检索结果-南通市图书馆

Improved Simulation of Summer Heavy Rainfall over Beijing and Henan by the YHGSM with Updated Subgrid Orographic Parameters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2024年第3期38卷 504-529页

作者： Yingjie WANG Jianping WU Kaijun ren College of Computer Science and Technology National University of Defense TechnologyChangsha410600China College of Meteorology and Oceanography National University of Defense TechnologyChangsha410600China

In numerical weather prediction(NWP),the parameterization of orographic drag plays an important role in representing subgrid orographic *** subgrid orographic parameters are the key input to the parameterization of orographic ***,the subgrid orographic parameters in most NWP models were produced based on elevation datasets generated many years ago,with a coarse resolution and low *** this paper,using the latest high-quality elevation data and considering the applicable scale range of the subgrid orographic parameters,we construct the orographic parameters,including the subgrid orographic standard deviation,anisotropy,orientation,and slope,that are required as input to the orographic gravity wave drag(OGWD)***,we introduce the newly constructed orographic parameters into the Yin-He Global Spectral Model(YHGSM),optimize the description of the orographic effect in the model,and improve the simulation of two typical heavy rainfall events in Beijing and Henan.

关键词： subgrid orographic parameters orographic drag heavy rainfall Yin-He Global Spectral Model(YHGSM) parameterization

加强国际动物实验注册平台建设——基于注册计划书的系统调查

在线全文

学校读者我要写书评

暂无评论

兰州大学学报（医学版） 2024年第8期50卷 72-77,86页

作者：易少威王陆军阮建华王浙丁奉兴奥琪任紫钰刘晏利吴才志罗雅婷牛牧町赵跃李朝霞马彬兰州大学基础医学院甘肃兰州730000 甘肃省妇幼保健院新生儿重症救护中心甘肃兰州730050 甘肃中医药大学公共卫生学院甘肃兰州730000 甘肃省第二人民医院科研和研究生科甘肃兰州730000 西北民族大学临床医学院甘肃兰州730000

目的详细分析国际动物实验注册平台研究计划书的流行病学特征,为动物实验注册的建设和完善提出有益建议。方法获取荷兰PCT和德国ASR动物实验注册平台截至2023年12月30日注册的动物实验原始计划书并提取信息,采取频数及构成百分比统计描... 详细信息

目的详细分析国际动物实验注册平台研究计划书的流行病学特征,为动物实验注册的建设和完善提出有益建议。方法获取荷兰PCT和德国ASR动物实验注册平台截至2023年12月30日注册的动物实验原始计划书并提取信息,采取频数及构成百分比统计描述数据。结果共纳入272篇注册计划书,其中PCT平台124篇,ASR平台148篇,来自于31个国家,涉及47个不同的研究领域,共包含11种不同动物;实验设计方法,仍有10.0%(27/272)的研究未提及随机分组,而且即使进行了随机分组的实验(132/272)均未提及隐蔽分组;24.6%(67/272)和35.3%(96/272)的研究未报告干预实施阶段和结局指标测量阶段的盲法应用情况;仅43.3%(97/224)实验在计划书规定时间内完成。结论动物实验的注册作为提高动物实验质量的重要措施,应该得到重视和推广,注册平台与研究者应合作优化注册平台机制,提高计划书质量,增强实验透明度,共同提高动物实验的质量,为动物实验的临床转化提供更可靠的基础。

关键词：动物实验动物实验注册动物实验转化注册平台注册计划书

On entire solutions of some Fermat type differential-difference equations

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 69-88页

作者： LONG Jian-ren QIN Da-zhuan School of Mathematical Sciences Guizhou Normal UniversityGuiyang 550025China

On one hand,we study the existence of transcendental entire solutions with finite order of the Fermat type difference *** the other hand,we also investigate the existence and growth of solutions of nonlinear different... 详细信息

关键词： entire solutions differential-difference equations existence finite order

Normalized Solution for p-Kirchhoff Equation with a L2-supercritical Growth

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第2期40卷 414-429页

作者： Zhi-min ren Yong-yi LAN School of Sciences Jimei UniversityXiamen 361005China

In this paper,we investigate the following p-Kirchhoff equation{∫R^(N)|u|^(2)dx=ρ,(a+b)∫RN(|Δu}^(p)+|u|^(p))dx)(-Δpu+|u|^(p-2u)=|u|^(s-2)u+μu,x∈R^(N),where a>0,b≥0,p>0 are constants,constants,p*=N-P/Np is the ... 详细信息

关键词： p-Kirchhoff equation normalized solution mountain-pass lemma

Is the spatial impact of digital financial inclusion on CO_(2) emissions real?A spatial fluctuation spillover perspective

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2024年第4期15卷 494-504页

作者： Jianda Wang Kangyin Dong Xiaohang ren School of International Trade and Economics University of International Business and EconomicsBeijing 100029China School of Business Central South UniversityChangsha 410083China

Digital financial inclusion(DFI)has the advantage of promoting information sharing,reducing transaction costs,and providing microloan platforms for small and medium-sized *** has also made outstanding contributions to decreasing CO_(2) ***,the volatility correlation between DFI and CO_(2) emissions is still relatively *** research uses the spatial autoregressive process with conditional heteroscedastic errors(SARspARCH)model to evaluate the spatial fluctuation spillover impacts of DFI on CO_(2) emissions in 284 Chinese cities covering the period 2011-2016 following the IPAT *** results indicate that CO_(2) emissions have significant spatial spillover and volatility *** fitted value of SARspARCH estimation results is more realistic than the SAR and spARCH *** alleviates average CO_(2) emissions in Chinese ***,spatial volatility weakens the negative influence of DFI on average carbon *** study provides insights from which governments can strengthen inter-regional communication and synergistic emission-reduction capabilities,and promote the digitization of the financial sector to achieve carbon neutrality goals.

