Extended role for insertion sequence elements in the antibiotic resistance of Bacteroides

作     者：József Sóki 

作者机构：Institute of Clinical Microbiology Albert Szent-Gyorgyi Clinical Center Faculty of Medicine University of Szeged H-6725 Szeged Hungary 

出 版 物：《World Journal of Clinical Infectious Diseases》 (世界临床传染病学杂志)

年 卷 期：2013年第3卷第1期

页      面：1-12页

学科分类：10[医学] 

基　　金：Supported by The Center of Excellence at the University of Szeged(TáMOP-421B)to József Sóki 

主　　题：Antibiotic resistance Antibiotic resistance genes Bacteroides fragilis Insertion sequence elements 

摘      要：The Bacteroides species are important micro-organisms, both in the normal physiology of the intestines and as frequent opportunistic anaerobic pathogens, with a deeply-rooted phylogenetic origin endowing them with some interesting biological features. Their prevalence in anaerobic clinical specimens is around 60%-80%, and they display the most numerous and highest rates of antibiotic resistance among all pathogenic anaerobes. In these antibiotic resistance mechanisms there is a noteworthy role for the insertion sequence(IS) elements, which are usually regarded as representatives of ‘selfish genes; the IS elements of Bacteroides are usually capable of up-regulating the antibiotic resistance genes. These include the cep A(penicillin and cephalosporin), cfx A(cephamycin), cfi A(carbapenem), nim(metronidazole) and erm F(clindamycin) resistance genes. This is achieved by outwardoriented promoter sequences on the ISs. Although some representatives are well characterized, e.g., the resistance gene-IS element pairs in certain resistant strains, open questions remain in this field concerning a better understanding of the molecular biology of theantibiotic resistance mechanisms of Bacteroides, which will have clinical implications.