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Virologica Sinica 2010年第5期25卷 352-360页

作者： Manoj Kumar Sukdeb nandi Sunil Chidri Virology Laboratory Centre for Animal Disease Research and DiagnosisIndian Veterinary Research Institute

A polyclonal antibody-based antigen-capture ELISA （AC-ELISA） has been developed for detection of Canine parvovirus （CPV） antigens in faecal samples of dogs. The assay uses rabbit anti-CPV polyclonal antibody as the capture antibody, guinea pig anti-CPV polyclonal antibody as tracing antibody and anti-guinea pig HrPO conjugate as the detection system. The optimum dilution of the capture antibody and the tracing antibody capable of detecting the CPV-2 antigens was found to be 1：1 600 and 1：400, respectively, in the check-board titration. In this study, a total of 152 samples （129 faecal samples and 23 cell culture supernatant） were tested both by AC-ELISA and by polymerase chain reaction （PCr）. Of the samples tested, 69 and 78 samples were found positive by AC-ELISA and PCr, respectively. The AC-ELISA had relative sensitivity, relative specificity and accuracy of 88.4%, 100.0% and 91.4% respectively. The analytical sensitivity of AC-ELISA was estimated to be 102.8 TCID50/mL whereas PCr sensitivity was 100.8 TCIDs0/mL. The AC-ELISA is a simple, quick and reliable method for screening large numbers of faecal samples of dogs suspected of CPV infection.

关键词： Canine parvovirus (CPV) Polyclonal antibody Antigen-capture ELISA(AC-ELISA)

前蛋白转化酶枯草溶菌素9抑制剂的临床研究及应用进展

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中华老年多器官疾病杂志 2024年第4期23卷 311-315页

作者：赵瑾陈鹏飞包楠迪中国人民解放军总医院京北医疗区红山口门诊部北京100091 中国人民解放军总医院第六医学中心心血管病医学部北京100853

前蛋白转化酶枯草溶菌素9(PCSK9)抑制剂可通过抑制肝细胞表面低密度脂蛋白受体的降解对脂质代谢起到调节作用。目前已有多项临床研究证明,PCSK9抑制剂单一药物或与他汀类药物联合使用可显著降低低密度脂蛋白胆固醇水平。本文综述了当前P... 详细信息

前蛋白转化酶枯草溶菌素9(PCSK9)抑制剂可通过抑制肝细胞表面低密度脂蛋白受体的降解对脂质代谢起到调节作用。目前已有多项临床研究证明,PCSK9抑制剂单一药物或与他汀类药物联合使用可显著降低低密度脂蛋白胆固醇水平。本文综述了当前PCSK9抑制剂的重要临床研究及应用进展,并简要总结了常见PCSK9抑制剂的安全性、有效性及临床应用现状。

关键词：前蛋白转化酶枯草溶菌素9 低密度脂蛋白胆固醇脂质代谢动脉粥样硬化

NOVEL SECOND-OrDEr CUrrENT MODE FILTErS USING CCIIs

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Journal of Electronics(China) 1996年第2期13卷 158-163页

作者： r. nandi(Dept. of Electronics & Telecommunication Engineering, Jadavpur University, Calcutta, INDIA-700032) Dept. of Electronics & Telecommunication Engineering Jadavpur University Calcutta INDIA

Two new current mode active-rC networks using the second generation current conveyer (CCII) devices are presented. The circuits provide high-Q bandpass (BP)/lowpass(LP) filter characteristics; the highpass(HP) response may also be obtained with suitable design. Current mode sine wave signal generation (Q→α) is possible by tuning a grounded resistor. With non-ideal CCIIs the design equations are slightly altered owing to CCII port current and voltage tracking errors (Ei,v).

