Anti-biofilm and remineralization effects of chitosan hydrogel containing amelogeninderived peptide on initial caries lesions
作者机构：State Key Laboratory of Oral DiseasesNational Clinical Research Center for Oral Diseasesand Department of Cariology and EndodonicsWest China Hospital of StomatologySichuan UniversityNo.143rd SectionRenmin Nan LuChengduPeople’s Republic of China
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2018年第5卷第2期
页 面：69-76页
核心收录：
基 金：National Natural Science Foundation of China(81470734) the Technology Program of Sichuan Province(2014SZ0024)
主 题：caries amelogenin-derived peptide chitosan remineralization
摘 要：In this study,we have designed a more clinically powerful anti-caries treatment by applying the amelogenin-derived peptide QP5 to the antibacterial carrier material chitosan in a hydrogel(CS-QP5 hydrogel),and characterized its effects on the inhibition of a cariogenic biofilm and the promotion of the remineralization of the initial caries *** results indicated that the CS-QP5 hydrogel sustainably inhibited the growth of the Streptococcus mutans biofilm,lactic acid production and the metabolic activity over a prolonged period of ***,the CS-QP5 hydrogel promoted the remineralization of early enamel lesions,which were indicated by surface microhardness(,polarized light microscopy and transverse *** conclusion,the CS-QP5 hydrogel shows good potential for caries control in the clinic because of its antibacterial effects as well as the remineralization of initial enamel carious lesions even in a biofilm model over a prolonged period of time.
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