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The impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CTP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

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Oncology Research 2025年第1期33卷 149-160页

作者： NASSER MULLA YOUSEF KATIB ASIM M.ALMUGHAMSI DUAA S.ALKHAYAT MOHAMED MOSAAD SAMIR T.ALFOTIH rawan alaofi Department of Internal Medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King Salman bin Abdulaziz Medical City Madinah42311Saudi Arabia Prince Mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi *** study aimed to investigate the patterns of HCC and the effect of TNM staging,Alfa-fetoprotein(AFP),and Child-Turcotte Pugh(CTP)on patients’overall survival(OS).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in OS among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in OS(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the OS in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CTP score and OS(p-value=0.02).CTP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in OS among viral and non-viral HCC patients(p-value=0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CTP score class C were all negatively associated with OS.

关键词： Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

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Soil organic matter amendments in date palm groves of the Middle Eastern and North African region:a mini-review

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Journal of Arid Land 2016年第1期8卷 77-92页

作者： rawan MLIH Roland BOL Wulf AMELUNG Nadhem BRAHIM Institute of Bio-Geoscience Agrosphere Institute (IBG-3) Juelich Research Center Institute of Crop Science and Resource Conservation (INRES)/Soil Science and Soil Ecology University of Bonn Faculty of Sciences of Tunis Department of Geology University of Tunis El Manar

Countries in the Middle Eastern and North African (MENA) region are among the most water-scarce regions in the world, and their dryland soils are usually poor in organic carbon content (<0.5%). In this study, we summarize examples of how people in the few oases of the MENA region overcome environmental challenges by sustainably managing economically important date production. On the basis of the limited studies found in the existing literature, this mini-review focuses on the role of traditional soil organic matter amendments beneath the soil surface as a key tool in land restoration. We conclude that soil organic matter amendments can be very successful in restoring soil water and preventing the soil from salinization.

关键词： review Middle Eastern and North African (MENA) drylands organic matter amendments oasis agrosystem date palm production

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Numerical Approach to Simulate the Effect of Corrosion Damage on the Natural Frequency of Reinforced Concrete Structures

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Structural Durability & Health Monitoring 2023年第3期17卷 175-194页

作者： Amthal Hakim Wael Slika rawan Machmouchi Adel Elkordi Department of Civil and Environmental Engineering Beirut Arab UniversityBeirut11520Lebanon Faculty of Engineering Beirut Arab UniversityBeirut11520Lebanon

Corrosion of reinforcing steel in concrete elements causes minor to major damage in different *** may lead to spalling of concrete cover,reduction of section’s capacity and can alter the dynamic *** the dynamic properties,natural frequency is to be a reliable indicator of structural integrity that can be utilized in non-destructive corrosion *** the correlation between natural frequency and corrosion damage has been reflected in different experimental programs,few attempts have been made to investigate this relationship in forward modeling and/or structural health monitoring *** can be attributed to the limited available data,the complex nature of corrosion,and the involvement of multidisciplinaryﬁ***,this study presents a numerical attempt to simulate the effect of corrosion damage on the natural frequency of the *** approach relies on simulating the time history response of the structure using a modiﬁed Bouc-Wen model that incorporates the nonlinear effects of ***,modal analysis is utilized to assess the change in dynamic properties in the frequency ***ﬁnish up,regression algorithms are employed toﬁnd optimal relationship between involved parameters,including corrosion damage as input,and natural frequency as *** efﬁciency of the suggested framework is illustrated in thirteen buildings with cantilevered column lateral force-resisting system and different levels of corrosion.

关键词： Corrosion concrete damage dynamic properties natural frequency nonlinear analysis modal analysis machine learning

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Three-dimensional Localization of Impacted Canines and Root Resorption Assessment Using Cone Beam Computed Tomography

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2014年第3期34卷 425-430页

作者： Eyad Almuhtaseb 毛靖 Derek Mahony rawan Bader 张智星 Department of Orthodontics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Orthodontics London Dental School London United Kingdom Ministry of Health Kingdom of Saudi Arabia

Summary： The purpose of this study was to develop a new way to localize the impacted canines from three dimensions and to investigate the root resorption of the adjacent teeth by using cone beam computed tomography （CBCT）. Forty-six patients undergoing orthodontic treatments and having impacted canines in Tongii Hospital were examined. The images of CBCT scans were obtained from KaVo 3D exam vision. Angular and linear measurements of the cusp tip and root apex according to the three planes （mid-sagittal, occlusal and frontal） have been taken using the cephalometric tool of the InVivo Dental Anatomage Version 5.1.10. The measurements of the angular and linear coordinates of the maxillary and mandibular canines were obtained. Using this technique the operators could envision the location of the impacted canine according to the three clinical planes. Adjacent teeth root *** 28.26 % was in the upper lateral incisors while 17.39% in upper central incisors, but no lower root resorption was found in our samples. Accurate and reliable localization of the impacted canines could be obtained from the novel analysis system, which offers a better surgical and orthodontic treatment for the patients with impacted canines.

