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case reports in clinical Medicine 2024年第7期13卷 227-233页

作者： Arja Alemu Nathan ross Department of Obstetrics and Gynecology AGC Tenwek Hospital Bomet Kenya Department of Obstetrics and Gynecology Soddo Christian Hospital Soddo Ethiopia

Background: Vaginal discharge syndrome is a common condition across the world with the main causes being infectious. rare causes include obstructed hemivagina with ipsilateral renal agenesis (OHVIrA syndrome). case Presentation: This case involves an 18-year-old woman with a 9-year history of vaginal discharge treated unsuccessfully by multiple physicians and different health facilities. After she presented to our hospital gynecology clinic with the same complaint she investigated with blood, urine, discharge wet-mount, pelvic ultrasound, and abdominopelvic computed tomography at different times. Preoperatively she was suspected to have OHVIrA syndrome which was successfully surgically treated with a full return of function. conclusion: This case emphasizes the need to consider non-infectious causes commonly congenital mullerian anomaly in young women presented with long-time vaginal discharge symptoms soon after menarche and which are nonresponding to different multiple medical treatments. In peripheral health institutions like ours, it is best to consider computed tomography if available but better not to forget at least abdominopelvic ultrasound to look for congenital Mullerian anomalies.

关键词： OHVIrA Syndrome Vaginal Discharge Syndrome Early Marriage

Symptom presentation and evolution in the first 48 hours after injury are associated with return to play after concussion in elite rugby Union

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Journal of Sport and Health Science 2024年第3期13卷 387-397页

作者： ross Tucker Matt cross Keith Stokes Lindsay Starling rosy Hyman Simon Kemp Stephen West Martin raftery Eanna Falvey James Brown Institute of Sport and Exercise Medicine(ISEM) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World rugby Ltd. Dublin D02 AE93Ireland Premiership rugby London SW1V 1PXUK centre for Health and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK collaborating centre on Injury and Illness Prevention in Sport(UKccIIS) University of BathClaverton Down BA27AYUK rugby Football Union London TW27BAUK London School of Tropical Medicine London WC1E 7HTUK Sport Injury Prevention research centre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Department of Medicine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland carnegie Applied rugby research(cArr)centre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background:return to play(rTP)in elite rugby is managed using a 6-stage graduated rTP protocol,which can result in clearance to play within 1 week of *** aimed to explore how symptom,cognitive,and balance presentation and evolution during concussion screens 2 h(head injury assessment(HIA2)and 48 h(HIA3)after injury were associated with time to rTP)to identify whether a more conservative graduated rTP may be ***:A retrospective cohort study was conducted in 380 concussed rugby players from elite men’s rugby over 3 consecutive *** were classified as shorter or longer returns,depending on whether rTP occurred within 7 days(allowing them to be considered to play the match 1 week after injury)or longer than 8 days,***,cognitive,and balance performance during screens was assessed relative to baseline(normal or abnormal)and to the preceding screen(improving or worsening).Associations between sub-test abnormalities and rTP time were explored using odds ratios(Or,longer ***).Median day absence was compared between players with abnormal or worsening results and those whose results were normal or ***:Abnormal symptom results during screens 2 h and 48 h after concussion were associated with longer return time(HIA2:Or=2.21,95%confidence interval(95%cI):1.39-3.50;HIA3:Or=3.30,95%cI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and 48 h post-injury was associated with longer return(HIA2:Or=2.49,95%cI:1.36-4.58;HIA3:Or=3.34,95%cI:1.10-10.15).Median days absence was greater in players with abnormal symptom results at both HIA2 and *** and balance performance were not associated with longer return and did not affect median days ***:Symptom presentation and evolution within 48 h of concussion were associated with longer rTP *** may guide a more conservative approach to rTP,while still adhering to individualized concussion management principles.

关键词： Brain injury concussion management General return to play Medical management

Bifidobacterium longum subsp. infantis ccFM1269 promotes intestinal barrier and release of IFN-β through TLr4-TrIF dependent way in growing mice

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Food Science and Human Wellness 2024年

作者： Mengfan Ding Bo Yang Bowen Li Haiqin chen renqiang Yu r.Paul ross catherine Stanton Shilong Jiang Jianxin Zhao Wei chen State Key Laboratory of Food Science and resources， Jiangnan University Teagasc Food research centre Nutrition and Metabolism research Division， Innovation center， Heilongjiang Feihe Dairy co.， Ltd. Department of Neonatology， Wuxi Maternity and child Health care Hospital， Affiliated Women's Hospital of Jiangnan University National Engineering research center for Functional Food， Jiangnan University School of Food Science and Technology， Jiangnan University PKUHSc-china Feihe Joint research Institute of Nutrition and Healthy Lifespan Development International Joint research center for Probiotics & Gut Health， Jiangnan University APc Microbiome Ireland， University college cork

