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Current trends in perioperative treatment of resectable gastric cancer

the Eighth China-Japan-Korea Joint Symposium on Enzyme Engineering

作者： Y.z.XIAO M.zhang H.H.GE S.X.zhang r.Jia Y.p.Wang laboratory of Microorganism and Gene technology School of Life SciencesAnhui University

laccase,a kind of polyphenol oxidase containing copper atoms,can oxidize an array of organic and inorganic substrates,including mono-,di-,and polyphenols,aminophenols,methoxyphenols as well as metal complexes:ferrocene,ferrocyanide or iodide,by concomitant four-electron reduction of oxygen to *** can be found in plants,insects and bacteria,but its major source is *** ***28-2 is a white-rot basidiomycete that selectively degrades lignin when grown on wood,and decreases the level of chemical oxygen demand in the wastewater produced in the process of straw *** studies indicate that this microorganism can be induced to secrete high levels of extracellular laccase,laccase isozyme,laccase B,was selectively induced by 3,5-dihydroxytoluene,and purified to homogeneity by two-step *** laccase B appeared as blue with a broad peak at about 600 nm and a shoulder peak at about 330 *** ratio of absorbance at 280 nm to that at 600 nm was *** molecule of laccase B had approximately four copper *** mass of laccase B was estimated to be 74 kDa on SDS-pAGE,72 kDa by FplC,and was determined to be 71454 Da by mass *** being treated with N-glycosidase F,laccase B lost 25%of its molecular *** isoelectric point of laccase B was *** optimal pH and temperature for oxidizing guaiacol were 4.7 and 45 ℃ *** half-life of the enzyme at 60 ℃ was 14.0 *** enzyme showed a good stability in a range of pH value 3.5 to *** K values of the enzyme toward substrates syringaldazine,guaiacol,ABtS,and DMOp were 28.0,1249.0,177.0and 109.8 μM,*** corresponding V are 504.0,1910.0,117.4 and159.0 uM ***,activity of laccase B was inhibited strongly by sodium azide and cyanide,mildly by SDS and trifluoroacetic acid,but only weakly by dimethyl sulfoxide.

关键词： 3,5-dihydroxytoluene laccase isozyme trametes sp.AH28-2

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 323-337页

作者： İbrahim Yıldız leyla Özer Elif Şenocak taşçı İbrahim Vedat Bayoglu Erman Aytac Department of Medical Oncology Acıbadem MAA Universityİstanbul 34567Turkey Department of Medical Oncology Acıbadem Universityİstanbul 34567Turkey Department of Medical Oncology Marmara Universityİstanbul 12345Turkey Department of Surgery Acibadem University School of MedicineIstanbul 34567Turkey

In the last few decades,the treatment strategy for locally advanced resectable gastric cancer(GC)has shifted to a multimodal approach,which potentially decreases recurrence risk and improves survival *** therapy leads to downstaging,increased curative resection rates,and prolonged disease-free and overall survival,by preventing micrometastases in patients with resectable *** of neoadjuvant therapy provides information about tumor biology and in vivo sensitivity.A consensus regarding the therapeutic approach for non-metastatic GC does not exist,and many clinical trials aim to clarify this *** in precision medicine and the role of immunotherapy have been the focus of research in GC ***,the current status and possible future developments of perioperative therapy for locally advanced resectable GC are reviewed,based on the most recent randomized clinical trials.

关键词： perioperative treatment Immunotherapy Neoadjuvant Chemotherapy Gastric cancer Adjuvant

扁平化责任制护理对微创介入治疗子宫肌瘤患者术后并发症及康复效果的影响

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河北医药 2024年第6期46卷 943-945,949页

作者：孙燕蕾麻莉郭艳平张鑫鑫孙丹丹叶梅中国人民解放军火箭军特色医学中心妇产科北京市100088

目的探讨扁平化责任制护理对微创介入治疗子宫肌瘤患者术后并发症及康复效果的影响。方法选取2020年5月至2021年3月收治子宫肌瘤患者90例,均接受微创介入导管栓塞子宫动脉术治疗,随机数字法下,常规护理患者45例纳为对照组,扁平化责任制... 详细信息

目的探讨扁平化责任制护理对微创介入治疗子宫肌瘤患者术后并发症及康复效果的影响。方法选取2020年5月至2021年3月收治子宫肌瘤患者90例,均接受微创介入导管栓塞子宫动脉术治疗,随机数字法下,常规护理患者45例纳为对照组,扁平化责任制护理患者45例纳为研究组,对2组所得护理结局对比分析。结果研究组患者肠蠕动时间、肛门排气时间均显著小于对照组(pppp>0.05),护理后研究组生活质量评分显著优于对照组(p<0.05)。结论微创介入导管栓塞子宫肌瘤患者治疗期间,辅助扁平化责任制护理,可促进术后患者消化功能恢复,改善患者排尿情况,提升患者生活质量,减少并发症发生可能性,临床护理效果较为明显。

