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Effect of quality of bowel preparation on quality indicators of adenoma detection rates and colonoscopy completion rates

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Gastroenterology report 2016年第2期4卷 148-153,I0003页

作者： Tarun rai Udayakumar Navaneethan Tushar Gohel Amareshwar Podugu Prashanthi N.Thota ravi P.kiran rocio Lopez Madhusudhan r.Sanaka Digestive Disease Institute The Cleveland ClinicClevelandOHUSA

Background and aim:Adequate bowel preparation is important for safe and effective *** indicators(QI)for colonoscopy include achieving at least 95%completion rate and an adenoma detection rate(ADr)of at least 25%in average-risk men and 15%in average-risk women aged over *** aim was to investigate the impact of bowel preparation on ADr and colonoscopy completion ***:This retrospective cohort study included patients who underwent colonoscopy between January 2008 and December *** main outcome measurements were ADr and colonoscopy completion rates to the ***:A total of 2519 patients was included;1030(41.0%)had excellent preparation,1145(45.5%)good-,240(9.5%)fair-,and 104(4.1%)poor *** completion rates were significantly lower in patients with poor or fair preparation(72.1%and 75.4%,respectively)than in those with good and excellent preparation(99.7%and 99.9%,respectively;Pr than the QI of 95%(Pr in men and women combined was similar in all four grades of preparation(excellent,good,fair and poor)at 24.2%vs.26.8%vs.32.1%vs.22.1%,respectively;P¼*** the groups had ADr above the QI(25%for men and 15%for women)with evidence of significantly higher ADr in the women with excellent or good preparation and in men with excellent,good or fair *** multivariate analysis,male gender was significantly associated with increased ADr(Preparation did not influence ***:Patients with fair and poor standards of preparation have significantly lower colonoscopy completion rates than those with excellent and good ***,there was no difference in ADr between the different grades of preparation.

关键词： bowel preparation adenoma detection rate colonoscopy completion rate quality indicators

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Lactobionic Acid as a New Synergist in Combination with Phosphonate-Zn(Ⅱ)System for Corrosion Inhibition of Carbon Steel

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Journal of Materials Science & Technology 2014年第1期30卷 77-89页

作者： S.Srinivasa rao B.V.Appa rao S.roopas kiran B.Sreedhar Department of Chemistry V.R.Siddhartha Engineering College(Autonomous) Department of Chemistry National Institute of Technology Warangal(NITW) INFN Sezione di Padova Inorganic & Physical Chemistry Division Indian Institute of Chemical Technology(IICT)

Studies on lactobionic acid introduced as a synergist in the presence of phosphonobutane-1,2,4-tricarboxylic acid （PBTC） and zinc ions for corrosion control of carbon steel in aqueous environment are presented. The investigations revealed that lactobionic acid （LBA） acts as an excellent synergist in corrosion inhibition. Optimum concentrations of all the three components of the ternary formulation are established by gravimetric studies. Potentiodynamic polarization studies indicate that the new ternary system is a mixed inhibitor. Impedance studies show that a protective film is formed on the metal surface in the presence of the inhibitor formulation. The film is found to exhibit its protective nature even at higher temperatures up to 60 ~C. Analysis of the protective film by X-ray photoelectron spectroscopy （XPS） and reflection absorption Fourier transform infrared （FTIr） spectroscopy infers the presence of Zn（OH）2, oxides and hydroxides of iron and the inhibitor molecules in the surface film probably in the form of a complex, [Zn（II）-PBTC-LBA]. The morphological studies by scanning electron microscopy （SEM） and the topographical studies by atomic force microscopy （AFM） also indicate the presence of protective film on the metal surface. A plausible mechanism of corrosion inhibition is proposed.

关键词： Corrosion inhibitor Carbon steel Synergism X-ray photoelectron spectroscopy Electrochemical impedance spectroscopy

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Colorectal cancer resection rates in patients with inflammatory bowel disease:a population-based study

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Gastroenterology report 2018年第4期6卷 263-269,I0001页

作者： Udayakumar Navaneethan Xiang Zhu Dennisdhilak Lourdusamy Vennisvasanth Lourdusamy Bo Shen ravi kiran Center for Interventional Endoscopy Florida HospitalOrlandoFL 32803USA Center for Inflammatory Bowel Diseases The Cleveland ClinicClevelandOH 44195USA Division of Colorectal Surgery Columbia University Medical Center/New York Presbyterian HospitalNew YorkNY 10032USA

