The expressional level of tankyrase-1 gene and its regulation in colorectal cancer in a Saudi population

作     者：HALA ABDULAZIZ M ALWARTHAN MOHAMMAD SAUD AL ANAZI NARASIMHA RPARINE RAMESA SHAFI BHAT GHADAH ALAMRO FTOON ALJARBOU SOOAD K AL-DAIHAN 

作者机构：Department of BiochemistryCollege of ScienceKing Saud UniversityP.O.Box 22452Zip code 11495RiyadhSaudi Arabia 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2019年第43卷第2期

页      面：51-57页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by King Abdulaziz City for Science and Technology(KACST) grant number(1-17-01-001-0056) 

主　　题：Gene expression TNKS1 cancer progression telomeres 

摘      要：Tankyrase1(TNKS1)plays an essential role in cancer progression by regulating telomere *** study aimed to determine expression of TNKS1 and its regulation in colorectal cancer(CRC)in 20 samples from Saudi *** expression of TNKS1 in CRC and paired normal tissues was measured by *** modification of TNKS1 promoter was determined by methylation-specific PCR while somatic mutation was analyzed by Sanger sequencing in exon 10 of the *** cancerous and normal tissues expressed TNKS1,but level of expression in CRC tissues was significantly associated with tumor stage though no other parameters;age,gender,and tumor location,showed any *** of TNKS1 was markedly higher in earlier(I,II)than in later(Ⅲ,Ⅳ)stages of CRC *** cancerous and healthy tissues had unmethylated *** sequencing of exon 10 masked any somatic mutation in the *** findings suggest that up-regulation of TNKS1 was inversely correlated with cancer progression in CRC,indicating that TNKS1 participates in the initiation of CRC by stabilizing telomere length in the first phase of cancer *** other than TNKS1 might play a role in malignant tumor progression and telomere maintenance in the late stages of CRC.