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redefining non-alcoholic fatty liver disease to metabolic associated fatty liver disease: Is this plausible?

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World Journal of Hepatology 2022年第1期14卷 158-167页

作者： Jalpa devi Aimun raees Amna Subhan Butt Department of Gastroenterology Liaquat University of Medical and Health SciencesJamshoro 74800Pakistan Department of Gastroenterology Aga Khan University HospitalKarachi 74800Pakistan

recently,a single letter change has taken the world by storm.A group of experts have developed a consensus to upgrade the term non-alcoholic fatty liver disease(NAFLD)to metabolic associated fatty liver disease(MAFLD),suggesting that MAFLD would more accurately reflect not only the disease pathogenesis but would also help in patient stratification for management with ***,the difference of opinion exists,which has made the NAFLD vs MAFLD debate the current talk of the *** review will focus on the plausibility and implications of redefining NAFLD as MAFLD.

关键词： Non-alcoholic fatty liver disease Metabolic associated fatty liver disease Fatty liver disease Non-alcoholic fatty liver review

Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第7期13卷 287-295页

作者： Yucinda YY Khor Siew-Keah Lee Dharmani devi M Wei Chih Ling Department of Pre-clinical Sciences M.Kandiah Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSelangorMalaysia Department of Pharmacology Faculty of MedicineUniversiti MalayaKuala LumpurMalaysia

Objective:To investigate the effect of epigallocatechin-3-gallate(EGCG)on endothelial dysfunction in spontaneously hypertensive rats(SHr).Methods:Wistar-Kyoto(WKY)rats and SHr were divided into four groups;WKY control,SHr control and SHr treated with EGCG(50 mg/kg/day)or losartan(10 mg/kg/day).The treatment was given daily for 4 weeks by oral gavage and the blood pressure was monitored by tail-cuff method every 3 *** endothelium-dependent relaxations were assessed in isolated phenylephrine-precontracted aortic rings at the end of *** vascular levels of reactive oxygen species,nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate were also ***,the expression of angiotensinⅡtype 1(AT_(1))receptor protein was ***:The systolic blood pressure was significantly decreased in SHr treated with *** impaired endothelium-dependent relaxation was significantly improved in aortic ring isolated from the EGCG-treated SHr *** also significantly increased the levels of nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate,while decreasing the level of reactive oxygen species and the protein expression of AT_(1)receptor in ***:EGCG attenuates endothelial dysfunction in SHr by decreasing oxidative stress and increasing vascular nitric oxide bioavailability,which may be modulated partly by inhibition of vascular AT_(1)*** increase in endothelium-dependent relaxation may contribute to a decrease in blood pressure in hypertensive animals.

关键词： Epigallocatechin-3-gallate Vascular protection Antihypertension Tetrahydrobiopterin Cyclic guanosine monophosphate Angiotensin typeⅠreceptor Spontaneously hypertensive rats

双功能离子液体在氯化物介质中萃取分离Eu^(3+)的应用

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Transactions of Nonferrous Metals Society of China 2022年第6期32卷 2061-2070页

作者： Bibhuti Bhusan MISHrA Niharbala devi Bhubaneswar-751030OdishaIndia

研究使用双功能离子液体萃取剂(Bif-ILEs)三辛基甲基氯化铵二(2-乙基己基)磷酸酯([A336][D2EHP])和十四烷基三己基氯化膦二(2-乙基己基)磷酸酯([P_(66614)][D2EHP])、以煤油作稀释剂从氯化物介质中萃取Eu^(3+)的过程,以开发环境友好的... 详细信息

