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阅读 2019年第92期 16-19页

作者： ed Emberley

绘本导读Hi!你听说过'怪物'吗?如果亲眼看见一个大怪物,你会感到害怕,还是会感到兴奋?不妨跟着这部创意十足、趣味十足的绘本,去赶走可怕的大绿怪吧!读完以后,你还能掌握一句了不起的魔咒,从此再也不惧怕任何怪物、黑暗、恐惧或是困难呢!

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Dose-dependent effect of histamine on antibody generation in vivo

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 112-116页

作者： Tripathi T Shahid M Khan HM Khan ra Siddiqui MU DePartment of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of Microbiology Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of Pharmacology Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Department of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University

Objective:To delineate immunomodulatory role of histamine on antibody generation pr of ile in rabbit in the present dose-dependent histamine ***:The cohort comprised of three groups(Ⅲ,ⅣandⅤ),containing six rabbits each,and received subcutaneous histamine 50μg/kg×bis in die(b.i.d.),100μg/kg×*** 200μg/kg X b.i.d.,respectively for 10 days (starting from the 1st day).They were subsequently immunized on the 3rd day with intravenous injection of sheep blood cell(SRBC)(1×10 cells/mL).GroupⅡ(positive control)(n=6) received vehicle(sterile distilled water) and immunized at day 3 similarly while groupⅠ(negative control) (n=6) remained non-immunized and received only *** experimentations were performed in *** samples were collected on pre-immunization(pre-I)(day 0),as well as on days 7-,14-,21-,28- and 58- post-immunization(post-I).Immunological parameters[total immunoglobulins(Igs),IgM and IgG]were analyzed by enzyme linked immunosorbent assay (ELISA) ***:Histamine could influence a detectable antibody response to SRBC as early as day 7-post-I,which lasted until day 58- *** results were found statistically significant(Pration(until its presence in the body),and the antibody generation titer in vivo were affected by the concentration of histamine.

关键词： Histamine Immumomodulation T-cell dependent antibody response Humoral immune response SRBC

EXERCISE，ANTIOXIDANTS，AND CARDIOPROTECTION

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中国运动医学杂志 2004年第1期23卷 57-63页

作者： ScottK.Powers Ph.D. ed.D. DepartmentofExerciseandSportSciences DepartmentofPhysiology UnwenityofFloridaGainesville FloridaU.S.A.

Cardiovascular disease continues to be the number one cause of death in the United States.

关键词：运动抗氧化剂心功能保护心血管疾病冠状动脉疾病

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Self-portraits

Self-portraits

Recognition and Management of Athletic Pubalgia

作者： Ernst Rebel Norbert Wolf (ed.)

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中国运动医学杂志 2011年第8期30卷 759-763页

作者： Paul R.Geisler ed.D,ATC Department of Exercise & Sport Sciences Ithaca CollegeNYUSA.

Introduction Whether termed"sports hernias","hockey groin",or"athletic pubalgia",insidious onset and vague groin and hip maladies seem to be on the rise in the last few years,creating much confusion as to the best way... 详细信息

关键词：《中国运动医学杂志》期刊摘要编辑部

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Paracremonium moubasheri,a new species from an alkaline sediment of Lake Hamra in Wadi-El-Natron,Egypt with a key to the accepted species

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Studies in Fungi 2019年第1期4卷 216-222页

作者： Al-Bedak OA Ismail MA Mohamed ra Assiut University Mycological Centre(AUMC) Assiut UniversityAssiutEgypt Department of Botany and Microbiology Faculty of ScienceAssiut UniversityAssiutEgypt

During surveys of extremophilic fungi in hypersaline,alkaline lakes of Wadi-El-Natron,Egypt,an interesting fungus was recovered from a mud sample collected from Lake Hamra in Wadi-El-Natron,*** likelihood analysis of Internal Transcribed Spacer(ITS)gene along with morphological comparisons of related taxa revealed a novel taxon,Paracremonium moubasheri which is described and illustrated in the current *** moubasheri can be distinguished from the known species of the genus by its large conidia,in addition to the presence of chlamydospores.