关键词： impacted canines root resorption cone beam computed tomography

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Community-acquired serious bacterial infections in the first 90 days of life:a revisit in the era of multi-drug-resistant organisms

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World Journal of Pediatrics 2019年第6期15卷 580-585页

作者： Dawood Yusef Tamara Jahmani Sajeda Kailani rawan Al-Rawi Wasim Khasawneh Miral Almomani Pediatric Infectious Diseases Jordan University of Science and TechnologyKing Abdullah University HospitalP.O.Box 3030Irbid 22110Jordan Faculty of Medicine Jordan University of Science and TechnologyIrbidJordan Pediatric Department Jordan University of Science TechnologyIrbidJordan

Background Infants in the first 90 days of life are more prone to develop serious bacterial infections(SBIs).Multi-drug-resistant organisms(MDROs)are emerging as important pathogens causing *** reviewed the epidemiology of SBIs in infants 0-90 days old and compared the clinical features,laboratory values and final outcome for SBIs due to MDROs *** Episodes of culture-proven SBIs(bacteremia,urinary tract infections,or meningitis)with age at onset of 0-90 days during a 7-year period were retrospectively *** care-associated infections were *** collected demo-graphics,clinical features,and laboratory and microbiology *** compared clinical characteristics,laboratory data,microbiologic results and final outcome for SBIs due to MDROs *** Ninety-four episodes(88 patients)including bacteremia(42.6%),urinary tract infections(54.3%)and meningi-tis(3.1%)were caused by Gram-negative bacteria(67%),and Gram-positive bacteria(33%).Escherichia coli,Klebsiella pneumoniae and GBS were the most common *** caused SBIs in 39 patients(44.3%).SBIs due to MDROs were associated with more delay in providing targeted antimicrobial therapy compared to non-MDROs(74.4%vs.0%,P≤0.001,but no difference in case-fatality rate(12.8%vs.12.2%,P=1.0).Clinical features or basic laboratory values were not statistically different between the two *** The bacteriology of SBIs in the first 90 days of life is changing to include more MDROs,which causes more delay in providing targeted antimicrobial *** of the local epidemiology is crucial to ensure appropriate antibiotics are provided in a timely manner.

关键词： Multi-drug-resistance organisms Neonates Serious bacterial infections Young infants

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KSUTraffic: A Microscopic Traffic Simulator for Traffic Planning in Smart Cities

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Computers, Materials & Continua 2021年第8期68卷 1831-1845页

作者： Najla Al-Nabhan Maha AlDuhaim Sarah AlHussan Haifa Abdullah Mnira AlHaid rawan AlDuhaishi Computer Science Department King Saud UniversityRiyadhSaudi Arabia

Simulation is a powerful tool for improving,evaluating and analyzing the performance of new and existing *** simulators provide tools for studying transportation systems in smart cities as they describe the evolution of traffic to the highest level of *** are many types of traffic simulators that allow simulating traffic in modern *** most popular traffic simulation approach is the microscopic traffic simulation because of its ability to model traffic in a realistic *** many cities of Saudi Arabia,traffic management represents a major challenge as a result of expansion in traffic demands and increasing number of ***,employing simulation to provide effective traffic management for local scenarios in Saudi Arabia is limited to a number of commercial products in both public and private *** simulators are usually expensive,closed source and inflexible as they allow limited *** this project,we developed a local traffic simulator“KSUtraffic”for traffic modeling,planning and analysis with respect to different traffic control strategies and *** modeled information specified by GIS and real traffic ***,we designed experiments that manipulate simulation parameters and the underlying *** visualizes traffic and provides statistical results on the simulated traffic which would help to improve traffic management and efficiency.

关键词： Simulation and modelling smart cities smart infrastructure traffic management and planning intelligent transportation

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Effects of high glucose and severe hypoxia on the biological behavior of mesenchymal stem cells at various passages

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World Journal of Stem Cells 2024年第4期16卷 434-443页

作者： Fatimah Almahasneh Ejlal Abu-El-Rub Ramada R Khasawneh rawan Almazari Department of Basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbid 21163Jordan

BACKGROUND Mesenchymal stem cells(MSCs)have been extensively studied for therapeutic potential,due to their regenerative and immunomodulatory *** passage and stress factors may affect the biological characteristics of MSCs,but the details of these effects have not been recognized *** To investigate the effects of stress factors(high glucose and severe hypoxia)on the biological characteristics of MSCs at different passages,in order to optimize the therapeutic applications of *** In this study,we investigated the impact of two stress conditions;severe hypoxia and high glucose on human adipose-tissue derived MSCs(hAD-MSCs)at passages 6(P6),P8,and ***,senescence and apoptosis were evaluated measuring WST-1,senescence-associated beta-galactosidase,and annexin V,*** Cells at P6 showed decreased proliferation and increased apoptosis under conditions of high glucose and hypoxia compared to control,while the extent of senescence did not change significantly under stress *** P8 hAD-MSCs cultured in stress conditions had a significant decrease in proliferation and apoptosis and a significant increase in senescence compared to counterpart cells at *** cultured in high glucose at P10 had lower proliferation and higher senescence than their counterparts in the previous passage,while no change in apoptosis was *** the other hand,MSCs cultured under hypoxia showed decreased senescence,increased apoptosis and no significant change in proliferation when compared to the same conditions at *** These results indicate that stress factors had distinct effects on the biological processes of MSCs at different passages,and suggest that senescence may be a protective mechanism for MSCs to survive under stress conditions at higher passage numbers.

