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Population-Based and Personalized Design of Total Knee replacement Prosthesis for Additive manufacturing Based on Chinese Anthropometric Data

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Engineering 2021年第3期7卷 386-394页

作者： C.S.Chui K.S.Leung J.Qin D.Shi P.Augat r.m.y.wong S.K.H.Chow X.y.Huang C.y.Chen y.X.Lai P.S.H.yung L.Qin W.H.Cheung Department of Orthcpaedics and Traumatology Faculty of MdicineThe Chinese University of Hong KongHong Kong 999077China Genter for Transiational medicine resarch and Development herzhet Institues of Advaned TechnologyChinese Academy of ScenesShenzhen 518055China Department of Orthopedirs and Traumatology Nanjing Drum Tower Hospital The Affiliated HospitalNanjing University Medial SchoolNanjing 210008China Institute for Biomechanics Berufgenos senschaftliche Unfallklinik MurnauMurnanu am Staffelsee 82418Cermany Instinute for Biomechanic Paracelsus Medical University SazburgSatzburg 5020Austria

At present,most total knee replacement(TKr)prostheses on the market are designed according to the sizes of ***,extensive studies have indicated that human anatomies differ among different ethnicities.A number of reports have indicated that Chinese TKr patients do not match with available *** this study,computed tomography(CT)images of 52 knees of Chinese men and women were used for anthropometric *** and geometric measurements were definedand used for correlation *** parameters from the measurement results were *** geometries of knees were measured as coordinates.A deformable three-dimensional(3D)knee modelbased on anatomical coordinates correlating with the identified key parameters was generated.A pros-thesis was then designed according to the analyzed *** matching analysis,bone resectionanalysis,and cadaveric trials were conducted and compared with commercial products to validate theproposed *** femoral component designed by this study resulted in the highest accuracy(rootmean square point-to-surface(rmS PS),(1.08±0.20)mm)and lowest amount of resected bone volume(27412mm^(3))in comparison with two commercial knee *** study suggests a new approachfor population-based patient-specific femoral prosthesis design With a single,easilty acquired dimen-sion-namely,epicondyle width(ECW)-as input,a patient-specific femoral prosthesis can be designed according to the analyzed measured data and manufactured by additive manufacturing(Am)***,the reconstructed femoral condylar surface was compared with the femoral condylar surfacein the original CT scanning data The average rmS PS distance of the reconstructed femoral condylar surface among all data was(1.10±0.18)mm,which is comparable to other statistical shape modeling methods using multiple radiographs as input *** is a need to develop an anthropometric-based knee prosthesis for the Chinese *** on

关键词： Additive manufacturing Population-based design Total knee replacement Knee prosthesis Anthropometric measurement

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Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

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Neural regeneration research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On wong Department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SmN1 delivery to correct all neurological and systemic perturbations

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Neural regeneration research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown rafael J.yáñez-muñoz Heidi r.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SmA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SmA was understood in 1995 when loss or impairment of the survival motor neuron 1(SmN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SmN2,which can produce low levels(approximately 10%)of the full-length functional SmN protein,has led to the generation of SmA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SmN2 copy number is used as a proxy for the prediction of disease severity,with higher SmN2 copy number typically being associated with reduced severity of SmA,although this relationship is not absolute:some individuals with low SmN2 copy number have less severe SmA phenotypes and vice ***,the etiology of SmA is further complicated by other factors,such as non-typical nucleotide variants and SmN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Heavy metal concentrations in edible bivalves and gastropods available in major markets of the Pearl river Delta

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Journal of Environmental Sciences 2001年第2期13卷 210-217页

作者： FANG Zhan-qiang CHEUNG r.y.H. wong m.H. Department of Biology South China Normal UniversityGuangzhou 510631China Department of Biology and Chemistry City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong Institute for Natural resources and Waste management and Department of BiologyHong Kong Bapt ist UniversityKowloon TongHong Kong

