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中华医学会第九次全国妇科肿瘤学术会议

作者：冯炜炜 rebecca T．Marquez 吕真刘劲松 Karen H．Lu 郁茵华 Robert C．Bast Jr 复旦大学附属妇产科医院 department of Experimental Therapeutics The University of Texas M．D．Anderson CancerHoustonTexas770030

目的:研究卵巢癌中印迹基因PEG4遗传及表遗传调节。方法:我们用cdNA微阵列法筛选在卵巢癌中降表达的印迹基因,并进一步采用基因转染及克隆形成试验研究PEG3的肿瘤抑制作用;用实时逆转录PCR、Pyrosequencing定量检测PEG3在10个卵巢癌细...

目的:研究卵巢癌中印迹基因PEG4遗传及表遗传调节。方法:我们用cdNA微阵列法筛选在卵巢癌中降表达的印迹基因,并进一步采用基因转染及克隆形成试验研究PEG3的肿瘤抑制作用;用实时逆转录PCR、Pyrosequencing定量检测PEG3在10个卵巢癌细胞株、42对卵巢癌组织及邻近正常组织中的表达、甲基化修饰及等位基因杂和性缺失(LOH)。5个正常卵巢上皮细胞株及5个正常人卵巢上皮作为

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原发性免疫缺陷病患者肿瘤发生情况:美国免疫缺陷网络注册患者肿瘤发病率分析

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中华临床免疫和变态反应杂志 2018年第2期12卷 236-246页

作者： Paul C.Mayor Kevin H.Eng Kelly L.Singel Scott I.Abrams Kunle Odunsi Kirsten B.Moysich Ramsay Fuleihan Elizabeth Garabedian Patricia Lugar Hans d.Ochs Francisco A.Bonilla rebecca H.Buckley Kathleen E.Sullivan Zuhair K.Ballas Charlotte Cunningham-Rundles Brahm H.Segal 白炜曾小峰中国医学科学院北京协和医学院北京协和医院风湿免疫科

研究背景评估了在美国免疫缺陷网络(USIdNET)注册的原发性免疫缺陷病(PIdds)患者的总体和器官特异性肿瘤发病率,并与监测、流行病学和最终结果项目(SEER)数据库中经年龄校正的人群的肿瘤发病率进行比较。目的假设PIdd患者由于免疫功能受... 详细信息

研究背景评估了在美国免疫缺陷网络(USIdNET)注册的原发性免疫缺陷病(PIdds)患者的总体和器官特异性肿瘤发病率,并与监测、流行病学和最终结果项目(SEER)数据库中经年龄校正的人群的肿瘤发病率进行比较。目的假设PIdd患者由于免疫功能受损,肿瘤发病率会增加。方法将2003年至2015年在USIdNET注册中心注册的PIdd (n=3658)患者的总体和器官特异性肿瘤发病率进行评估,并与SEER数据库中经年龄校正的人群发病率进行比较。结果与年龄相匹配的SEER人群相比,观察到PIdd患者罹患肿瘤的相对危险率为1. 42倍(Pdd的男性患癌症的风险是年龄校正的男性人群的1. 91倍(Pdd女性患者的总体肿瘤发病率与经年龄校正的女性人群相比并无差异。对SEER数据库中最常见的4个恶性肿瘤——肺癌、结肠癌、乳腺癌和前列腺癌的发病率进行分析,PIdd患者中这些肿瘤的发病没有显著增加。男性和女性PIdd患者的淋巴瘤发病率均显著增加(男性10倍,Pdd患者的肿瘤发病率较高。在特定的PIdd人群中淋巴瘤发病率的增高是导致总体肿瘤发病率提高的主要原因,而常见的实体肿瘤的风险没有增加。这些数据表明免疫系统在预防特定肿瘤方面有一定的作用。

关键词：原发性免疫缺陷病普通变异性免疫缺陷病肿瘤白血病淋巴瘤美国免疫缺陷网络

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Focal Segmental Glomerulosclerosis in Côte d’Ivoire: Epidemiological, Clinical and Pathological Aspects

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Open Journal of Pathology 2022年第4期12卷 146-155页

作者： N’dah Kouame Justin Tia Weu Melanie Akpro Sedy Louess de Randorphe Lagou delphine Amélie Toure Ibrahiman Kobenan Atta Anne rebecca Abouna Alain didier Guei Monley Cyr Tuo Wonko-Tian Alice Oka Kouamé Hubert diopo Sery Patrick Olivier delma Samuel Cherif Ibrahima Traore Moussa Amekoudi Eyram Ouattara Belarsi Safiatou Yao Kouame Hubert Ackoundou Nguessan Clément Adonis Koffi Laurence Yao Gnangoran Victor Gnionsahie dazé Apolinaire Mohenou Isidore Jean-Marie diomandé department of Anatomic Pathology University Teaching Hospital of Bouake Bouake Ivory Coast department of Nephrology University Teaching Hospital of Bouake Bouake Ivory Coast department of Nephrology University Teaching Hospital of Yopougon Abidjan Ivory Coast department of Anatomic Pathology University Teaching Hospital of Cocody Abidjan Ivory Coast department of Nephrology University Teaching Hospital of Treichville Abidjan Ivory Coast department of Nephrology University Teaching Hospital of Blaise Compaore Ouagadougou Burkina Faso department of Anatomic Pathology University Teaching Hospital of Donka Conakry Guinea department of Nephrology University Teaching Hospital of Sylvanus Olympio Lome Togo department of Nephrology University Teaching Hospital of Treichville Abidjan Ivory Coast

