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协同设计：基于复制型数据库实现并行设计的途径

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协同设计：基于复制型数据库实现并行设计的途径

伴或不伴增生性玻璃体视网膜病变的视网膜脱离患者细胞因子基因多态性的初步研究

2007年CAD/CAM学术交流会议

作者： Femando Alonso Carlos González Luis pastor 宋英杰 SENEr集团通力有限公司

缩短船期、降低设计成本、以及越来越复杂的船舶设计带来的压力,要求船厂人幅度改进造船模式以提高能力,而与此同时,船厂的设计队伍和设计能力则越来越难以满足要求。这就造成了船厂越来越多地需要利用协同设计环境,将重要的设计任务、... 详细信息

缩短船期、降低设计成本、以及越来越复杂的船舶设计带来的压力,要求船厂人幅度改进造船模式以提高能力,而与此同时,船厂的设计队伍和设计能力则越来越难以满足要求。这就造成了船厂越来越多地需要利用协同设计环境,将重要的设计任务、特别是详细设计阶段的工作进行外包,这就需要有能力使异地的设计团队的工作能够同步地进行协调。本文分析了两种常用的途径,即并行方式和分布方式,但着眼于并行解决方案,以此发展了数据库和网络通讯等基础技术的应用,引出一个更高效的解决方案。使用全三维的造船 CAD/CAM 系统,并将全船的产品模型集成到单一的数据库中,也能够部分地解决异地协同的问题,但在建立起一个有效的解决方案之前,仍然会存在一些挑战。本文描述了 SENEr 的解决方法和实践。在这个领域,SENEr 是一个扮演着双重角色的公司,既开发船舶设计软件、同时也是船舶设计机构,目前 SENEr 正在开发与关系型数据库匹配的软件工具、以及相关的数据库管理软件,以实现一个远程并行设计环境,其中的主要技术为数据库复制技术,更准确的表述是：同步模式下的多主复制(multimaster replication)技术。还有另外一些问题,如需要对项目(project)中某些受限制的数据实行访问控制。因为从船厂的观点出发,作为信息的拥有青(设计的最终使用者),出于一定程度的保密需要、或某些信息处于更新和完善之中,这些数据是不可以随意访问和修改的。文章最后讨论了这一解决方案的可伸缩性问题,以测试其在一个大量用户的环境下的实现程度。

关键词：船舶设计协同设计并行设计

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 48-49页

作者： Sanabria ruiz-Colmenares M. r. pastor Jimeno J. C. Garrote Adrados J. A. 潘家鸿(译) Instituto de Oftalmobiologa Aplicada (IOBA) Facultad de Medicina C/Ramón y Cajal no7 47005 Valladolid Spain 不详

Purpose:Cytokines and other growth factors such as interleukins play an important role in the pathogenesis of proliferative vitreoretinopathy(PVr).Interindividual variations in cytokine production seem to correlate with some cytokine gene *** purpose of this study was to analyse the distribution of these cytokine gene variants in patients with rhegmatogenous retinal detachment(rD)with and without ***:Single nucleotide polymorphisms were analysed for five cytokines:tumour necrosis factor-α(TNF-α),transforming growth factor-β 1(TGF-β 1),interferon-γ(IFN-γ),interleukin-6(IL-6)and interleukin-10(IL-10).Patients were divided into two surgically treated groups of rD patients:group rD had 27 patients with rD,and group PVr had 31 patients with rD complicated by PVr.A control group was composed of 46 ethnically matched healthy ***:The genotype distribution of the TGF-β 1 codon 10 polymorphism differed between PVr and rD patients(p=0.018)and between PVr patients and controls in codon 25(p =0.011).There was a higher frequency of TGF-β 1 codon 10 allele T in PVr patients compared with rD patients(p=0.023).No statistically significant differences between groups were observed for the other polymorphisms ***:An association between the TGF-β 1 genetic profile and the development of PVr was detected in this *** studies are necessary to confirm this finding and to establish its clinical relevance.

