检索结果-南通市图书馆

Treatment of End-Stage Coronary Artery Disease with the Mode of Combination of Disease and Syndrome:A Case Report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2021年第6期27卷 461-464页

作者： BAI rui-na WANG Pei-li GU Feng TAN Juan WANG Cheng-long CHEN Ke-ji Cardiovascular Diseases Center Xiyuan HospitalChina Academy of Chinese Medical SciencesNational Clinical Research Center for Chinese Medicine CardiologyBeijing(100091)China

Coronary artery disease(CAD)remains the leading cause of mortality *** advanced pharmacologic development and invasive revascularization therapy,a small but not insignificant number of patients show progression to end... 详细信息

关键词： Coronary mortality therapy

Synthesis, chemical nuclease activity, and in vitro cytotoxicity of benzimidazole-based Cu(Ⅱ)/Co(Ⅱ) complexes

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2017年第7期28卷 1539-1546页

作者： Jin-An Zhao Huai-Bin Yu Shuang-Cheng Zhi rui-na Mao Ji-Yong Hu Xiao-Xiao Wang College of Material and Chemical Engineering Henan University of Urban Construction College of Chemistry and Molecular Engineering Zhengzhou University

In this study, novel mono/di-nuclear Cu（p-2-bmb）（OH）（Cl O4）（1） and Co2（p-2-bmb）2Cl4（2）（p-2-bmb = 1-（（2-（pyridin-2-yl）-benzoimidazol-1-yl）methyl）-1H-benzotriazole） complexes with the nitrogen heterocyclic benzimidazole-based ligand were synthesized and characterized. The two complexes showed antiproliferative effects in various carcinoma cell lines, especially complex 1 in the SMMC7721 tumor cell line. Complex 1 was also able to pass through the cell membrane and enter the nucleus and mitochondrion. An analysis of in vitro chemical nuclease activity revealed that complex 1 partially intercalated to calf thymus Dna and exhibited strong unwinding activity against p BR322 superhelical plasmid Dna. The comet assay and flow cytometry analysis confirmed that 1 caused extensive Dna damage and arrested SMMC7721 tumor cells at G2/M phase of the cell cycle, leading to loss of mitochondrial membrane potential and apoptosis. These results suggest that these benzimidazole-based metal complexes could be potential anti-cancer agents.

关键词： Cu(II)/Co(II) complexes Benzimidazole-based ligand Chemical nuclease activity Apoptosis Anti-cancer agents

Severe Mycoplasma Pneumonia in Child with Bilateral Parapneumonic Effusion Successfully Treated with Integrated Chinese and Western Medicine: A Case Report

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2018年第9期24卷 683-685页

作者： ZENG Wen-ying LI Yan XU Zhi-lan XIE Xiao-lei XU Feng-qin rui na Department of Comprehensive Medicine Xiyuan HospitalChina Academy of Chinese Medical Sciences Department of Paediatrics Xiyuan HospitalChina Academy of Chinese Medical Sciences

Mycoplasma pneumonia is a common community-acquired pneumonia （CAP） in Asia. Children suffering from M. pneumoniae tend to progress quickly and develop severe pneumonia with a poor prognosis.（1） Effective management of M. pneumoniae infections include macrolides, tetracyclines or fluoroquinolones, however, antibiotic resistance may lead to unsatisfied clinical outcome. Chinese medicine （CM） is widely used in China and some Asian countries, which have good efficacy in the treatment of M. pneumoniae, especially for severe M. Pneumonia infection.（2） It has obvious advantages in terms of fever reduction and appetite improvement. Here we report a case of a child diagnosed with severe pneumonia who received antibiotics for 20 days but with suboptimal result, however, he experienced an optimal response to CM.