研究使用双功能离子液体萃取剂(Bif-ILEs)三辛基甲基氯化铵二(2-乙基己基)磷酸酯([A336][D2EHP])和十四烷基三己基氯化膦二(2-乙基己基)磷酸酯([P_(66614)][D2EHP])、以煤油作稀释剂从氯化物介质中萃取Eu^(3+)的过程,以开发环境友好的铕萃取工艺。通过改变关键工艺参数,研究Eu^(3+)的萃取行为。萃取研究表明,铵基离子液体[A336][D2EHP]对Eu^(3+)的萃取效率优于膦基离子液体[P_(66614)][D2EHP]。例如,使用0.05 mol/L[A336][D2EHP]可以定量萃取Eu^(3+),而需要0.1 mol/L的[P_(66614)][D2EHP]才能达到相同的Eu^(3+)萃取率。对于[A336][D2EHP],铕的萃取为吸热过程。反萃实验表明,使用20%HNO_(3)(体积分数)可以将100%的Eu^(3+)从两种负载的离子液体中反萃下来。在pH值3.2时,分离因子(bY/Eu)最高,达到653.59;在相同pH值下,Eu^(3+)对La^(3+)的分离因子为30.6。采用0.2 mol/L[A336][D2EHP]、相比O/A=1:1和1:2的两级错流萃取,可从废灯管荧光粉浸出液中回收99.98%的Eu和99.99%的Y。

关键词：铕双功能离子液体溶剂萃取分离荧光粉

Indian Traditional Treatments for Psoriasis:A Critical Appraisal of Available Evidence Supporting Efficacy

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Chinese Journal of Integrative Medicine 2023年第1期29卷 69-73页

作者： Nayak Deeksha Dayanand Arul Amuthan Sathish Pai Ballambat Shama Prasada Kabbekodu Vasudha devi Department of Pharmacology Kasturba Manipal Medical CollegeManipal Academy of Higher EducationManipal576104India Department of Dermatology Venerology and LeprosyKasturba Medical CollegeManipal Academy of Higher EducationManipal576104India Department of Cell and Molecular Biology Manipal School of Life SciencesManipal Academy of Higher EducationManipal576104India Centre for Cardiovascular Pharmacology Manipal Academy of Higher EducationManipal576104India

Objective To examine data from studies supporting the clinical efficacy of medical approaches from India traditional systems of medicines like Ayurveda,Unani,Siddha,and Homeopathy for psoriasis using outcome indicators employed in clinical practice and *** Searches were conducted between December 2019 and September 2020 in databases PubMed,Scopus,Web of Science and Ovid Medline using search terms including traditional,complementary,psoriasis,Kushtha,Ayurveda,Siddha,Unani,Homeopathy and *** trials,case series and case reports published from India were *** Data of 17 selected studies were *** efficacy in terms of improvement in Psoriasis Area and Severity Index(PASI)score or/and percentage reduction in score(PASI 50,PASI 75 and PASI 90)or/and patient-reported outcomes using instruments like Dermatology Life Quality Index and Psoriasis Disability Index were *** studies reported good improvement as per the study specific ***,study characteristics,including study design,sample size,follow-up period,inclusion and exclusion criteria were heterogeneous,and the choice of outcome measures was not adequate to conclude the effectiveness of *** use of some herbs as common ingredients in several formulations across different systems of medicines were noted in analyzing individual *** Future studies must incorporate a comprehensive study design with specific outcome measures like PASI,PASI 75,PASI 90,quality of life parameters,compliance to medications,adverse reactions,remission period,relapse rate and cost-effectiveness with long term *** currently available evidence on the roles of these herbs at molecular level in psoriasis is preliminary.

关键词： psoriasis traditional treatment Indian efficacy herb clinical

Adiponectin as a therapeutic target for diabetic foot ulcer

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World Journal of Diabetes 2023年第6期14卷 758-782页

作者： Mona Mohamed Ibrahim Abdalla Jaiprakash Mohanraj Sushela devi Somanath Department of Physiology Human Biology DivisionSchool of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia Department of Biochemistry Human Biology DivisionSchool of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia Department of Microbiology School of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia

The global burden of diabetic foot ulcers(DFUs)is a significant public health concern,affecting millions of people *** wounds cause considerable suffering and have a high economic ***,there is a need for effective strategies to prevent and treat *** promising therapeutic approach is the use of adiponectin,a hormone primarily produced and secreted by adipose *** has demonstrated anti-inflammatory and antiatherogenic properties,and researchers have suggested its potential therapeutic applications in the treatment of *** have indicated that adiponectin can inhibit the production of pro-inflammatory cytokines,increase the production of vascular endothelial growth factor,a key mediator of angiogenesis,and inhibit the activation of the intrinsic apoptotic ***,adiponectin has been found to possess antioxidant properties and impact glucose metabolism,the immune system,extracellular matrix remodeling,and nerve *** objective of this review is to summarize the current state of research on the potential role of adiponectin in the treatment of DFUs and to identify areas where further research is needed in order to fully understand the effects of adiponectin on DFUs and to establish its safety and efficacy as a treatment for DFUs in the clinical *** will provide a deeper understanding of the underlying mechanisms of DFUs that can aid in the development of new and more effective treatment strategies.

关键词： Diabetic foot ulcer Adiponectin Anti-inflammatory Adipose tissue Antioxidants Wound healing

Semi Markov process inspired selfish aware co-operative scheme for wireless sensor networks(SMPISCS)

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Cybersecurity 2019年第1期2卷 76-90页

作者： Kanchana devi V Ganesan r School of Computing Science and Engineering VIT University Chennai CampusChennaiTamilNaduIndia

In Wireless Sensor Network(WSN),energy and packet forwarding tendencies of sensor nodes plays a potential role in ensuring a maximum degree of co-operation under data *** quantified level of co-operation signifies the performance of the network in terms of increased throughput,packet delivery rate and decreased delay depending on the data being aggregated and level of control *** performance of a sensor network is highly inclined by the selfish behaving nature of sensor nodes that gets revealed when the residual energy ranges below a bearable level of activeness in packet *** selfish sensor node needs to be identified in future through reliable forecasting mechanism for improving the lifetime and packet delivery *** Markov Process Inspired Selfish aware Co-operative Scheme(SMPISCS)is propounded for making an attempt to mitigate selfish nodes for prolonging the lifetime of the network and balancing energy consumptions of the *** model provides a kind of sensor node’s behavior for quantifying and future forecasting the probability with which the node could turn into *** experiments are carried out through Network Simulator 2 and the performance are analyzed based on varying the number of selfish sensor nodes,number of sensor nodes and range of detection threshold.

关键词： Information security routing overhead Selfish sensor nodes Semi Markov process Wireless sensor networks

Ensemble of Handcrafted and Deep Learning Model for Histopathological Image Classification

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Computers, Materials & Continua 2022年第11期73卷 4393-4406页

作者： Vasumathi devi Majety N.Sharmili Chinmaya ranjan Pattanaik ELaxmi Lydia Subhi r.M.Zeebaree Sarmad Nozad Mahmood Ali S.Abosinnee Ahmed Alkhayyat Department of Computer Science Engineering Vignan’s Nirula Institute of Technology and Science for WomenGuntur522005India Department of Computer Science Engineering Gayatri Vidya Parishad College of Engineering for WomenVisakhapatnam530048India Department of Computer Science and Engineering Ajay Binay Institute of Technology CuttackOdisha750314India Department of Computer Science and Engineering Vignan’s Institute of Information TechnologyVisakhapatnam530049India Energy Department Technical College of EngineeringDuhok Polytechnic UniversityDuhokIraq Computer Technology Engineering College of Engineering TechnologyAl-Kitab UniversityIraq Computer Technical Engineering Department College of Technical EngineeringThe Islamic UniversityNajaf54001Iraq College of Technical Engineering The Islamic UniversityNajafIraq