关键词： SARspARCH model Spatial fluctuation spillover effect CO_(2)emissions Digital financial inclusion(DFI) China

Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： JIANG Xiao-ying SHI Li-ping ZHU Jun-long BAI ren-ren XIE Tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification

Commentary:The central lymphatic drainage in pharmacological,surgical and physical therapies of Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第7期14卷 3291-3293页

作者： Lixuan ren Jianping Ye Metabolic Disease Research Center Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450000China Tianjian Laboratory of Advanced Biomedical Sciences Academy of Medical SciencesZhengzhou UniversityZhengzhou 450001China

Alzheimer’s disease(AD)is a prevalent neurodegenerative disease in the aged *** of AD remains largely unknown and no effective drugs are available in clinical settings to reverse or delay the disease *** recent years,the brain’s lymphatic systems,including glymphatic3 that exists in the brain interstitial space and meningeal lymphatic vessels4 that presents within the dural sinuses,have been found to play an important role in the AD pathogenesis.

关键词： Ab Central lymphatic drainage Surgery NPLP AD

Two simple memristive maps with adaptive energy regulation and digital signal process verification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第5期25卷 382-394页

作者： Feifei YANG Lujie ren Jun MA Zhigang ZHU College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhou 730050China Department of Physics Lanzhou University of TechnologyLanzhou 730050China School of Information Science and Engineering Dalian Polytechnic UniversityDalian 116034China

Mathematical models can produce desired dynamics and statistical properties with the insertion of suitable nonlinear terms,while energy characteristics are crucial for practical application because any hardware realizations of nonlinear systems are relative to energy *** involvement of memristive terms relative to memristors enables multistability and initial-dependent property in memristive *** this study,two kinds of memristors are used to couple a capacitor or an inductor,along with a nonlinear resistor,to build different neural *** corresponding circuit equations are derived to develop two different types of memristive oscillators,which are further converted into two kinds of memristive maps after linear *** Hamilton energy function for memristive oscillators is obtained by applying the Helmholz theorem or by mapping from the field energy of the memristive *** Hamilton energy functions for both memristive maps are obtained by replacing the gains and discrete variables for the memristive oscillator with the corresponding parameters and *** two memristive maps have rich dynamic behaviors including coherence resonance under noisy excitation,and an adaptive growth law for parameters is presented to express the self-adaptive property of the memristive maps.A digital signal process(DSP)platform is used to verify these *** scheme will provide a theoretical basis and experimental guidance for oscillator-to-map transformation and discrete map-energy calculation.

关键词： Hamilton energy Discrete memristor Self-adaptive regulation Digital signal process(DSP)implementation

Precise phase adjustment and antibacterial property of copper sulfide particles in confined mesoporous silica nanoreactor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第2期85卷 113-121页

作者： Shiyu Xu Jinyong Wu Zhongzhen ren Dechao Niu Low Dimensional Materials Chemistry Laboratory Key Laboratory for Ultrafine Materials of Ministry of EducationFrontier Science Center of the Materials Biology and Dynamic ChemistryShanghai Engineering Research Center of Hierarchical NanomaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China

Bacteria-caused wound infection greatly threatens human health,thus developing an efficient and safe antibacterial agent without drug resistance is still a great ***,a confined vulcanization strategy is proposed to construct copper sulfides-loaded dual-mesoporous silica nanospheres(Cux-Sy@DMSNs)with various crystal phases for reactive oxygen species(ROS)-mediated and photothermal antibacterial *** the pore confinement of DMSNs,the crystal phases of copper sulfides including CuS,Cu_(9)S_(5)and Cui.96S can be easily controlled by changing the vulcanization *** relationships between the crystal phases and photothermal properties as well as peroxidase-like activity of copper sulfides were systematically *** show that the obtained CuS@DMSNs exhibited higher photothermal ability with remarkable photothermal conversion efficiency of 36.86%in the second near-infrared region(NIR-II)and better peroxidase-like activity,compared to those of Cu_(9)S_(5)@DMSNs and Cu_(1.96)S@*** a result,the in vitro experiments showed the good antibacterial effect against both gram-negative *** and gram-positive *** under 1064 nm laser irradiation and the presence of H_(2)O_(2).Besides,the CCK-8 assay indicated that CuS@p-DMSNs have minimal cytotoxicity against normal human umbilical vein endothelial cells at the ranged ***,the resultant CuS@p-DMSNs could act as a promising antibacterial agent for deep wound bacterial infection treatment.

关键词： Copper sulfides Mesoporous silica Photothermal Reactive oxygen species Antibacterial agent