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Pathophysiology and treatment of Barrett's esophagus

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World Journal of Gastroenterology 2010年第30期16卷 3762-3772页

作者： Daniel s Oh steven r DeMeester Department of surgery The University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States

Gastroesophageal reflux disease (GErD) affects an estimated 20% of the population in the United states. About 10%-15% of patients with GErD develop Barrett’s esophagus, which can progr.s. to adenocarcinoma, currently the most prevalent type of esophageal cancer. The esophagus is normally lined by squamous mucosa, therefore, it is clear that for adenocarcinoma to develop, there must be a sequence of events that r.s.lt in transformation of the normal squamous mucosa into columnar epithelium. This sequence begins with gastroesophageal reflux, and with continued injury metaplastic columnar epithelium develops. This article reviews the pathophysiology of Barrett’s esophagus and implications for its treatment. The effect of medical and surgical therapy of Barrett’s esophagus is compared.

关键词： Gastroesophageal reflux disease Barrett’s esophagus Lower esophageal sphincter Esophageal motility Proton pump inhibitors Antireflux surgery

Nucleoside modified mrNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural regeneration r.s.arch 2025年第8期20卷 2311-2312页

作者： Kr.s.tián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for.s.ontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expr.s.ion of growth inhibitory factors,lack or.s.ppr.s.ion of proper guidance cues,and profound inflammatory r.s.onses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural regeneration r.s.arch 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair Ahmed WMatthijs Blankesteijn sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CArIM-school for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neur.s.ience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma sciences r.s.arch University of BirminghamEdgbastonBirminghamUK MHeNs-school for Mental Health and Neur.s.ience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer.s.disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(csVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term csVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular.s.aces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CsVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

Dispersion sensitivity analysis&consistency im provement of APFsDs

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Defence Technology（防务技术） 2017年第4期13卷 316-322页

作者： sangeeta sharma Panda L.K. Gite A. Anandaraj r.s. Deodhar D.K. Joshi K.M. rajan Armament r.s.arch Development Establishment (ArDE) Defence Research Development Organization Ministry of Defence Government of India Pashan Pune Maharashtra 411 021 India

The purpose of this study is to investigate and quantify some possible sources of dispersion of 120 mm APFsDs tank ammunition both experimentally and *** paper aims to point out the most influential source during In-Bore Balloting Motion phase as well as in External Ballistics phase of the ammunition and quantifies its effect on *** obtained from flight trials is critically analysed and parameters affecting dispersion such as initial yaw/pitch rates,yaw/pitch dampening,plane start angle,launch spin,clearance,centre of gravity shift,dynamic imbalance angle,cr.s. wind,*** observed and,later on,studied in detail by extensive External Ballistics Monte Carlo(EBMC)simulation and six Degree of Freedom(6-DOF)trajectory *** Bore Balloting Motion simulation shows that reduction in r.s.dual spin by about 5%r.s.lts in dr.s.ic56%reduction in first maximum yaw.A correlation between first maximum yaw and r.s.dual spin is *** of data analysis are used in design modification for existing *** of designs are evaluated numerically before freezing five designs for further *** designs are critically assessed in ter.s.of their comparative performance during In-bore travel&external ballistics *** are validated by free flight trials for the finalised design.

关键词： APFsDs Dispersion Consistency Accuracy Yaw rate spin Muzzle jump factor In-bore dynamics Monte Carlo simulation

semantic segmentation of Lumbar Vertebrae Using Meijering U-Net(MU-Net)on spine Magnetic r.s.nance Images

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Computer Modeling in Engineering & sciences 2025年第1期142卷 733-757页

作者： Lakshmi s V V shiloah Elizabeth Darmanayagam sunil retmin raj Cyril Department of Computer.s.ience and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic r.s.nance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic r.s.nance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae L1 to L5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MrI images of 515 patients in the Lumbar.s.ine MrI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(PA),98.66%of dice similarity coefficient(DsC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic r.s.nance imaging(MrI) semantic segmentation lumbar vertebrae deep learning U-Net model

Combinatorial therapies for.s.inal cord injury repair

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Neural regeneration r.s.arch 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António J.salgado Nuno A.silva Life and Health sciences r.s.arch Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune r.s.onse, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for.s.inal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addr.s.ing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Predicting Maximum Lifespan Limits at Mean Menopausal Age

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Journal of Mathematical r.s.arch with Applications 2025年第1期 133-142页

作者： M.sUMATHI s.ANTONY CArLA Department of Mathematics N.M.S.S.Vellaichamy Nadar College r.s.arch scholar (Part-time) Madurai Kamaraj University

The age at which a woman enters natural menopause has also been associated to death from any cause. Menopause is a natural component of aging that happens between the ages of 45 and 55, with the average menopausal age being 51. Previous r.s.arch has revealed the age at which women reach menopause, but there is no evidence to support the link between menopause and longevity. We made a study in assessing the limits of maximum lifespan at menopausal age in our previous article. In this paper, we aim to predict the maximum lifespan of women at mean menopausal age.

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A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei Lv sam s.Yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University school of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing r.s.arch inter.s. as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corr.s.veness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery compr.s.ng CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnsO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

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高分子复合材料加工工程