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Spat.al and t.mporal pat.erns of forest.fires in t.e Cent.al Mont.:relat.onships wit. regional climat.

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Ecological Processes 2024年第1期13卷 66-79页

作者： Pablo Eugenio Villagra Erica Cesca Leandro Manuel Alvarez Silvia Delgado ricardo Villalba Inst.t.t. Argent.no de Nivología Glaciología y Ciencias Ambient.les–CONICEt.CCt.Mendoza Facult.d de Ciencias Agrarias Universidad Nacional de Cuyo

Background Nat.ral and ant.ropogenic wildfires burn large areas of arid and semi-arid forest. wit. significant.socio-economic and environment.l impact.. Fire regimes are cont.olled by climat., veget.t.on t.pe, and ant.ropogenic fact.rs such as ignit.on sources and human-induced dist.rbances. Project.ons of climat. and land-use change suggest.t.at.t.ese cont.olling fact.rs will change, alt.ring fire regimes in t.e near fut.re. In t.e sout.ern Cent.al Mont., Mendoza, Argent.na, t.e fact.rs t.at.modulat. t.e fire t.mporal and spat.al variabilit. are poorly underst.od. We reconst.uct.d t.e fire hist.ry of sout.east.of Mendoza from 1984 t. 2023 and invest.gat.d t.e relat.onships bet.een fire ext.nt.and climat. variabilit. at.seasonal and int.rannual scales. Burned areas were det.rmined using Google Eart. Engine by processing Landsat.5-t., Landsat.7-Et.+, and Landsat.8-OLI-t.RS sensor *** t.e region exhibit.d high spat.al and t.mporal variabilit. in fire occurrence, being a mosaic of areas wit. different.fire hist.ries and recovery t.mes. Bet.een 1985 and 2023, fire recurrence ranged from sit.s unburned t. sit.s wit. up t. 14 fires. t.e occurrence of large fires was st.ongly favored by a combinat.on of a year wit. abundant.spring–early summer precipit.t.on, which favors fuel accumulat.on, followed by a year of low spring–early summer precipit.t.on. Precipit.t.on and burnt.area showed a very pronounced 6–7 year cycle, suggest.ng a dominant.climat.c cont.ol on fire *** Fire dist.ibut.on in sout.east.rn Mendoza forest. is not.homogeneous, result.ng in a mosaic of pat.hes wit. different.fire hist.ries. t.is het.rogeneit. may be relat.d t. veget.t.on pat.erns and land use. t.e t.mporal variabilit. of fires is st.ongly influenced by climat. variabilit., which would promot. fuel product.on and subsequent.drying. Large fires are concent.at.d in periods of high int.rannual precipit.t.on variabilit.. Climat. change scenarios predict.an increase in t.m

关键词： Fire recurrence Fire mapping Recovery t.me Climat. Dry forest Wildfire

Dysregulat.d microRNAs in t.pe 2 diabet.s and breast.cancer:Pot.nt.al associat.d molecular mechanisms

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World Journal of Diabet.s 2024年第6期15卷 1187-1198页

作者： Alex Cleber Improt.-Caria Filipe Ferrari João Lucas Pent.ado Gomes Paloma Brasilio Villalt. Úrsula Paula RenóSoci ricardo St.in Edilamar M Oliveira Laborat.ry of Biochemist.y and Molecular Biology of t.e Exercise Physical Education and Sport SchoolUniversity of São PauloSão Paulo 05508-030Brazil Graduat. Program in Cardiology and Cardiovascular Sciences Federal University of Rio Grande do SulHospital de Clínicas de Porto AlegrePorto Alegre 90035003Brazil Laborat.ry of Met.bolic Disorders(Labdime) School of Applied SciencesUniversity of Campinas-UNICAMPCampinas 13484-350Brazil Depart.ent. of Int.rnal Medicine Molecular Pharmacology and PhysiologyCenter for Regenerative MedicineUSF Health Heart InstituteMorsani College of MedicineUniversity of South FloridaTampaFL 33602United States

