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Acquired sensorineural hearing loss,oxidative stress,and micrornAs

neural regeneration research 2025年第9期20卷 2513-2519页

作者： Desmond A.nunez ru C.Guo Division of Otolaryngology–Head&neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding rnA sequences known as micrornAs(mirnAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLInE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamirs,""hypoxia,""micrornAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** mir-34a and mir-29b levels increase with age in *** mirnAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIrT1/P GC-1α),SIrT

关键词： hearing loss hypoxia micrornAs oxidative stress sensorineural

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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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neural regeneration research 2025年第8期20卷 2218-2230页

作者： rahul Mittal Keelin McKenna Grant Keith Evan McKenna Joana r.n.Lemos Jeenu Mittal Khemraj Hirani Diabetes research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

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3D tomographic analysis of equatorial plasma bubble using GnSS-TEC data from Indonesian GnSS network

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Earth and Planetary Physics 2025年第1期9卷 127-136页

作者： Ihsan naufal Muafiry Prayitno Abadi Teguh n.Pratama Dyah r.Martiningrum Sri Ekawati Yuandhika GWismaya Febrylian FChabibi Gatot HPramono research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Dept.of Physics Faculty of ScienceUniversiti Teknologi MalaysiaJohor BahruMalaysia Dept.Earth Planet Sci. Hokkaido UniversitySapporoJapan School of Electrical Engineering Telkom UniversityBandungIndonesia

Equatorial Plasma Bubbles(EPBs)are ionospheric irregularities that take place near the magnetic *** most commonly occur after sunset during the equinox months,although they can also be observed during other *** phenomenon significantly disrupts radio wave signals essential to communication and navigation *** national network of Global navigation Satellite System(GnSS)receivers in Indonesia(>30°longitudinal range)provides an opportunity for detailed EPB *** explore this,we conducted preliminary 3D tomography of total electron content(TEC)data captured by GnSS receivers following a geomagnetic storm on December 3,2023,when at least four EPB clusters occurred in the Southeast Asian *** and extracted TEC depletion with a 120-minute running average were then used as inputs for a 3D tomography *** 2D spatial distribution consistently captured the four EPB clusters over *** tomography results were validated through a classical checkerboard test and comparisons with other ionospheric data sources,such as the Global Ionospheric Map(GIM)and International reference Ionosphere(IrI)*** of the results demonstrates the capability of the Indonesian GnSS network to measure peak ionospheric *** findings highlight the potential for future three-dimensional research of plasma bubbles in low-latitude regions using existing GnSS networks,with extensive longitudinal coverage.

关键词： EPB Indonesian GnSS network 3D tomography

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La3+ substitution-adjusted magnetic and optical properties with enhanced photocatalytic activity and stability of copper zinc nickel ferrites for wastewater treatment applications

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Journal of rare Earths 2025年第2期43卷 319-328页

作者： n.S.Al-Bassami General Studies Department Jubail Industrial College

Copper-zinc-nickel（Cu-Zn-ni） ferrite nanoparticles are used for wastewater treatment ***,low degradation efficiency and stability are two main issues that make them unsuitable for actual production *** this paper,the citrate-nitrate auto-combustion method was applied for the formation of Cu0.5Zn0.25ni0.25LaxFe2-xO4;（0≤x≤0.1;step 0.02）(CZnL) *** the substitution process entails the replacement of a small ion with a larger one,the lattice constant and crystallite size does not exhibit a consistent incremental *** behavior is justified and *** size of all the CZnL ferrite nanoparticles is in the range of 8-12 nm,and the lattice constant is in the range of 8.6230 to 8.4865 *** morphological analysis conducted using field emission-scanning electron microscopy（FE-SEM） reveals that the CZnL exhibits agglomerated spherical *** energy dispersive X-ray spectrameter（EDAX） analysis was employed to confirm the elemental composition of CZnL *** the process entails the substitution of Fe3+magnetic ions with nonmagnetic ions La3+,the magnetic parameters of CZnL nanoferrites show a general decreasing trend as *** 20 K,saturation magnetization Ms shows an overall drop in its values from 59.302 emu/g at x=0.0-41.295 emu/g at x=0.1,the smallest value of 37.87 emu/g is recorded at x=*** highest coercivity（Hc=125.9 Oe） and remanence（Mr=13.32 emu/g） are recorded for x=0.08 and x=0.04 nanoferrite,*** band gap of all the CZnL nanoferrites was determined using the Kubelka-Munk function and Tauc plot for direct permitted *** doping modifies the band gap（within 1.86-1.75 eV）,increases light absorption,induces efficient e/h separation and charge migration to *** nanoferrite Cu0.5Zn0.25ni0.25La0.06Fe1.94O4achieves a degradation efficiency of 97.3% for methylene blue（MB） dye removal after just 60 *** five recycling processes,the nanoc

关键词： Copper-zinc-nickel Ferrite Photocatalytic properties rare earths Wastewater treatment

