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Reduced macular thickness and vascular density in abnormal glucose metabolism patients:A meta-analysis of optical coherence tomography(OCT)and OCT angiography studies

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Chinese Medical Journal 2024年第9期137卷 1054-1068页

作者： xiangyu Fu xiang ren Wenyue Chen Danian Chen Department of Ophthalmology West China HospitalSichuan UniversityChengduSichuan 610041China Research Laboratory of Ophthalmology and Vision Sciences State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Ophthalmology The People’s Hospital of Guizhou ProvinceGuiyangGuizhou 550002China

Background:Alterations in macular thickness and vascular density before clinically visible diabetic retinopathy(DR)remain *** study aimed to determine whether retinal manifestations in abnormal glucose metabolism(AGM)patients differ from those in the healthy ***:PubMed,Embase,and Web of Science were searched between 2000 and *** eligibility criteria were AGM patients without *** and secondary outcomes measured by optical coherence tomography(OCT)and OCT angiography(OCTA)were analyzed and expressed as standardized mean differences(SMDs)with 95%confidence intervals(CIs).A random-effects model was used in the data *** potential publication bias for the variables was evaluated using Egger’s ***:A total of 86 observational studies involving 13,773 participants and 15,416 eyes were *** revealed that compared to healthy controls,the total macular thickness of AGM patients was thinner,including the thickness of fovea(-0.24,95%CI[-0.39,-0.08];P=0.002,I^(2)=87.7%),all regions of parafovea(-0.32,95%CI[-0.54,-0.11];P=0.003;I^(2)=71.7%)and the four quadrants of perifovea;the thickness of peripapillary retinal nerve fiber layer(pRNFL),macular retinal nerve fiber layer(mRNFL),and ganglion cell layer(GCL)also *** indicated that the superficial and deep vascular density decreased,the foveal avascular zone(FAZ)area enlarged,and the acircularity index(AI)reduced in AGM ***:Retinal thinning and microvascular lesions have occurred before the advent of clinically detectable DR;OCT and OCTA may have the potential to detect these preclinical ***:PROSPERO;http://***/prospero/;***42021269885.

关键词： Abnormal glucose metabolism Optical coherence tomography Optical coherence tomography angiography Diabetic retinopathy Prediabetes Meta-analysis

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Coinfection with hepatic cystic and alveolar echinococcosis with abdominal wall abscess and sinus tract formation:A case report

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World Journal of Hepatology 2024年第2期16卷 279-285页

作者： Miao-Miao Wang Xiu-Qing An Jin-Ping Chai Jin-Yu Yang Ji-De A xiang-ren A School of Continuing Education Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Internal Medicine-Cardiovascular Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina Department of General Surgery Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina Department of Hepatic Hydatidosis Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina Department of Medical Laboratory Medicine Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina

BACKGROUND Hepatic cystic and alveolar echinococcosis coinfections,particularly with concurrent abscesses and sinus tract formation,are extremely *** article presents a case of a patient diagnosed with this unique presentation,discussing the typical imaging manifestations of both echinococcosis types and detailing the diagnosis and surgical treatment experience *** SUMMARY A 39-year-old Tibetan woman presented with concurrent hepatic cystic and alveolar echinococcosis,accompanied by abdominal wall abscesses and sinus tract *** conventional imaging examinations suggested only hepatic cystic echinococcosis,but intraoperative and postoperative pathological examination revealed the *** radical resection of the lesions,the patient’s condition improved,and she was discharged soon *** outpatient follow-ups confirmed no recurrence of the hydatid lesion and normal surgical wound *** mixed hepatic cystic and alveolar echinococcosis with abdominal wall abscesses and sinus tract formations are rare,the general treatment approach remains consistent with that of simpler infections of alveolar *** Lesions involving the abdominal wall and sinus tract formation,may require radical ***-term prognosis includes albendazole and follow-up examinations.

关键词： Cystic echinococcosis Alveolar echinococcosis Abdominal wall abscess Surgical treatment Sinus tract Case report

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语文是一门典型的人文课程——以朱光潜关于语文与思想关系的讨论为中心

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北京师范大学学报（社会科学版） 2024年第3期 90-100页

作者：任翔北京师范大学文学院北京100875

在推进教育强国建设的今天,深入理解语文与思想的关系尤为重要,具体表现在三方面:语文与思想是同时发生、相互成就的统一体;语文的最高标准是“精确妥帖”,思想必须与语文同一,风格必须与人格同一,锤炼语文也就是锻造品格;语文是时代的... 详细信息

在推进教育强国建设的今天,深入理解语文与思想的关系尤为重要,具体表现在三方面:语文与思想是同时发生、相互成就的统一体;语文的最高标准是“精确妥帖”,思想必须与语文同一,风格必须与人格同一,锤炼语文也就是锻造品格;语文是时代的镜像,思想随时代发展而发展,语文也随思想发展而更新,语文在与时代的互动中不断丰富着自己。以朱光潜先生为代表的前辈学人用他们的智慧洞察了语文的本质,不但解答了文学、语言学、哲学、美学的重要问题,也解答了语文教育的主要问题,使我们进一步认清语文课程的性质,明确语文是一门典型的人文课程,这样可以更好地推进语文学科理论建设,为语文教育注入了新的思想、新的方法。

