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Immunogenic potential and protective efficacy of formalin inactivated circulating Indian strain of West nile virus

Asian Pacific Journal of Tropical Medicine 2014年第12期7卷 946-951页

作者： Pritom Chowdhury siraj Ahmed Khan rashmee Topno Prafulla Dutta r.n.s.yadav Jagadish Mahanta regional Medical research Centre ICMR(NE Region)DibrugarhAssamIndia Centre for studies in Biotechnology Dibrugarh UniversityDibrugarh-786004AssamIndia

Objective:To assess the best suitable condition for virus *** to study the immunogenic potential and protective efficacy of a circulating West nile virus(WnV) strain in ***:Bulk preparation of circulating WnV:WnIrGC07(GeneBank ID:HQ246154).was undertaken in a bioreaclor using *** Inactivation was done in three different conditions:22 ℃.4 ℃ and room *** virus preparations were evaluated for antigenicity by ELIsA and toxicity by cell proliferation *** efficacy was done in-viro on swiss albino mice against standard Indian WnV and Japanese encephalitis virus(JKV)*** and cell mediated immune response was evaluated in mice sera by ELIsA and neutralization ***:Inactivation at 22 ℃ was found to be more suitable in terms of less toxicity and high *** same was selected to study the immune response and efficacy in *** induced neutralizing antibody titre of 1:625 and high EgG *** vivo experiment showed 100% protective efficacy against WnV and 20.8% cross protective efficacy against *** assessment of cellular immunity through immunized mice revealed augmentation of high levels of pro-inflammatory cytokines and moderate levels of anti—cytokines indicating a mixed balance of Th1 and Th2 ***:Findings suggest that formalin inactivated Indian WnV strain has a good immunogenic *** is the first study on assessment of immunogenic potential of a lineage 5 strain of *** study reveals that it would be a promising and effective candidate for vaccine studies which warrants further evaluation.

关键词： West nile virus Assam Immunization Efficacy neutralizing antibody Cytokine

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Tailored design of novel Co0-Coδ+dual phase nanoparticles for selective CO2 hydrogenation to ethanol

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Journal of Environmental sciences 2025年第3期149卷 598-615页

作者： subhasis Das Ganapati D.yadav Department of Chemical Engineering Institute of Chemical TechnologyNathalal Parekh MargMatunga 400019MumbaiIndia

Catalytic hydrogenation of CO_(2)to ethanol is a promising solution to address the greenhouse gas(GHG)emissions,but many current catalysts face efficiency and cost *** based catalysts are frequently examined due to their abundance,cost-efficiency,and effectiveness in the reaction,where managing the Co^(0)to Co^(δ+)ratio is *** this study,we adjusted support nature(Al_(2)O_(3),MgO-MgAl_(2)O_(4),and MgO)and reduction conditions to optimize this balance of Co^(0)to Co^(δ+)sites on the catalyst surface,enhancing ethanol *** selectivity of ethanol reached 17.9%in a continuous flow fixed bed micro-reactor over 20 mol%Co@MgO-MgAl_(2)O_(4)(CoMgAl)catalyst at 270°C and 3.0 MPa,when reduced at 400°C for 8 *** results coupled with activity analysis confirmed that mild reduction condition(400°C,10%H_(2)balance n_(2),8 h)with intermediate metal support interaction favoured the generation of partially reduced Co sites(Co^(δ+)and Co^(0)sites in single atom)over MgO-MgAl_(2)O_(4)surface,which promoted ethanol synthesis by coupling of dissociative(CHx^(∗))/non-dissociative(CHxO^(∗))intermediates,as confirmed by density functional theory ***,the CoMgAl,affordably prepared through the coprecipitation method,offers a potential alternative for CO_(2)hydrogenation to yield valuable chemicals.

关键词： CO_(2)hydrogenation Ethanol Co-based catalysts Metal support ineraction DFT analysis

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La3+ substitution-adjusted magnetic and optical properties with enhanced photocatalytic activity and stability of copper zinc nickel ferrites for wastewater treatment applications

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Journal of rare Earths 2025年第2期43卷 319-328页

作者： n.s.Al-Bassami General studies Department Jubail Industrial College

Copper-zinc-nickel（Cu-Zn-ni） ferrite nanoparticles are used for wastewater treatment ***,low degradation efficiency and stability are two main issues that make them unsuitable for actual production *** this paper,the citrate-nitrate auto-combustion method was applied for the formation of Cu0.5Zn0.25ni0.25LaxFe2-xO4;（0≤x≤0.1;step 0.02）(CZnL) *** the substitution process entails the replacement of a small ion with a larger one,the lattice constant and crystallite size does not exhibit a consistent incremental *** behavior is justified and *** size of all the CZnL ferrite nanoparticles is in the range of 8-12 nm,and the lattice constant is in the range of 8.6230 to 8.4865 *** morphological analysis conducted using field emission-scanning electron microscopy（FE-sEM） reveals that the CZnL exhibits agglomerated spherical *** energy dispersive X-ray spectrameter（EDAX） analysis was employed to confirm the elemental composition of CZnL *** the process entails the substitution of Fe3+magnetic ions with nonmagnetic ions La3+,the magnetic parameters of CZnL nanoferrites show a general decreasing trend as *** 20 K,saturation magnetization Ms shows an overall drop in its values from 59.302 emu/g at x=0.0-41.295 emu/g at x=0.1,the smallest value of 37.87 emu/g is recorded at x=*** highest coercivity（Hc=125.9 Oe） and remanence（Mr=13.32 emu/g） are recorded for x=0.08 and x=0.04 nanoferrite,*** band gap of all the CZnL nanoferrites was determined using the Kubelka-Munk function and Tauc plot for direct permitted *** doping modifies the band gap（within 1.86-1.75 eV）,increases light absorption,induces efficient e/h separation and charge migration to *** nanoferrite Cu0.5Zn0.25ni0.25La0.06Fe1.94O4achieves a degradation efficiency of 97.3% for methylene blue（MB） dye removal after just 60 *** five recycling processes,the nanoc