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Shade coffee plantations maintain woody plant diversity and structure in a cloud forest landscape of southern Mexico

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Journal of Forestry research 2021年第2期32卷 637-648页

作者： Edson AAlvarez-Alvarez r.ca.los almazán-nunez Fernando González-García Marlene Brito-Millán Alfredo Méndez-Bahena Sergio García-Ibáñez Maestría en recursos naturales y Ecología Facultad de Ecología MarinaUniversidad Autónoma de Guerrero39390 AcapulcoGuerreroMexico Laboratorio Integral de Fauna Silvestre Facultad de Ciencias Químico-BiológicasUniversidad Autónoma de Guerrero39090 Chilpancingo de los BravoGuerreroMexico red Biología y Conservación de Vertebrados Instituto de EcologíaA.C.CP 91073 XalapaVeracruzMexico University of california Institute for Mexico and the United States(UC MEXUS) Cuerpo Académico Biodiversidad y Gestión Ambiental SustentableFacultad de Ciencias Químico-BiológicasUniversidad Autónoma de Guerrero39090 Chilpancingo de los BravoGuerreroMexico Laboratorio de Biología de la Conservación Facultad de Ciencias Químico-BiológicasUniversidad Autónoma de Guerrero39090 Chilpancingo de los BravoGuerreroMexico Laboratorio de Ecología Cuantitativa Facultad de Ecología MarinaUniversidad Autónoma de Guerrero39390 AcapulcoGuerreroMexico

Cloud forest ecosystems of the Latin American tropics are highly threatened by changes in land-use such as expanding croplands and livestock pastures that promote shifts in the structure and composition of plant communities in these ***,shade coffee plantations represent a forest management alternative that has been shown to maintain biodiversity in these *** this study,we evaluated changes in the composition,diversity,and structure of Mexican cloud-forest woody species for three land use categories:cattle pastures,shade coffee plantations and advanced succession *** each category,fifteen 0.28-ha plots were established and the composition and diversity of vegetation was *** of species was analyzed using ordination methods,and alpha diversity was compared using Hill ***-seven woody species belonging to 40 families were *** richness and diversity was high in both the advanced successional forest and coffee plantations compared to cattle *** composition and structure was similar between late succession forests and coffee plantations with both land uses also being more structurally complex than cattle *** results show how shade coffee cultivation is a land-use activity that maintains woody plant communities in a manner that aligns with biodiversity conservation.

关键词： Land uses Late succession Plant diversity Shade coffee Vegetation structure

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nucleoside modified mrnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural regeneration research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Green synthesis of glycolic acid through the electrocatalytic reduction of oxalic acid over black TiO_(2): An experimental and theoretical study

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Journal of Energy Chemistry 2025年第1期100卷 544-556页

作者： Hugo Olvera-Vargas Oscar Andrés Jaramillo-Quintero Luis Darío Alarcón León Orlando castro-Ocampo Christian A.Celaya Marina E.rincón Jesús Muñiz Instituto de Energías renovables Universidad Nacional Autónoma de México(IER-UNAM)Priv.Xochicalco s/nCol.CentroTemixcoMorelos.CP 62580Mexico Centro de nanociencias y nanotecnología Universidad Nacional Autónoma de México(UNAM)Km 107Carretera Tijuana-EnsenadaEnsenadaB.C.C.P.22800Mexico

Herein,we present the electrocatalytic four-electron hydrogenation of oxalic acid into glycolic acid using black TiO_(2)as an *** acid is an abundant compound found in several sources of organic *** results showed a high selectivity of black TiO_(2)toward glycolic acid,with the formation of glyoxylic acid being the rate-limiting step (glyoxylic acid is the two-electron intermediate).The highest Faradaic efficiency (FE) of 69.6%±8.3% was achieved at 10.2 mA cm^(-2)in 4 h of electrolysis using an H-type cell operated at room temperature,with 50.2%±3.8% of oxalic acid conversion (degradation kinetic constant k=0.0042±0.0001 min-1),58.8%±7.0%of reaction yield and 1.2±0.18 g L-1of glycolic acid production.A theoretical model of black TiO_(2)coming from anatase TiO_(2)was implemented by introducing Ti3+defects,which gave black TiO_(2)the theoretical capability to easily transform oxalic acid into glycolic acid as experimentally *** reaction mechanism was supported and described in detail by density functional theory calculations,which revealed that surface Ti^(3+)states were the main catalytic *** is the first time that a detailed step-by-step mechanism at the atomic level has been proposed for this electrocatalytic reaction,which represents a valuable contribution to the understanding of this process of high energy/environmental *** is also the first time that black TiO_(2)has been used as an electrocatalyst for this sustainable process.

关键词： Chemical energy storage Electrochemical hydrogenation Density functional theory renewable energy Oxalic acid

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural regeneration research 2025年第4期20卷 1031-1041页

作者： ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOr),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Sex differences in aging and injured brain

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neural regeneration research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural regeneration research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with mirnAs or lncrnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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