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Microarray analysis of signalling interactions between inflammation and angiogenesis in subchondral bone in temporomandibular joint osteoarthritis

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Biomaterials Translational 2024年第2期5卷 175-184页

作者： Qin W. Gao J. Yan J. Han x. Lu W. Ma Z. Niu L. Jiao K. Department of Stomatology Tangdu Hospital and State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China State Key Laboratory of Oral and Maxillofacial reconstruction and regeneration and National Clinical research Centre for Oral Diseases Shaanxi Key Laboratory of Stomatology School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China

Inflammation and angiogenesis, the major pathological changes of osteoarthritis (OA), are closely associated with joint pain; however, pertinent signalling interactions within subchondral bone of osteoarthritic joints and potential contribution to the peripheral origin of OA pain remain to be elucidated. Herein we developed a unilateral anterior crossbite mouse model with osteoarthritic changes in the temporomandibular joint. Microarray-based transcriptome analysis, besides quantitative real-time polymerase chain reaction, was performed to identify differentially expressed genes (DEGs). Overall, 182 DEGs (fold change ≥ 2, P re identified between the control and unilateral anterior crossbite groups: 168 were upregulated and 14 were downregulated. On subjecting significant DEGs to enrichment analyses, inflammation and angiogenesis were identified as the most affected. Inflammation-related DEGs were mainly enriched in T cell activation and differentiation and in the mammalian target of rapamycin/nuclear factor-κB/tumour necrosis factor signalling. Furthermore, angiogenesis-related DEGs were mainly enriched in the Gene Ontology terms angiogenesis regulation and vasculature development and in the KEGG pathways of phosphoinositide 3-kinase-protein kinase B/vascular endothelial growth factor/hypoxia-inducible factor 1 signalling. Protein– protein interaction analysis revealed a close interaction between inflammation-and angiogenesis-related DEGs, suggesting that phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (Pi3kcd), cathelicidin antimicrobial peptide (Camp), C-x-C motif chemokine receptor 4 (Cxcr4), and MYB proto-oncogene transcription factor (Myb) play a central role in their interaction. To summarize, our findings reveal that in subchondral bone of osteoarthritic joints, signal interaction is interrelated between inflammation and angiogenesis and associated with the peripheral origin of OA pain; moreover, our data highlight potential t

关键词： angiogenesis inflammation osteoarthritic pain osteoarthritis subchondral bone temporomandibular joint (TMJ)

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TcPO2 changes are more pronounced than SpO2 changes during simulated altitude changes in a hypobaric oxygen chamber: a nonrandomized controlled trial

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Emergency and Critical Care Medicine 2024年第3期4卷 105-110页

作者： Li Y. Chen L. Fu Z. Wang Z. Sun S. Luan x. Ma D. Hu T. School of Nursing and rehabilitation Shandong University Shandong Jinan China Department of Emergency and Critical Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Department of Pulmonary and Critical Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Emergency Management Center of State Grid Shandong Electric Power Company Shandong Jinan China School of Nursing and rehabilitation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China School of Mechanical Engineering Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Background: Hypoxia is a significant risk factor of hypertension. However, no studies have used transcutaneous tissue partial pressure of oxygen (TcPO2) and partial pressure of carbon dioxide (TcPCO2) monitors to measure the respective partial pressures in healthy individuals. Oxygen saturation (SpO2) is often used for traditional monitoring of vital signs. This study investigated the changes in TcPO2 and SpO2 values during rapid changes in altitude. The trial was registered at *** (registration no. NCT06076057). Methods: Healthy adult volunteers were instructed to sit vertically in a hypobaric oxygen chamber, which ascended from 0 m to 2500 m at a uniform speed within 10 min. The Danish radiometer TCM4 was used to measure TcPO2 and TcPCO2 with the ventral side of the upper arm as the measurement site. The Shenzhen Kerokan P0D-1 W pulse oximeter was used to measure heart rate and SpO2, with values recorded once every 500 m. results: Altogether, 49 healthy volunteers were recruited between March 2023 and August 2023. With increasing altitude, TcPO2 and SpO2 decreased significantly (P ring the ascent from 0 m, TcPO2 began to change statistically at 500 m (P reas SpO2 began to change statistically at 1000 m (P rence in TcPO2 was greater than the difference in SpO2. At 1000 m, there were statistically significant changes in TcPO2 and SpO2 (P 500 m, statistical significance was identified between TcPO2 in both sexes (P rt rate was observed at the different elevations (P ressure hypoxic environments, TcPO2 changed more dramatically than SpO2 © Wolters Kluwer Health, Inc. All rights reserved.