关键词： Analog signal processing Active filters CCII

Effect of pyroxenite and olivine minerals as source of MgO in hematite pellet on improvement of metallurgical properties

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Journal of Central South University 2015年第9期22卷 3302-3310页

作者： Jagannath Pal Satadal Ghorai Bikash nandi Tapas Chakraborty Goutam Das T.Venugopalan CSIr-National Metallurgical Laboratory Tata Steel

Pelletization of hematite ore requires high fineness and very high induration temperature（~1325 ℃） owing to its poor diffusion bonding unlike magnetite ore. Further, high-alumina hematite pellets show very high reduction degradation index（rDI） during low temperature（500-650 ℃） reduction due to their volume expansion and lattice distortion. Noamundi（India） hematite ore contains very high Al2O3（2.3%） with adverse ratio of alumina to silica（~2） for which, it shows very high rDI. In this work, the acid pellets prepared from Noamundi ore fines of optimum Blaine fineness show good cold crushing strength（CCS）. However, it shows very high rDI（77%）. In order to reduce rDI, Mg O in form of two different gangue-containing fluxes, such as pyroxenite and olivine in varying quantities has been added. The optimum requirement and performance of these fluxes has been examined and compared. Both pyroxenite and olivine fluxed pellets show significant lowering of rDI（26% and 23%, respectively） and improvement of other properties, viz CCS, swelling indices etc with good reducibility（70%-77%）. Finally, a good quality acidic hematite pellet was developed from high-alumina ore without using any lime which is very important charge material in combination of basic sinter in blast furnace.

关键词： hematite pellet high-alumina ore reduction degradation index(rDI) pyroxenite flux olivine flux effect of MgO

In-Situ Hydrothermal Synthesis of Bi–Bi2O2CO3 Heterojunction Photocatalyst with Enhanced Visible Light Photocatalytic Activity

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Nano-Micro Letters 2017年第2期9卷 58-67页

作者： Prasenjit Kar Tuhin Kumar Maji ramesh nandi Peter Lemmens Samir Kumar Pal Department of Chemical Biological and Macromolecular Sciences S.N.Bose National Centre for Basic SciencesBlock JDSector ⅢSaltLakeKolkata 700106India Institute for Condensed Matter Physics TU BraunschweigMendelssohnstraße 338106 BrunswickGermany Laboratory for Emerging Nanometrology TU BraunschweigBrunswickGermany

Bismuth containing nanomaterials recently received increasing attention with respect to environmental applications because of their low cost, high stability and nontoxicity. In this work, Bi–Bi_2O_2CO_3 heterojunctions were fabricated by in-situ decoration of Bi nanoparticles on Bi_2O_2CO_3 nanosheets via a simple hydrothermal synthesis approach. X-ray diffraction(XrD), scanning electron microscopy(SEM), transmission electron microscopy(TEM) and high-resolution TEM(HrTEM) were used to confirm the morphology of the nanosheet-like heterostructure of the Bi–Bi_2O_2CO_3 composite. Detailed ultrafast electronic spectroscopy reveals that the in-situ decoration of Bi nanoparticles on Bi_2O_2CO_3 nanosheets exhibit a dramatically enhanced electron-hole pair separation rate, which results in an extraordinarily high photocatalytic activity for the degradation of a model organic dye, methylene blue(MB) under visible light illumination. Cycling experiments revealed a good photochemical stability of the Bi–Bi_2O_2CO_3 heterojunction under repeated irradiation. Photocurrent measurements further indicated that the heterojunction incredibly enhanced the charge generation and suppressed the charge recombination of photogenerated electron-hole pairs.

