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cells therapy for Parkinson's disease-so close and so far away

Science china(Life Sciences) 2009年第7期52卷 610-614页

作者： ren zhenhua & zhang yu cell therapy center,xuanwu hospital,capital medical university and key laboratory of neurodegeneration,ministry of education,beijing 100053,china cell therapy center Xuanwu Hospital Capital Medical University and Key Laboratory of Neurodegeneration Ministry of Education Beijing China

One of the strategies of treating Parkinson's disease(PD) is the replacement of lost neurons in the substantia nigra with healthy dapamingergic *** sources for cells range from autologous grafts of dopamine secreting cells,fetal ventral mesencephalon tissue,to various stem cell *** the past quarter century,many experimental replacement therapies have been tried on PD animal models as well as human patients,yet none resulted in satisfactory outcomes that warrant wide *** progress in stem cell biology has shown that nuclear transfer embryonic stem cells(ntES) or induced pluripotent stem cells(iPS) derived cells can be used to successfully treat rodent PD models,thus solving the problem of immunorejection and paving the way for future autologous transplantations for treating ***,however,post mortem analysis of patients who received fetal brain cell transplantation revealed that implanted cells are prone to degeneration just like endogenous neurons in the same pathological area,indicating long-term efficacy of cell therapy of PD needs to overcome the degenerating environment in the brain.A better understanding of neurodegeneration in the midbrain appeared to be a necessary step in developing new cell therapies in Parkinson's *** is likely that future cell replacement will focus on not only ameliorating symptoms of the disease but also trying to slow the progression of the disease by either neuroprotection or restoring the micro-environment in the midbrain.

关键词： Parkinson’s disease dopamine neurons cell replacement transplantation stem cell fetal ventral mesencephalon carotid body embryonic stem cells nuclear transfer embryonic stem cells induced pluripotent stem cells

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Labeling of cynomolgus monkey bone marrow-derived mesenchymal stem cells for cell tracking by multimodality imaging

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Science china(Life Sciences) 2011年第11期54卷 981-987页

作者： ren zhenhua WANG JiaYin ZOU ChunLin GUAN yunQian zhang yu Alex cell therapy center Xuanwu Hospital Capital Medical University and Key Laboratory of Neurodegeneration Ministry of Education Beijing 100053 China Department of Anatomy Anhui Medical University Hefei 230032 China

Recently,transplantation of allogeneic and autologous cells has been used for regenerative medicine.A critical issue is monitoring migration and homing of transplanted cells,as well as engraftment efficiency and functional capability in *** of superparamagnetic iron oxide(SPIO) particles by magnetic resonance imaging(MRI) has been used in animal models and clinical settings to track labeled cells.A major limitation of MRI is that the signals do not show biological characteristics of transplanted cells in *** marrow mesenchymal stem cells(MSCs) have been extensively investigated for their various therapeutic properties,and exhibit the potential to differentiate into cells of diverse *** this study,cynomolgus monkey MSCs(cMSCs) were labeled with Molday ION Rhodamine-BTM(MIRB),a new SPIO agent,to investigate and characterize the biophysical and MRI properties of labeled cMSCs in vitro and in *** results indicate that MIRB is biocompatible and useful for cMSCs labeling and cell tracking by multimodality *** method is helpful for detection of transplanted stem cells in vivo,which is required for understanding mechanisms of cell therapy.

关键词： bone marrow mesenchymal stem cells MRI Molday ION Rhodamine-BTM transplantation nonhuman primate

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Characterizing the induction of diabetes in juvenile cynomolgus monkeys with different doses of streptozotocin

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Science china(Life Sciences) 2012年第3期55卷 210-218页

作者： ZOU ChunLin WANG JiaYin WANG ShuYan HUANG Fen ren zhenhua CHEN ZhiGuo zhang yu cell therapy center Xuanwu HospitalCapital Medical UniversityBeijing 100053China key laboratory of Neurogeneration Ministry of EducationBeijing 100053China center for Translational Medicine Guangxi Medical UniversityGuangxi 530021China Guangxi Nanning Wincon TheraCeUs Biotechnologies Co. Guangxi 530003China

