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Highly Efficient Synthesis of Au130（SPh-Br）50 Nanocluster

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Chemical Research in Chinese Universities 2018年第5期34卷 719-722页

作者： ren xiuqing FU Xuemei LIN Xinzhang LIU Chao HUANG Jiahui YAN Jinghui School of Chemistry & Environmental Engineering Changchun University of Science and Technology Changchun 130022 P. R. China Gold Catalysis Research Center State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023P. R. China University of Chinese Academy of Sciences Beijing 100049 R R. China

We reported the synthesis ofAul3o（SPh-Br）50（Br-Ph-SH=4-bromothiophenol） nanocluster with high purity and high yield via ＂size focusing＂ and ＂ligand exchange＂ processes. The time of synthetic process was significantly reduced compared with previous synthetic routine. AU130（SPh-Br）50 was determined by UV-Vis absorption spectros- copy and matrix-assisted laser desorption ionization（MALDI） mass spectroscopy. Thermo-gravimetric analysis （TGA） and size-exclusion chromatogram（SEC） analyses confirmed the purity of AU130（SPh-Br）50. The yield of gold nanoc- lusters was 20%（based on HAuCl4）.

关键词： Au130 Gold nanocluster Thiolate ligand

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护理文件书写质量现状与持续改进的体会

护理实践与研究 2008年第18期5卷 74-76页

作者：任秀清安徽省黄山市人民医院感染科 245000

目的:提高护理文件书写质量,防范护理纠纷。方法:根据《医疗事故处理条例》要求,结合我省《病历书写规范》相关内容对所在科室评价病历环节质量、归档病历的终末质量,通过自查、互查、质控员监控、护士长督查,及时发现错误,纠正不足,并... 详细信息

目的:提高护理文件书写质量,防范护理纠纷。方法:根据《医疗事故处理条例》要求,结合我省《病历书写规范》相关内容对所在科室评价病历环节质量、归档病历的终末质量,通过自查、互查、质控员监控、护士长督查,及时发现错误,纠正不足,并对存在问题进行分析、总结、点评。结果:我科护理记录水平逐步规范、质量不断提高。结论:及时找出护理记录中存在的问题,通过持续改进,可逐步完善护理文件书写质量。

关键词：护理文件现状持续改进

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低成本齿轮齿条机构在重型机床中的应用

制造技术与机床 2009年第6期 134-135页

作者：牛学义任秀青金霖龙济南一机床集团有限公司山东济南250022

论述重型数控车床中齿轮齿条机构的消π应用和一种低成本的齿轮消隙机构。

关键词：齿轮齿条齿轮消π 齿轮消隙

中药治疗消渴病汗证的优选中药与组方规律研究

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亚太传统医药 2023年第9期19卷 183-188页

作者：任秀清孔畅高华孙丰雷山东中医药大学山东济南250000 山东中医药大学附属医院山东济南250000

目的:运用数据挖掘技术挖掘中文数据库中医药治疗消渴病汗证的组方用药规律。方法:收集、整理中国知网、维普、万方数据库和中国生物医学文献数据库收录的期刊文献为资料来源,建立消渴病汗证方剂文献研究数据库,对数据库中的中药进行频... 详细信息

目的:运用数据挖掘技术挖掘中文数据库中医药治疗消渴病汗证的组方用药规律。方法:收集、整理中国知网、维普、万方数据库和中国生物医学文献数据库收录的期刊文献为资料来源,建立消渴病汗证方剂文献研究数据库,对数据库中的中药进行频次分析、关联分析、复杂网络分析和系统聚类分析。结果:在符合纳入标准文献中共整理出70个方剂,其中黄芪、牡蛎、生地黄、五味子、龙骨是频数较高的单味药,药物五味以甘味、苦味为主,四气以寒性药物居多,归经以肝、肺、肾经为主,药物功效中补虚药、活血化瘀药、清热药是使用最多的。系统聚类分析时共聚类出5类药物,主要功效是以益气固表、滋阴泻火、滋补肝肾、敛阴止汗、调和营卫为主。结论:说明消渴病汗证的病机主要与气虚、阴虚、瘀血相关,现代医家治疗消渴病汗证的主要原则为益气养阴、活血化瘀,在辨证的基础上加用固表敛汗之品。

关键词：数据挖掘消渴病汗证优选中药用药规律

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一种加工小孔的可调整镗刀

制造技术与机床 2007年第8期 110-110页

作者：牛学义张彩虹任秀青济南一机床集团有限公司山东济南250022

在“轻骑”摩托车中，其变速箱壳体几乎都是压铸异形铸铝件（如图1）。其上有些小孔、盲孔位置精度反映，效率很高，刀具经修磨可多次重复使用，减小了刀具费用。

关键词：小孔可调整镗刀加工变速箱壳体位置精度重复使用摩托车

Anti-biofilm and remineralization effects of chitosan hydrogel containing amelogeninderived peptide on initial caries lesions

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Regenerative Biomaterials 2018年第2期5卷 69-76页

作者： Qian ren Zhongcheng Li Longjiang Ding xiuqing Wang Yumei Niu Xi Qin Xuedong Zhou Linglin Zhang State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseasesand Department of Cariology and EndodonicsWest China Hospital of StomatologySichuan UniversityNo.143rd SectionRenmin Nan LuChengduPeople’s Republic of China