t.pe 2 diabet.s(t.D)is a mult.facet.d and het.rogeneous syndrome associat.d wit. complicat.ons such as hypert.nsion,coronary art.ry disease,and not.bly,breast.cancer(BC).t.e connect.on bet.een t.D and BC is est.blished t.rough processes t.at.involve insulin resist.nce,inflammat.on and ot.er *** t.is comprehension t.e specific cellular and molecular mechanisms linking t.D t. BC,especially t.rough microRNAs(miRNAs),remain *** are regulat.rs of gene expression at.t.e post.t.anscript.onal level and have t.e funct.on of regulat.ng t.rget.genes by modulat.ng various signaling pat.ways and biological ***,t.e signaling pat.ways and biological processes regulat.d by miRNAs t.at.are associat.d wit. t.D and BC have not.yet.been *** review aims t. ident.fy dysregulat.d miRNAs in bot. t.D and BC,exploring pot.nt.al signaling pat.ways and biological processes t.at.collect.vely cont.ibut. t. t.e development.of BC.

关键词： t.pe 2 diabet.s Breast.cancer MicroRNAs Molecular mechanisms

Dist.ibut.d represent.t.ons of at.ms and mat.rials for machine learning

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npj Comput.t.onal Mat.rials 2022年第1期8卷 415-423页

作者： Luis M.Ant.nes ricardo Grau-Crespo Keit. t.But.er Depart.ent.of Chemist.y University of ReadingWhiteknightsReadingRG66DXUK SciML Scientific Computing DepartmentRutherford Appleton LaboratoryHarwellOX110QXUK

t.e use of machine learning is becoming increasingly common in comput.t.onal mat.rials *** build effect.ve models of t.e chemist.y of mat.rials,useful machine-based represent.t.ons of at.ms and t.eir compounds are *** derive dist.ibut.d represent.t.ons of compounds from t.eir chemical formulas only,via pooling operat.ons of dist.ibut.d represent.t.ons of *** compound represent.t.ons are evaluat.d on t.n different.t.sks,such as t.e predict.on of format.on energy and band gap,and are found t. be compet.t.ve wit. exist.ng benchmarks t.at.make use of st.uct.re,and even superior in cases where only composit.on is ***,we int.oduce an approach for learning dist.ibut.d represent.t.ons of at.ms,named SkipAt.m,which makes use of t.e growing informat.on in mat.rials st.uct.re dat.bases.

关键词： represent.t.ons operat.ons compet.t.ve

t.e effect. of low-volume combined t.aining on healt.-relat.d physical fit.ess out.omes in act.ve young adult.: A cont.olled clinical t.ial

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运动医学与健康科学(英文) 2023年第1期5卷 74-80页

作者： ricardo Mart.ns Nuno Loureiro Depart.ent.of Art. Humanities and SportsSchool of EducationPolytechnic Institute of BejaLaboratory of Physical Activity and HealthBejaPortugal

t.e effect. of combined t.aining(Ct.on improving general healt. are well known,however,few st.dies have invest.gat.d t.e effect. of low-volume ***,t.e aim of t.is st.dy is t. invest.gat. t.e effect. of 6 weeks of lowvolume Ct.on body composit.on,handgrip st.engt.(HGS),cardiorespirat.ry fit.ess(CRF)and affect.ve response(AR)t. *** healt.y,act.ve young adult.man(meanSD,[20.061.66]years;[22.232.76]kg/m2)performed eit.er a low-volume Ct.EG,n?9),or maint.ined a normal life(CG,n?9).t.e Ct.was composed of t.ree resist.nce exercises followed by a high int.nsit.-int.rval t.aining(HIIt.on cycle ergomet.r performed t.ice a *** measures of t.e body composit.on,HGS,maximal oxygen consumpt.on(V_O2max)and AR t. exercise were t.ken at.baseline and aft.r t.aining for ***,an ANOVA t.st.of repeat.d measures and t.t.st.paired samples were used wit. a p*** result. showed t.at.EG improved HGS(pre:[45.6711.84]kg ***:[52.4411.90]kg,pt.ough,for all measures t.e body composit.on had not.significant.differences bet.een weeks(p>0.05),nevert.eless t.e feeling scale was posit.ve in all weeks and wit.out.significant.differences bet.een t.em(p>0.05).Last.y,for act.ve young adult.,t.e low-volume Ct.improved HGS,CRF and had a posit.ve out.ome in AR,wit. less volume and t.me spent.t.an t.adit.onal exercise recommendat.ons.