关键词： In A Case Report Severe Mycoplasma Pneumonia in Child with Bilateral Parapneumonic Effusion Successfully Treated with Integrated Chinese and Western Medicine Figure

Endothelial glycocalyx as a potential theriapeutic target in organ injuries

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2019年第8期132卷 963-975页

作者： rui-na Cao Li Tang Zhong-Yuan Xia rui Xia Department of Anesthesiology The First Affiliated Hospital of Yangtze UniversityJingzhouHubei 434000China Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei 430061China

Objective:The endothelial glycocalyx(eGC)is a dynamic and multicomponent layer of macromolecules found at the surface of vascular endothelium,which is largely *** has recently been recognized that eGC is a major regulator of endothelial function and may have therapeutic value in organ *** study aimed to explore the role of the eGC in various pathologic and physiologic conditions,by reviewing the basic research findings pertaining to the detection of the eGC and its clinical *** also explored different pharmacologic agents used to protect and rebuild the *** sources:An in-depth search was performed in the PubMed database,focusing on research published after 2003 with keywords including eGC,permeability,glycocalyx and injuries,and glycocalyx *** selection:Several authoritative reviews and original studies were identified and reviewed to summarize the characteristics of the eGC under physiologic and pathologic conditions as well as the detection and protection of the ***:The eGC degradation is closely associated with pathophysiologic changes such as vascular permeability,edema formation,mechanotransduction,and clotting cascade,together with neutrophil and platelet adhesion in diverse injury and disease states including inflammation(sepsis and trauma),ischemia-reperfusion injury,shock,hypervolemia,hypertension,hyperglycemia,and high na+as well as diabetes and *** strategies for protecting and rebuilding the eGC should be explored through experimental test and clinical ***:Disturbance of the eGC usually occurs at early stages of various clinical pathophysiologies which can be partly prevented and reversed by protecting and restoring the *** eGC seems to be a promising diagnostic biomarker and therapeutic target in clinical settings.

关键词： Endothelial glycocalyx Permeability Injuries Glycocalyx protection

MdbHLH162 connects the gibberellin and jasmonic acid signals to regulate anthocyanin biosynthesis in apple

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2024年第2期66卷 265-284页

作者： Jian-Ping An rui-rui Xu Xiao-na Wang Xiao-Wei Zhang Chun-Xiang You Yuepeng Han Apple technology innovation center of Shandong Province College of Horticulture Science and EngineeringShandong Agricultural UniversityTai-An 271018China CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenHubei Hongshan LaboratoryThe Innovative Academy of Seed Design of Chinese Academy of SciencesWuhan 430074China College of Biology and Oceanography Weifang UniversityWeifang 261061China

Anthocyanins are secondary metabolites induced by environmental stimuli and developmental *** positive regulators of anthocyanin biosynthesis have been reported,whereas the anthocyanin repressors have been *** the signal transduction pathways of gibberellin(GA)and jasmonic acid(JA)and their regulation of anthocyanin biosynthesis have been investigated,the cross-talk between GA and JA and the antagonistic mechanism of regulating anthocyanin biosynthesis remain to be *** this study,we identified the anthocyanin repressor MdbHLH162 in apple and revealed its molecular mechanism of regulating anthocyanin biosynthesis by integrating the GA and JA ***162 exerted passive repression by interacting with MdbHLH3 and MdbHLH33,which are two recognized positive regulators of anthocyanin ***162 negatively regulated anthocyanin biosynthesis by disrupting the formation of the anthocyanin-activated MdMYB1-MdbHLH3/33complexes and weakening transcriptional activation of the anthocyanin biosynthetic genes MdDFR and MdUF3GT by MdbHLH3 and *** GA repressor MdRGL2a antagonized MdbHLH162-mediated inhibition of anthocyanins by sequestering MdbHLH162 from the MdbHLH162-MdbHLH3/33 *** JA repressors MdJAZ1 and MdJAZ2 interfered with the antagonistic regulation of MdbHLH162 by MdRGL2a by titrating the formation of the MdRGL2a-MdbHLH162 *** findings reveal that MdbHLH162 integrates the GA and JA signals to negatively regulate anthocyanin *** study provides new information for discovering more anthocyanin biosynthesis repressors and explores the cross-talk between hormone signals.

