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Molecular Diagnosis of Sexual Differentiation Disorders in Burkina Faso

Journal of Biosciences and Medicines 2024年第3期12卷 1-15页

作者： Bazie Bapio Valérie Elvira Jean Télesphore Sawadogo Soumaïla Zohoncon théodora Mahoukèdè Tall Ahmadou Bado Prosper Soubeiga Serge théophile Ouattara Moussa Sorgho Abel Kiendrebeogo Touwendpoulimdé Isabelle Yonli Albert theophane Djigma Florencia Millogo/Traore Timongo Françoise Danielle Simpore Jacques centre National de la recherche Scientifique et Technologique (cNrST) Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso Université Joseph KI-ZErBO Unité de Formation en Sciences de la Vie et de la Terre Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE) Ouagadougou Burkina Faso centre de recherche Biomoléculaire Pietro Annigonie (cErBA) Ouagadougou Burkina Faso centre Hospitalier Universitaire régional de Ouahigouya Ouagadougou Burkina Faso centre Hospitalier Universitaire Yalgado Ouedraogo Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

Sex development anomalies represent a group of congenital pathologies in which chromosomal, gonadal and anatomical sex differentiation is atypical. the aim of our study was to use molecular biology techniques to elucidate sex in cases of anomalies of sexual differentiation in Burkina Faso. this cross-sectional study took place from March 2023 to June 2023. Oral and blood samples were collected respectively using sterile swabs and stored on Swab Kits and NUcLEIcardTM (https://***/product-ranges/nucleic-card/) were used to determine gonosome profiles. Extraction was carried out using the DNA Swap solution Kit and the DNA IQ System Kit, and a PowerPlex? 21 kit (Promega) for amplification. the Applied Biosystems 9700 thermal cycler was used for Pcr followed by 36 cm capillary electrophoresis in the Applied Biosystems 3130 prism sequencer. Sequence files were analyzed using GeneMapper IDX v. 3.2 software. Seven (07) patients were registered during the study period. there were 4 cases of XX DSD or 46, XX DSD and 3 cases of XY DSD or 46, XY DSD. the median age of our patients was 16 years. civilian sex was male in 4 cases and female in 3. the most frequent reason for consultation was micropenis in 3 cases, followed by primary amenorrhea and sex ambiguity. there were 03 cases of discrepancy between genetic sex and civil sex. the accessibility of molecular diagnosis is little known to clinicians. XX DSDs or 46, XX DSDs were the most frequent (4/7) in our study. the problem facing this situation is early diagnosis to help prevent complications in Burkina Faso.

关键词： Gonosome DSD Abnormal Sexual Development Burkina Faso

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Dynamic Event-Triggered consensus control for Input constrained Multi-Agent Systems With a Designable Minimum Inter-Event Time

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IEEE/cAA Journal of Automatica Sinica 2024年第3期11卷 649-660页

作者： Meilin Li Yue Long Tieshan Li Hongjing Liang c.L.Philip chen the School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731China IEEE the Yangtze Delta region Institute University of Electronic Science and Technology of ChinaHuzhou 313000 the Laboratory of Electromagnetic Space cognition and Intelligent control Beijing 100089China the School of computer Science and Engineering South China University of TechnologyGuangzhou 510006

this paper investigates the consensus control of multi-agent systems(MASs) with constrained input using the dynamic event-triggered mechanism(ETM).consider the MASs with small-scale networks where a centralized dynamic ETM with global information of the MASs is first ***,a distributed dynamic ETM which only uses local information is developed for the MASs with large-scale *** is shown that the semi-global consensus of the MASs can be achieved by the designed bounded control protocol where the Zeno phenomenon is eliminated by a designable minimum inter-event *** addition,it is easier to find a trade-off between the convergence rate and the minimum inter-event time by an adjustable ***,the results are extended to regional consensus of the MASs with the bounded control *** simulations show the effectiveness of the proposed approach.