关键词： Altitude change Low-pressure oxygen chamber Transcutaneous oxygen saturation Transcutaneous partial pressure of oxygen

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Genotypes and Phenotypes of Uygur Children with xeroderma Pigmentosum: A Case Study in xinjiang, China

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International Journal of Dermatology and Venereology 2024年第3期7卷 144-149页

作者： Qiu Y. Wang W.-J. Liang J.-Q. Yakeya B. Wang P. Zhang J.-Z. Kang x.-J. Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China xinjiang Clinical research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China xinjiang Key Laboratory of Dermatology research (xJYS1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Objective: xeroderma pigmentosum (xP) is a rare autosomal recessive dermatosis caused by genetic defects of DNA repair. This study was performed to detect and analyze the genes of 2 Uygur patients with xP and their families and assess the patients' phenotypes, which may enrich the understanding of the genetic skin disorder spectrum in xinjiang area. Methods: We collected the clinical data from 2 patients with xP and peripheral blood samples from the patients and their family members. The patients' DNA was sequenced and detected by Sanger sequencing, and gene mutations were screened. results: The proband in family 1 presented with brown maculae at the exposure site and squamous cell carcinoma secondary to a facial rash. The proband had a homozygous nucleotide variation of xPC c.2251-2A> G (A change from A to G in the penultimate position of the intron before the 2251 position in the coding region), which was a shear mutation. In this family, both parents were heterozygous, and no similar mutation detected in the sister. In family 2, the proband had scattered black brown spots and papules on the trunk and limbs. and his younger sister was also a patient. The proband and his younger sister had homonucleotide variation of xPA c.631C> T, which was nonsense mutation, resulting in the codon for Arg No.211 being changed into termination codon (***211x), thus terminating the peptide chain synthesis prematurely. All the normal individuals in the two families were heterozygotes, and homozygous mutations occurred in all the patients, which was consistent with the autosomal recessive inheritance. Conclusion: xP is rare in Uygur population. This study expanded the mutation spectrum of xP and provided a basis for early diagnosis, treatment, prognostic prediction, and prenatal genetic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences, and Chinese Medical Association, published by Wolters Kluwer, Inc.

关键词： gene mutation xeroderma pigmentosum xPA gene xPC gene

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Determination of the number ofψ(3686)events taken at BESⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis x.C.Ai r.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-r.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko r.A.Briere A.Brueggemann H.Cai x.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang G.r.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen H.Y.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen x.r.Chen x.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi r.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding x.x.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong x.Dong M.C.Du S.x.Du Y.Y.Duan Z.H.Duan P.Egorov Y.H.Fan J.Fang J.Fang S.S.Fang W.x.Fang Y.Fang Y.Q.Fang r.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao x.B.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.x.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo r.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han F.Hanisch x.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou x.T.Hou Y.r.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu S.L.Hu T.Hu Y.Hu G.S.Huang K.x.Huang L.Q.Huang x.T.Huang Y.P.Huang T.Hussain F.Hölzken N.Hüsken N.in der Wiesche J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji x.B.Ji x.L.Ji Y.Y.Ji x.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang x.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing x.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki x.L.Kang x.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz r.Kiuchi O.B.Kolcu B.Kopf M.Kuessner x.Kui N.Kumar A.Kupsc W.Kühn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.B.Li H.J.Li H.N.Li Hui Li J.r.Li J.S.Li Ke Li L.J.Li L.K.Li Lei Li M.H.Li P.r.Li Q.M.Li Q.x.Li r.Li S.x.Li T.Li W.D.Li W.G.Li x.Li x.H.Li x.L.Li x.Z.Li xi Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics SB rAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion research GmbH D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

