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螺旋波纹波导回旋行波放大器的研究

真空电子技术 2024年第4期 15-19页

作者：高俊强李波高福舒国响尹华碧何文龙深圳大学射频异质异构集成国家重点实验室广东深圳518060 深圳大学电子与信息工程学院广东深圳518060 深圳大学微电子研究院广东深圳518060

介绍了一种工作频率范围在200~220 GHz,输出功率为7 kW的回旋管行波放大器。70 keV、1.5 A、大回旋电子束的回旋模式的三次谐波与五折螺纹波导互作用区域中传播的类TE 31模式发生共振相互作用,实现宽带放大。大回旋电子束由一个磁会切(C... 详细信息

介绍了一种工作频率范围在200~220 GHz,输出功率为7 kW的回旋管行波放大器。70 keV、1.5 A、大回旋电子束的回旋模式的三次谐波与五折螺纹波导互作用区域中传播的类TE 31模式发生共振相互作用,实现宽带放大。大回旋电子束由一个磁会切(CUSP)电子枪所产生,所设计的类TE 31模式具有理想的色散特性,其色散特性通过理论预测,计算机模拟和实验相结合来设计优化。三维粒子仿真(CST PIC)模拟得到了输出功率和增益分别为约7 kW和51.5 dB,输入信号功率为50 mW,3 dB瞬时增益带宽约为20 GHz。

关键词：太赫兹放大器回旋行波放大器螺纹波导互作用区域色散特性

Design of Self-Recon gurable Multiarm Robot Mechanism Based on Deployable Kinematic Chains

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Chinese Journal of Mechanical Engineering 2020年第5期 44-60页

作者： Fu-Qun Zhao Sheng guo Hai-jun Su Hai-Bo Qu Ya-Qiong Chen School of Mechanical Electronic and Control Engineering Beijing Jiaotong University Department of Mechanical and Aerospace Engineering The Ohio State University

As the structures of multiarm robots are serially arranged, the packaging and transportation of these robots are often inconvenient. The ability of these robots to operate objects must also be improved. Addressing this issue, this paper presents a type of multiarm robot that can be adequately folded into a designed area. The robot can achieve different operation modes by combining different arms and objects. First, deployable kinematic chains(DKCs) are designed, which can be folded into a designated area and be used as an arm structure in the multiarm robot mechanism. The strategy of a platform for storing DKCs is proposed. Based on the restrictions in the storage area and the character-istics of parallel mechanisms, a class of DKCs, called base assembly library, is obtained. Subsequently, an assembly method for the synthesis of the multiarm robot mechanism is proposed, which can be formed by the connection of a multiarm robot mechanism with an operation object based on a parallel mechanism structure. The formed parallel mechanism can achieve a reconfigurable characteristic when different DKCs connect to the operation object. Using this method, two types of multiarm robot mechanisms with four DKCs that can switch operation modes to perform different tasks through autonomous combination and release operation is proposed. The obtained mechanisms have observable advantages when compared with the traditional mechanisms, including optimizing the occupied volume during transportation and using parallel mechanism theory to analyze the switching of operation modes.

关键词：

Orange-derived extracellular vesicles nanodrugs for efficient treatment of ovarian cancer assisted by transcytosis effect

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Acta Pharmaceutica Sinica B 2023年第12期13卷 5121-5134页

作者： Feng Long Yao Pan Jinheng Li Suinan Sha Xiubo Shi Haoyan guo Chuanqing Huang Qian Xiao Chao Fan Xingmei Zhang jun-Bing Fan Ying Wang Cancer Research Institute Experimental Education/Administration CenterKey Laboratory of Functional Proteomics of Guangdong ProvinceSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Neurobiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

Extracellular vesicles(EVs)have recently received much attention about the application of drug carriers due to their desirable properties such as nano-size,biocompatibility,and high ***,we demonstrate orange-derived extracellular vesicles(OEV)nanodrugs(DN@OEV)by modifying cRGD-targeted doxorubicin(DOX)nanoparticles(DN)onto the surface of OEV,enabling significantly enhancing tumor accumulation and penetration,thereby efficiently inhibiting the growth of ovarian *** obtained DN@OEV enabled to inducement of greater transcytosis capability in ovarian cancer cells,which presented the average above 10-fold transcytosis effect compared with individual *** was found that DN@OEV could trigger receptor-mediated endocytosis to promote early endosome/recycling endosomes pathway for exocytosis and simultaneously reduce degradation in the early endosomes-late endosomes-lysosome pathway,thereby inducing the enhanced *** particular,the zombie mouse model bearing orthotopic ovarian cancer further validated DN@OEV presented high accumulation and penetration in tumor tissue by the transcytosis *** study indicated the strategy in enhancing transcytosis has significant implications for improving the therapeutic efficacy of thedrugdelivery system.