关键词： Acremonium-like Hypersaline Hypocreales new taxon Phylogeny

Extrahepatic hepcidin production:The intriguing outcomes of recent years

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World Journal of Clinical Cases 2019年第15期7卷 1926-1936页

作者： raêd Daher Thibaud Lefebvre HervéPuy Zoubida Karim UniversitéParis Diderot Bichat siteParis 75018France Inflammation Research Center(CRI) INSERM U1149/ERL CNRS 8252Paris 75018France Laboratory of Excellence GR-ExParis 75018France

Hepcidin is the hyposideremic hormone regulating iron *** is a defensin-like disulfide-bonded peptide with antimicrobial *** main site of hepcidin production is the liver where its synthesis is modulated by iron,inflammation and erythropoietic ***,hepcidin locally produced in several peripheral organs seems to be an important actor for the maintenance of iron homeostasis in these *** review highlights the presence of peripheral hepcidin and its potential *** the role of extrahepatic hepcidin could be of great physiological and therapeutic importance for several specific pathologies.

关键词： Hepcidin Extrahepatic hepcidin Iron metabolism Bacterial infection Inflammation

Immunotherapy:A new standard in the treatment of metastatic clear cell renal cell carcinoma

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World Journal of Clinical Oncology 2022年第1期13卷 28-38页

作者： Maja Popovic Gorana Matovina-Brko masa Jovic Lazar S Popovic Department of Medical Oncology Oncology Institute of VojvodinaUniversity of Novi SadSremska Kamenica Faculty of Medicine University of Novi SadNovi Sad 21000Serbia

Renal cell cancer(RCC)represents 2%-3% of all adulthood cancers and is the most common malignant neoplasm of the kidney(90%).In the mid-nineties of the last century,the standard of treatment for patients with metastatic RCC was *** and pazopanib were registered in 2007 and 2009,respectively,and have since been the standard first-line treatment for metastatic clear cell RCC(mccRCC).Renal cell cancer is a highly immunogenic tumor with tumor infiltrating cells,including CD8+T lymphocytes,dendritic cells,natural killer cells(NK)and *** observation led to the design of new clinical trials in which patients were treated with *** the growing evidence that proangiogenic factors can have immunomodulatory effects on the host’s immune system,the idea of combining angiogenic drugs with immunotherapy has emerged,and new clinical trials have been *** the last few years,several therapeutic options have been approved[immunotherapy and immunotherapy/tyrosine kinase inhibitors(TKI)]for the first-line treatment of ***/ipilimumab is approved for the treatment of patients with intermediate and poor *** checkpoint inhibitors(pembrolizumab,nivolumab,avelumab)in combination with TKI(axitinib,lenvatinib,cabozantinib)are approved for the treatment of patients regardless of their International mRCC Database Consortium prognostic group and PD-L1 *** is no specific and ideal biomarker that could help in selecting the ideal patient for the appropriate first-line treatment.

关键词： Renal cell carcinoma Immunotherapy Checkpoint inhibitors Biomarkers Tumor microenvironment Programmed cell death 1 receptor

Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

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Chinese Journal of Integrative Medicine 2022年第9期28卷 802-808页

作者： Bo-ra Jeon Muhammad Irfan Seung Eun Lee Jeong Hoon Lee Man Hee Rhee Laboratory of Physiology and Cell Signaling College of Veterinary MedicineKyungpook National UniversityDaegu41566Republic of Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal Science(NIHHS)Eumseong27709Republic of Korea

Objective:To examine the antiplatelet and antithrombotic activity of Rumex acetosella ***:Standard light aggregometry was used for platelet aggregation,intracellular calcium mobilization assessed using Fura-2/AM,granule secretion(ATP release)by luminometer,and fibrinogen binding to integrin α_(Ⅱb)β_(3) detected using flow *** blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase(MAPK)and phosphoinositide 3-kinase(PI3K)/Akt ***:Rumex acetosella displayed the ability to inhibit platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin α_(Ⅱb)β_(3).Rumex acetosella has also down-regulated MAPK and PI3K/Akt phosphorylation(all Pract exhibits antiplatelet activity via modulating GPVI signaling,and it may protect against the development of platelet-related cardiovascular diseases.

关键词： antiplatelet ethnomedicine integrinα_(Ⅱb)β_(3) mitogen-activated protein kinase Rumex acetosella L.

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