Background and objective:Inflammatory bowel disease(IBD)is associated with an increased risk of colorectal cancer(CrC).This study aimed to analyse the trends in rates of resection for IBD-related CrC in the ***:We used the Nationwide Inpatient Sample from 1995 to *** trends in age-adjusted rates of resection for CrC in the setting of IBD were analysed using multivariate Joinpoint regression *** primary outcome was surgical resection of CrC in the setting of ***:We included 3597168 IBD discharges in the present study,of which 275479 underwent CrC resection between 1995 and *** annual CrC resection rates among IBD population decreased significantly from 1995 to *** decrease was significant in all age groups with an annual decrease of 393(Pr 100000 IBD discharges between 1995 and 2012 for age groups 18–39,40–49,50–74 and>75 years,*** annual IBD-CrC resection rate per 100000 IBD discharges for proximal CrC decreased by 149(Prespectively,and the annual distal CrC resections per 100000 IBD discharges decreased by 104(Prespectively,for age groups 18–39,40–49,50–74 and>75 years,between 1995 and *** multivariate Poisson regression analysis,after adjustment for age and sex,CrC resections decreased by 3.9%each year from 1995 to ***:CrC resection rates among IBD patients have continued to decrease annually from 1995 to *** is a population-level decrease in resection of both proximal and distal CrC reflecting a decreasing incidence of IBD-related CrC incidence in the USA.

关键词： Colorectal cancer inflammatory bowel disease Crohn’s disease ulcerative colitis surgery

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Biological evaluation of some important medicinal plants from Poonch valley, Azad Kashmir, Pakistan

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Journal of Traditional Chinese Medicine 2019年第6期39卷 753-763页

作者： Farmeen kiran Muhammad Azam Khan riffat Batool Sobia Kanwal Syed Lal Shah Tariq Mahmood Department of Plant Sciences Quaid-i-Azam University IslamabadIslamabad 45320Pakistan Department of Botany Government Boys Degree College HajiraHajira 12160Pakistan Department of Zoology University of Gujrat Sub-Campus RawalpindiRawalpindi 46000Pakistan Pakistan Museum of National History Pakistan Science FoundationIslamabadIslamabad 44000Pakistan

OBJECTIVE:To estimate the phytochemical composition,antioxidant,antifungal,cytotoxic and phytotoxic activities of three important medicinal plants of Poonch valley,Azad Kashmir ***:Phytochemicals were investigated for both qualitative(phenols,flavonoids,alkaloids and saponins)and quantitative(total phenolic and flavonoid contents)analysis of plant extracts prepared in ethanol,ethyl acetate and ***,antioxidant potential was investigated by screening botanical extracts against 2,2-diphenyl-1-picrylhydrazyl scavenging assay,phosphomolybdenum and total reducing power ***,disc diffusion method was used for determination of antifungal potential of all extracts against four pathogenic ***,brine shrimp cytotoxicity assay was conducted for cytotoxic potential and radish seed germination assay was carried out for estimation of allelopathic potential of plant ***:Phytochemical evaluation showed the presence of phenolics,flavonoids,alkaloids and saponins in almost all *** addition to significant antioxidant potential,rubia cordifolia(ethanolic extract)revealed highest amount of phenolics and *** said plant also exhibited good cytotoxic *** plant extracts highest antifungal activity and allelopathic potential was recorded by Oxalis latifolia(ethyl acetate extract).Ethanol and ethyl acetate were observed to be the best choice of *** best solvents-based results were obtained by Ethanol followed by Ethyl acetate and ***:For further studies,rubia cordifolia and Oxalis latifolia are the most promising medicinal plants of Poonch valley,Azad Kashmir Pakistan at molecular level in order to isolate the compounds concerning with pronounced activities.

关键词： Melinis repens Oxalidaceae rubia Cytotoxins Pakistan

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Feeder-free differentiation of human iPSCs into natural killer cells with cytotoxic potential against malignant brain rhabdoid tumor cells

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Bioactive Materials 2024年第6期36卷 301-316页

作者： Sonia kiran Yu Xue Drishty B.Sarker Yan Li Qing-Xiang Amy Sang Department of Chemistry and Biochemistry Florida State UniversityTallahasseeFL 32306-4390USA Department of Chemical and Biomedical Engineering FAMU-FSU College of EngineeringFlorida State UniversityTallahasseeFL32310-6046USA Institute of Molecular Biophysics Florida State UniversityTallahasseeFL32306-4380USA