In this study,we have designed a more clinically powerful anti-caries treatment by applying the amelogenin-derived peptide QP5 to the antibacterial carrier material chitosan in a hydrogel(CS-QP5 hydrogel),and characterized its effects on the inhibition of a cariogenic biofilm and the promotion of the remineralization of the initial caries *** results indicated that the CS-QP5 hydrogel sustainably inhibited the growth of the Streptococcus mutans biofilm,lactic acid production and the metabolic activity over a prolonged period of ***,the CS-QP5 hydrogel promoted the remineralization of early enamel lesions,which were indicated by surface microhardness(,polarized light microscopy and transverse *** conclusion,the CS-QP5 hydrogel shows good potential for caries control in the clinic because of its antibacterial effects as well as the remineralization of initial enamel carious lesions even in a biofilm model over a prolonged period of time.

关键词： caries amelogenin-derived peptide chitosan remineralization

Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3930-3944页

作者： Xin Tang Chuanxi Wang Lei Wang Feifei ren Runqiao Kuang Zhenhua Li Xue Han Yiming Chen Guodong Chen xiuqing Wu Jie Liu Hengwen Yang Xingzhong Liu Chen Wang Hao Gao Zhinan Yin Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai Institute of Translational MedicineZhuhai People’s Hospital Affiliated with Jinan UniversityJinan UniversityZhuhai 519000China Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of ChinaJinan UniversityGuangzhou 510632China Department of Respirology Capital Medical UniversityBeijing 100069China Biomedical Translational Research Institute Health Science Center(School of Medicine)Jinan UniversityGuangzhou 510632China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100190China Department of Respiratory and Critical Care Medicine the Second Affiliated Hospital of Xi’an Jiaotong University(Xibei Hospital)Xi’an 710004China

Interleukin(IL)-17A,a pro-inflammatory cytokine,is a fundamental function in the onset and advancement of multiple immune *** uncover the primary compounds with IL-17A inhibitory activity,a large-scale screening of the library of traditional Chinese medicine constituents and microbial secondary metabolites was conducted using splenic cells from IL-17A-GFP reporter mice cultured under Th17-priming *** results indicated that some aureane-type sesquiterpene tetraketides isolated from a wetland mud-derived fungus,Myrothecium gramineum,showed remarkable IL-17A inhibitory *** new aureane-type sesquiterpene tetraketides,myrogramins A-I(1,4-11),and two known ones(2 and 3)were isolated and identified from the *** 1,3,4,10,and 11 exhibited significant IL-17A inhibitory *** them,compound 3,with a high fermentation yield dosedependently inhibited the generation of IL-17A and suppressed glycolysis in splenic cells under Th17-priming ***,compound 3 suppressed immunopathology in both IL-17A-mediated animal models of experimental autoimmune encephalomyelitis and pulmonary *** results revealed that aureane-type sesquiterpene tetraketides are a novel class of immunomodulators with IL-17A inhibitory activity,and hold great promise applications in treating IL-17A-mediated immune diseases.

关键词： Aureane-type sesquiterpene tetraketides IL-17A Experimental autoimmune encephalomyelitis Pulmonary hypertension

A Novel Approach for Identifying the Heme-Binding Proteins from Mouse Tissues

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Genomics, Proteomics & Bioinformatics 2003年第1期1卷 78-86页

作者： Xiaolei Li Xiaoshan Wang Kang Zhao Zhengfeng Zhou Caifeng Zhao ren Yan Liang Lin Tingting Lei Jianning Yin Rong Wang Zhongsheng Sun Znyuan Xu Jingyue Bao xiuqing Zhang Xiaoli Feng Siqi Liu Beijing Genomics Institute Chinese Academy of Sciences Beijing 101300China

Heme is a key cofactor in aerobic life, both in eukaryotes and prokaryotes. Because of the high reactivity of ferrous protoporphyrin IX, the reactions of heme in cells are often carried out through heme-protein complexes. Traditionally studies of heme-binding proteins have been approached on a case by case basis, thus there is a limited global view of the distribution of heme-binding proteins in different cells or tissues. The procedure described here is aimed at profiling heme-binding proteins in mouse tissues sequentially by 1) purification of heme-binding proteins by heme-agarose, an affinity chromatographic resin; 2) isolation of heme-binding proteins by SDS-PAGE or two-dimensional electrophoresis; 3) identification of heme-binding proteins by mass spectrometry. In five mouse tissues, over 600 protein spots were visualized on 2DE gel stained by Commassie blue and 154 proteins were identified by MALDI-TOF, in which most proteins belong to heme related. This methodology makes it possible to globally characterize the heme-binding proteins in a biological system.

关键词： herne heme-agarose proteomics mouse

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逐步Ⅰ型区间删失数据下的参数估计

南京师大学报（自然科学版） 2011年第3期34卷 7-12页

作者：任瑞周秀轻南京师范大学数学科学学院江苏南京210046

针对逐步Ⅰ型区间删失数据,用EM算法确定参数的极大似然估计,根据缺失信息原则计算出了MLE的渐近协方差,并在该数据下证明了MLE的相合性和渐近正态性.

关键词：逐步Ⅰ删失数据 EM算法缺失信息原则相合性渐近正态性