关键词：朱光潜语文与思想形式与内容语文教育

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Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

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Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： xiang ren Tan Mary C.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh Tuck Wah Soong Jason K.W.Lee Ivan C.C.Low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Centre for Translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance Centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore Campus for Research Excellence and Technological Enterprise(CREATE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(T_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(T_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:T_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in T_(re).With the development of hyperthermia,T_(br)increases and dovetails with the rising T_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both T_(re)and T_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity Cognition Heat stress Hyperthermia Motor function

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复杂网络视角下金融与科技耦合的脆弱性研究

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科学学研究 2024年第6期42卷 1200-1210页

作者：王仁祥黄家祥武汉理工大学经济学院湖北武汉430070

金融科技化和科技金融化已成为经济发展的常态及特征,对金融与科技耦合的脆弱性研究是对系统性风险的“基因性”探究,具有重要价值和意义。基于经济高质量发展背景,构建金融与科技耦合网络模型对我国金融与科技耦合的脆弱性展开研究。... 详细信息

金融科技化和科技金融化已成为经济发展的常态及特征,对金融与科技耦合的脆弱性研究是对系统性风险的“基因性”探究,具有重要价值和意义。基于经济高质量发展背景,构建金融与科技耦合网络模型对我国金融与科技耦合的脆弱性展开研究。实证表明:首先,金融业与科技业的行业耦合度随经济向高质量转型发展整体上呈上升趋势,高质量科技创新成为促进科技业自身发展及金融与科技良性耦合的关键。其次,中小型企业在提升耦合网络效率上发挥着重要作用,中小型企业之间紧密耦合现象是金融与科技耦合系统的一个重要结构特征。再次,金融与科技耦合的脆弱性在不断下降,极其重要性企业对耦合系统的风险影响力逐渐减弱。研究还发现,企业规模仍然是决定其脆弱性冲击力(脆弱性被激发所形成的冲击力)的关键,中国工商银行、中国建设银行等国有大型商业银行脆弱性冲击力最强,但其风险外溢性较弱。最后从破解中小型企业投融资难题、风险监管策略选择及降低耦合脆弱性三方面给出政策建议。

关键词：金融科技耦合脆弱性复杂网络经济高质量发展脆弱性冲击力

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Clinical feasibility of laparoscopic left lateral segment liver resection with magnetic anchor technique:The first clinical study from China

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1336-1343页

作者： Miao-Miao Zhang Ji-Gang Bai Dong Zhang Jie Tao Zhi-Min Geng Zhuo-Qun Li Yu-xiang ren Yu-HanZhang Yi Lyu Xiao-Peng Yan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Shaanxi Provincial Key Laboratory of Magnetic Medicine The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Zonglian College Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Qide College Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Magnetic anchor technique(MAT)has been applied in laparoscopic cholecystectomy and laparoscopic appendectomy,but has not been reported in laparoscopic partial *** To evaluate the feasibility of the MAT in laparoscopic left lateral segment liver *** Retrospective analysis was conducted on the clinical data of eight patients who underwent laparoscopic left lateral segment liver resection assisted by MAT in our department from July 2020 to November *** Y-Z magnetic anchor devices(Y-Z MADs)was independently designed and developed by the author of this paper,which consists of the anchor magnet and magnetic grasping *** time,intraoperative blood loss,intraoperative accidents,operator experience,postoperative incision pain score,postoperative complications,and other indicators were evaluated and *** All eight patients underwent a MAT-assisted laparoscopic left lateral segment liver resection,including three patients undertaking conventional 5-port and five patients having a transumbilical single-port *** mean operation time was 138±34.32 min(range 95-185 min)and the mean intraoperative blood loss was 123±88.60 mL(range 20-300 mL).No adverse events occurred during the *** Y-Z MADs showed good workability and maneuverability in both tissue and organ *** particular,the operators did not experience either a“chopstick”or“sword-fight”effect in the single-port laparoscopic *** The results show that the MAT is safe and feasible for laparoscopic left lateral segment liver resection,especially,exhibits its unique abettance for transumbilical single-port laparoscopic left lateral segment liver resection.