Juvenile （2-3 years old） cynomolgus monkeys are frequently used as recipients in non-human primate islet transplantation studies. The aim of this study was to examine the effects of different doses of streptozotocin （STZ）, and find the optimal dose for inducing diabetes in these monkeys. Fifteen juvenile （2-3 years old） cynomolgus monkeys were separated into three groups and administered with different doses of STZ （100, 68 or 60 mg kg-l）. Basal and glucose-stimulated blood glucose, in- sulin, and C-peptide levels, as well as body weights were monitored. Hepatic and renal function tests and pancreatic immuno- histochemistry were performed before and after STZ treatment. Monkeys treated with both 100 and 68 mg kg-1 of STZ exhib- ited continuous hyperglycemia, which coincided with a nearly complete loss of islet 13-cells. Two monkeys received 60 mg kg-1 of STZ, but only one became completely diabetic. During the first week following STZ treatment, hepatic and renal func- tion slightly increased in these three groups. However. 24 hours post-STZ, serum total bile acid levels were significantly in- creased in monkeys treated with 100 mg kg-1 than those treated with 68 mg kg-I of STZ （P〈0.05）. These data suggest that 100 mg kg-1 and 68 mg kg-1 of STZ can safely induce diabetes in cynomolgus monkeys aged 2-3 years, but 68 mg kg-1 of STZ, rather than 100 mg kg-1 of STZ, may be more appropriate for inducing diabetes in these monkeys. Furthermore, body surface area, rather than body weight, was a more reliable determinant of dosage, where 700 mg m-2 of STZ should be the lower limit for inducing diabetes in juvenile monkeys.

关键词： cynomolgus monkeys diabetes streptozotocin

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FTO stabilizes MIS12 and counteracts senescence

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Protein & cell 2022年第12期13卷 954-960页

作者： Sheng zhang Zeming Wu yue Shi Si Wang Jie ren Zihui yu Daoyuan Huang Kaowen Yan Yifang He Xiaoqian Liu Qianzhao Ji Beibei Liu Zunpeng Liu Jing Qu Guang-Hui Liu Weimin Ci Xiaoqun Wang Weiqi zhang State key laboratory of Brain and Cognitive Science CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of Brain-Intelligence Technology(Shanghai)Institute of BiophysicsChinese Academy of SciencesBeijing 100101China State key laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China university of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China beijing Institute for Stem cell and Regenerative Medicine Beijing 100101China CAS key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China china National center for Bioinformation Beijing 100101China Advanced Innovation center for Human Brain Protection and National Clinical Research Center for Geriatric DisordersXuanwu HospitalCapital Medical UniversityBeijing 100053China Aging Translational Medicine center International Center for Aging and CancerXuanwu HospitalCapital Medical UniversityBeijing 100053China Chongqing renji hospital University of Chinese Academy of SciencesChongqing 400062China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China State key laboratory of Stem cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China beijing Institute for Brain Disorders Beijing 100069China

Dear Editor, N6-methyladenosine(m6A)is an abundant epitranscriptomic modification that regulates messenger RNA(mRNA)*** m6A modification regulates mRNA splicing,transport,stability,and translation through coordinated activities by methyltransferases(writers),binding proteins(readers),and demethylases(erasers)(Huang et al.,2020;Wu et al.,2020).Among m6A regulators,fat mass of obesity-associ-ated protein(FTO),is the first discovered eraser with RNA m6A demethylation activity(Jia et al.,2011).Since then,FTO has been reported to play m6A-dependent roles in a variety of physiological processes including adipogenesis,neuro-genesis and tumorigenesis(Fischer et al.,2009;Li et al.,2017;Huang et al.,2020).Consequently,FTO deficiency in mice leads to dramatic phenotypes,such as decreased fat mass and impaired brain development(Fischer et al.,2009;Li et al.,2017).Similarly,inhibition of FTO reduces tumori-genesis in multiple types of cancer models,while FTO is highly expressed in many cancers(Huang et al.,2020).