关键词： Exercise Concurrent.t.aining Handgrip st.engt. Cardiorespirat.ry fit.ess Affect.ve response Unt.ained

Combining flamelet.generat.d manifold and machine learning models in simulat.on of a non-premixed diffusion flame

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Energy and AI 2023年第4期14卷 173-188页

作者： Kaimeng Li Pourya Rahnama ricardo Novella Bart.Somers Power&Flow–Depart.ent.of Mechanical Engineering.t.chnical Universit. of Eindhoven.P.O.Box 513 5600 MB EindhovenThe Netherlands CMt.Mot.res t.ermicos.Universidad Polit.ecnica de Valencia.Camino de Vera s/n E-46022 ValenciaSpain

Flamelet.Generat.d Manifold(FGM)is an example of a chemist.y t.bulat.on or a flamelet.met.od t.at.is under at.ent.on because of it. accuracy and speed in predict.ng combust.on ***,t.e main problem in applying t.e model is a large amount.of memory *** way t. solve t.is problem is t. apply machine learning(ML)t. replace t.e st.red t.bulat.d *** different.machine learning met.ods,including t.o Art.ficial Neural Net.orks(ANNs),a Random Forest.RF),and a Gradient.Boost.d t.ees(GBt.,are t.ained,validat.d,and compared in t.rms of various performance *** progress variable source t.rm and t.ansport.propert.es are replaced wit. t.e ML *** at.ent.on was paid t. t.e progress variable source t.rm due t. it. high gradient.and wide range of it. value in t.e cont.ol variables *** preprocessing is shown t. play an essent.al role in improving t.e performance of t.e *** ensemble models,namely RF and GBt.exhibit.high t.aining efficiency and accept.ble *** t.e ot.er hand,t.e ANN models have lower t.aining errors and t.ke longer t. *** four models are t.en combined wit. a one-dimensional combust.on code t. simulat. a count.rflow non-premixed diffusion flame in engine-relevant.*** predict.ons of t.e ML-FGM models are compared wit. det.iled chemical simulat.ons and t.e original FGM model for key combust.on propert.es and represent.t.ve species profiles.

关键词： Flamelet.models t.bulat.d chemist.y models Comput.t.onal fluid dynamics Machine learning Non-premixed diffusion flame

Cont.ol-based Fault.Current.Limit.r for Minimizing Impact.of Dist.ibut.d Generat.on Unit. on Prot.ct.on Syst.ms

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Journal of Modern Power Syst.ms and Clean Energy 2023年第2期11卷 643-650页

作者： Pablo E.Muñoz ricardo J.Mant. Sergio A.González Inst.t.t. LEICI UNLPCONICETLa Plata 1900La PlataArgentina Commission of Scient.fic Researches of t.e Buenos Aires Province(CICpBA) La PlataArgentina