关键词： Magnetosurgery/magnetic surgery Magnetic anchor technique Laparoscopic hepatectomy Transumbilical singleport laparoscopy Magnet

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Epidemiological characteristics of tuberculosis incidence and its macro-influence factors in Chinese mainland during 2014-2021

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Infectious Diseases of Poverty 2024年第3期13卷 43-57页

作者： Le-le Deng Fei Zhao Zhuo-wei Li Wei-wei Zhang Guang-xue He xiang ren National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Pharmacy Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical ScienceBeijing Key Laboratory of Drug Clinical Risk and Personalized Medication EvaluationBeijing 100730China Miyun District Center for Disease Control and Prevention Beijing 101500China School Of Public Health Binzhon Medical UniversityYantai 264000China Division of Infectious Disease Key Laboratory of Surveillance and Early-Warning On Infectious DiseaseChinese Center for Disease Control and PreventionBeijing 102206China

Background Tuberculosis(TB)remains a pressing public health issue,posing a significant threat to individuals'well-being and *** study delves into the TB incidence in Chinese mainland during 2014-2021,aiming to gain deeper insights into their epidemiological characteristics and explore macro-level factors to enhance control and *** TB incidence data in Chinese mainland from 2014 to 2021 were sourced from the National Notifiable Disease Reporting System(NNDRS).A two-stage distributed lag nonlinear model(DLNM)was constructed to evaluate the lag and non-linearity of daily average temperature(℃,Atemp),average relative humidity(%,ARH),average wind speed(m/s,AWS),sunshine duration(h,SD)and precipitation(mm,PRE)on the TB incidence.A spatial panel data model was used to assess the impact of demographic,medical and health resource,and economic factors on TB *** A total of 6,587,439 TB cases were reported in Chinese mainland during 2014-2021,with an average annual incidence rate of 59.17/100,*** TB incidence decreased from 67.05/100,000 in 2014 to 46.40/100,000 in 2021,notably declining from 2018 to 2021(APC=-8.87%,95%CI:-11.97,-6.85%).TB incidence rates were higher among males,farmers,and individuals aged 65 years and *** analysis revealed a significant cluster in Xinjiang,Qinghai,and Xizang from March 2017 to June 2019(RR=3.94,P71.73%),low sunshine duration(<6.18 h)increased the risk of TB incidence,while extreme low wind speed(<2.79 m/s)decreased the *** spatial Durbin model showed positive associations between TB incidence rates and sex ratio(β=1.98),number of beds in medical and health institutions per 10

关键词： Tuberculosis Surveillance Epidemiological characteristics Incidence Influence factor Distributed lag nonlinear model(DLNM) Spatial panel model China

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Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF

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Chinese Chemical Letters 2024年第3期35卷 379-383页

作者： Zhi-Wu Tong Ting-Ting Wang Pei Yang Jia-Lin Sun Chen-Peng Zhang Salman Khan Xin-Cun Wang Rui-Hua Jiao Hui-Ming Ge Wen-Ying Zhuang Gang Hu ren xiang Tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Insitute of Microbiology Chinese Academy of SciencesBeijing 100101China

Fungal symbionts co-evolve with hosts and microbial co-inhabitants to acquire an unpredictable potential for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and *** we present the chemical characterization of acatulides A-G(1-7)as architecturally unprecedented macrolides from the solid-state culture of Acaulium album H-JQSF,an arthropod-associated *** acatulide structures were elucidated by spectroscopic analysis,modified Mosher's method and single-crystal X-ray *** plausible biosynthetic pathways for compounds 1-4 are ***,acatulides B-D(2-4)and G(7)were demonstrated to be neuroprotective against the 1-methyl-4-phenylpyridinium(MPP+)-induced damage to SH-SY5Y cells and nematode Caenorhabditis elegans(***).

关键词： Acaulium album Macrolides Acatulides A–G Mosher’s method Neuroprotective

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Teaching Practice of Architecture Courses based on Virtual Simulation

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Journal of Landscape Research 2024年第4期16卷 80-82页

作者： SUN Qianqian ren xiang LI Haibin DAI Huijuan ZHENG Xin Xi’an University of Science and Technology Xi’anShaanxi 710054China

Virtual simulation teaching of architecture courses is a teaching mode based on the deep integration of information technology and design class in intelligent *** the background of new engineering,relying on a national virtual simulation laboratory,the exploration of green low-carbon simulation in architecture courses is of great importance for improving the dimension of scientific thinking of architecture *** this study,based on the background of architecture curriculum construction,the practical content of the teaching reform of architecture courses based on virtual simulation was expounded from three dimensions of reshaping teaching objectives,updating teaching content and improving teaching *** practical paths of teaching reform of architecture courses were put forward under virtual simulation experiment teaching,namely building teaching teams,strengthening pilot courses,reforming teaching methods,optimizing classroom teaching content and evaluation methods,constructing practical classroom teaching form in line with the learning situation of architecture courses,building a smart learning platform,and closely combining resource construction,application and curriculum *** study has important practical significance for optimizing and improving the teaching system of professional courses,adapting to the needs of the industry,enhancing competitiveness,and promoting the construction of first-class architecture courses.

关键词： Architectural design Virtual simulation New engineering Green building Teaching reform

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解密baccatin Ⅲ生物合成途径,奠定紫衫烷可持续获取途径

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Science Bulletin 2024年第9期69卷 1182-1184页

作者：谭仁祥陈晓亚 State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210023China State Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China

The characterization and reconstitution of Taxus enzymes leading to taxoids (diterpenoids with the taxane skeleton seen in the taxol molecule)[1–5] are exciting and may tempt researchers to update the episode about t... 详细信息

关键词： prescribed skeleton baccatin

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