关键词： anthocyanin biosynthesis bHLH transcription factor gibberellin jasmonic acid regulatory network transcriptional regulation

急性期脱水状态与脑出血90天预后的相关性研究

在线全文

学校读者我要写书评

暂无评论

医药论坛杂志 2024年第15期45卷 1611-1615页

作者：位亚敏赵亚楠牛瑞娜邓文静郑州大学第一附属医院神经重症病区郑州450000

目的探讨急性期脱水状态与脑出血90天预后的相关性。方法回顾性分析郑州大学第一附属医院2021年9月至2023年1月211名基底节区脑出血住院患者的数据。计算发病后第7天血尿素氮肌酐(blood urea nitrogen/creatinine on day 7,7dBUN/Cr)比... 详细信息

目的探讨急性期脱水状态与脑出血90天预后的相关性。方法回顾性分析郑州大学第一附属医院2021年9月至2023年1月211名基底节区脑出血住院患者的数据。计算发病后第7天血尿素氮肌酐(blood urea nitrogen/creatinine on day 7,7dBUN/Cr)比值作为急性期水合状态的指标。根据90天改良Rankin量表(modified rankin scale,mRS)评分将患者分为预后不良组和预后良好组,采用logistic回归分析确定90天不良预后的危险因素。描绘受试者工作曲线(receiver operating curve,ROC)比较各因素对预后的预测价值。根据7dBUN/Cr最佳截断值将患者分为脱水组和非脱水组,采用logistic回归分析比较两组患者的临床特征资料。有序logistic回归分析确定脱水对脑出血功能结局的影响。结果预后不良组初始血肿体积、入院时美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)、7dBUN/Cr比值、中性粒细胞/淋巴细胞比值、高血压史、高渗药物史均高于预后良好组,差异有统计学意义(P<0.05)。回归分析显示NIHSS评分、血肿体积、7dBUN/Cr比值是脑出血后90天不良预后的独立危险因素。在ROC曲线下,7dBUN/Cr比值(area under the curve,AUC=0.753,95%CI:0.685~0.817)与血肿体积(AUC=0.784,95%CI:0.718~0.844)预测预后能力相当(P=0.507)。7dBUN/Cr比值定义脱水的最佳截断值为20.5(敏感性77.1%,特异性71.5%)。单因素分析显示初始血肿体积、入院NIHSS评分、90天mRS评分、中性粒细胞/淋巴细胞比值、高渗药物史在脱水组和非脱水组间存在明显差异,多因素分析显示90天mRS评分与脱水独立相关。与非脱水组患者比较,脱水组患者表现出向更差功能结局转变(OR为6.14,95%CI:3.60~10.48,P<0.001)。结论急性期脱水状态与脑出血患者90天不良预后有关。预防脑出血急性期脱水和针对脱水的补液治疗是否可改善脑出血患者预后还需进一步前瞻性研究证实。

关键词：脱水脑出血血尿素氮肌酐预后

SYNTHESIS AND CHARACTERIZATION OF ZEROVALENT PALLADIUM COMPLEXES

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1991年第4期2卷 331-334页

作者： Zhen Feng XI rui na YANG Dou Man JIN Henan Institute of Chemistry Zhengzhou 450003

A series of nine Pd(0)complexes(L)Pd(L')[L=bis(diphenylphosphino) methane(dppm),1,2-bis(diphenylphosphino)ethane(dppe),and 1,1'-bis(diphenyl- phosphino)ferrocene(dppf),respectively;L=dibenzylideneacetone(dba),2,3,5, 6-tetrachloro-1.4-benzoquinone(q)and 2,3-dichloro-1,4-naphthoquinone(nq)] were synthesized and characterized by means of elemental analyses,IR,UV, 1~H-NMR and^(31)P-NMR *** redox wave peak potentials of the ferrocenyl group of complexes with dppf were measured by using CV *** showed that all the diphosphorus ligands behaved as chelating bidentate ligand and dba,q,nq were coordinated to the Pd(0)atom through their C=C moieties,not their carbonyl *** data also showed that there were interactions between the two different ligands in each complex.