Natural killer(NK)cells are cytotoxic immune cells that can eliminate target cells without prior *** induced pluripotent stem cells(iPSCs)provide a robust source of NK cells for safe and effective cell-based immunotherapy against aggressive *** this in vitro study,a feeder-free iPSC differentiation was performed to obtain iPSC-NK cells,and distinct maturational stages of iPSC-NK were *** cells of CD56^(bright)CD16^(bright)phenotype showed upregulation of CD56,CD16,and NK cell activation markers NKG2D and NKp46 upon IL-15 exposure,while exposure to aggressive atypical teratoid/rhabdoid tumor(ATrT)cell lines enhanced NKG2D and NKp46 *** cell exposure also increased CD107a degranulation markers and stimulated IFN-γsecretion in activated NK ***56^(bright)CD16^(bright)iPSC-NK cells showed a ratio-dependent killing of ATrT cells,and the percentage lysis of CHLA-05-ATrT was higher than that of *** iPSC-NK cells were also cytotoxic against other brain,kidney,and lung cancer cell *** NK maturation yielded CD56^(-ve) CD16^(bright)cells,which lacked activation markers even after exposure to interleukins or ATrT cells-indicating diminished *** and characterization of different NK phenotypes from iPSCs,coupled with their promising anti-tumor activity against ATrT in vitro,offer valuable insights into potential immunotherapeutic strategies for brain tumors.

关键词： Human induced pluripotent stem cells Natural killer cells Atypical teratoid rhabdoid tumor Cytotoxicity Cytokine activation

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Expansion of human umbilical cord derived mesenchymal stem cells in regenerative medicine

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World Journal of Stem Cells 2024年第4期16卷 410-433页

作者： Shafiqa Naeem rajput Bushra kiran Naeem Anwar Ali Asmat Salim Irfan Khan Dr.Panjwani Center for Molecular Medicine and Drug research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270SindhPakistan Surgical Unit 4 Dr.Ruth KM Pfau Civil HospitalKarachi 74400Pakistan Department of Physiology University of KarachiKarachi 75270Pakistan Center for regenerative Medicine and Stem Cells research and Department of Ophthalmology and Visual SciencesThe Aga Khan UniversityKarachi 74800SindhPakistan

BACKGrOUND Stem cells are undifferentiated cells that possess the potential for self-renewal with the capacity to differentiate into multiple *** humans,their limited numbers pose a challenge in fulfilling the necessary demands for the regeneration and repair of damaged tissues or *** suggested that mesenchymal stem cells(MSCs),necessary for repair and regeneration via transplantation,require doses ranging from 10 to 400 million ***,the limited expansion of MSCs restricts their therapeutic *** To optimize a novel protocol to achieve qualitative and quantitative expansion of MSCs to reach the targeted number of cells for cellular transplantation and minimize the limitations in stem cell therapy *** Human umbilical cord(hUC)tissue derived MSCs were obtained and *** cultured cells were subjected to the following evaluation pro-cedures:Immunophenotyping,immunocytochemical staining,trilineage differentiation,population doubling time and number,gene expression markers for proliferation,cell cycle progression,senescence-associatedβ-galactosidase assay,human telomerase reverse transcriptase(hTErT)expression,mycoplasma,cytomegalovirus and endotoxin *** Analysis of pluripotent gene markers Oct4,Sox2,and Nanog in recultured hUC-MSC revealed no significant *** immunophenotypic markers CD90,CD73,CD105,CD44,vimentin,CD29,Stro-1,and Lin28 were positively expressed by these recultured expanded MSCs,and were found negative for CD34,CD11b,CD19,CD45,and *** recultured hUC-MSC population continued to expand through passage *** gene expression of Pax6,BMP2,and TGFb1 showed no significant variation between recultured hUC-MSC ***,a significant increase(Prved in recultured *** senescence markers(hTErT expression andβ-galactosidase activity)did not show any negative effect on recultured hUC-

关键词： Human umbilical cord Mesenchymal stem cells Expansion Cell proliferation In vitro expansion Senescence

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Synthesis and anti-inflammatory activity of 2-substituted-((N,N-disubstituted)-1,3-benzoxazole)-5-carboxamides

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药学学报 2010年第6期45卷 730-734页

作者： reena M kiran G rajyalakshmi G Venkateshwa rao J Sarangapani M Department of Pharmaceutical Chemistry Talla Padmavati College of Pharmacy Department of Pharmaceutical Chemistry College of Pharmaceutical SciencesKakatiya University

A series of 2-substituted-((N,N-disubstituted)-1,3-benzoxazole)-5-carboxamides derivatives were synthesized by the reaction of 2-substituted-5-carbomethoxy benzoxazole with different secondary *** newly synthesized compounds were characterized on the basis of spectral(FT-Ir,1H NMr,MS) & elemental *** these compounds were screened for anti-inflammatory activity using carrageenan induced rat paw edema *** of these compounds exhibited significant *** the tested compounds Ve,Vg,Vf and Va were considered to have potent anti-inflammatory activity and was comparable with standard.