关键词：微创介入子宫肌瘤扁平化责任制护理消化功能并发症

reconstruction of the anterior skull base with radial forearm free tissue transfer:case series and literature review

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plastic and Aesthetic research 2016年第1期3卷 47-51页

作者： Windy A.Olaya lauren t.Daly Emily G.Clark thomas Scholz Vincent laurence Keyianoosh z.paydar Garrett A.Wirth Gregory r.D.Evans Aesthetic and plastic Surgery Institute University of California IrvineOrangeCA 92868USA.

Aim:reconstruction of the anterior skull base offers an especially complex challenge as the impermeable separation of the dural space and the upper aerodigestive tract must be *** propose the use of the radial forearm free flaps(rFFF)as a superb method of re-establishing integrity in anterior skull base ***:literature review and retrospective analysis of 4 single-institution cases of anterior skull base defects reconstructed with a *** were collected on successful and unsuccessful defect repairs,complication rates,and length of ***:the indications for surgery were pneumocephalus,recurrent brain abscesses,recurrent frontal sinus mucoceles,and cerebrospinal fluid *** the 4 cases,1 was complicated by a small dehiscence of the craniotomy site,1 developed infection,and 2 required further ***:the use of rFFF is an excellent option for reconstruction of defects in the anterior skull base,especially those complicated by radiation,prior surgery,or *** with skull base defects are inherently at high risk for post-surgical *** rFFF transfers healthy,viable,well-vascularized tissue to prevent further infections and provides a reliable barrier between the dural and sinonasal *** can reduce the need for repeat neurosurgical operations and hospitalizations.

关键词： Aterior skull base defect reconstruction plastic surgery free flap radial forearm free flap

Direct Dynamical test for Deterministic Chaos.

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Direct Dynamical Test for Deterministic Chaos.

reperfusion arrhythmias in acute myocardial infarction

作者： J. GAO and z. zHENG laboratory for Nonlinear Mechanics of Continuous Media Institute of Mechanics, Chinese Academy of Sciences Beijing 100080, p.r. China

We present a direct and dynamical method to distinguish low-dimensional deterministic chaos from noise. We define a series of time-dependent curves which are closely related to the largest lyapunov exponent. For a chaotic time series, there exists an envelope to the time-dependent curves, while for a white noise or a noise with the same power spectrum as that of a chaotic time series, the envelope cannot be defined. When a noise is added to a chaotic time series, the envelope is eventually destroyed with the increasing of the amplitude of the noise.

关键词：

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中华医学杂志(英文版) 1993年第7期106卷 517-517页

作者： r l Gao K B Yao J l Chen Y J Yang Y S Xu z J Chen Cardiovascular Institute Chinese Academy of Medical Sciences Beijing.

In 27 patients with acute myocardial infarction (MI) and their infarct-related coronary artery being completely occluded who received thrombolytic therapy or percutaneous transluminal coronary angioplasty, reperfusion was confirmed by immediate coronary angiography in 24. reperfusion arrhythmias (rA) occurred in 19 (79.2%) of the patients, including ventricular arrhythmias in 13 (54.2%). Ventricular fibrillation and sustained ventricular tachycardia developed in 2 (8.4%) and accelerated idioventricular rhythm in 5 (20.8%), the latter was a reliable indicator of coronary recanalization. transient sinus bradycardia or AV block occurred in 10 (66.7%) of the 15 patients with inferoposterior MI. the occurrence of rA was not related to the duration of ischemia; ventricular rA was also not related to the location of MI and the occurrence and severity of ischemic arrhythmias before reperfusion.

关键词： INtrAVENOUS StrEptOKINASE tHrOMBOlYSIS MECHANISMS

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ElECtrOCHEMICAl NOISE ANAlYSIS OF tHE INFlUENCE OF tHE zn^(2+)IONS CONCENtrAtION ON zINC ElECtrOplAtING

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Acta Metallurgica Sinica(English letters) 2005年第2期18卷 137-144页