Bifidobacterium longum subsp. infantis is a commensal bacterium that predominates in the infant gut， playing a critical role in both preventing foreign infections and facilitating immune development. This study aimed to explore the effects of B. longum subsp. infantis supplementation on interferon-beta (IFN-β) secretion and intestinal barrier improvement in growing mice. Female and male mice were orally administered either saline or B. longum subsp. infantis ccFM1269 or I5TI (1 × 109cFU/mice per day， n = 8) from 1-week-age until 3-， 4-， and 5-week-age. rNA sequencing analysis revealed that ccFM1269 exhibited potential antiviral capacity through increasing 2’-5’ oligoadenylate synthetase (OAS). Additionally， ccFM1269 supplementation significantly increased colonic IFN-β levels which combined with OAS in 3-week-old female and male mice by activating the TLr4-TrIF-dependent signaling pathway. However， this effect was not observed in 4- and 5-week-old mice. Furthermore， both ccFM1269 were found to modulate the gut microbiota composition and enhance the intestinal barrier function in 3-， 4-， and 5-week-old mice. In summary， the results of this study suggested that B. longum subsp. infantis ccFM1269 promoting intestinal barrier and releasing IFN-β in growing mice was in a strain-specific and time-dependent manner.

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Bifidobacterium breve ccFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption

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Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan Ding Xiaoming Liu Haiqin chen Jianxin Zhao r.Paul ross catherine Stanton Shilong Jiang Wei chen Bo Yang Nutrition and Metabolism research Division， Innovation center， Heilongjiang Feihe Dairy co.， Ltd. National Engineering research center for Functional Food， Jiangnan University State Key Laboratory of Food Science and Technology， Jiangnan University PKUHSc-china Feihe Joint research Institute of Nutrition and Healthy Lifespan Development APc Microbiome Ireland， University college cork School of Food Science and Technology， Jiangnan University International Joint research center for Probiotics & Gut Health， Jiangnan University Teagasc Food research centre

This study endeavors to investigate the effects of Bifidobacterium breve ccFM1078 on bone formation and resorption balance in growing BALB/c mice. Newborn BALB/c mice were assigned to the control group (administration saline) and the ccFM1078 group (administration B. breve ccFM1078， 3 × 109cFU/day) in 3-， 4-， and 5-week tests. All the groups have male and female distinctions. Our findings demonstrate that B. breve ccFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and proteins expression related to the GH/IGF-1 axis and Gs/PKA/crEB signaling pathways， as well as downstream osteogenic and osteoclastic differentiation factors. The effects of B. breve ccFM1078 were different with age and gender dependent. This finding suggests B. breve ccFM1078 may have potential applications in regulating bone metabolism in the growth period population.

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Prediction and control of cholera outbreak:Study case of

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Infectious Disease Modelling 2024年第3期9卷 892-925页

作者： c.Hameni Nkwayep r.GlèlèKakaï S.Bowong Laboratory of Mathematics Department of Mathematics and Computer ScienceUniversity of DoualaPO Box 24157DoualaCameroon IrD Sorbonne UniversityUMMISCOF-93143BondyFrance Biomathematics and Forest Modeling University of Abomey-CalaviCalaviBenin

This paper deals with the problem of the prediction and control of cholera outbreak using real data of *** first develop and analyze a deterministic model with seasonality for the cholera,the novelty of which lies in the incorporation of undetected *** present the basic properties of the model and compute two explicit threshold parametersr_(0)and r_(0).that bound the effective reproduction number,from below and above,that is r_(0)≤r_(0)≤r_(0).We prove that cholera tends to disappear whenr_(0)≤1,while when r_(0)>1,cholera persists uniformly within the ***,assuming that the cholera transmission rates and the proportions of newly symptomatic are unknown,we develop the EnKf approach to estimate unmeasurable state variables and these unknown parameters using real data of cholera from 2014 to 2022 in *** use this result to estimate the upper and lower bound of the effective reproduction number and reconstructed active asymptomatic and symptomatic cholera cases in cameroon,and give a short-term forecasts of cholera in cameroon until *** simulations show that(i)the transmission rate from free Vibrio cholerae in the environment is more important than the human transmission and begin to be high few week after May and in October,(ii)90%of newly cholera infected cases that present the symptoms of cholera are not diagnosed and(iii)60.36%of asymptomatic are detected at 14%and 86%of them recover *** future trends reveals that an outbreak appeared from July to November 2023 with the number of cases reported monthly peaked in October *** impulsive control strategy is incorporated in the model with the aim to avoid or prevent the cholera *** the first year of monitoring,we observed a reduction of more than 75%of incidences and the disappearance of the peaks when no control are available in cameroon.A second monitoring of control led to a further reduction of around 60%of incidences the following year,showing how