关键词： Bi nanoparticles Bi–Bi2O2CO3 nanosheets Heterojunction Hydrothermal method Charge separation Visible light photocatalytic activity

Systematic bio‑fabrication of aptamers and their applications in engineering biology

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Systems Microbiology and Biomanufacturing 2023年第2期3卷 223-245页

作者： rongfeng Cai Xin Chen Yuting Zhang Xiaoli Wang nandi Zhou The Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China

Aptamers are single-stranded DNA or rNA molecules that have high affinity and selectivity to bind to specific *** to antibodies,aptamers are easy to in vitro synthesize with low cost,and exhibit excellent thermal stability and *** these features,aptamers have been widely used in biology and medicine-related *** the meantime,a variety of systematic evolution of ligands by exponential enrichment(SELEX)technologies have been developed to screen aptamers for various *** to the characteristics of targets,customizing appropriate SELEX technology and post-SELEX optimization helps to obtain ideal aptamers with high affinity and *** this review,we first summarize the latest research on the systematic bio-fabrication of aptamers,including various SELEX technologies,post-SELEX optimization,and aptamer modification *** procedures not only help to gain the aptamer sequences but also provide insights into the relationship between structure and function of the *** latter provides a new perspective for the systems bio-fabrication of ***,on this basis,we review the applications of aptamers,particularly in the fields of engineering biology,including industrial biotechnology,medical and health engineering,and environmental and food safety *** the encountered challenges and prospects are discussed,providing an outlook for the future development of aptamers.

关键词： Aptamer SELEX Engineering biology Biosensors

Pre-treatment of rocks prior to comminution--A critical review of present practices

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International Journal of Mining Science and Technology 2017年第2期27卷 339-348页

作者： Somani Aditya nandi Tapas K. Pal Samir K. Majumder Arun K. Department of Mining Engineering Indian Institute of TechnologyKharagpur 721302India Cryogenic Engineering Centre Indian Institute of TechnologyKharagpur 721302India

It has been an established fact that comminution processes, crushing and grinding, are most energy intensive processes which account for more than half of the total energy consumed in mineral *** alternative pre-treatment methods have been tried by experts around the globe. Although these methods yielded positive results in terms of reduction in energy consumption in crushing and particularly, in grinding operations at laboratory scale, their industrial application still remains an unresolved issue and challenge. Present review paper describes each one of these methods along with outcome of earlier studies and issues that need to be addressed through further rigorous experimental *** also suggests the direction in which future studies can be carried out to meet the primary objective of making comminution processes more energy efficient than today they are.

关键词： Comminution rock breakage Microwave Thermal shock

Scale‐wise interaction fusion and knowledge distillation network for aerial scene recognition

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CAAI Transactions on Intelligence Technology 2023年第4期8卷 1178-1190页

作者： Hailong Ning Tao Lei Mengyuan An Hao Sun Zhanxuan Hu Asoke K.nandi School of Computer Science and Technology Xi'an University of Posts and TelecommunicationsShaanxi Key Laboratory of Network Data Analysis and Intelligent ProcessingXi'anChina Xi'an Key Laboratory of Big Data and Intelligent Computing Xi'anChina School of Electronic Information and Artificial Intelligence Shaanxi University of Science and TechnologyXi'anChina School of Computer Central China Normal UniversityWuhanChina Department of Electronic and Electrical Engineering Brunel University LondonLondonUK Xi'an Jiaotong University Xi'anChina

Aerial scene recognition(ASr)has attracted great attention due to its increasingly essential *** of the ASr methods adopt the multi‐scale architecture because both global and local features play great roles in ***,the existing multi‐scale methods neglect the effective interactions among different scales and various spatial locations when fusing global and local features,leading to a limited ability to deal with challenges of large‐scale variation and complex background in aerial scene *** addition,existing methods may suffer from poor generalisations due to millions of to‐belearnt parameters and inconsistent predictions between global and local *** tackle these problems,this study proposes a scale‐wise interaction fusion and knowledge distillation(SIF‐KD)network for learning robust and discriminative features with scaleinvariance and background‐independent *** main highlights of this study include two *** the one hand,a global‐local features collaborative learning scheme is devised for extracting scale‐invariance features so as to tackle the large‐scale variation problem in aerial scene ***,a plug‐and‐play multi‐scale context attention fusion module is proposed for collaboratively fusing the context information between global and local *** the other hand,a scale‐wise knowledge distillation scheme is proposed to produce more consistent predictions by distilling the predictive distribution between different scales during *** experimental results show the proposed SIF‐KD network achieves the best overall accuracy with 99.68%,98.74%and 95.47%on the UCM,AID and NWPU‐rESISC45 datasets,respectively,compared with state of the arts.