Histopathology is the investigation of tissues to identify the symptom of *** histopathological procedure comprises gathering samples of cells/tissues,setting them on the microscopic slides,and staining *** investigation of the histopathological image is a problematic and laborious process that necessitates the expert’s *** the same time,deep learning(DL)techniques are able to derive features,extract data,and learn advanced abstract data *** this view,this paper presents an ensemble of handcrafted with deep learning enabled histopathological image classification(EHCDL-HIC)*** proposed EHCDLHIC technique initially performs Weiner filtering based noise removal *** the images get smoothened,an ensemble of deep features and local binary pattern(LBP)features are *** the classification process,the bidirectional gated recurrent unit(BGrU)model can be *** the final stage,the bacterial foraging optimization(BFO)algorithm is utilized for optimal hyperparameter tuning process which leads to improved classification performance,shows the novelty of the *** validating the enhanced execution of the proposed EHCDL-HIC method,a set of simulations is *** experimentation outcomes highlighted the betterment of the EHCDL-HIC approach over the existing techniques with maximum accuracy of 94.78%.Therefore,the EHCDL-HIC model can be applied as an effective approach for histopathological image classification.

关键词： Histopathological image classification machine learning deep learning handcrafted features bacterial foraging optimization

An Investigation of Molecular Targeting of MMP-9 for Endometriosis Using Algal Bioactive Molecules

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Phyton-International Journal of Experimental Botany 2022年第3期91卷 569-582页

作者： Farnaz Nabiya Anchana devi Chenniappan rajamiriyam Marichamy MubarakAli Davoodbasha Jung-Wan Kim P.G.&research Department of Biotechnology Women’s Christian CollegeChennai600006Tamil NaduIndia School of Life Sciences B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennai600048Tamil NaduIndia Division of Bioengineering Incheon National University119 Academy-roSongdo 1(il)-dongYeonsu-guIncheon22012Korea

Endometriosis is a chronic inflammatory disease that occurs due to the presence of endometrial tissue outside the uterine *** affects from 5%to 10%of women of reproductive *** levels of matrix metalloproteinase(especially MMP-9)have been observed in women suffering from ***,the aim of this study was to investigate the naturally anti-inflammatory compounds available from an algal source that can target the MMP-9 by various in silico *** target 1L6J(Crystal structure of human matrix metalloproteinase MMP-9)structure was retrieved from the PDB *** compounds such as Eckol,Sargafuran,Vitamin E,Docosahexaenoic acid,Fucoidan and Elagolix were selected based on‘Lipinski’s rule of five’using the PubChem *** pharmacokinetics,ADMET properties and biological activity of these compounds were predicted computationally using databases such as PreADME,SWISS-ADME,pkCSM and *** analysis of the bioactive compounds with the target was performed by AutoDock *** LigPlot v.2.2,the target residues interacting with the compounds were visualised in a 2D *** on the results,Eckol exhibited the highest binding energy value of−7.82 kcal/mol,whereas the Elagolix(control drug)showed a binding energy of−4.88 *** conclude that Eckol can be a potent inhibitor of target MMP-9 with least side effects when compared to the control ***,this compound can be effectively explored by further in vitro and in vivo studies to develop more effective treatments for Endometriosis.

关键词： Endometriosis matrix metalloproteinase anti-inflammatory PubChem AutoDock 4.2.6 LigPlot v.2.2 eckol

Loss of Exchange Symmetry in Multiqubit States under Ising Chain Evolution

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Chinese Physics Letters 2011年第2期28卷 39-42页

作者： Sudha B.G.Divyamani A.r.Usha devi Department of Physics Kuvempu UniversityShankaraghattaShimoga-577451India DAMTP Centre for Mathematical SciencesWilberforce RoadCambridgeCB3OWAUK Department of Physics Bangalore UniversityBangalore-560056India Inspire Institute Inc. McLeanVA 22101USA.

Keeping in view of importance of exchange symmetry aspects in studies on spin squeezing of multiqubit states,we show that the one-dimensional Ising Hamiltonian with nearest neighbor interactions does not retain the exchange symmetry of initially symmetric multiqubit *** we show that among 4-qubit states obeying exchange symmetry,all states except W class(and their linear combination)lose their symmetry under time evolution with Ising *** the loss of symmetry of the initially symmetric states to rotational asymmetry of the one-dimensional Ising Hamiltonian with more than 3 qubits,we indicate that all N-qubit states(N>5)obeying permutation symmetry lose their symmetry after time evolution with Ising Hamiltonian.

关键词： symmetry Ising qubit