The expressional level of tankyrase-1 gene and its regulation in colorectal cancer in a Saudi population
作者机构：Department of BiochemistryCollege of ScienceKing Saud UniversityP.O.Box 22452Zip code 11495RiyadhSaudi Arabia
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2019年第43卷第2期
页 面：51-57页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：funded by King Abdulaziz City for Science and Technology(KACST) grant number(1-17-01-001-0056)
主 题：Gene expression TNKS1 cancer progression telomeres
摘 要：Tankyrase1(TNKS1)plays an essential role in cancer progression by regulating telomere *** study aimed to determine expression of TNKS1 and its regulation in colorectal cancer(CRC)in 20 samples from Saudi *** expression of TNKS1 in CRC and paired normal tissues was measured by *** modification of TNKS1 promoter was determined by methylation-specific PCR while somatic mutation was analyzed by Sanger sequencing in exon 10 of the *** cancerous and normal tissues expressed TNKS1,but level of expression in CRC tissues was significantly associated with tumor stage though no other parameters;age,gender,and tumor location,showed any *** of TNKS1 was markedly higher in earlier(I,II)than in later(Ⅲ,Ⅳ)stages of CRC *** cancerous and healthy tissues had unmethylated *** sequencing of exon 10 masked any somatic mutation in the *** findings suggest that up-regulation of TNKS1 was inversely correlated with cancer progression in CRC,indicating that TNKS1 participates in the initiation of CRC by stabilizing telomere length in the first phase of cancer *** other than TNKS1 might play a role in malignant tumor progression and telomere maintenance in the late stages of CRC.
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