关键词： Vibrio cholerae Mathematical models Ensemble Kalman filterBasic reproduction number Impulsive control

cr-induced fusion reactions to synthesize superheavy elements

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Nuclear Science and Techniques 2024年第5期35卷 122-130页

作者： S.Madhu H.c.Manjunatha N.Sowmya B.M.rajesh L.Seenappa r.S.Susheela Department of Physics R V College of EngineeringBangalore 560074India Visvesvaraya Technological University BelagaviKarnataka 590018India Department of Physics Government First Grade CollegeSrinivasapurKarnataka 563135India Department of Physics Government First Grade CollegeDevanahallyKarnataka 562110India Department of Physics Government First Grade CollegeMulbagalKarnataka 563131India Department of Physics Government First Grade collegeNanjangudOoty RoadMysore 571301India

We investigated ^(50,52-54)cr-induced fusion reactions for the synthesis of the superheavy element in the 104≤Z≤122 *** cross sections produced in this investigation using ^(54)cr projectiles were compared with those obtained in prior *** estimated cross sections from this analysis are consistent with the findings of prior *** the current study,the predicted cross section was found to be 42fb at 236 MeV for ^(53)cr+^(243)Am,23.2 fb at 236 MeV for ^(54)cr+^(247)cm,95.6 fb at 240 MeV for ^(53)cr+248Bk,and 1.33 fb at 242 MeV for ^(53)cr+***,these projected cross sections with excitation energy and beam energy will be useful in future cr-induced fusion reaction investigations.

关键词： Fusion cross sections compound nucleus formation probability Survival probability Evaporation residue cross sections

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巴西油气勘探开发历程:从陆上到超深水

石油勘探与开发 2024年第4期51卷 796-806页

作者： ANJOS Sylvia M c SOMBrA cristiano L SPADINI Adali r 巴西国家石油公司里约热内卢20231-030巴西

21世纪以来,随着桑托斯盆地深水盐下获得一系列重大油气发现,巴西东部海域成为全球深水油气勘探与生产的热点区域。通过全面回顾巴西油气勘探开发历程,系统阐述了从陆上到海域、从浅水到深水—超深水直至盐下勘探的探索实践、战略转变... 详细信息

21世纪以来,随着桑托斯盆地深水盐下获得一系列重大油气发现,巴西东部海域成为全球深水油气勘探与生产的热点区域。通过全面回顾巴西油气勘探开发历程,系统阐述了从陆上到海域、从浅水到深水—超深水直至盐下勘探的探索实践、战略转变、重大突破和关键理论技术。巴西国家石油公司(简称巴西国油)自1953年成立以后的15年间,在陆上古生界克拉通盆地和断陷盆地进行了勘探,并于断块和三角洲砂体圈闭获得了一些中小型油气发现。20世纪70年代,应用重力流沉积模式和高质量三维地震等勘探新技术,在坎波斯盆地浅水中发现Namorado和Enchova等油田,随后深水盐上勘探获得突破,成功发现Marlim、roncador等大型油田。21世纪初,通过盐下含油气系统、碳酸盐岩成储成藏模式和核磁共振测井等理论技术攻关,推动桑托斯盆地下白垩统湖相碳酸盐岩陆续获得Tupi(Lula)、Buzios、Mero等世界级超深水盐下大油田的系列重大发现。在复杂的深水作业环境下,油气开发工程面临巨大挑战,巴西国油通过启动深水研发计划(PrOcAP),开发并实施窄压力窗口控压钻井、加压钻井液帽钻井、多段智能完井、水下采油及浮式生产平台开发和流动保障等关键技术,显著提升了钻完井、油气田开发和输运的效率及安全性。此外,在浮式采储卸油系统建产规模受限的情况下,推进全球最大规模的cO_(2)捕集、驱油利用与埋存工程(ccUS-EOr),有效减少温室气体排放并提高了原油采收率。上述理论技术的发展和应用,也为全球深水油气勘探开发提供了宝贵经验。未来巴西油气勘探将继续聚焦深水盐下碳酸盐岩和盐上浊积岩,并在古生界天然气等勘探领域持续寻求新的发现,同时通过技术创新和战略合作,促进巴西石油天然气行业的可持续发展。

关键词：巴西深水盐下勘探坎波斯盆地桑托斯盆地浊积岩湖相碳酸盐岩深水开发流动保障

Spatial analysis of Dengue through the reproduction numbers relating to socioeconomic features:case studies on two Brazilian urban centers