关键词： SYNTHESIS AND CHARACTERIZATION OF ZEROVALENT PALLADIUM COMPLEXES

水药麻骨风醇提液对类风湿关节炎大鼠模型血清IL-6、TNF-ɑ水平以及踝关节软组织VEGF、MMP-3表达的影响

在线全文

学校读者我要写书评

暂无评论

黔南民族医专学报 2024年第1期37卷 7-12页

作者：曾升友梁子聪陆瑞娜刘琦张乐少雄罗甸县中医医院贵州罗甸550100 黔南民族医学高等专科学校贵州都匀558013 黔南州人民医院贵州都匀558000

目的:观察麻骨风醇提物对牛II型胶原诱导关节炎大鼠血清TNF-ɑ、IL-6和踝关节软组织VEGF、MMP-3阳性表达的影响,初步探讨麻骨风治疗类风湿关节炎的药理机制。方法:采用牛Ⅱ型胶原诱导大鼠关节炎模型,将60只SD大鼠随机分为空白组、模型... 详细信息

目的:观察麻骨风醇提物对牛II型胶原诱导关节炎大鼠血清TNF-ɑ、IL-6和踝关节软组织VEGF、MMP-3阳性表达的影响,初步探讨麻骨风治疗类风湿关节炎的药理机制。方法:采用牛Ⅱ型胶原诱导大鼠关节炎模型,将60只SD大鼠随机分为空白组、模型组和麻骨风醇提取物低、中、高剂量组,每组10只。初次致炎24 h后,除空白组和模型组外,给予灌胃给药1次/d,连续给药4周,采用ELISA法测定IL-6、TNF-ɑ水平,免疫组化法测定踝关节软组织VEGF、MMP-3的阳性表达。结果:与空白组比较,模型组大鼠血清IL-6、TNF-ɑ的含量和踝关节软组织VEGF、MMP-3的阳性表达明显增高(P<0.05);与模型组比较,低剂量组、中剂量组、高剂量组大鼠IL-6、TNF-ɑ的含量和踝关节软组织VEGF的阳性表达明显降低(P<0.05),中剂量组、高剂量组大鼠踝关节软组织MMP-3的阳性表达明显降低(P<0.05)。结论:水药麻骨风可以降低RA大鼠血清IL-6、TNF-ɑ的含量和踝关节软组织VEGF、MMP-3的阳性表达,起到抑制炎症因子释放,缓解RA的发展进程。

关键词：类风湿关节炎买麻藤炎症因子

SYNTHEIS，　SITUCTURE　AND　CHARACTERIZATION　OF　BINUCLEAR　Cu（II）　COMPLEX　［Cu（C6H5COO）2（C5H6N2）］2．（C4H8O）2

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1994年第12期 1063-1066页

作者： rui na YANG and Dou Man JIN (Henan Institute of Chemistry, Zhengzhou 450003)

ＳＹＮＴＨＥＩＳ，ＳＩＴＵＣＴＵＲＥＡＮＤＣＨＡＲＡＣＴＥＲＩＺＡＴＩＯＮＯＦＢＩＮＵＣＬＥＡＲＣｕ（ＩＩ）ＣＯＭＰＬＥＸ［Ｃｕ（Ｃ６Ｈ５ＣＯＯ）２（Ｃ５Ｈ６Ｎ２）］２．（Ｃ４Ｈ８Ｏ）２￥ＲｕｉＮａＹＡＮＧａｎｄＤｏ... 详细信息

ＳＹＮＴＨＥＩＳ，ＳＩＴＵＣＴＵＲＥＡＮＤＣＨＡＲＡＣＴＥＲＩＺＡＴＩＯＮＯＦＢＩＮＵＣＬＥＡＲＣｕ（ＩＩ）ＣＯＭＰＬＥＸ［Ｃｕ（Ｃ６Ｈ５ＣＯＯ）２（Ｃ５Ｈ６Ｎ２）］２．（Ｃ４Ｈ８Ｏ）２￥ＲｕｉＮａＹＡＮＧａｎｄＤｏｕＭａｎＪＩＮ(Ｈｅｎａ...

关键词： II COMPLEX BINUCLEAR Cu AND