关键词： Fischer impaired

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Single-nucleus transcriptomic landscape of primate hippocampal aging

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Protein & cell 2021年第9期12卷 695-716页

作者： Hui zhang Jiaming Li Jie ren Shuhui Sun Shuai Ma Weiqi zhang Yang yu yusheng Cai Kaowen Yan Wei Li Baoyang Hu Piu Chan Guo-Guang Zhao Juan Carlos Izpisua Belmonte Qi Zhou Jing Qu Si Wang Guang-Hui Liu State key laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State key laboratory of Stem cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Advanced Innovation center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China CAS key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China university of Chinese Academy of Sciences Beijing 100049China china National center for Bioinformation Beijing 100101China Aging Translational Medicine center Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Sino Danish CollegeUniversity of Chinese Academy of SciencesBeijing 101408China Sino Danish Center for Education and ResearchBeijing 101408China Department of Obstetrics and Gynecology Center for Reproductive MedicinePeking University Third HospitalBeijing 100191China beijing Institute for Stem cell and Regenerative Medicine Beijing 100101China Stem cell Research center Peking University Third HospitalBeijing 100191China Gene Expression laboratory Salk Institute for Biological StudiesLa JollaCAUSA

The hippocampus plays a crucial role in learning and memory,and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative *** a systematic profiling of the aging effects on various hippocampal cell types in primates is still ***,we reported a variety of new aging-associated phenotypic changes of the primate *** include,in particular,increased DNA damage and heterochromatin erosion with time,alongside loss of proteostasis and elevated *** understand their cellular and molecular causes,we established the first single-nucleus transcriptomic atlas of primate hippocampal *** the 12 identified cell types,neural transiently amplifying progenitor cell(TAPC)and microglia were most affected by ***-depth dissection of gene-expression dynamics revealed impaired TAPC division and compromised neuronal function along the neurogenesis trajectory;additionally elevated pro-inflammatory responses in the aged microglia and oligodendrocyte,as well as dysregulated coagulation pathways in the aged endothelial cells may contribute to a hostile microenvironment for *** rich resource for understanding primate hippocampal aging may provide potential diagnostic biomarkers and therapeutic interventions against age-related neurodegenerative diseases.

关键词： aging hippocampus primate single-cell RNA sequencing

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Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility

Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Mo...

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2015中国遗传学会大会

作者： Jicheng Chen Ning Hou Chong zhang Yan Teng Xuan Cheng zhenhua Li Jie ren Jian Zeng Rui Li Wei Wang Xiao Yang yu Lan odel Organism Division E-institutes of Shanghai UniversitiesShanghai Jiaotong University State key laboratory of Proteomics Collaborative Innovation Center for Cardiovascular DisordersGenetic Laboratory of Development and DiseaseInstitute of Biotechnology Department of Cardiovascular Electrophysiology Research College of Basic MedicineCapital Medical University

As a master component of endosomal sorting complex required for transport proteins,hepato-cyte growth factor-regulated tyrosine kinase substrate(Hgs)participates multiple cellular ***,the physiological role of Hgs in smooth muscle cells(SMCs)is by far *** we explored the in vivo function of Hgs in SMCs by using a conditional gene knockout *** deficiency in SMCs uniquely led to a progressive dilatation of esophagus with a remarkable thinning muscle *** note,the mutant esophagus showed a decreased contractile responsiveness to potassium chloride and acetylcholine ***,an increase in the inhibitory neurites along with an intense infiltration of T lymphocytes in the mucosa and muscle layer were ***,Hgs deficiency in SMCs resulted in a disturbed expression of a set of genes involved in neurotrophin and inflammation,suggesting that defective SMC might be a novel source for excessive production of cytokines and chemokines which may trigger the neu-ronal dysplasia and ultimately contribute to the compromised esophageal *** data suggest potential implications in the pathogenesis of related diseases such as gastroesophageal reflux disease.

关键词： hepatocyte growth factor-regulated tyrosine kinase substrate smooth muscle cell esophageal motility inhibitory nenrite inflammation

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Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

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Protein & cell 2022年第3期13卷 220-226页

作者： Jinghui Lei Xiaoyu Jiang Wei Li Jie ren Datao Wang Zhejun Ji Zeming Wu Fang Cheng yusheng Cai Zheng-Rong yu Juan Carlos Izpisua Belmonte Chunyi Li Guang-Hui Liu Weiqi zhang Jing Qu Si Wang Advanced Innovation center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State key laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State key laboratory of Stem cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine center Xuanwu HospitalCapital Medical UniversityBeijing 100053China CAS key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Institute of Antler Science and Product Technology Changchun Sci-Tech UniversityChangchun 130000China university of Chinese Academy of Sciences Beijing 100049China National laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China china National center for Bioinformation Beijing 100101China beijing Institute for Stem cell and Regenerative Medicine Beijing 100101China Department of Orthopaedics Peking University First HospitalBeijing 100034China Gene Expression laboratory Salk Institute for Biological StudiesLa JollaCAUSA

