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第一讲牙周病的自然病程

口腔医学纵横 1987年第3期 187-189页

作者： r.n.powell 韩乃明

robin ***博士曾是英国伦敦University College Hospital Medical School的牙周病学教授,担任过1973年度国际牙科研究协会(IADr)牙周病研究组秘书,曾任英国牙周病协会1974—1975年度会长。现在他是澳大利亚昆士兰大学牙学院公共预防牙... 详细信息

robin ***博士曾是英国伦敦University College Hospital Medical School的牙周病学教授,担任过1973年度国际牙科研究协会(IADr)牙周病研究组秘书,曾任英国牙周病协会1974—1975年度会长。现在他是澳大利亚昆士兰大学牙学院公共预防牙科学教授,兼任《当代牙科学》杂志(Dentistry Today)主编。 1984年,他应邀来山东医科大学讲学、工作。在山医期间,计作了8次讲座,讲述了有关牙周病学、龋病学、儿童牙科学和预防牙科学目前发展现状及流行的观点。其录音和有关资料由川医韩乃明医师整理成文,我们选择其中四讲在本刊连载。整理稿经华西医科大学仝月华教授审阅。

关键词：牙周病学炎症病理牙周病牙周炎牙周袋菌斑自然病程

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第二讲牙周治疗展望

口腔医学研究 1987年第4期 243-245页

作者： r.n.powell 韩乃明

流行病学研究表明:牙龈炎是流行性极高的疾病。在澳大利亚和中国的情况也是如此。在澳大利亚,牙科医生与总人口的比例为1:2100。即便这样也不可能使每个患有牙龈炎的人得到治疗。在中国,牙科医生与人口的比例为1:250000,要治疗每个龈炎... 详细信息

流行病学研究表明:牙龈炎是流行性极高的疾病。在澳大利亚和中国的情况也是如此。在澳大利亚,牙科医生与总人口的比例为1:2100。即便这样也不可能使每个患有牙龈炎的人得到治疗。在中国,牙科医生与人口的比例为1:250000,要治疗每个龈炎患者就更不可能了。因此,需要适当集中地使用牙科医生。牙科医生的责任可能就在于:选择最可能发生破坏性牙周病的患者,提供预防或早期治疗措施。这一部分只占人群中较小的比例。许多国家是有人力给这部分人作预防和治疗工作的。为了能恰当地选择病人,应很好地理解整个疾病过程。这主要包括:①牙菌斑的致病力;②局部免疫反应;③个体对疾病的易感性。

关键词：牙周治疗活动性螺旋体青少年牙周炎牙周病牙周疾病探诊出血菌斑牙周致病菌

Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

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neural regeneration research 2025年第2期20卷 475-476页

作者： Jackson powell Tobias Steinschaden rose Horowitz Yuanquan Song raymond G.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PnS)and the poor regenerative capacity of the central nervous system(CnS)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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neural regeneration research 2025年第8期20卷 2218-2230页

作者： rahul Mittal Keelin McKenna Grant Keith Evan McKenna Joana r.n.Lemos Jeenu Mittal Khemraj Hirani Diabetes research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

nucleoside modified mrnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural regeneration research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural regeneration research 2025年第4期20卷 1031-1041页

作者： ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOr),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Sex differences in aging and injured brain

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neural regeneration research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural regeneration research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with mirnAs or lncrnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

Making bridges between preclinical and clinical insights into age-related cognitive decline

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neural regeneration research 2025年第8期20卷 2321-2322页

作者： David VC Brito Clévio nóbrega Algarve Biomedical Center-research Institute(ABC-rI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight