检索结果-南通市图书馆

Efficacy and safety of ecabet sodium on functional dyspepsia:A prospective,double-blinded,randomized,multi-center controlled trial

引用

World journal of Gastroenterology 2006年第17期12卷 2756-2761页

作者： jun Haeng Lee jae j kim ki-Baik Hahm Dong Ho Lee Nayoung kim Sung Kook kim jong jae Park Seok reyol Choi jong Hun Lee Soo Teik Lee Eun Hyun Lee jong Chul rhee Department of Medicine Sungkyunkwan University School of Medicine SeoulKorea Department of Gastroenterology Ajou University School of Medicine SuwonKorea Department of Internal Medicine Seoul National University Bundang Hospital SeoungnamGyeonggi-doKorea Department of Internal Medicine Kyungpook National University College of Medicine DaeguKorea Department of Internal Medicine Korea University Guro Hospital SeoulKorea Department of Internal Medicine Dong-A University BusanKorea Department of Internal Medicine Chonbuk National University College of Medicine ChonjuKorea Department of Preventive Medicine Graduate School of Public Health Ajou UniversitySuwonKorea

AIM： To compare ecabet sodium and cimetidine in relieving symptoms of functional dyspepsia. METHODS： We performed a multi-center, prospective, randomized, double-blinded controlled trial to compare the clinical efficacy of ecabet sodium and cimetidine in patients with functional dyspepsia. Two-hundred and seventy-two patients with dyspeptic symptoms fulfilling the rome-II criteria were enrolled from 7 centers. In the study group （115 patients）, 1.5 g ecabet sodium was given twice a day. In the control group （121 patients）, 400 mg cimetidine was given twice a day. Symptoms and parameters of quality of life were analyzed at baseline, 3, 14, and 28 d after initiating the treatment. rESULTS： Two-hundred and thirty-six patients completed the clinical trial. After 4 wk of treatment, the rates of improvement in patients with dyspeptic symptoms were not different between two groups （77.4% in the ecabet group and 79.3% in the cimetidine group, respectively, P 〉 0.05）. Likewise, the rates of symptomatic improvement were not different at 3 d and 14 d. The parameters of quality of life did not change significantly during the study period in both groups. There was no clinically significant adverse event in both groups.

关键词： Functional dyspepsia Ecabet sodium Cimetidine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extended role for insertion sequence elements in the antibiotic resistance of Bacteroides

引用

World journal of Clinical Infectious Diseases 2013年第1期3卷 1-12页

作者： józsef Sóki Institute of Clinical Microbiology Albert Szent-Gyorgyi Clinical Center Faculty of Medicine University of Szeged H-6725 Szeged Hungary

The Bacteroides species are important micro-organisms, both in the normal physiology of the intestines and as frequent opportunistic anaerobic pathogens, with a deeply-rooted phylogenetic origin endowing them with some interesting biological features. Their prevalence in anaerobic clinical specimens is around 60%-80%, and they display the most numerous and highest rates of antibiotic resistance among all pathogenic anaerobes. In these antibiotic resistance mechanisms there is a noteworthy role for the insertion sequence(IS) elements, which are usually regarded as representatives of ‘selfish' genes; the IS elements of Bacteroides are usually capable of up-regulating the antibiotic resistance genes. These include the cep A(penicillin and cephalosporin), cfx A(cephamycin), cfi A(carbapenem), nim(metronidazole) and erm F(clindamycin) resistance genes. This is achieved by outwardoriented promoter sequences on the ISs. Although some representatives are well characterized, e.g., the resistance gene-IS element pairs in certain resistant strains, open questions remain in this field concerning a better understanding of the molecular biology of theantibiotic resistance mechanisms of Bacteroides, which will have clinical implications.

关键词： Antibiotic resistance Antibiotic resistance genes Bacteroides fragilis Insertion sequence elements

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

比较普萘洛尔联合催产素催产与单用催产素催产的随机双盲试验

引用

世界核心医学期刊文摘（妇产科学分册） 2006年第8期2卷 25-26页

作者： Palomki O. Uotila j. Tammela O. 朱磊 Department of Obstetrics and Gynaecology Tampere University Hospital (TAUH) PL 2000 33521 Tampere Finland

Objective: To compare the combination of intravenous propranolol and oxytocin with oxytocin only in augmentation of labour. Study design: A prospective randomized double-blind study in an obstetric department of a large university hospital in Finland. A total of 107 parturients with arrested first stage of labour owing to inadequate uterine contractility were randomized to receive intravenously once or twice a 2 mg dose of propranolol or placebo combined with oxytocin infusion. The main outcome measure was the effect of intravenous propranolol on the frequency of Caesarean section among parturients with arrested labour. The secondary outcome measures were the duration of labour, the required dosage of oxytocin, CTG readings, neonatal outcome and maternal and cord plasma levels of β - adrenoceptor-binding component of propranolol. Categorial variables between the groups were compared using Chi square and Fisher’ s exact tests. Continuous variables were compared using the Mann-Whitney U-test and Student’ s t-test. results: No reduction in Caesarean section rate was found in the propranolol group. Seventy-three percent of the parturients in the propranolol group and 85% in the placebo group had spontaneous vaginal delivery, rr = 0.86 (95% CI 0.70- 1.05). The percentage proportion of the augmented part of labour was significantly shorter in the propranolol group than in the placebo group. No differences in the required oxytocin dosage or CTG pathology were found between the groups. Propranolol was found to be safe for the neonates. The concentrations of its β -adrenoceptor-binding component after a 2 mg intravenous dose were quite similar in parturients and neonates at the time of delivery. The active drug component crossed placental barriers with an average neonate umbilical artery/parturient venous plasma ratio of 0.7. After a 4 mg dose the active drug concentrations in parturients were rather similar to those measured after 2 mg dose, whereas in neonates there were s

关键词：普萘洛尔随机双盲产程停滞 β肾上腺素受体新生儿结局宫缩乏力胎心监护产程时间第一产程双

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Serum measurements of testosterone, insulin-like growth factor 1, and insulin-like growth factor binding protein-3 in the diagnosis of prostate cancer among Korean men

引用

Asian journal of Andrology 2008年第2期10卷 207-213页

作者： Sung Kyu Hong Byung Kyu Hart jae Seung jeong Seong jin jeong ki Hyuk Moon Seok Soo Byun Sang Eun Lee Department of Urology Seoul National University Bundang Hospital Seongnam 463-707 Korea

Aim： To investigate the relationships of serum testosterone, insulin-like growth factor （IGF）- 1 and IGF-binding protein （IGFBP）-3 levels with prostate cancer risk and also with known prognostic parameters of prostate cancer in Korean men who received radical retropubic prostatectomy （rrP） for clinically-localized prostate cancer. Methods： Serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 were determined in 592 patients who subsequently received prostate biopsy. results were compared between patients who eventually received rrP for prostate cancer （n = 159） and those who were not diagnosed with prostate cancer from biopsy （control group, n = 433）. Among the prostate cancer only patients, serum hormonal levels obtained were analyzed in relation to serum prostate specific antigen （PSA）, pathological T stage and pathological Gleason score. results： Prostate cancer patients and the control group demon- strated no significant differences regarding serum levels of total testosterone, free testosterone, IGF-I and IGFBP-3 across the different age groups. Among the cancer only patients, no significant associations were observed for serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 levels with pathological T stage, pathological Oleason score and preoperative PSA. Conclusion： Our data indicate that simple quantifications of serum testosterone and IGF-1 along with IGFBP-3 levels might not provide useful clinical information in the diagnosis of clinically localized prostate cancer in Korean men. Also, our results suggest that serum levels of testosterone, IGF-1 and IGFBP-3 might not be significantly associated with known prognostic factors of clinically localized prostate cancer in Korean men. （Asian j Androl 2008 Mar; 10： 207-213）

关键词： prostate prostate cancer testosterone insulin-like growth factor insulin-like growth factor-binding protein-3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pure color and stable blue-light emission-alternating copolymer based on fluorene and dialkoxynaphthalene

Pure color and stable blue-light emission-alternating copoly...

引用

13th Asian Chemical Congress

作者： Park jong-Won Shin Dong-Cheol kim Seul-Ong kim Yun-Hi KWON SOON-ki School of Materials Science and Engineering Engineering Research InstituteGyeongsang National University SK Corporation Taejon 305-712 Department of Chemistry Gyeongsang National University

＜正＞A new blue-light emitting polymer that alternates between fluorene and alkoxynaphthalene structure has been *** fluorene and naphthalene units were highly distorted with an angle of 76.22 according to theoretica... 详细信息

关键词： OLED dialkoxynaphthalene blue-light emission

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Metastatic type 1 gastric carcinoid:A real threat or just a myth?

引用

World journal of Gastroenterology 2013年第46期19卷 8687-8695页

作者： Simona Grozinsky-Glasberg Dimitrios Thomas jonathan r Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia reissman Gregory Kaltsas David j Gross Neuroendocrine Tumor Unit Endocrinology and Metabolism ServiceDepartment of MedicineHadassah-Hebrew University Medical Center Endocrine Unit Department of PathophysiologyNational University of Athens Moffitt Cancer Center Tampa Department of Internal Medicine Division of HepatologyGastroenterologyEndocrinology and MetabolismCharité Universit tsmedizin Department of Medical Sciences Section of Endocrine OncologyUppsala University Institute of Endocrinology Soroka Ben Gurion University Hospital Department of Surgery Shaare-Zedek Medical CenterThe Hebrew University School of Medicine

AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were ***’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and *** were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also *** evaluation of response to treatment was defined using established WHO ***:We studied twenty consecutive patients with a mean age of 55.1 *** mean follow-up period was 83 *** patients had regional lymph node metastases and 8 patients had liver *** primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the *** disease was stable in all but 3 patients who had progressive liver *** patients remained alive during the follow-up ***:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated ki-67 index and high serum gastrin levels.

关键词： Metastatic gastric carcinoids Gastrin Chro-mogranin A Somatostatin analogues Stomach neuro-endocrine tumor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

早产儿成年后的动态血压及其变异

引用

中华高血压杂志 2015年第3期23卷 299-299页

作者： Sipola-Lepp?nen M Karvonen r Tikanm?ki M Matinolli HM Martikainen S Pesonen AK r?ikk?nen K j?rvelin Mr Hovi P Eriksson jG V??r?sm?ki M Kajantie E 赵狄练桂丽

早产儿成年后血压高于足月产儿成年后的血压。许多研究针对早产,但很少研究评估作为心血管病独立危险因素的血压变异。该研究在42例孕早期（〈34周）早产青年成人,72例孕晚期（34～36周）早产及103例对照（≥37周）中探讨早产与24h动态... 详细信息

早产儿成年后血压高于足月产儿成年后的血压。许多研究针对早产,但很少研究评估作为心血管病独立危险因素的血压变异。该研究在42例孕早期（〈34周）早产青年成人,72例孕晚期（34～36周）早产及103例对照（≥37周）中探讨早产与24h动态血压的关系。72.4%的研究对象的睡眠经加速度传感器睡眠监测证实。

关键词： 24h动态血压血压变异早产儿成年独立危险因素加速度传感器睡眠监测心血管病

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

结构性植骨修复膝关节翻修术中严重骨缺损的临床效果及相关分析(英文)

引用

中华关节外科杂志（电子版） 2009年第4期3卷 15-19页

作者：盛璞义 Esa jamsen Matti Lehto Yrj T Konttinen jorma Pajamki Pekka Halonen Coxa人工关节置换医院中山大学附属第一医院骨科关节外科广州510180 坦佩雷大学医学院芬兰赫尔辛基大学中心医院医学部

目的探讨同种异体结构性植骨在膝关节翻修术中大块骨缺损中应用的临床效果和意义。方法1994～2001年芬兰坦佩雷大学医院应用单一翻修假体及同种异体骨结构性植骨治疗膝关节置换术大块骨缺损患者10例（膝），男1例，女9例，平均年龄70岁... 详细信息

目的探讨同种异体结构性植骨在膝关节翻修术中大块骨缺损中应用的临床效果和意义。方法1994～2001年芬兰坦佩雷大学医院应用单一翻修假体及同种异体骨结构性植骨治疗膝关节置换术大块骨缺损患者10例（膝），男1例，女9例，平均年龄70岁（61—77岁），平均随访5年（1～8年），所有手术均由两名高年资专科医师执行，采取KSS评分评估术前术后膝关节功能。结果最后随访时，患者膝关节KSS评分由术前的平均39分（4～51分）提高至81分（28—102分；P〈0．05）；疼痛评分由术前的18分（0—30分）提高至42分（10—50分；P〈0．05）。2例出现假体周围透亮线（〈1mm），但没有任何松动症状；所有结构性植骨均获得满意的愈合，最后随访时没有出现吸收征象，1例患者术后出现膝前疼痛，经髌骨表面置换后症状消失。结论同种异体骨结构性植骨应用在膝关节翻修术中大块骨缺损中可取得满意的临床效果，重建下肢力线、第三代骨水泥技术的应用及有由专科医师实施手术是获得良好临床效果的保证。

关键词：关节成形术置换膝翻修术同种异体骨

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

1995—2004年芬兰耐药结核分枝杆菌分离株分子基因学分析

引用

国际结核病与肺部疾病杂志 2008年第3期3卷 93-98页

作者： H.j.Marttila j.Mkinen M.Marjamki P.ruutu H.Soini 尚美 Mycobacterial reference Laboratory National Public Health InstituteTurku Department of Infectious Disease Epidemiology National Public Health InstituteHelsinkiFinland

背景:利用现代分子生物学来帮助我们理解结核分枝杆菌的传播和流行病学机理。目的:分析耐药结核分枝杆菌分子流行病学和1995—2004年芬兰耐异烟肼及利福平相关突变菌株。设计:对3959株新结核分枝杆菌菌株进行了药物敏感性试验,如有必要... 详细信息

背景:利用现代分子生物学来帮助我们理解结核分枝杆菌的传播和流行病学机理。目的:分析耐药结核分枝杆菌分子流行病学和1995—2004年芬兰耐异烟肼及利福平相关突变菌株。设计:对3959株新结核分枝杆菌菌株进行了药物敏感性试验,如有必要,所有的耐药性表型菌株都进行了IS6110限制性片段长度多态性和间隔寡核苷酸分型分析。对耐异烟肼及利福平菌株分别进行了katG 315位密码子和rpoB耐性基因测序。结果:在测试的3959(92.4%为培养阳性)株分离株中,183个(4.6%)对至少一种一线抗结核药耐药;14(0.4%)株为耐多药。37株(20.4%)耐性菌株属于17个簇,其中最大的簇包括4个分离株。北京家族占所有耐药菌株的8.8% (16株)。在异烟肼耐药菌株中,katG的Ser315Thr突变占46.7%(56株);在利福平耐药菌株中rpoB突变占85.7%(18株)。结论:耐药结核病在芬兰传染率很少,尤其在本地和外来人口间。如果存在产生耐多药的危险因素,筛查异烟肼和利福平耐药相关突变是可行的。

关键词：分枝杆菌,结核全国调查分子流行病学耐药突变

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

DESIGN AND IMPLEMENTATION OF rEAL-TIME PHYSICS SIMULATION ENGINE FOr e-ENTErTAINMENT

引用

International journal of Modeling, Simulation, and Scientific Computing 2013年第S01期4卷 20-39页

作者： MYUNGSOO BAE YOUNG j.kiM Computer Science and Engineering Ewha Womans University SeoulKorea

We present our recent research results regarding the designing and implementation of real-time physics simulation engines,which aim at developing physics-inspired e-entertainment such as computer games,mobile applications,interactive TV and other smart media in *** real-time physics engine consists of three functional components:rigid body dynamics simulation,deformable body simulation,and data-driven physics *** core simulation techniques to realize these simulation components include real-time collision detection and response,large-scale model simulation,and character model *** this paper,we highlight these features and demonstrate their *** also showcase some of the gaming applications that we have integrated our physics engine into.

关键词： real-time physics simulation engine rigid body dynamics simulation deformable body simulation data-driven simulation.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：