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Infectious Disease Modelling 2024年第1期9卷 142-157页

作者： Ana T.c.Silva rejane c.Dorn Lívia r.Tomás Leonardo B.L.Santos Lacita M.Skalinski Suani T.r.Pinho Departamento de Física Universidade Estadual de Feira de SantanaAv.Transnordestinas/n.Novo HorizonteFeira de Santana44036-900BABrazil Instituto de Física Universidade Federal da BahiaRua Barão de Jeremoabo s/nCampus Universitário de OndinaSalvador40170-115BABrazil centro Nacional de Monitoramento e Alertas de Desastres Naturais(cEMADEN) Estrada Dr.Altino Bondensan500São Josédos Campos12247-016SPBrazil Universidade Estadual de Santa cruz Campus Soane Nazaréde AndradeRodovia Jorge AmadoKm 16SalobrinhoIlhéus45662-900BABrazil Instituto de Saúde coletiva Universidade Federal da BahiaR.Basílio da Gamas/n-CanelaSalvador40110-140BABrazil Instituto Nacional de ciência e Tecnologia-Sistemas complexos Virtual InstitutionBrazil

The study of the propagation of infectious diseases in urban centers finds a close connection with their population's social characteristics and *** work performs a spatial analysis of dengue cases in urban centers based on the basic reproduction numbers,r0,and incidence by planning areas(PAs),as well as their correlations with the Human Development Index(HDI)and the number of *** analyzed dengue epidemics in 2002 at two Brazilian urban centers,Belo Horizonte(BH)and rio de Janeiro(rJ),using PAs as spatial *** results reveal heterogeneous spatial scenarios for both cities,with very weak correlations between r0 and both the number of trips and the HDI;in BH,the values of r0 show a less spatial heterogeneous pattern than in *** BH,there are moderate correlations between incidence and both the number of trips and the HDI;meanwhile,they weakly correlate for ***,the absence of strong correlations between the considered measures indicates that the transmission process should be treated considering the city as a whole.

关键词： Dengue Mathematical mode lBasic reproduction number Urban mobility Urban indices

A transient shift in equatorial hydrology and vegetation during the Eocene Thermal Maximum 2

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Geoscience Frontiers 2024年第5期15卷 174-181页

作者： Gaurav Srivastava Harshita Bhatia Poonam Verma Yogesh P.Singh Shailesh Agrawal Torsten Utescher r.c.Mehrotra Birbal Sahni Institute of Palaeosciences 53 University RoadLucknow 226007India Academy of Scientific and Innovative research(AcSIr) Ghaziabad 201002India Senckenberg research Institute and Natural History Museum Frankfurt/M.Senckenberg Research Station of Quaternary PalaeontologyWeimerGermany Institute for Geosciences University of BonnNussallee 853115 BonnGermany

The equatorial evergreen forests nourish the world’s biodiversity hotspots and are considered the lungs of the ***,their future survival is uncertain,due to anthropogenically increased carbon emissions and changes in the hydrological *** the changes in the hydrological cycle in the equatorial region due to an increase in carbon emission is of prime *** early Paleogene hyperthermal events are potential analogs to understand the consequences of high carbon emission on the hydrological *** this communication,we quantify the terrestrial seasonal climate using the plant proxy and infer that during the Eocene Thermal Maximum 2 when atmospheric carbon dioxide concentration was>1000 ppmv near the palaeo-equator(~0.6°N),the rainfall decreased significantly,leading to the expansion of deciduous *** study raises important questions about the future survival of equatorial rainforests and biodiversity hotspots under increased carbon emissions.

关键词： coexistence approach climate ETM-2 Global warming Hyperthermal Paleogene

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完美数及其相关问题

数学进展 2024年第4期53卷 673-689页

作者：蔡天新 Tyler ross 浙江大学数学科学学院杭州浙江310058

完美数问题是最古老的数学问题之一,可能来源于古希腊的毕达哥拉斯学派,被意大利当代数学家奥迪弗雷迪列为面向21世纪的“四大数学难题”之首.本文对古老的完美数问题及相关的梅森素数进行综述,尤其是对其拓展为平方完美数、立方完美数... 详细信息

完美数问题是最古老的数学问题之一,可能来源于古希腊的毕达哥拉斯学派,被意大利当代数学家奥迪弗雷迪列为面向21世纪的“四大数学难题”之首.本文对古老的完美数问题及相关的梅森素数进行综述,尤其是对其拓展为平方完美数、立方完美数及S-完美数以后所产生的问题进行了综述.

关键词：完美数平方完美数立方完美数 S-完美数