Dear Editor,Stem cell therapy holds enormous and revolutionary promise to treat various age-related diseases,such as diabetes,heart failure,and Parkinson’s ***,low retention and survival rate of delivered stem cells,partially due to immunological rejection,constitute major hurdles for the clinical implementation of stem cell therapy(Lei et al.,2021a).Since mounting evidence showed that several types of stem cells mainly exert their therapeutic effects through the secretion of paracrine effects,exosomes,which are released by stem cells and execute most paracrine functions,have begun to draw attention in the field(Tran and Damaser,2015).Exosomes are membrane-enclosed vesicles with an average diameter of∼100 nanometers secreted by the cells,containing cytokines.

关键词： Exosomes holds mount

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Deciphering primate retinal aging at single-cell resolution

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Protein & cell 2021年第11期12卷 889-898页

作者： Si Wang yuxuan Zheng Qingqing Li Xiaojuan He Ruotong ren Weiqi zhang Moshi Song Huifang Hu Feifei Liu Guoqiang Sun Shuhui Sun Zunpeng Liu Yang yu Piu Chan Guo-Guang Zhao Qi Zhou Guang-Hui Liu Fuchou Tang Jing Qu State key laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China beijing Advanced Innovation center for Genomics School of Life SciencesPeking UniversityBeijing 100871China State key laboratory of Stem cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China university of Chinese Academy of Sciences Beijing 100049China Advanced Innovation center for Human Brain Protection and National Clinical Research center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Institute for Stem cell and Regeneration CASBeijing 100101China ministry of education key laboratory of cell Proliferation and Differentiation Biomedical Pioneering Innovation CenterBeijing 100871China Peking-Tsinghua center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China National laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Disease Genomics and Individualized Medicine laboratory Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Department of Obstetrics and Gynecology Center for Reproductive MedicinePeking University Third HospitalBeijing 100191China Stem cell Research center Peking University Third HospitalBeijing 100191China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Dear Editor, The retina is a light-sensitive highly-organized tissue,which is vulnerable to aging and age-related retinal ***,progressive retinal degeneration leads to visual function deterioration and vision impairment in the elderly(Lin et al.,2016).In diseases such as age-related macular degeneration(AMD),retinitis pigmentosa(RP)and diabetic retinopathy(DR),pathological process lacking effective treatments profoundly and negatively impact on the quality of life in the elderly(Lin et al.,2016;Chen et al.,2019).Thus,an in-depth molecular assessment of the mechanisms driv-ing retinal aging is of urgent scientific and medical importance.

关键词： degeneration aging resolution

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The landscape of aging

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Science china(Life Sciences) 2022年第12期65卷 2354-2454页

作者： yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan zhang Xia zhang Wenhui zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie ren Liang zhang Jun Wang Weiqi zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu State key laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China beijing Institute for Stem cell and Regenerative Medicine Beijing 100101China Frontier Science center for Immunology and Metabolism Medical Research InstituteCollege of Life SciencesWuhan UniversityWuhan 430071China CAS key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China university of Chinese Academy of Sciences Beijing 100049China State key laboratory of Stem cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS key laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China CAS key laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Peking university International Cancer Institute Peking University Health Science CenterPeking UniversityBeijing 100191China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China State key laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China Colorectal Cancer center/Department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200072China Department of Geriatrics Medical Center on Aging of Shanghai Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China International laboratory in Hematology and Cancer Shanghai Jiaotong University School of Med

Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to *** is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and ***,the growing emphasis on “healthy aging” raises a series of important questions in life and social *** recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological *** an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels.

关键词： aging mechanism intervention

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Biomarkers of aging

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Science china(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen yu Chen yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang yuanxin Yang Yilin Ying Le zhang Weiwei zhang Wenwan zhang Xing zhang Zhuo zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie ren Ruibao ren Moshi Song Zhou Songyang Yi Eve Sun yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui yue Cuntai zhang Hongbo zhang Liang zhang Weiqi zhang Yong zhang yun-Wu zhang Zhuohua zhang Tongbiao Zhao yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State key laboratory of Stem cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan key laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei key laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem cell Translational Research center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS key laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai key laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China key laboratory of Regenerative Medicine of ministry of education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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