关键词： constrained input designable minimum inter-event time directed communication topology dynamic event-triggered mechanism MASs consensus control

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the preface: Interplay of topological and magnetic orders in the Mn-Bi-Te family

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National Science review 2024年第2期11卷 6-7页

作者： Fu-chun Zhang Hai-Zhou Lu X.c.Xie Kavli Institute for theoretical Sciences University of Chinese Academy of Sciences Department of Physics Southern University of Science and Technology (SUSTech) International center for Quantum Materials School of Physics Peking University

the discovery and synthesis of MnBi2Te4in 2013 initially garnered little attention [1]. Yet, the revelation of its topological properties in 2019 [2–6] sparked a surge of research into the MnBiTe family. these extensive studies are primarily driven by two objectives:the realization of a high-temperature quantum anomalous Hall effect （QAHE） and the exploration of exotic phases born from the interplay of topological and magnetic orders,

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Prescribed-Time Nash Equilibrium Seeking for Pursuit-Evasion Game

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IEEE/cAA Journal of Automatica Sinica 2024年第6期11卷 1518-1520页

作者： Lei Xue Jianfeng Ye Yongbao Wu Jian Liu D.c.Wunsch Key Laboratory of Measurement and control of complex Systems of Engineering Ministry of EducationNanjing 210096 School of Automation Southeast UniversityNanjing 210096China Department of Electrical and computer Engineering Missouri University of Science and TechnologyRollaMO 65409 USA IEEE

Dear Editor,this letter is concerned with prescribed-time Nash equilibrium(PTNE)seeking problem in a pursuit-evasion game(PEG)involving agents with second-order *** order to achieve the prior-given and user-defined convergence time for the PEG,a PTNE seeking algorithm has been developed to facilitate collaboration among multiple pursuers for capturing the evader without the need for any global ***,it is theoretically proved that the prescribedtime convergence of the designed algorithm for achieving Nash equilibrium of ***,the effectiveness of the PTNE method was validated by numerical simulation results.A PEG consists of two groups of agents:evaders and *** pursuers aim to capture the evaders through cooperative efforts,while the evaders strive to evade *** is a classic noncooperative *** has attracted plenty of attention due to its wide application scenarios,such as smart grids[1],formation control[2],[3],and spacecraft rendezvous[4].It is noteworthy that most previous research on seeking the Nash equilibrium of the game,where no agent has an incentive to change its actions,has focused on asymptotic and exponential convergence[5]-[7].

关键词： seeking prescribed convergence

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Flexible neural probes:a review of the current advantages,drawbacks,and future demands

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 153-167页

作者： Sara PIMENTA Joao r.FrEITAS JoséH.cOrrEIA cMEMS-UMinho University of MinhoGuimarães4800-058Portugal LABBELS-Associate Laboratory Braga/GuimarãesPortugal

Brain diseases affect millions of people and have a huge social and economic *** use of neural probes for studies in animals has been the main approach to increasing knowledge about neural network ***,neuroscientists are trying to develop new and more effective therapeutic approaches to treating neurological *** implementation of neural probes with multifunctionalities(electrical,optical,and fluidic interactions)has been increasing in the last few years,leading to the creation of devices with high temporal and spatial *** the applicability of,and elements integrated into,neural probes has also led to the necessity to create flexible interfaces,reducing neural tissue damage during probe implantation and increasing the quality of neural acquisition *** this paper,we review the fabrication,characterization,and validation of several types of flexible neural probes,exploring the main advantages and drawbacks of these ***,future developments and applications are ***,this review aims to present the currently available flexible devices and future appropriate avenues for development as possible guidance for future engineered devices.

关键词： Brain knowledge Flexible interface Multifunctional probe

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results of the Second Life Metabolism Travel Awards 2024

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Life Metabolism 2024年第3期3卷 1-2页

作者： John r.Speakman Shenzhen Key Laboratory of Metabolic Health Center for Energy Metabolism and ReproductionShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Institute of Biological and Environmental Sciences University of AberdeenAberdeenAB242TZScotlandUnited Kingdom

this year is the second year of the Life Metabolism Travel Prize Awards for PhD students and *** three 700 US$awards are generously sponsored by Sable Systems-Promethion(china)who manufacture metabolic *** I announce the winners and their interesting projects,I will just reiterate how the judging of the awards *** first remove anything from the submission that would identify the sex,affiliation,or ethnicity of the applicant.