关键词：细胞因子基因多态性增生性玻璃体视网膜病变孔源性视网膜脱离转化生长因子-β 肿瘤坏死因子-α 初步细胞因子生成 PVr

Enrichment of resveratrol in Wine through a New Vinification Procedure

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Journal of Life Sciences 2015年第7期9卷 327-333页

作者： raul Francisco pastor Magdalena raquel Gargantini Marcelo Murgo Sebastian Prieto Humberto Manzano Carla Aruani Claudia In6s Quini Maria-Isabel Covas roberto H6ctor Iermoli Section Polyphenols Wine and Health Fourth Chair in Internal Medicine Clinics Hospital University of Buenos Aires BuenosAires C1408FZB Argentina Department Special Analytical Standards National Wine Institute Mendoza M5500AAR Argentina Department Oenological and Sensory Studies National Wine Institute Mendoza M5500AAR Argentina NUPrOAS Handesbolag Sicka Alle Nacka 13165 Sweden

Sulphur dioxide is used in the vinification process as an antimicrobial agent, but it is also considered as an important risk factor for liver diseases. Stilbenes have inhibitory effects on the growth of lactic acid bacteria strains isolated from wine. The authors investigated the viability of obtaining free-SO2 resveratrol-enriched red wines. Substitution of sulfite （7 g/100kg） for resveratrol （150 mg/L and 300 mg/L） in the vinification process did not change the basic physical and chemical properties of wine or its sensorial profile To the best of the authors＇ knowledge this is the first time that this type of vinification procedure is reported.

关键词： Vinification sulfur dioxide resveratrol wine enrichment.

Decipher the role of DNA methylation valley in the mammalian development

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Decipher the role of DNA methylation valley in the mammalian...

Occurrence of Antimicrobials in river Water Samples from rural region of the State of rio de Janeiro, Brazil

第二届全国发育生物学大会

作者： Hui Zheng Yuanyuan Li Lei Wei Ah Young Lee Wenhao Zhang Bo Huang Xuehui Liu Yiran Zang Jose C.pastor-Pareja Xiaowo Wang Wei Xie Tsinghua University School of Life Sciences MOE Key Laboratory of Bioinformatics and Bioinformatics Division Center for Synthetic and Systems BiologyTNLIST/Department of AutomationTsinghua University Ludwig Institute for Cancer research San Diego BranchLa JollaCA Tsinghua University THU-PKU Center for Life Sciences

DNA methylation valleys(DMVs)are unusually large genomic loci that are devoid of DNA *** from us and others have shown that,unlike typical hypomethylated regions in the genome,promoters with DMVs are strongly enriched for developmental genes and genes encoding for transcription *** are highly conserved across vertebrates,suggesting they may play important roles in *** DMVs remain mostly DNA methylation free in normal cells,they are frequently methylated in *** date,how DMVs are regulated and maintained hypomethylated remains largely ***,we will discuss the regulation of DMVs in the human and mouse genomes,as well as their possible roles in transcription.

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Journal of Environmental Protection 2016年第2期7卷 230-241页

作者： Mychelle Alves Monteiro Bernardete Ferraz Spisso Julia rodrigues Martins pastor dos Santos rafaela Pinto da Costa rosana Gomes Ferreira Mararlene Ulberg Pereira Talita da Silva Miranda Bárbara rodrigues Geraldino de Andrade Luiz Antonio d’Avila Chemistry School/Federal University of rio de Janeiro (EQ/UFrJ) Rio de Janeiro Brazil National Institute for Quality Control in Health/Oswaldo Cruz Foundation (INCQS/FIOCrUZ) Rio de Janeiro Brazil University Centre of Barra Mansa (UBM) Barra Mansa Brazil National of Institute of Cancer (INCA) Rio de Janeiro Brazil

The occurrence of antimicrobials in the aquatic environment and drinking water has raised the question of their impact on the environment and public health. Animal production is one of the most expressive activities of Brazilian agribusiness. In order to ensure the productivity and competitiveness of the sector, the use of drugs for therapeutic and prophylactic purposes is a common practice. Due to the continuous release of antimicrobials into the environment, the aim of this study was to compare the frequency of detection of tetracyclines and sulfonamides in surface water collected from rural areas in Lidice District of rio Claro, in the State of rio de Janeiro, Brazil. An investigative study was conducted with 24 river water samples analyzed by high-performance liquid chromatography coupled to tandem mass spectrometry and the aim of this study was to determine residues of sulfonamides and tetracyclines based on the USEPA method 1694. The results indicated the presence of sulfamethoxazole and oxytetracycline concentrations at the ng·L-1 level. The applied method showed overall good performance with recoveries above 57%, method detection limits ≤ 7.17 ng·L-1, method quantification limits ≤ 23.90 ng·L-1 and good linearity.