Dist.ibut.d generat.on unit.(DGUs)bring some problems t. t.e exist.ng prot.ct.on syst.m,such as t.ose associat.d wit. prot.ct.on blinding and sympat.et.c *** is known t.at.fault.current.limit.rs(FCLs)help minimize t.e negat.ve impact.of DGUs on t.e prot.ct.on *** t.is paper,a cont.ol-based FCL is proposed,i.e.,t.e FCL is int.grat.d int. t.e DGU cont.ol *** t.is end,a predict.ve cont.ol st.at.gy wit. fault.current.limit.t.on is *** t.is way,a DGU is cont.olled,not.only for power exchange wit. t.e power grid but.also t. limit.it. fault.current.*** proposal is posed as a const.ained opt.mizat.on problem allowing t.king int. account.t.e current.limit.explicit.y in t.e design process as a closed-loop solut.on.A linear approximat.on is proposed t. cope wit. t.e inherent.nonlinear *** proposal does not.require incorporat.ng ext.a equipment.or mechanisms in t.e cont.ol loop,making t.e design process *** evaluat. t.e proposed cont.ol-based FCL,bot. prot.ct.on blinding and sympat.et.c t.ipping scenarios are *** cont.ol confines t.e DGU current. wit.in t.e const.aint. quickly,avoiding large t.ansient.***,t.e impact.on t.e prot.ct.on syst.m is reduced wit.out.t.e necessit. t.at.t.e DGU goes out.of service.

关键词： Dist.ibut.d generat.on dist.ibut.on net.ork prot.ct.on power elect.onic convert.r fault.current.limit.r model-based predict.ve cont.oller

Development.and validat.on of SuperDEM for non-spherical part.culat. syst.ms using a superquadric part.cle met.od

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Part.cuology 2022年第2期20卷 74-90页

作者： Xi Gao Jia Yu ricardo J.F.Port.l Jean-François Diet.ker Mehrdad Shahnam William A.Rogers Nat.onal Energy t.chnology Laborat.ry MorgantownWV 26506USA Leidos Research Support.t.am MorgantownWV 26506USA Cent.o de Invest.gação em Modelação e Ot.mização de Sist.mas Mult.funcionais Instituto Superior de Engenharia de LisboaPolytechnic Institute of Lisbon1959-007 LisboaPortugal Inst.t.t. de Engenharia Mecânica–Inst.t.t. Superior t.cnico Universidade de Lisboa1049-001 LisboaPortugal

t.is art.cle present. t.e development.and validat.on of t.e Superquadric Discret. Element.Met.od(SuperDEM)for non-spherical part.cle simulat.on using a superquadric part.cle met.od in open-source CFD suit. MFiX.A superquadric part.cle-part.cle cont.ct.algorit.m wit. accelerat.ng and st.bilizing st.at.gy was developed.A superquadric part.cle-arbit.ary wall cont.ct.algorit.m was developed,which enables t.e simulat.on in complex *** solver was validat.d by comparing wit. experiment.l dat. generat.d in t.is st.dy or available in t.e *** include cylinder cont.ct.ng wit. a wall,st.t.c packing of M&M chocolat. candies in a cylindrical cont.iner,st.t.c packing of cylinders in a cylindrical cont.iner,dynamic angle of repose of cylinders in a rot.t.ng drum,and discharging of chocolat. candies from a ***,MPI parallelizat.on of t.e solver was implement.d and t.e parallel performance of t.e solver using MPI was assessed t.rough large-scale simulat.ons of 1 million,10 million,and 100 million part.cles on up t. 6800 cores,which demonst.at.s t.at.t.e SuperDEM solver has great.pot.nt.al for indust.ial-scale syst.ms simulat.on.

关键词： DEM Part.cle Non-spherical Superquadric Parallelizat.on MFiX

Localized micronut.ient.pat.hes induce lat.ral root.foraging and chemot.opism in Nicot.ana at.enuat.

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Journal of Int.grat.ve Plant.Biology 2017年第10期59卷 759-771页

作者： Abigail P. Ferrieri ricardo A. R. Machado Carla C. M. Arce Danny Kessler lan t. Baldwin Mat.hias Erb Depart.ent.of Molecular Ecology Max Planck Institute for Chemical Ecology 07745 Jena Germany Inst.t.t. of Plant.Sciences University of Bern 3013 Bern Switzerland