The number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BESⅢdetector

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全球涡旋经向偏转的遥感研究:物理机制与海洋学应用

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中国科学：地球科学 2024年第3期54卷 830-844页

作者：陈戈陈笑炎中国海洋大学深海圈层与地球系统前沿科学中心海洋技术学院青岛266100 崂山实验室区域海洋动力学与数值模拟功能实验室青岛266237

研究普遍认为海洋涡旋的经向运动遵循气旋涡向极地偏转、反气旋涡向赤道偏转的规律,然而,这一极性主导的传统认知在全球和区域上均存在一定的偏差和误导性.本文深入探索了涡旋经向运动的本质规律,发现涡旋的时空地转性、海表温度的热衰... 详细信息

研究普遍认为海洋涡旋的经向运动遵循气旋涡向极地偏转、反气旋涡向赤道偏转的规律,然而,这一极性主导的传统认知在全球和区域上均存在一定的偏差和误导性.本文深入探索了涡旋经向运动的本质规律,发现涡旋的时空地转性、海表温度的热衰减以及背景流场的拖曳作用是涡旋经向偏转的主要机制,并得到以下主要结论:(1)涡旋经向偏转由极性主导是一个伪命题,得出这一结论是由于涡旋轨迹的归一化拟合存在偏差和不对称性;相反,涡旋经向偏转更多是由地理位置决定的,且不受涡旋极性的影响;(2)地转调整效应对调制涡旋经向偏转起着关键作用,对于空间(时间)上的非地转涡旋,无论涡旋极性如何,均呈现出向极地(赤道)的偏转趋势;(3)影响涡旋经向偏转的物理机制与其运动方向相关,西向运动涡旋主要受到海表温度的热衰减影响,东向涡旋则主要受到背景流场的拖曳作用.深入理解涡旋的经向偏转规律及物理机制,对于实现涡旋轨迹高精度预测,以及海洋环境监测和保护具有重要意义.

关键词：海洋涡旋涡旋传播涡旋经向偏转卫星遥感观测地转调整

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Temperature and structure measurements of heavy-ion-heated diamond using in situ x-ray diagnostics

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Matter and radiation at Extremes 2024年第4期9卷 80-89页

作者： J.Lutgert P.Hesselbach M.Schorner V.Bagnoud r.Belikov P.Drechsel B.Heuser O.SHumphries P.Katrik B.Lindqvist C.Qu r.redmer D.riley G.Schaumann S.Schumacher A.Tauschwitz D.Varentsov K.Weyrich x.Yu B.Zielbauer Zs.Major P.Neumayer D.Kraus Institut fur Physik Universitat RostockAlbert-Einstein-Str.2318059 RostockGermany GSI Helmholtzzentrum fur Schwerionenforschung Planckstr.164291 DarmstadtGermany Institut für Angewandte Physik Goethe-Universität Frankfurt am MainMax-von-Laue-Str.160438 Frankfurt am MainGermany Institut fur Geowissenschaften Goethe-Universitat Frankfurt am MainAltenhoferallee 160438 Frankfurt am MainGermany Helmholtz-Zentrum Dresden-rossendorf Bautzner Landstr.40001328 DresdenGermany European xFEL GmbH Holzkoppel 422869 SchenefeldGermany Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastUniversity RoadBelfast BT71NNUnited Kingdom Institut für Kernphysik Technische Universität DarmstadtSchlossgartenstr.964289 DarmstadtGermany State Key Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsPeking UniversityBeijing 100871China Helmholtz Institut Jena Frobelstieg 307743 JenaGermany

We present in situ measurements of spectrally resolved x-ray scattering and x-ray diffraction from monocrystalline diamond samples heatedwith an intense pulse of heavy *** this way,we determine the samples’heating dynamics and their microscopic and macroscopic structuralintegrity over a timespan of several *** the ratio of elastic to inelastic scattering with state-of-the-art density functionaltheory molecular dynamics simulations allows the inference of average temperatures around 1300 K,in agreement with predictions fromstopping power *** simultaneous diffraction measurements show no hints of any volumetric graphitization of the material,butdo indicate the onset of fracture in the diamond *** experiments pave the way for future studies at the Facility for Antiproton andIon research,where a substantially increased intensity of the heavy ion beam will be available.