关键词： Copper-zinc-nickel Ferrite Photocatalytic properties rare earths Wastewater treatment

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Growth of stimulated raman instability by a density-modulated electron beam in laser-plasma interactions

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Communications in Theoretical Physics 2025年第1期77卷 164-171页

作者： Pinki yadav Devki nandan Gupta Jyotsna sharma Department of Physics and Astrophysics University of DelhiDelhi 110007India Department of Physics South Asian UniversityNew Delhi 110068India Department of Physics Motilal Nehru CollegeUniveristy of DelhiDelhi 110021India

A way to enhance the growth of stimulated raman instability in laser-plasma interactions was *** relies on the application of density modulation of a co-propagating electron beam in *** the stimulated raman scattering process,an electromagnetic pump wave decays into a low-frequency wave and a scattered electromagnetic sideband *** this process,the pump wave produces an oscillatory velocity associated with the plasma electrons and the beam *** oscillatory velocities combine with the existing low-frequency mode,producing ponderomotive force that drives high-frequency sideband *** sidebands couple to the pump wave,driving the beam-mode.A modulation of the electron beam density enhances the growth rate of the *** theoretical calculations show about 40%enhancements in growth of raman instability at resonance(where the electron beam density modulation parameter approaches to unity)for the plasma density of the order of 10^(18)cm^(-3).

关键词： raman instability fluid dynamics plasma fusion

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A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： s.sAUrABH r.KIrAn D.sInGH r.VAIsH V.s.CHAUHAn school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(Hr), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： bio-inspired composite plate finite element method (FEM) Green-Lagrange helicoidal inverse hyperbolic shear deformation theory (IHsDT) nonlinear O322

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Graphene derivatives as efficient hole transport materials for lead-free double perovskite（Cs2snI6） solar cells: a numerical study

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Optoelectronics Letters 2025年第3期21卷 155-159页

作者： sarita yadav saral K.GUPTA Chandra Mohan singh nEGI Department of Physical science Banasthali Vidyapith

The double perovskite Cs2snI6has notable optical and electrical characteristics, rendering it a highly prospective candidate for deployment as the absorber layer in perovskite solar cells （PsCs）. We simulated the performance of PsCs using lead-free Cs2snI6double perovskite absorber layer and graphene derivatives, namely graphene oxide （GO） and reduced graphene oxide （rGO）, as hole transport layers （HTLs）. Our findings show that r GO offers an excellent hole extraction property with minimal interfacial recombination compared to GO.

关键词： A

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Green synthesis of glycolic acid through the electrocatalytic reduction of oxalic acid over black TiO_(2): An experimental and theoretical study

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Journal of Energy Chemistry 2025年第1期100卷 544-556页

作者： Hugo Olvera-Vargas Oscar Andrés Jaramillo-Quintero Luis Darío Alarcón León Orlando Castro-Ocampo Christian A.Celaya Marina E.rincón Jesús Muñiz Instituto de Energías renovables Universidad Nacional Autónoma de México(IER-UNAM)Priv.Xochicalco s/nCol.CentroTemixcoMorelos.CP 62580Mexico Centro de nanociencias y nanotecnología Universidad Nacional Autónoma de México(UNAM)Km 107Carretera Tijuana-EnsenadaEnsenadaB.C.C.P.22800Mexico

Herein,we present the electrocatalytic four-electron hydrogenation of oxalic acid into glycolic acid using black TiO_(2)as an *** acid is an abundant compound found in several sources of organic *** results showed a high selectivity of black TiO_(2)toward glycolic acid,with the formation of glyoxylic acid being the rate-limiting step (glyoxylic acid is the two-electron intermediate).The highest Faradaic efficiency (FE) of 69.6%±8.3% was achieved at 10.2 mA cm^(-2)in 4 h of electrolysis using an H-type cell operated at room temperature,with 50.2%±3.8% of oxalic acid conversion (degradation kinetic constant k=0.0042±0.0001 min-1),58.8%±7.0%of reaction yield and 1.2±0.18 g L-1of glycolic acid production.A theoretical model of black TiO_(2)coming from anatase TiO_(2)was implemented by introducing Ti3+defects,which gave black TiO_(2)the theoretical capability to easily transform oxalic acid into glycolic acid as experimentally *** reaction mechanism was supported and described in detail by density functional theory calculations,which revealed that surface Ti^(3+)states were the main catalytic *** is the first time that a detailed step-by-step mechanism at the atomic level has been proposed for this electrocatalytic reaction,which represents a valuable contribution to the understanding of this process of high energy/environmental *** is also the first time that black TiO_(2)has been used as an electrocatalyst for this sustainable process.

关键词： Chemical energy storage Electrochemical hydrogenation Density functional theory renewable energy Oxalic acid

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nucleoside modified mrnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural regeneration research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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neural regeneration research 2025年第11期20卷 3213-3214页

作者： sheharyar s.Baig Ali n.Ali Arshad Majid sheffield Institute for Translational neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(Vns)and stroke:stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive Vns paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatments of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,sTOP-AUsT,and TrAIGE did not show improvements in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

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Olfactory receptors in neural regeneration in the central nervous system

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neural regeneration research 2025年第9期20卷 2480-2494页

作者： rafael Franco Claudia Garrigós Toni Capó Joan serrano-Marín rafael rivas-santisteban Jaume Lillo Molecular neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Ciberned network Center for Biomedical research in neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain school of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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