship between PCT and both DCT and GAT ***,two multivariable linear regression models were *** each of them,the dependant variable was intraocular pressure（IOP）as determined using GAT and DCT *** both of the models the predictive variable was PCT though lOWESS regression pattern was used to model the relationship between the dependant variables and the predictor *** and sex were also introduced control variables along with their first-degree interactions with *** outcome measures include amount of IOP variation explained through regression models（R2）and regression coefficients（B）.RESUlTS：Subjects included 109 eyes of 109 healthy *** regression suggested that a 2nd-degree polynomial would be suitable to model the relationshipbetween both DCT and GAT with *** PCT was introduced in both models as a linear and quadratic *** age nor sex nor interactions were statistically significant in both *** GAT model,R2was 17.14%（F=9.02;P=0.0002）,PCT linear term B was-1.163（95%CI：-1.163,-0.617）.PCT quadratic term B was 0.00081（95%CI：0.00043,0.00118）.For DCT model R2was 14.28%（F=9.29;P=0.0002

关键词： Goldmann applanation tonometry dynamic contour tonometry peripheral corneal thickness corneal thickness

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal Michele l Barbeau Charys M Martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

Impacts of brood parasitism by shiny cowbird Molothrus bonariensis on the breeding success of a small host, the black-backed water tyrant Fluvicola albiventer

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Current Zoology 2024年第4期70卷 539-547页

作者： lorena Vanesa Sovrano Evelina Jesica leon Rodrigo Ezequiel lorenzón Pamela Fernanda Olguin Adolfo Héctor Beltzer Alejandro raúl Giraudo laboratorio de Biodiversidad y Conservacion de Tetrapodos Instituto Nacional de Limnologia(INALICONICET-UNL)Paraje El Pozo s/nSanta Fe(3000)Argentina Departamento de Biologia Universidad Autonoma de Entre RiosKm 10.5 RP 11Oro Verde(3100)Entre RiosArgentina Departamento de Biologia Universidad Nacional del LitoralFacultad de Humanidades y CienciasParaje Ei Pozo s/nSanta Fe(3000)Argentina

The shiny cowbird Molothrus bonariensis parasitizes many species with different life-history traits and has a detrimental effect on the survival of the progeny of the *** response,hosts have developed numerous antiparasitic ***,we examined the effects of brood parasitism by shiny cowbird on the clutch and brood sizes(83 nests)in a small host,the black-backed water tyrant Fluvicola *** also studied whether the death of parasite nestlings was related to the care of the foster parents and whether the host had any antiparasitic defense against the shiny *** results indicate that brood parasitism significantly decreased the host hatching and fledging *** majority of nest failures(57%)were caused by brood *** cowbird parasitism occurred in 52%of nests and the intensity of parasitism was 1.23±0.53 eggs per parasitized *** the total host eggs,54%were *** the incubation stage,20 nests(47%)were abandoned because of egg punctures by shiny cowbirds *** two parasitic fledglings were recorded,while the remaining nestlings either died from starvation(n=12)or predation(n=3).Foster parents abandoned parasitic nestlings between 5 and 10 days *** findings demonstrate that the shiny cowbird has very low rates of fledging success when parasitizing black-backed water ***,parasitism had a high reproductive cost in the black-backed water tyrant because a very low proportion(7%)of the parasitized nests(n=43)were successful.

关键词： brood parasitism host defenses nest desertion shiny cowbird small host.

Input database related uncertainty of Biome-BGCMuSo agroenvironmental model outputs

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International Journal of Digital Earth 2021年第11期14卷 1582-1601页

作者： Nándor Fodor lászlóPásztor Brigitta Szabó Annamária laborczi Klára Pokovai Dóra Hidy Roland Hollós Erzsébet Kristóf Anna Kis laura Dobor AnikóKern Thomas Grünwald Zoltán Barcza Centre for Agricultural Research Agricultural InstituteMartonvásárHungary Centre for Agricultural Research Institute for Soil SciencesBudapestHungary Department of Meteorology Eötvös Loránd UniversityBudapestHungary Faculty of Science-Excellence Center Eötvös Loránd UniversityMartonvásárHungary Faculty of Forestry and Wood Sciences Czech University of Life Sciences PraguePraha-SuchdolCzech Republic Department of Geophysics and Space Science Eötvös Loránd UniversityBudapestHungary Institute of Hydrology and Meteorology Technische Universität DresdenTharandtGermany

Gridded model assessments require at least one climatic and one soil database for carrying out the *** are several parallel soil and climate database development projects that provide sufficient,albeit considerably different,observation based input data for crop model based impact *** input database related uncertainty of the Biome-BGCMuSo agro-environmental model outputs was investigated using three and four different gridded climatic and soil databases,respectively covering an area of nearly 100.000 km2 with 1104 grid ***,temporal,climate and soil database selection related variances were calculated and compared for four model outputs obtained from 30-year-long *** choice of the input database introduced model output variability that was comparable to the variability the year-to-year change of the weather or the spatial heterogeneity of the soil *** database selection could be a decisive factor in carbon sequestration related studies as the soil carbon stock change estimates may either suggest that the simulated ecosystem is a carbon sink or to the contrary a carbon source on the long *** evaluation of the input database quality seems to be an inevitable and highly relevant step towards more realistic plant production and carbon balance simulations.

关键词： Input data gridded data soil parameters climatic parameters uncertainty propagation

Moore-Penrose Inverse and Semilinear Equations

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Advances in linear Algebra & Matrix Theory 2018年第1期8卷 11-17页

作者： Hugo leiva raúl Manzanilla Yachay Tech School of Mathematical Sciences and Information Technology Imbabura Ecuador

In this paper, we study the existence of solutions for the semilinear equation , where A is a , , and is a nonlinear continuous function. Assuming that the Moore-Penrose inverse AT(AAT)-1?exists (A denotes the transposed matrix of A) which is true whenever the determinant of the matrix AAT is different than zero, and the following condition on the nonlinear term satisfied . We prove that the semilinear equation has solutions for all. Moreover, these solutions can be found from the following fixed point relation .

关键词： Semilinear Equations Moore-Penrose Inverse Rothe’s Fixed Point Theorem