关键词： remove Travel Awards

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Single atom cu-N-c catalysts for the electro-reduction of cO_(2) to cO assessed by rotating ring-disc electrode

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Journal of Energy chemistry 2024年第1期88卷 169-182,I0004页

作者： S.Pérez-rodríguez M.Gutiérrez-roa c.Giménez-rubio D.ríos-ruiz P.Arévalo-cid M.V.Martínez-Huerta A.Zitolo M.J.Lázaro D.Sebastián Instituto de carboquímica(cSIc) Miguel Luesma Castán 450018 ZaragozaSpain Instituto de catálisis y Petroleoquímica(cSIc) Marie Curie 228049 MadridSpain Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190France

the electrochemical cO_(2) reduction reaction(cO_(2)rr) to controllable chemicals is considered as a promising pathway to store intermittent renewable energy. Herein, a set of catalysts based on copper-nitrogendoped carbon xerogel(cu-N-c) are successfully developed varying the copper amount and the nature of the copper precursor, for the efficient cO_(2)rr. the electrocatalytic performance of cu-N-c materials is assessed by a rotating ring-disc electrode(rrDE), technique still rarely explored for cO_(2)rr. For comparison, products are also characterized by online gas chromatography in a H-cell. the as-synthesized cu-Nc catalysts are found to be active and highly cO selective at low overpotentials(from -0.6 to -0.8 V ***) in 0.1 M KHcO_(3), while H_(2) from the competitive water reduction appears at larger overpotentials(-0.9 V vs. rHE). the optimum copper acetate-derived catalyst containing cu-N_(4) moieties exhibits a cO_(2)-to-cO turnover frequency of 997 h^(-1) at -0.9 V vs. rHE with a H_(2)/cO ratio of 1.8. these results demonstrate that rrDE configuration can be used as a feasible approach for identifying electrolysis products from cO_(2)rr.

关键词： cu-N-c carbon xerogel rotating ring disc electrode carbon dioxide reduction reaction carbon monoxide

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Excellent photoluminescence and electrochemical properties of Sm^(3+) doped ca_(2)MgSi_(2)O_(7) nanophosphor:Display and electrochemical sensor applications

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Journal of rare Earths 2024年第6期42卷 1046-1055,I0002页

作者： r.B.Basavaraj K.Sureshkumar D.P.Aarti M.B.Madhusudana reddy G.Nagaraju T.ramakrishnappa G.r.Navyashree K.r.Venkatesha Babu K.S.Hemalatha Department of Physics BMS Institute of Technology and ManagementBangalore560064India Department of chemistry BMS Institute of Technology and ManagementBangalore560064India Department of chemistry School of Applied SciencesREVA UniversityBangalore560064India Energy Materials researchLaboratory Department of ChemistrySiddaganga Institute of TechnologyTumakuru57203KarnatakaIndia School of Physical Sciences REVA UniversityBangalore560057Indi Department of Physics Govt.Science CollegeBengaluru560001India Department of Physics Maharani Science College for WomenMaharani Cluster UniversityBengaluru560001India

A series of orange-red light emitting ca_(2)MgSi_(2)O_(7):Sm^(3+)nanopowders were fabricated via low-cost ecofriendly green combustion technique using Aloe vera gel as *** phase purity of the samples were confirmed by the powder X-ray diffraction(PXrD)*** single-phase tetragonal structure is observed from the PXrD results with no additional impurity *** band gap energy of the fabricated powders was estimated by diffuse reflectance spectra(DrS)and is found to be in the range of 4.01-5.98 eV.A high resolution scanning electron microscope(SEM)was used to study the morphological behaviour of the ***-like structures are observed from the SEM *** particle size was evaluated by transmission electron microscopy(TEM)and is found to be~50 *** interplanar distance is found to be 0.53 *** properties were systematically studied in *** phosphors are successfully excited at 403 nm NUV light,producing reddish-orange characteristic *** emission peaks are centered at 558(^(4)G_(5/2)→^(6)H_(5/2)),607(^(4)G_(5/2)→^(6)H_(7/2))and 645 nm(^(4)G_(5/2)→^(6)H_(9/2)),*** the observed peaks the red emanation(^(4)G_(5/2)→^(6)H_(7/2))is stronger than the orange emission(^(4)G_(5/2)→^(6)H_(5/2))in the current *** photoluminescent concentration quenching is noticed above 5 mol%Sm^(3+)ion doping *** dipole-dipole interaction resulting in cross relaxation is found to be the principal cause of concentration quenching *** color features such as commission Internationale de I’Eclairage(cIE)and correlated color temperature(ccT)were studied in *** optimized chromaticity coordinates were estimated to be(0.6363,0.3632),which fall in the reddish-orange *** average ccT value obtained is 3362 *** average color purity is found to be~82%.Sm^(3+)incorporated ca_(2)MgSi_(2)O_(7) samples are possible contender for single white light generation commercial candidates owing to