关键词： Mesenchymal stem cells High glucose Hypoxia Stressful microenvironment Serial passage Senescence Apoptosis

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Budd-Chiari syndrome associated with coeliac disease:case report and literature review

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Gastroenterology Report 2018年第4期6卷 308-312,I0002页

作者： Khaled Ali Jadallah Enas Walid Sarsak Yara Mohammad Khazaleh rawan Mohammad Khair Barakat Department of Internal Medicine King Abdullah University HospitalIrbidJordan

We report a case of Budd-Chiari syndrome occurring in a patient with coeliac disease,who presented with symptoms of increased abdominal girth,right upper quadrant pain and shortness of breath for three weeks prior to *** assessment revealed the presence of moderate ascites,hepatosplenomegaly and right-sided pleural *** diagnostic work-up established a diagnosis of chronic Budd-Chiari ***,complete screening for pro-thrombotic factors was negative.A review of the literature on this association disclosed only 28 similar cases,with the majority of them describing individuals of North African ***,in the majority of cases no specific thrombotic factor could be identified,suggesting that coeliac disease may play a role in this thrombotic disorder.

关键词： coeliac disease Budd-Chiari syndrome hepatic vein thrombosis

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Non-alcoholic fatty liver disease:Is surgery the best current option and can novel endoscopy play a role in the future?

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World Journal of Hepatology 2022年第9期14卷 1704-1717页

作者： Mandour Omer Mandour Mohammed El-Hassan rawan M Elkomi Jude A Oben Department of Gastroenterology and Hepatology Guys&St Thomas HospitalLondonSE17EHUnited Kingdom King’s College London School of Life Course SciencesFaculty of Life Sciences and MedicineLondon SE17EHUnited Kingdom

alcohol as the leading cause of cirrhosis in the Western *** remains to be a licensed pharmacological treatment for *** loss is advised for all patients with *** patients however,struggle to lose the recommended weight with lifestyle modification *** drugs have either failed to show significant improvement of steatosis or are poorly *** surgery has been shown to reduce liver steatosis and regress liver *** pathophysiology is not fully understood,however recent evidence has pointed towards changes in the gut microbiome following *** endoscopic treatment options provide a minimally invasive alternative for weight *** controlled trials are now required for further clarification.

关键词： Obesity Metabolic associated fatty liver disease Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Bariatric endoscopy Bariatric surgery©The Author(s)2022.Published by Baishideng Publishing Group Inc.All rights reserved

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The use of new class α-amino nitrile modified magnetic adsorbents for removal of Cd(II) from aqueous medium: Sorbent modification vs. α-amino nitrile addition to the adsorption medium

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Emerging Contaminants 2024年第1期10卷 32-46页

作者： Eyad A.Younes Amjad H.El-Sheikh rawan B.Alsmadi Department of Chemistry Faculty of ScienceThe Hashemite UniversityP.O.Box 330127Zarqa13133Jordan

In the present work,some novel α-amino nitriles were prepared:amino-2-(anthracen-9-yl)acetonitrile(AAN),and 2-(naphthalen-1-yl)-2-((triethoxysilyl)propyl)amino)acetonitrile(Si-AN).With the aid of other organic compounds(3-aminopropyl triethoxysilane“APTES”and tetraethyl orthosilicate“TEOS”),the following carbon nanotubes“CNT”and magnetite“Mag”based adsorbents were prepared:CNT-AAN,Mag-SiO_(2),Mag-SiO_(2)-APTES,Mag-SiO_(2)-*** FT-IR,1H and 13C NMR spectroscopy proved the formation of(C triple bond N)and(NH-)bonds which indicated successful amino nitrile modification of the *** ability of the above-mentioned adsorbents to remove cadmium“Cd(II)”from water was studied at various pH *** modification with AAN reduced Cd(II)uptake,while all Mag modifications increased Cd *** addition of AAN to the extraction medium with CNT sorbent reduced Cd(II)*** addition of TEOS and Si-AN to the extraction medium for Cd(II)removal using Mag was studied where a positive impact was *** on the above experiments,it was decided to use Mag as adsorbent with the addition of Si-AN to the extraction *** optimization recommended pH 8 and Cd:Si-AN molar ratio of 1:*** maximum adsorption capacity towards Cd(II)achieved in this study was 65 mg g^(−1).The method selectivity,re-usability and applicability on well water and tap water samples gave appropriate *** adsorption of Cd(II)on Mag in the presence of Si-AN was fast,endothermic,spontaneous,favored and physi-sorption was predominant.

关键词： Amino nitriles Magnetite Carbon nanotubes Cadmium uptake

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