关键词： heated intense structure

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青藏高原及其周边侏罗纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 1211-1243页

作者：李建国饶馨牟林崔肖辉李鑫罗辉刘培学中国科学院南京地质古生物研究所中国科学院生物演化与环境卓越创新中心南京210008 中国科学院大学南京学院南京211135

侏罗纪是青藏高原构造演化的重要阶段,它结束了古特提斯构造演化,即将迎来印度板块的向北漂移和新特提斯的消减.地层时代是地质历史重建的基础.本文对近年来所取得的一些地层学、古生物新发现和新进展进行了综合和梳理,为青藏高原侏罗... 详细信息

侏罗纪是青藏高原构造演化的重要阶段,它结束了古特提斯构造演化,即将迎来印度板块的向北漂移和新特提斯的消减.地层时代是地质历史重建的基础.本文对近年来所取得的一些地层学、古生物新发现和新进展进行了综合和梳理,为青藏高原侏罗系建立了一个新的多重地层划分对比和时代框架.该框架包括巴颜喀拉、羌塘、拉萨-冈底斯和藏南喜马拉雅四个分区.其中,综合生物地层框架得到了很大的补充和细化,包括了一系列在青藏高原侏罗系中常见并在国际侏罗系划分对比中具有重要作用的化石门类,如海相的菊石、双壳、腕足、放射虫、有孔虫和沟鞭藻以及陆相的孢子花粉和轮藻等.通过菊石标准分子或特征属种,建立了该生物地层框架与国际地层委员会2020年侏罗纪地质年表(GTS 2020)的标准分带的对比.以此为基础,建立了青藏高原主要区块间侏罗系的横向对比.生物群对比揭示,侏罗纪时拉萨-冈底斯区与羌塘区的关系比与藏南喜马拉雅更紧密,它们总体属于东特提斯洋北缘海区同一个特征相似的生物地理区系,不太支持雅鲁藏布江缝合带特提斯是弧后小盆地的观点.综合地层、生物和沉积特征,研究认为,班公湖-怒江特提斯在晚三叠世开始张裂,可能在早侏罗世晚期已有初始洋壳增生形成;中侏罗世晚期班公湖-怒江洋发展至顶峰,随后开始收缩,羌塘地块向南俯冲与拉萨-冈底斯地块发生碰撞和拼合.

关键词：生物地层年代地层特提斯雅鲁藏布缝合带班公湖-怒江缝合带

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氢安全建模研究进展

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化工进展 2024年

作者：程崇律单聪慧张孟凡 WEN x Jennifer 徐宝鹏萨里大学可持续发展研究所大连理工大学能源与动力学院

氢能对于实现国家“双碳”目标至关重要。由于氢气独特的性质，在储存、运输和使用过程中极易发生泄漏，从而引发严重的安全事故，这成为制约氢能源大规模应用的主要障碍之一。为了更好地应对氢能利用过程中的安全挑战，开展风险研究至... 详细信息

氢能对于实现国家“双碳”目标至关重要。由于氢气独特的性质，在储存、运输和使用过程中极易发生泄漏，从而引发严重的安全事故，这成为制约氢能源大规模应用的主要障碍之一。为了更好地应对氢能利用过程中的安全挑战，开展风险研究至关重要。本文简要介绍了氢气的基本理化特性，讨论了氢气和液氢泄漏、扩散、射流火焰以及爆炸的建模方法，总结了氢气和液氢在泄漏、扩散、射流燃烧和爆炸等过程中的演化规律以及内在机理，深入分析了影响上述过程的多种关键因素，例如气体种类、储存条件、泄漏条件、环境条件和通风条件等，重点关注了CFD方法在当前研究中的应用；指出了当前研究的不足之处，并就未来的发展方向提出建议。对于促进氢能安全研究、完善事故预防和应急响应机制具有重要指导意义。

关键词：氢泄漏扩散燃烧爆炸数值模拟

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轻质铝基熵合金:概述与未来趋势

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Science China Materials 2024年第1期67卷 31-46页

作者：崔立莹张展陈晓光 Department of Applied Science University of Quebec at Chicoutimi555boulevard de l’UniversiteSaguenay G7H 2B1QCCanada