关键词： Antimicrobial LC-MS/MS Surface Water Sulfonamides Tetracyclines

A Modular Simulation Tool of an Orchestrator for Allocating Virtual resources in SDN

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通讯和计算机（中英文版） 2014年第1期11卷 88-99页

作者： Aurelio Javier Garcia Cristina Cervello-pastor Yury Jimenez Department of Telematics Engineering Universitat Politbcnica de Catalunya Barcelona 08860 Spain

SDN (Software-Defined Networking) and NFV (Network Functions Virtualization) are technologies for enabling innovative network architectures. Nevertheless, a fundamental problem in instantiation of VNs (Virtual Networks), performed by NFV, is an optimal allocation of resources offered by one or more SDN domain networks. The process of instantiation of VNs is performed in several phases, including splitting and mapping algorithms. For each one of these phases, researchers have developed algorithms, being possible to obtain different results combining them. This paper introduces a modular and flexible graphical discrete event simulation tool for solving the complete virtual resource allocation in SDN domain networks problem. A Java-based tool has been developed to integrate existing and future algorithms related to each phase of the process. The simulator is a test-bed in which researchers can select the appropriate algorithm in each phase and display the results in a graphical form, while obtaining a performance evaluation of the selected and proposed algorithms.

关键词：仿真工具虚拟资源最优分配 SDN 模块化映射算法网络架构迷走神经

A Novel Approach to Measure the Total Antioxidant Power of Wines through Near Infrared Spectroscopy and Its relevance in Human Nutrition

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Journal of Health Science 2019年第4期7卷 209-214页

作者： raúl Francisco pastor María Laura Mariani Marianela G. Villach Pablo N. Cascón Miriam Giudice Elena pastor Isabel pastor roberto H. Iermoli Alicia B. Penissi research Institute Faculty of Medical SciencesUniversidad del AconcaguaMendoza M5500CKCArgentina Polyphenols Wine and HealthInternal Medicine IV ChairHospital de ClínicasUniversidad de Buenos AiresCiudad de Buenos Aires C1120AAFArgentina

Wine is the product of the alcoholic fermentation of the grape (Vitis vinifera). As such, it is a hydroalcoholic solution with a variable content of nutritional and functional (polyphenols) molecules, the latter involved in its antioxidant potential. The organoleptic variables of wine, together with its potential positive effects on health of a light-moderate intake, have always been topics of great interest within the cultures. In the label of wine, alcohol is the only declared variable. On the other hand, there is no information about the content of “positive” molecules, such as those associated with the antioxidant power. This value could be very important to classify the wines, helping oenologist and nutritionist in qualifying them as a component of Mediterranean diet. Moreover, one of the most critical aspects in evaluating the role of wine in human health through epidemiological prospective studies is the quality of the products used and their antioxidant potential. This research aimed to optimize and validate an analytical approach based on a portable device (SCIO?), using NIrS (near-infrared reflectance spectroscopy). It allows the measure of TAP (total antioxidant power) of wine through the glass. research findings are promising. To the best of our knowledge, this is the first time that an easy-to-use and cheap hand-held scanner is validated to measure the TAP of a beverage.

关键词： TAP of wines near-infrared spectroscopy of wines NIrS portable device

西班牙南部15种山黧豆(豆科)种子蛋白的营养特性

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饲料博览 2011年第4期21卷 4-4页

作者： pastor C E Juan r.pastor J E Alaiz M Vioque J

试验对西班牙的15种山黧豆种子蛋白的营养特性进行了分析,研究表明,山黧豆中蛋白质含量为17.7%～25.6%,平均含量为22.4%。其中含有大量的必需氨基酸,主要包括亮氨酸、赖氨酸、苯丙氨酸、苏氨酸和缬氨酸。但是所有物种赖氨酸含量超过粮... 详细信息

试验对西班牙的15种山黧豆种子蛋白的营养特性进行了分析,研究表明,山黧豆中蛋白质含量为17.7%～25.6%,平均含量为22.4%。其中含有大量的必需氨基酸,主要包括亮氨酸、赖氨酸、苯丙氨酸、苏氨酸和缬氨酸。但是所有物种赖氨酸含量超过粮农组织的建议,所有物种色氨酸的含量范围限制为0.5%～0.8%,对含硫氨酸即蛋氨酸和胱氨酸也有一定限制。在对山黧豆的研究中,其蛋白质体外消化率为76.0%～86.5%,平均蛋白质体外消化率为80.5%。营养指标例如蛋白质效率比,都相当于高品质蛋白质。蛋白质消化率校正氨基酸评分与其他豆科植物如小扁豆或花生等相似。在种子蛋白氨基酸组成的数据的基础上进行相似性的分析显示,在这个群体中根据形态特征对这些种类进行相关性的分类。研究结果认为培育野生和非耕种山黧豆品种作为良好蛋白质资源对研究有重大意义。

关键词：干豆山黧豆种子蛋白氨基酸营养品质

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.r. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan r. Astalos S. Atashi r.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.r. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan r. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUArK GLUON TAGGING