作者： z.zhang C.S.Wu Q.Y.Cai F.H.Cao J.Q.zhang DepartmentofChemistry ZhejiangUniversityHangzhou310027China DepartmentofChemistry ZhejiangUniversityHangzhou310027China／／StateKeyLaboratoryforCorrosionandProtectionInstituteofMetalResearchTheChineseAcademyofSciencesShenyang110016China

the influence of the concentration of zn2+ ions on zinc electroplating process was investigated by means of electrochemical noise (EN) and cyclic voltammetry methods in conjunction with the scanning electron microscopy (SEM) technique. It was found that the EN generated during the electroplating of dentritic or large polymeric zinc deposit has large potential oscillation amplitude and positive potential drift while the compact zinc deposit possesses small noise amplitude and little potential drift. With the change of rate determining step from diffusion-control through mixed-control to activation-control, the maximum relative energy obtained from wavelet analysis defined from the region with larger scales to those with smaller scales, and the EDp (relative energy distribution plot) can be us, as 'fingerprints' of EN to characterize the electroplating process and the deposit structure. the results also showed that electrochemical noise technique can give more information about the electrodeposit structure than other normal electrochemical measurements, such as linear potential sweep method and cyclic voltammetry technique.

关键词： zinc electroplating zinc ions concentration electrochemical noise electrodeposit structure

经鼻胆管吲哚菁绿导航在老年胆管结石患者序贯治疗中的应用

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腹腔镜外科杂志 2024年第9期29卷 683-687页

作者：蔡小丹冯伟马垚汪启乐陈思颖刘加宁江苏省人民医院宿迁医院普外科江苏宿迁223800 徐州医科大学附属宿迁医院肝胆胰外科徐州医科大学附属宿迁医院消化内科

目的:探讨经鼻胆管吲哚菁绿导航在内镜十二指肠乳头括约肌小切开联合球囊扩张术(ESBD)后序贯行腹腔镜胆囊切除术(lC)治疗老年胆管结石患者中的应用价值。方法:选取2020年1月至2023年1月收治的胆囊结石伴胆总管结石的60例老年患者,采用E... 详细信息

目的:探讨经鼻胆管吲哚菁绿导航在内镜十二指肠乳头括约肌小切开联合球囊扩张术(ESBD)后序贯行腹腔镜胆囊切除术(lC)治疗老年胆管结石患者中的应用价值。方法:选取2020年1月至2023年1月收治的胆囊结石伴胆总管结石的60例老年患者,采用ESBD序贯lC的治疗方案,根据lC术中是否经鼻胆管注射吲哚菁绿行术中导航分为常规组(n=30)与导航组(n=30),对比分析两组患者临床资料。结果:两组一般资料差异无统计学意义,均成功完成ESBD序贯lC,导航组术中证实肝门区胆管分型异常2例,无中转开腹、胆管损伤。常规组与导航组手术时间[(68.43±27.40)min vs.(63.17±23.25)min]、术中出血量[(12.37±5.53)ml vs.(11.03±4.66)ml]、lC术后住院时间[(4.90±0.99)d vs.(4.77±0.94)d]差异无统计学意义(p>0.05),术后鼻胆管造影胆囊管残端长度[(10.67±2.61)mm vs.(5.87±2.47)mm]差异有统计学意义(plC的安全性具有积极作用。

关键词：胆管结石吲哚菁绿内镜十二指肠乳头括约肌小切开球囊扩张术胆囊切除术,腹腔镜老年人

2018-2022年四川省泸州市孕妇碘营养状况监测结果分析

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中国地方病防治 2024年第2期39卷 118-121页

作者：苟钊杨培基李劲松吴斗琼马玲泸州市疾病预防控制中心四川646300 西南医科大学公共卫生学院

目的了解2018-2022年泸州市孕妇碘营养状况,为碘缺乏病防治提供依据。方法按照《全国碘缺乏病监测方案》(2016版),采用多阶段分层整群随机抽样,采集孕妇随意尿样及其家中食盐样品,并测定碘含量。结果共检测孕妇尿样、盐样各3 500份,... 详细信息

目的了解2018-2022年泸州市孕妇碘营养状况,为碘缺乏病防治提供依据。方法按照《全国碘缺乏病监测方案》(2016版),采用多阶段分层整群随机抽样,采集孕妇随意尿样及其家中食盐样品,并测定碘含量。结果共检测孕妇尿样、盐样各3 500份,尿碘中位数为155.3μg/l;2019、2020年孕妇尿碘中位数低于其余年份(均pz=-0.297,p=0.766);孕早期孕妇尿碘中位数高于孕中期和孕晚期孕妇(z=3.195、3.068,p=0.001、0.002);各县(区)孕妇尿碘中位数差异有统计学意义(H=36.592,pp<0.05)。结论 2018-2022年泸州市孕妇整体碘适宜,碘盐食用情况良好,符合国家消除碘缺乏病的标准,但孕妇仍存在碘缺乏风险。今后应继续做好碘营养状况监测工作并加强孕期合理碘营养宣传教育力度。

关键词：孕妇碘尿碘盐碘