关键词： Extracellular vesicles Transcytosis Cancer treatment Drug delivery system Targeted modification Receptor-mediated endocytosis Intracellular trafficking Recycling endosome

Bevacizumab rescue therapy extends the survival in patients with recurrent malignant glioma

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Chinese Journal of Cancer Research 2013年第2期25卷 206-211页

作者： Lin-Bo Cai Juan Li Ming-Yao Lai Chang-guo Shan Zong-De Lian Wei-Ping Hong jun-Jie Zhen Qing Zhou Li-Chao Wang Department of Oncology Guangdong 999 Brain Hospital

Objective： We retrospectively studied the efficacy of bevacizumab as salvage therapy for recurrent malignant glioma with a focus on the overall survival （OS）. Methods： Patients who received a therapy other than surgery for recurrent malignant glioma were included. Efficacy was evaluated using MRI. Neurological function was evaluated using the Response Assessment in Neuro-Oncology （RANO）. The survival rate was calculated using the Kaplan-Meier method. Results： Fifty-one patients with recurrent glioma （31 grade Ⅲ, 20 grade Ⅳ） were included. Among them, 22 subjects （43.1%） received bevacizumab. The median OS was 10.2 months （range, 1 to 27 months）. Patients receiving bevacizumab had comparable OS （a median of 9.9 vs. 10.0 months） and similar 6-month survival rate （43% vs. 34%） to those who did not receive bevacizumab. A subgroup analysis failed to notice any significant difference in grade Ⅲ glioma patients receiving bevacizumab vs. those who did not. The median survival was significantly longer at 8.9 months （range, 4 to 13 months） in grade Ⅳ glioma patients receiving bevacizumab than in those who did not （5.6 months, range, 2 to 7 months, P=0.042）. The 6-month survival rate was higher （83 %） in those who received bevacizumab than in those who did not （47 %, P=0.046）. No grade 3/4 adverse events were observed in any patient. Conclusions： Bevacizumab, as a rescue therapy, provides a survival benefit for recurrent grade IV glioma.

关键词： Bevacizumab recurrent malignant glioma

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不同用量有机肥对鲜食玉米产量和品质的影响

湖南农业科学 2024年第3期 32-36页

作者：周雯郭萍杨石奇汤洪舒畅杨德胜龙军刘颂阳益阳市农业科学院湖南益阳413046

以华美甜168(甜玉米)、金穗2008(糯玉米)为试验品种,展开不同用量有机肥对不同品种鲜食玉米营养成分和产量的影响试验,设4个施肥处理,分别为不施基肥(CK)、100%复合肥基施(CF)、50%有机肥+50%复合肥混合基施(MF)、100%有机肥基施(OF)。... 详细信息

以华美甜168(甜玉米)、金穗2008(糯玉米)为试验品种,展开不同用量有机肥对不同品种鲜食玉米营养成分和产量的影响试验,设4个施肥处理,分别为不施基肥(CK)、100%复合肥基施(CF)、50%有机肥+50%复合肥混合基施(MF)、100%有机肥基施(OF)。结果表明:在2个品种中,有机肥和复合肥混合基施与复合肥基施,均能显著提高采收期单株干物质量、穗位高、穗长和收获指数,进而显著增加产量;2个玉米品种中有机肥和复合肥混合基施、有机肥基施均能提高玉米的食味品质、籽粒水分、可溶性糖,降低玉米皮渣率。综合玉米产量、食味品质和营养成分来看,玉米种植中以有机肥和复合肥1∶1基施是一种适宜方案。

关键词：鲜食玉米有机肥产量品质

血清网膜素-1和前列腺特异性抗原与多囊卵巢综合征相关性的临床研究

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中国医药 2024年第9期19卷 1383-1387页

作者：秦莉莉孙丽霞郭俊王浩然刘梦晨张文娟山东第一医科大学第二附属医院生殖医学科泰安271000 山东省德州市平原县第一人民医院产科德州253100 青岛大学附属泰安市中心医院血液科泰安271000 青岛大学附属泰安市中心医院生殖遗传科泰安271000

目的探讨血清网膜素-1和前列腺特异性抗原(PSA)与多囊卵巢综合征(PCOS)之间的关系,为PCOS的诊疗策略提供新思路。方法选取2021年2—12月在山东第一医科大学第二附属医院生殖医学门诊就诊的PCOS患者40例为PCOS组,选取同期因输卵管因素或... 详细信息