molluscs are able to accumulate heavy metals and impose health hazard to consumers. The main objective of the present study is to investigate the heavy metal concentrations in edible bivalves and gastropods available in major markets of the Pearl river Delta. Fourteen species of edible molluscs were purchased from six markets in Hong Kong and Guangdong Province. The fresh of these biota were tested for their cadmium (Cd), copper (Cu), zinc (Zn), lead (Pb), nickel (Ni), chromium (Cr), antimony (Sb) and tin (Sn) concentrations (based on wet weight). The results indicated that amongst the 14 edible molluscs, only Cd, Pb, Ni, Cr, Sb and Sn concentrations in three species (ruditapes philippinarum, Perna viridis and Hemifusus tuba) were within the local regulatory limits. Over 60% of bivalve species exceeded maximum permitted levels of Cd (2 mug/g) and Cr (1 mug/g), while over 40% of gastropod species exceeded the maximum levels of Sb (1 mug/g) and Cr (1 mug/g). most of the samples collected from Hong Kong had significantly higher contents of Pb and Sb, but similar levels of Cd, Cu and Zn when compared with samples collected across the border ( p respectively). In general, the molluscs purchased in Guangdong markets had higher metal contents than those purchased from the Hong Kong markets. When compared with the Provisional Tolerable Weekly Intake or maximum Acceptable Daily Load recommended by FAO/WHO Expert Committee on Food Additives, Cd levels of five species (Anadara ferruginea, Pinna pectinata, Chlamys nobilis, Babylonia lutosa and Hemifusus terntanus) and Cr levels of seven species ( Anadara ferruginea, Paphia undulata, Pinna pectinata, Babylonia lutosa, Hemifusus terntanus, Cymbium melo and Cipangopaludina chinensis) were higher than both the human daily acceptable limits (for Cd and Cr respectively) and the local regulatory levels (for Cd and Cr respectively).

关键词： heavy metals edible molluscs human health Pearl river Delta

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QUASI-INTErPOLATING OPErATOrS AND THEIr APPLICATIONS IN HyPErSINGULAr INTEGrALS

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Journal of Computational mathematics 1998年第4期16卷 337-344页

作者： wong, rH Lu, y Dalian Univ Technol Inst Math Sci Dalian 116024 Peoples R China

The purpose of this paper is to propose and study a class of quasi-interpolating operators in multivariate spline space S-1/2(Delta(mn)(2*)) on non-uniform type-2 triangulation. Based on the operators, we construct cubature formula for two-dimensional hypersingular integrals. Some computing work have been done and the results are quite satisfactory.

关键词： hypersingular integral finite-part integral quasi-interpolating operator non-uniform type-2 triangulation

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Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie yuanhui Guo yun Chen Hao Zhang Jiawei Xiao maoxiang Hou Huilong Liu Li ma Xin Chen Chingping wong State Key Laboratory of Precision Electronic manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.r.Groh moein yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Asymptotic Properties of a modified Semi-Parametric mLE in Linear regression with right-Censored Data

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Acta mathematica Sinica,English Series 2002年第2期18卷 405-416页

作者： wong George y.C. Strang Cancer Prevention Center.428 E 72nd Street.New york.Ny 10021.USA

Consider a linear regression model y=β'X+*** y may be right censored and the cdf F+o of e is *** show that a modified semi-parametric *** by .is strongly consistent under certain regularity *** F_o is discontinuous,then P(≠βi.o.)=0, which means that P(=βif the sample size is large)=*** latter property has not been reported for the existing *** contrast,most estimators,such as the Buckley-James estimator and m-estimators .satisfy that P(≠βi.o.)=1.

关键词： Consistency Super-efficiency Semi-parametric mLE

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Synthesis of self-assembled nanorod vanadium oxide bundles by sonochemical treatment

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Journal of Natural Gas Chemistry 2009年第3期18卷 312-318页

作者： y.H.Taufiq-yap y.C.wong Z.Zainal m.Z.Hussein Centre of Excellence for Catalysis Science and Technology Faculty of ScienceUniversiti Putra Malaysia Department of Chemistry Faculty of ScienceUniversiti Putra Malaysia

Self-assembled nanorod of vanadium oxide bundles were synthesized by treating bulk V2O5 with high intensity sonochemical technique. The synthesized materials were characterized by X-ray diffraction （XrD）, scanning electron microscope （SEm）, transmission electron microscope （TEm） and temperature-programmed reduction （TPr） in H2. Catalytic behaviour of the materials over anaerobic n-butane oxidation was studied through temperature-programmed reaction （TPrn）. Catalytic evaluation of the sonochemical treated V2O5 products was also studied on microreactor. XrD patterns of all the vanadium samples were perfectly indexed to V2O5. The morphologies of the nanorod vanadium oxides as shown in SEm and TEm depended on the duration of the ultrasound irradiation. Prolonging the ultrasound irradiation duration resulted in materials with uniform, well defined shapes and surface structures and smaller size of nanorod vanadium oxide bundles. H2-TPr profiles showed that larger amount of oxygen species were removed from the nanorod V2O5 compared to the bulk. Furthermore, the nanorod vanadium oxide bundles, which were produced after 90, 120 and 180 min of sonochemical treatment, showed an additional reduction peak at lower temperature （-850 K）, suggesting the presence of some highly active oxygen species. TPrn in n-butane/He over these materials showed that the nanorod V2O5 with highly active oxygen species showed markedly higher activity than the bulk material, which was further proven by catalytic oxidation of n-butane.

关键词： nanorod vanadium oxide sonochemical treatment butane oxidation

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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural regeneration research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

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