Focal segmental glomerulosclerosis (FSGS) is characterized histologically by hyalinosis and sclerosis of glomeruli associated or not with podocyte involvement. The objective of our work was to clarify the epidemiological aspects and histological variants of FSGS in Côte d’Ivoire. Materials and Methods: This was a descriptive retrospective study, conducted from January 2015 to december 2019 using the renal biopsy registers (RB) of the Pathological Anatomy and Cytology departments of the Teaching Hospital of Cocody and Bouake in collaboration with the Nephrology Services of Côte d'Ivoire and the sub-region. The biopsies underwent conventional histopathology and/or immunofluorescence techniques. The parameters analyzed were: frequency, age, gender, proteinuria, biopsy indications and histological aspects and the different correlations between histological aspects and socio-demographic characteristics. Results: FSGS represented 58.1% (n = 104) of glomerular nephropathies. The average age of patients was 32.1 ± 13.3 years, with extremes of 13 and 70 years. The sex ratio was equal to 1. Nephrotic syndrome (68.9%), chronic renal failure (14.3%) and acute renal failure (10.1%) were the main indications for renal biopsy (RB). The mean proteinuria at the time of diagnosis was 4 ± 3.7 g/24 h. It was massive (3.5 g/24 h) in 42.3% of patients. FSGS was primary in 29.8% (n = 31) and secondary in 70.2% (n = 73) of patients, of which 27.9% (n = 35) was due to HIV. According to the Columbia classification, 62.5% NOS type was found;23.1% collapsing type;7.7% tip lesion type;4.8% cell type and 1.9% perihilary type. Conclusion: FSGS is a complex heterogeneous entity. It affects young people in our context with a homogeneous gender distribution. Understanding its histogenesis is essential for optimal patient management.

关键词： Kidney Glomerulus Histology FSGS Côte d’Ivoire

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Rotational assisted endoscopic retrograde cholangiopancreatography in patients with reconstructive gastrointestinal surgical anatomy

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World Journal of Gastrointestinal Endoscopy 2015年第3期7卷 278-282页

作者： Majed El Zouhairi James B Watson Svetang V desai david K Swartz Alejandra Castillo-Roth Mahfuzul Haque Paul S Jowell Malcolm S Branch rebecca A Burbridge division of Gastroenterology Duke University Medical Center Northern New Mexico Gastroenterology Associates

AIM: To evaluate the success rates of performing therapy utilizing a rotational assisted enteroscopy device in endoscopic retrograde cholangiopancreatography(ERCP) in surgically altered anatomy patients. METHOdS: Between June 1, 2009 and November 8, 2012, we performed 42 ERCPs with the use of rotational enteroscopy for patients with altered anatomy(39 with gastric bypass Roux-en-Y, 2 with Billroth Ⅱ gastrectomy, and 1 with hepaticojejunostomy associated with liver transplant). The indications for ERCP were: choledocholithiasis: 13 of 42(30.9%), biliary obstruction suggested on imaging: 20 of 42(47.6%), suspected sphincter of Oddi dysfunction: 4 of 42(9.5%), abnormal liver enzymes: 1 of 42(2.4%), ascending cholangitis: 2 of 42(4.8%), and bile leak: 2 of 42(4.8%). All procedures were completed with the Olympus SIF-Q180 enteroscope and the Endo-Ease discovery SB overtube produced by Spirus Medical. RESULTS: Successful visualization of the major ampulla was accomplished in 32 of 42 procedures(76.2%). Cannulation of the bile duct was successful in 26 of 32 procedures reaching the major ampulla(81.3%). Successful therapeutic intervention was completed in 24 of 26 procedures in which the bileduct was cannulated(92.3%). The overall intention to treat success rate was 64.3%. In terms of cannulation success, the intention to treat success rate was 61.5%. Ten out of forty two patients(23.8%) required admission to the hospital after procedure for abdominal pain and nausea, and 3 of those 10 patients(7.1%) had a diagnosis of post-ERCP pancreatitis. The average hospital stay was 3 ***: It is reasonable to consider an attempt at rotational assisted ERCP prior to a surgical intervention to alleviate biliary complications in patients with altered surgical anatomy.

