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Phytochemical constituents and antibacterial activity of some green leafy vegetables

Asian Pacific Journal of Tropical Biomedicine 2014年第3期4卷 189-193页

作者： ramesa shafi bhat Sooad Al-Daihan Biochemistry Department College of ScienceKing Saud UniversityP.O.Box 22452Riyadh 11495.Saudi Arabia

Objective:To investigate the antibacterial activity and photochemicals of five green leafy vegetables against a panel of five bacteria ***:Disc diffusion method was used to determine the antibacterial activity,while kanamycin was used as a reference *** phytochemical screening of the extracts was performed using standard ***:All methanol extracts were found active against all the test bacterial *** maximum extracts shows antibacterial activity which range from 6 to 15 *** and carbohydrates was found in all the green leaves,whereas ***,*** were found in most of the test ***:The obtain result suggests that green leafy vegetables have moderate antibacterial activity and contain various pharmacologically active compounds and thus provide the scientific basis for the traditional uses of the studied vegetables in the treatment of bacterial infections.

关键词： Green leafy vegetables Antibacterial activity Phytochemical screening.

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Prenatal exposure to the fluoride containing psychiatric drug fluoxetine and anti-oxidative alterations in the neonatal rat brain

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BIOCELL 2019年第2期43卷 65-71页

作者： ramesa shafi bhat AMINA EL GEZEERY ABIR BEN BACHAN MONA AWAD ALONAZI LEENA SALEH ALSUHAIBANI AFAF EL-ANSARY Biochemistry Department College of ScienceKing Saud University Human Genetic Department Medical Research instituteAlexandria UniversityEgypt Central Laboratory Female Centre for Scientific and Medical StudiesKing Saud UniversitySaudi Arabia Medicinal Chemistry Department National Research CentreDokkiCairoEgypt

Fluoride is a key ingredient of many psychiatric drugs like fluoxetine(Prozac■Fluoxetine■).Pregnant women frequently use this drug as they suffer from depression and anxiety disorders during this *** is able to reach the fetus through the placenta and passes to the newborn through *** the present study,female Wistar rats were treated with 5,10,and 20 mg/L fluoxetine(containing 94% fluorides)from pregnancy day 10 to day *** delivery,the levels of the enzymatic antioxidants in the brain of their offspring at postnatal day 2 were *** results showed that,in all fluoxetine exposed groups compared with the control group,there was a significant decrease(P0.05)in the activity of malondialdehyde and creatine *** results suggest that fluoxetine may be a developmental neurotoxicant due to presence of fluoride hence must be used carefully during pregnancy.

关键词： Antidepressant Brain Neonate Prozac Oxidative stress

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The expressional level of tankyrase-1 gene and its regulation in colorectal cancer in a Saudi population

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BIOCELL 2019年第2期43卷 51-57页

作者： HALA ABDULAZIZ M ALWARTHAN MOHAMMAD SAUD AL ANAZI NARASIMHA RPARINE ramesa shafi bhat GHADAH ALAMRO FTOON ALJARBOU SOOAD K AL-DAIHAN Department of Biochemistry College of ScienceKing Saud UniversityP.O.Box 22452Zip code 11495RiyadhSaudi Arabia

Tankyrase1(TNKS1)plays an essential role in cancer progression by regulating telomere *** study aimed to determine expression of TNKS1 and its regulation in colorectal cancer(CRC)in 20 samples from Saudi *** expression of TNKS1 in CRC and paired normal tissues was measured by *** modification of TNKS1 promoter was determined by methylation-specific PCR while somatic mutation was analyzed by Sanger sequencing in exon 10 of the *** cancerous and normal tissues expressed TNKS1,but level of expression in CRC tissues was significantly associated with tumor stage though no other parameters;age,gender,and tumor location,showed any *** of TNKS1 was markedly higher in earlier(I,II)than in later(Ⅲ,Ⅳ)stages of CRC *** cancerous and healthy tissues had unmethylated *** sequencing of exon 10 masked any somatic mutation in the *** findings suggest that up-regulation of TNKS1 was inversely correlated with cancer progression in CRC,indicating that TNKS1 participates in the initiation of CRC by stabilizing telomere length in the first phase of cancer *** other than TNKS1 might play a role in malignant tumor progression and telomere maintenance in the late stages of CRC.

关键词： Gene expression TNKS1 cancer progression telomeres

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Association between preterm birth risk and polymorphism and expression of the DNA repair genes OGG1 and APE1 in Saudi women

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BIOCELL 2018年第1期42卷 1-6页

作者： ARWA OSAMA NEMER MOHAMMAD SAUD AL ANAZI ramesa shafi bhat ARJUMAND S.WARSY ZENEB A BABAY MOHAMMAD HADDAR JILANI SHAIK SOOAD AL-DAIHAN Department of Biochemistry College of Science Genome Research Chair Department of BiochemistryCollege of Science Central Laboratory Female Center for Medical Studies and Scientific Section Department of Obs/Gyn College of MedicineKing Saud UniversityP.O.Box 22452Zip code 11495RiyadhSaudi Arabia

Genomic instability and mutations caused by increases in oxidative stress during pregnancy can damage the fetoplacental unit and can upshot preterm *** damage to DNA may possibly be involved in etiology of preterm birth(PTB)which can be repaired by DNA repair *** the present study,we assessed the association of base excision repair gene family by analyzing the association of single nucleotide polymorphisms and genes expression in 8-oxoguanine glycosylase-1(OGG1)and apurinic-apyrimidinic endonuclease 1(APE1)genes with risk of preterm birth in Saudi *** analyzed genotypes of four single nucleotide polymorphisms(SNPs)(rs1052133,rs293795,rs2072668 and rs2075747)in OGG1 gene and three SNPs(rs1130409,rs3136814,and rs3136817)in APE1 gene using TaqMan Genotyping assay kits in 50 pairs of preterm cases and individually matched ***,gene expression level was explored by RT-PCR in 10 pairs of preterm placental tissues and individually matched normal placental *** OGG1 SNP,rs1052133(OR=0.497;c2=1.11;p=0.292)and rs2072668(OR=0.408;c2=1.90;p=0.167)and one APE1 SNP rs3136817(OR=0.458;c2=0.40;p=0.527)showed nonsignificant protective effect against PTB *** expression of both genes under study was found lower in the PTB *** and allele frequencies of both gene SNPs did not show any association with the risk of preterm delivery in Saudi women(P˃0.05).However,synthesis and release of OGG1 and APE1 proteins decreased in preterm placental tissues compared to term delivery reflects the probability of being one of the mechanisms leading to preterm birth.

关键词： Preterm birth OGG1 and APE1 genes Oxidative stress SNPs

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