关键词： Green combustion Photoluminescence Orange-red emission color purity Sensors rare earths

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Vitamin B-reath easier:vitamin B6 derivatives reduce IL-33 to limit lung inflammation

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cellular & Molecular Immunology 2023年第12期20卷 1527-1529页

作者： Hēth r.Turnquist thomas E.Starzl Transplantation Institute University of Pittsburgh School of MedicineDepartment of Immunologyand Department of SurgeryUniversity of Pittsburgh School of MedicinePittsburghPAUSA McGowan Institute for regenerative Medicine University of PittsburghPittsburghPAUSA

It has been known for some time that low PLP blood levels are common in asthmatic patients,and supplementation with vitamin B6 may reduce the severity of asthma symptoms[12].In the current study,a comparison of PLP levels in the plasma of asthmatic patients(n=52)and healthy controls(n=58)confirmed lower PLP concentrations in asthmatic patients,which correlated with reduced lung function and increased circulating eosinophils,suggestive of increased type 2 *** several mouse models of acute lung inflammation,they confirmed that systemic or local administration of PLP reduced lung inflammation and eosinophil density,suggesting that PLP concentration may be directly controlling immune responses that lead to the development of allergic airway ***2s constitutively express ST2,and IL-33 profoundly promotes ILc2 expansion and secretion of IL-5 and IL-13 to mediate allergic reactions and support host defenses against parasitic *** reduces the number of type 2 innate lymphoid cells(ILc2s)and their expression of IL-5 and ***,diet-induced vitamin B6 deficiency in mice increased papain-induced lung inflammation,including increasing the proportion of IL5+and IL-13+*** authors revealed that PLP treatment decreased IL-33 levels in the bronchoalveolar lavage fluid(BALF)and lung and targeting IL-33 with an antibody during papain-induced lung inflammation did not reduce inflammation beyond that of PLP treatment *** important clue to the regulation of IL-33 was that PLP treatment did not modify IL-33 mrNA ***,pyridoxal(PL)treatment of a human alveolar basal epithelial cell line(A549)stably expressing full-length IL-33 with a hemagglutinin(HA)tag established that PL exposure potently decreased intracellular IL-33 protein *** researchers used this cell line to explore the underlying mechanisms and verified that PL conversion to PLP by pyridoxal kinase(PDXK)controlled the stability of *** with these data,th

关键词： vitamin inflammation inhibited

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A collocation Technique via Pell-Lucas Polynomials to Solve Fractional Differential EquationModel for HIV/AIDS with Treatment compartment

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computer Modeling in Engineering & Sciences 2024年第10期141卷 281-310页

作者： Gamze Yıldırım Suayip Yüzbası Department of Mathematics Faculty of ScienceAkdeniz UniversityAntalya07058Turkey Department of Mathematics Faculty of Basic ScienceGebze Technical UniversityKocaeli41400Turkey Department of Mathematics Faculty of ScienceBartın UniversityBartın74100Turkey

In this study,a numerical method based on the Pell-Lucas polynomials(PLPs)is developed to solve the fractional order HIV/AIDS epidemic model with a treatment *** HIV/AIDS mathematical model with a treatment compartment is divided into five classes,namely,susceptible patients(S),HIV-positive individuals(I),individuals with full-blown AIDS but not receiving ArV treatment(A),individuals being treated(T),and individuals who have changed their sexual habits sufficiently(r).According to the method,by utilizing the PLPs and the collocation points,we convert the fractional order HIV/AIDS epidemic model with a treatment compartment into a nonlinear system of the algebraic ***,the error analysis is presented for the Pell-Lucas approximation *** aim of this study is to observe the behavior of five populations after 200 days when drug treatment is applied to HIV-infectious and full-blown AIDS *** demonstrate the usefulness of this method,the applications are made on the numerical example with the help of *** addition,four cases of the fractional order derivative(p=1,p=0.95,p=0.9,p=0.85)are examined in the range[0,200].Owing to applications,we figured out that the outcomes have quite decent ***,we understand that the errors decrease when the value of N *** figures in this study are created in *** outcomes indicate that the presented method is reasonably sufficient and correct.

关键词： collocation method fractional differential equations HIV/AIDS epidemic model Pell-Lucas polynomials

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