关键词： benzoxazole anti-inflammatory activity carrageenan

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Transmitter-receiver Path Selection for Cell range Extension Using Multi-Hop D2D

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Computers, Materials & Continua 2021年第8期68卷 2075-2093页

作者： Farah Akif kiran Sultan Aqdas N.Malik Ijaz M.Qureshi Saba Mahmood Department of Electrical Engineering International Islamic UniversityIslamabad44000Pakistan Department of CIT FASKing Abdulaziz UniversityJeddah21551Saudi Arabia Department of Electrical Engineering Air UniversityIslamabad44000Pakistan Department of Computer Science Bahria UniversityIslamabad44000Pakistan

Conventional approach of dealing with more users per coverage area in cellular networks implies densifying the amount of(Access Point)AP which will eventually result in a larger carbon *** this paper,we propose a base station off-loading and cell range extension(CrE)scheme based on multi-hop device-to-device(MHD2D)path selection between transmitter and receiver *** paper also provides derivations of upper and lower bounds for energy efficiency,capacity,and transmit *** proposed path selection scheme is inspired by the foraging behavior of honey *** present the algorithm as a modified variant of the artificial bee colony algorithm(MVABC).The proposed optimization problem is modeled as a minimization problem where we optimize the Energy Efficiency(EE).The proposed path selection MVABC is compared with the Genetic Algorithm(GA)and also with classical artificial bee colony(ABC)through simulations and statistical *** student’s t-test,p-value,and standard error of means(SEM)clearly show that MVABC based path selection out-performs the GA and classical ABC *** based approach is 66%more efficient when compared with classic ABC and about 62%efficient when compared with GA based scheme.

关键词： Multi-hop ultra-dense D2D path-selection ABC GA

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The capture of carbon dioxide by transition metal aluminates, calcium aluminate, calcium zirconate, calcium silicate and lithium zirconate

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Frontiers of Chemical Science and Engineering 2011年第4期5卷 477-491页

作者： Ganesh TILEKAr.kiran SHINDE Kishor KALE reshma rASKAr Abaji GAIKWAD Chemical Engineering and Process Development Division National Chemical LaboratoryPune 411008India

The capture of CO_(2) by transition metal(Mn,Ni,Co and Zn)aluminates,calcium aluminate,calcium zirconate,calcium silicate and lithium zirconate was carried out at pre-and post-combustion *** prepared metal adsorbents were characterized by X-ray diffraction(XrD),scanning electron microscope(SEM),surface area analysis and acidity/alkalinity *** different experimental variables affecting the adsorbents ability to capture CO_(2),such as the mol ratio of metal ions,the pressure of CO_(2),the exposure time and the temperature of the adsorbent were also *** zirconate captured 13.85 wt-%CO_(2) at 650℃ and 2.5 atm and calcium silicate captured 14.31 wt-%at 650℃.Molecular sieves(13X)and carbon can only capture a negligible amount of CO_(2) at high temperatures(300℃–650℃).However,the mixed metal oxides captured reasonable amount of CO_(2) at these higher *** addition,calcium aluminate,calcium zirconate,calcium silicate and lithium zirconate adsorbents captured CO_(2) at both pre and post-combustion *** trend for the amount of captured carbon dioxide over the adsorbents was calcium aluminaterconater-conate

关键词： captured CO_(2) pre-combustion temperature characterization calcium silicate calcium zirconate

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Development and Validation of UV Spectrophotometric Method to Study Stress Degradation Behaviour of rizatriptan Benzoate

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光谱学与光谱分析 2015年第1期35卷 137-140页

作者： Kempwade Amolkumar Taranalli Ashok Jadhav kiran KLE University's College of Phyarmacy Nehrunagar Belgaum 590010 India

rizatriptan benzoate is a 5HT 1B/1Dreceptor agonist which is prescribed for the treatment of *** the present study new,simple,specific ultraviolet spectrophotometric method for rizatriptan benzoate was developed and *** degradation studies were carried out in acidic,alkaline and neutral pH *** absorbance maxima peak was found to be 224 nm and linearity was observed in the concentration range of 0.5~2.5μg·mL-1 with regression coefficient value of 0.998 *** method was validated and found to be *** percent recovery for rizatriptan benzoate was found to be 98.576±*** bulk drug was found to be stable in neutral and acidic pH conditions but got degraded in 1N NaOH solution.

关键词： rizatriptan benzoate UV spectroscopy Stress degradation Validation

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