新一代合金——高熵合金的出现,揭示了熵效应在合金设计中的重要意义.受这一概念的启发,轻质铝基熵合金这一概念被提出.随着对低密度结构材料的需求不断增加,这些新型合金在各种应用中具有巨大的潜力.本文综述了轻质铝基熵合金的发展背... 详细信息

新一代合金——高熵合金的出现,揭示了熵效应在合金设计中的重要意义.受这一概念的启发,轻质铝基熵合金这一概念被提出.随着对低密度结构材料的需求不断增加,这些新型合金在各种应用中具有巨大的潜力.本文综述了轻质铝基熵合金的发展背景、设计原理、制造方法、微观结构和力学性能、高温应用,及其发展前景.通过对当前研究的全面调查,本文重点研究分析了122种密度低于4.0 g cm-3的铝基熵合金.轻质铝基熵合金可以弥补传统铝和钛合金在机械性能和密度方面的差距.轻质铝基熵合金优异的热稳定性使其有望成为在高温下使用的结构材料.此外,本文还讨论了轻质铝基熵合金领域的未来发展趋势.机器学习作为有效计算工具,可以极大地提高合金的开发效率.

关键词：高温应用合金设计新型合金机器学习铝基计算工具高熵合金微观结构

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青藏高原及其周边奥陶纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 992-1025页

作者：方翔甄勇毅王光旭魏鑫陈中阳梁艳武学进李文杰李超詹仁斌张元动现代古生物学和地层学国家重点实验室中国科学院南京地质古生物研究所南京210008 Geological Survey of New South Wales W.B.Clarke Geoscience CentreNSW 2753Australia 中国科学院大学北京100049

青藏高原奥陶系代表该地区未变质沉积地层的最古老记录,是解读该地区早期地质历史和生物演化的关键层段.青藏高原地区奥陶系底部地层存在不同程度的缺失,但具有下奥陶统弗洛阶、中奥陶统达瑞威尔阶,以及上奥陶统桑比阶、凯迪阶和赫南特... 详细信息

青藏高原奥陶系代表该地区未变质沉积地层的最古老记录,是解读该地区早期地质历史和生物演化的关键层段.青藏高原地区奥陶系底部地层存在不同程度的缺失,但具有下奥陶统弗洛阶、中奥陶统达瑞威尔阶,以及上奥陶统桑比阶、凯迪阶和赫南特阶,可划分为喜马拉雅、冈底斯-察隅、羌塘-昌都、松潘-甘孜、喀喇昆仑-昆仑-阿尔金等地层区,并可与周边的滇缅马、印支、柴达木-祁连、塔里木-天山和扬子区(西缘)等地层区进行综合地层对比.笔石、牙形刺和头足类是青藏高原地区奥陶系最常见的、据以构建该地区生物地层框架的化石门类.青藏高原奥陶纪生物群具有鲜明的生物古地理区系特色,其中头足类在早-中奥陶世以珠角石类繁盛为特征,显示与华北板块具有密切亲缘关系,但到晚奥陶世则以喇叭角石和直角石类繁盛为特征,表现出与华南的密切关系.青藏高原的奥陶纪多门类动物群及其生物古地理演化,为冈瓦纳东北缘地区的奥陶纪古板块重建提供了重要依据.西藏南部喜马拉雅地体、拉萨地体及周边的滇缅马地体在寒武纪晚期-奥陶纪早期经历了库尔加克运动,这次影响深远的构造热事件造成了奥陶纪地层与下伏基底地层之间的角度不整合接触关系,这一间断面在青藏高原大部分地区存在.西藏南部中奥陶统发育鲕粒灰岩和暖水生物群,指示当时位于赤道附近的低纬度地带.喜马拉雅地体及滇缅马地体的上奥陶统普遍发育大套具有网纹结构的海相碳酸盐岩红层,可与华南扬子区的同期地层进行对比,二者可能具有相同或相似的成因背景.奥陶纪末全球性冰期与海平面下降事件也造成了滇西和缅甸掸邦等地区普遍缺失凯迪晚期地层,对青藏高原的申扎和聂拉木等地区也有较大影响.

关键词：奥陶系年代地层岩石地层生物地层生物古地理生物和地质事件

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