关键词： deep learning image analysis image classification information fusion

常规颈动脉超声结合超声造影评估大动脉炎活动性的研究

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中风与神经疾病杂志 2024年第10期41卷 867-871,F0002页

作者：尹楠迪白洋娄喆王旭金友贺杨军马春燕中国医科大学附属第一医院辽宁沈阳110002

目的应用超声造影(CEUS)对大动脉炎(TA)患者的颈动脉管壁增强程度进行半定量分级,探讨常规颈动脉超声联合CEUS评估TA活动性的价值。方法根据美国风湿病协会分类标准纳入59例TA患者,根据美国国立研究院评分确定临床活动期及非活动期,根据... 详细信息

目的应用超声造影(CEUS)对大动脉炎(TA)患者的颈动脉管壁增强程度进行半定量分级,探讨常规颈动脉超声联合CEUS评估TA活动性的价值。方法根据美国风湿病协会分类标准纳入59例TA患者,根据美国国立研究院评分确定临床活动期及非活动期,根据CEUS增强等级分为3组,分析CEUS等级及常规超声参数与疾病临床活动性参数的相关性,同时探讨对疾病临床活动的预测价值。结果(1)颈动脉CEUS增强等级、管壁厚度及血管外径与NIH评分、红细胞沉降率、C反应蛋白均呈正相关,其中CEUS增强等级相关性最高(r值分别为0.438、0.560、0.471,P<0.01)。(2)CEUS≥2级及CEUS 3级预测疾病临床活动的工作者受试特征曲线下面积(AUC)分别为0.782和0.725(P<0.001),敏感度分别为77%和53%,特异度分别为80%和92%。(3)管壁厚度≥1.95 mm联合CEUS≥2级预测疾病临床活动的AUC为0.804(P<0.001),敏感度为80%,特异度为81%,优于与单独使用管壁厚度的预测效能(Z=2.535,P=0.011)。结论TA患者颈动脉CEUS增强等级及管壁厚度与疾病临床活动性显著相关,管壁厚度结合CEUS增强等级可有效评估TA的临床活动性。

关键词：大动脉炎超声造影疾病活动性管壁厚度

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Analysis of a fractional-order SIS epidemic model with saturated treatment

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International Journal of Modeling, Simulation, and Scientific Computing 2021年第1期12卷 185-212页

作者： Soovoojeet Jana Manotosh Mandal Swapan Kumar.nandi T.K.Kar Department of Mathematics Ramsaday College Amta-711401HowrahWest BengalIndia Department of Mathematics Tamralipta Mahavidyalaya Tamluk-721636West BengalIndia Department of Mathematics Nayabasat P.M.Sikshaniketan Paschim Medinipur-721253West BengalIndia Department of Mathematics Indian Institute of Engineering Science and Technology Shibpur Howrah-711103West BengalIndia

In this paper,we propose and analyze a fractional-order SIS epidemic model with the saturated treatment and disease *** existence and uniqueness,nonnegativity and finiteness of solutions for our suggested model have been *** equilibria of the model are found and their local and global stability analyses are also ***,the conditions for fractional backward and fractional Hopf bifurcation are also analyzed in both the commensurate and incommensurate fractional-order *** study how the control parameter and the order of the fractional derivative play role in local as well as global stability of equilibrium points and Hopf *** have demonstrated the analytical results of our proposed model system through several numerical simulations.

关键词： Caputo fractional differentiation SIS epidemic model global asymptotic stability treatment control fractional Hopf bifurcation fractional backward bifurcation