Nut.ient. are dist.ibut.d unevenly in t.e *** plast.cit. in root.growt. and proliferat.on may enable plant. t. cope wit. t.is variat.on and effect.vely forage for essent.al nut.ient.. However, how micronut.ient. shape root.archit.ct.re of plant. in t.eir nat.ral environment. is poorly underst.od. We used a combinat.on of field and laborat.ry-based assays t. det.rmine t.e capacit. of Nicot.ana at.enuat. t. direct.root.growt. t.wards localized nut.ient.pat.hes in it. nat.ve environment. Plant. growing in nat.re displayed a part.cular root.phenot.pe consist.ng of a single primary root.and a few long, shallow lat.ral root.. Analysis of bulk soil surrounding t.e lat.ral root. revealed a st.ong posit.ve correlat.on bet.een lat.ral root.placement.and micronut.ient.gradient., including copper, iron and zinc. In laborat.ry assays, t.e applicat.on of localized micronut.ient.salt. close t. lat.ral root.t.ps led t. root. bending in t.e direct.on of copper and iron. t.is form of chemot.opism was absent.in et.ylene and jasmonic acid deficient.lines,suggest.ng t.at.it.is cont.olled in part.by t.ese t.o hormones. t.is work demonst.at.s t.at.direct.d root.growt. underlies foraging behavior, and suggest. t.at.chemot.opism and micronut.ient.guided root.placement.are import.nt.fact.rs t.at.shape root.archit.ct.re in nat.re.

关键词： Localized micronut.ient.pat.hes induce lat.ral root.foraging and chemot.opism in Nicot.ana at.enuat.

Charact.rizat.on and genet.c manipulat.on of primed st.m cells int. a funct.onal na?ve st.t. wit. ESRRB

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World Journal of St.m Cells 2016年第10期8卷 355-366页

作者： ricardo Ant.nio Rossello Andreas Pfenning Jason t.Howard Ut. Hochgeschwender Depart.ent.of Science and t.chnology Sistema Universitario Ana G. Méndez Metropolitan University San Juan 00928 Puerto Rico Depart.ent.of Biochemist.y University of Puerto Rico - Medical Sciences Campus San Juan 00921 Puerto Rico Massachuset.s Inst.t.t. of t.chnology Cambridge MA 02139 United States Howard Hughes Medical Inst.t.t. Chevy Chase MD 20815-6789 United States Duke Neurot.ansgenic Laborat.ry Duke University Medical Center Durham NC 27710 United States

AIM t. ident.fy differences bet.een primed mouse embryonic st.m cells(ESCs) and fully funct.onal naive ESCs; t. manipulat. primed cells int. a naive st.t.. MEt.ODS We have cult.red 3 lines of cells from different.mouse st.ains t.at.have been shown t. be naive or primed as det.rmined by generat.ng germline-t.ansmit.ing *** were put.t.rough a bat.ery of t.st. t. measure t.e different.feat.res. RNA from cells was analyzed using microarrays, t. det.rmine a priorit. list.of t.e different.ally expressed genes. t.ese were lat.r validat.d by quant.ficat.onal real-t.me polymerase chain react.on. Viral casset.es were creat.d t. induce expression of different.ally expressed genes in t.e primed cells t.rough lent.viral t.ansduct.on. Primed reprogrammed cells were subject.d t. in-vivo incorporat.on *** Most.result. show t.at.bot. primed and naive cells have similar feat.res(morphology, proliferat.on rat.s, st.m cell genes expressed). However, t.ere were some genes t.at.were different.ally expressed in t.e na?ve cells relat.ve t. t.e primed cells. Key upregulat.d genes in na?ve cells include ESRRB, ERAS, At.X, RNF17, KLF-5, and MYC. Aft.r over-expressing some of t.ese genes t.e primed cells were able t. incorporat. int. embryos in-vivo, re-acquiring a feat.re previously absent.in t.ese cells. CONCLUSION Alt.ough t.ere are no not.ble phenot.pic differences, t.ere are key differences in gene expression bet.een t.ese na?ve and primed st.m cells. t.ese differences can be overcome t.rough overexpression.

关键词： ESRRB ERAS Induced st.m cells Overexpression C-myc