目的探讨血清网膜素-1和前列腺特异性抗原(PSA)与多囊卵巢综合征(PCOS)之间的关系,为PCOS的诊疗策略提供新思路。方法选取2021年2—12月在山东第一医科大学第二附属医院生殖医学门诊就诊的PCOS患者40例为PCOS组,选取同期因输卵管因素或男方因素来就诊的月经规律的不孕患者40例作为对照组。检测所有患者的肝功能、肾功能及空腹血糖、空腹胰岛素、血脂、生殖内分泌激素、网膜素-1和PSA水平;比较2组间上述各项指标间的差异。结果PCOS组的促黄体生成素、促黄体生成素/促卵泡生成素、睾酮、腰围、腰臀比、甘油三酯、空腹胰岛素、稳态模型胰岛素抵抗指数(HOMA-IR)和PSA水平均显著高于对照组,网膜素-1水平显著低于对照组,差异均有统计学意义(均P<0.05)。相关性分析结果显示,网膜素-1与睾酮、HOMA-IR、丙氨酸转氨酶呈负相关(r=-0.479,P=0.033;r=-0.450,P=0.046;r=-0.679,P=0.001);PSA与睾酮、空腹胰岛素、HOMA-IR呈正相关(r=0.562,P=0.010;r=0.472,P=0.035;r=0.574,P=0.008),与网膜素-1呈负相关(r=-0.472,P=0.036)。结论血清网膜素-1及PSA均与PCOS患者胰岛素抵抗和高雄激素血症密切相关。

关键词：多囊卵巢综合征网膜素-1 前列腺特异性抗原胰岛素抵抗高雄激素血症

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总体

外国文学 2005年第6期 42-49页

作者：郭军北京语言大学外语学院英语系北京100083

概说在由卢卡奇、葛兰西等所开启的西方马克思主义思想体系中,总体是一个怀特海所说的'主词'(God-term),在对该词这一地位的奠定上,卢卡奇功不可没.

关键词：总体西方马克思主义《历史与阶级意识》马克思主义哲学思想体系卢卡奇葛兰西怀特海论文集圣经

老年肺癌放化疗期间并发肺部感染危险因素及其与FOXO3A基因多态性的关联

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中华医院感染学杂志 2024年第18期34卷 2736-2740页

作者：郝松艳亚国伟徐海丽南阳医学高等专科学校第一附属医院中西医结合肿瘤科河南南阳473058

目的探讨老年肺癌(LC)放化疗患者肺部感染的危险因素及其与叉头盒O组转录因子3A(FOXO3A)基因特定位点多态性的关联。方法选取2020年6月-2023年6月在南阳医学高等专科学校第一附属医院就诊的老年LC患者213例,按照治疗期间肺部感染发生... 详细信息

目的探讨老年肺癌(LC)放化疗患者肺部感染的危险因素及其与叉头盒O组转录因子3A(FOXO3A)基因特定位点多态性的关联。方法选取2020年6月-2023年6月在南阳医学高等专科学校第一附属医院就诊的老年LC患者213例,按照治疗期间肺部感染发生情况分为感染组(n=47)和非感染组(n=166),对感染病原菌分布进行分析,检测两组FOXO3A基因rs12212067位点多态性;多因素Logistic回归分析接受放化疗期间发生肺部感染的危险因素。结果 47例感染患者共分离出56株病原菌,其中革兰阴性菌35株,占比为62.50%;感染组FOXO3A基因rs12212067位点TT、TC基因型频率和T等位基因频率均高于非感染组(P4周期、无预防性使用抗菌药物占比均高于非感染组(P<0.05);多因素Logistic回归分析显示,年龄和化疗周期是接受放化疗的老年LC患者发生肺部感染的危险因素(P<0.05),预防性使用抗菌药物是保护因素(P<0.05)。结论老年LC放化疗患者肺部感染以革兰阴性菌为主,FOXO3A基因rs12212067位点TT基因型是发生肺部感染的危险基因型,年龄和化疗周期是接受放化疗期间发生肺部感染的危险因素,预防性使用抗菌药物是保护因素。

关键词：肺癌放射治疗化学治疗叉头盒O组转录因子3A 基因多态性肺部感染危险因素

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溧水方言“VVVV”式的考察

南京社会科学 2005年第2期 86-92页

作者：郭骏南京大学中文系博士生南京210093

本文就江苏溧水方言属于构形重叠的“VVVV”式 ,对其语法性质、重叠模式、对“V”的选择、体特征与出现语境及语用功能、主要语法功能、与“VV”式及其他重叠式的比较等方面作简要考察 ,试图从语义、语法、语用等不同角度来阐释其规律... 详细信息

本文就江苏溧水方言属于构形重叠的“VVVV”式 ,对其语法性质、重叠模式、对“V”的选择、体特征与出现语境及语用功能、主要语法功能、与“VV”式及其他重叠式的比较等方面作简要考察 ,试图从语义、语法、语用等不同角度来阐释其规律性特征。

关键词：溧水方言 “VVVV”式语法性质重叠模式体特征语用功能