关键词： Gastric bypass Gastrostomy Cholangiopancreatography Endoscopic retrograde double-Balloon enteroscopy Ampulla of vater Sphincterotomy Endoscopic Pancreatitis Retrospective studies

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Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver

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World Journal of Gastroenterology 2013年第19期19卷 2883-2893页

作者： Sumaiya Chowdhury Yiqian Chen Tsun-Wen Yao Katerina Ajami Xin M Wang Yury Popov detlef Schuppan Patrick Bertolino Geoffrey W McCaughan denise MT Yu Mark d Gorrell Centenary Institute and Sydney Medical School University of SydneySydneyNSW 2006Australia division of Gastroenterology and Hepatology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States Molecular Hepatology Centenary InstituteNewtownSydneyNSW 2042Australia

AIM:To investigate the expression of dipeptidyl peptidase(dPP) 8 and dPP9 in lymphocytes and various models of liver ***:dPP8 and dPP9 expression were measured in mouse splenic Cd4 + T-cells,Cd8 + T-cells and B-cells(B220 +),human lymphoma cell lines and mouse splenocytes stimulated with pokeweed mitogen(PWM) or lipopolysaccharide(LPS),and in dithiothreitol(dTT) and mitomycin-C treated Raji ***8 and dPP9 expression were measured in epidermal growth factor(EGF) treated Huh7 hepatoma cells,in fibrotic liver samples from mice treated with carbon tetrachloride(CCl 4) and from multidrug resistance gene 2(Mdr2 /Abcb4) gene knockout(gko) mice with biliary fibrosis,and in human end stage primary biliary cirrhosis(PBC).RESULTS:All three lymphocyte subsets expressed dPP8 and dPP9 ***8 and dPP9 expression were upregulated in both PWM and LPS stimulated mouse splenocytes and in both Jurkat T-and Raji B-cell ***8 and dPP9 were downregulated in dTT treated and upregulated in mitomycin-C treated Raji ***9transfected Raji cells exhibited more annexin V + cells and associated ***8 and dPP9 mRNA were upregulated in CCl 4 induced fibrotic livers but not in the lymphocytes isolated from such livers,while dPP9 was upregulated in EGF stimulated Huh7 *** contrast,intrahepatic dPP8 and dPP9 mRNA expression levels were low in the Mdr2 gko mouse and in human PBC compared to non-diseased ***:These expression patterns point to biological roles for dPP8 and dPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis.

关键词： dipeptidyl peptidase Cd26 Lymphocytes Liver fibrosis Biliary fibrosis

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悉尼宣言——从基本原则视角重新审视法庭科学的本质

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证据科学 2023年第4期31卷 498-512页

作者：克劳德·鲁丽贝卡·布赫弗兰克·克里斯皮诺彼得·德·福雷斯特克里斯·伦纳尔皮埃尔·玛格特米歇尔·米兰达纳娅姆·尼克达恩利奥利维尔·里博阿拉斯泰尔·罗斯希拉·威利斯何晓丹(译) 张保生(校) 澳大利亚悉尼科技大学法庭科学中心国际法庭科学协会芬兰国家调查局法庭科学实验室加拿大魁北克大学化学、生物化学和物理系犯罪调查实验室美国纽约市立大学约翰·杰伊刑事司法学院澳大利亚西悉尼大学理学院瑞士洛桑大学刑事科学学院美国纽约州立大学法明代尔州立学院英国邓迪大学利弗休姆法医学研究中心澳大利亚维多利亚法医学院中国政法大学司法文明协同创新中心中国政法大学司法鉴定科学研究院中国政法大学证据科学研究院/证据科学教育部重点实验室

与其他更成熟的学科不同,人们对法庭科学的本质尚缺乏共识和广泛认可,其目的和基本原则仍然缺失,甚至被歪曲。虽然许多法庭科学先辈都认识到这一点,并将其视为学科发展之关键所在,但这种基础研究却长期受到忽视。《悉尼宣言》试图超越... 详细信息

与其他更成熟的学科不同,人们对法庭科学的本质尚缺乏共识和广泛认可,其目的和基本原则仍然缺失,甚至被歪曲。虽然许多法庭科学先辈都认识到这一点,并将其视为学科发展之关键所在,但这种基础研究却长期受到忽视。《悉尼宣言》试图超越组织、技术和规程的视角,通过研究其基础理论,重新审视法庭科学的本质。它的内容包括法庭科学的定义和七项基本原则,强调了现场痕迹在案件调查中的关键作用。《悉尼宣言》还讨论了法庭科学家工作的关键特征,包括案情、时间不对称性、一系列不确定性、广泛的科学知识、伦理、批判性思维和逻辑推理等。《悉尼宣言》认为这些原则应成为法庭科学执业的基础,并指导其教育和研究方向。最终,这些原则将使法庭科学在整体上更加相关、有效和可靠。

关键词：痕迹原则符号线索案情时间不对称性不确定性伦理批判性思维逻辑推理

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