检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

性别不同时心衰对于药物治疗的反应(法国)

世界核心医学期刊文摘（心脏病学分册） 2005年第6期1卷 42-42页

作者： Juillière Y. Berder V. Brembilla-Perrot B. Selton-Suty c. 王永兴 cardiologie CHU Nancy-Brabois Allèe du Morvan 54500 Vandoeuvre-les-Nancy France

The general profile of women with cardiac failure differs from that of the male population, especially with respect to aetiology and prognosis. Women are often older, have preserved systolic function more often and a higher incidence of risk factors such as hypertension and diabetes. Moreover, global mortality is lower in women. From the therapeutic point of view, women with symptomatic left ventricular dysfunction probably benefit from AcE inhibitors but those with asymptomatic dysfunction have no reduction in mortality with this class of drugs. In addition, treatment with AcE inhibitors is usually interrupted in women because of a higher incidence of secondary effects. The poorer tolerance could be explained by the profile of women with cardiac failure. The large scale multicentre trials with betablockers included very few women. In MErIT-HF, in which there was a large number of women(23%), the female subgroup was the only one in which a benefit in mortality was not demonstrated. However, a retrospective analysis of the data of this subgroup plus a meta-analysis of all trials with betablockers does show improved mortality with this class of drugs in women. In a retrospective study of the DIG study, there seems to be a difference in the effects of digoxin between men and women: the prescription of digoxin is associated with a higher overall mortality in women. Finally, women seem to require diureticsmore often than do men. There are many explanations for the differences observed in therapeutic responses between men and women. The role of sex hormones is often evoked, although it has never been clinically proved. The treatment of heart failure in women should take clinical and biological factors specific to women into account and may explain the relative inefficacy of certain forms of treatment.

关键词：药物治疗左心室功能不全 β受体阻断剂无症状亚组收缩功能副作用发生率荟萃分析多中心试验生物学因素

The Optical Design Of Dye-Sensitized Nanocrystalline Solar cells

在线全文

学校读者我要写书评

暂无评论

The Optical Design Of Dye-Sensitized Nanocrystalline Solar C...

2004全国太阳能光化学与光催化学术会议

作者： Xizhe Liu, Q.B. Meng. c.X Gao, B.F. Xue, H.X. Wang, ***, O. Sato and A. Fujishima ((Beijing National Laboratory for condensed Matter Physics.lnstitute of Physics, chinese Academy of Sciences, Beijing, 100080, china qbmeng@aphy. iphy. ac. cn & cxgao599@yahoo. com, cn State Key Laboratory of Superhard Materials,Institute of Atoms and Molecules, JiLin University, changchun, 130012, china. reseach Laboratory for Optical Science, Kanagawa Academy of Science and Technology, KSP BLDG. EAST 412, Sakado, Kawasaki 213-0012, Japan)

＜正＞ Dye-Sensitized Nanocrystalline Solar cells（DSSc）is a new kind of solar cell,which may be analternative to conventional silicon-based solar *** factors determine the overall efficiency ofsuch a cell for example TiO2 films,dyes,electrolyte,optical property of materials *** most ofthese factors have been studied extensively,the optical process in DSSc was studied very *** anoptical device,DSSc’S optical property is certainly *** this paper we developed a model,which

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

催化作用中的某些结构化学问题

chinese Journal of Structural chemistry 1989年第5期8卷 349-356页

作者：万惠霖蔡启瑞厦门大学化学系厦门大学物理化学研究所

本文综述了过渡金属、过渡金属络合物和金属氧化物催化作用中结构化学问题研究的某些重要进展。内容包括过渡金属和过渡金属原子簇上化学吸附和催化作用的结构敏感性问题,过渡金属络合物催化的不对称合成的最新进展及其高对映体选择性... 详细信息

本文综述了过渡金属、过渡金属络合物和金属氧化物催化作用中结构化学问题研究的某些重要进展。内容包括过渡金属和过渡金属原子簇上化学吸附和催化作用的结构敏感性问题,过渡金属络合物催化的不对称合成的最新进展及其高对映体选择性的一般机理,和金属复氧化物催化剂体系中的相间结构匹配,以及低碳烃选择氧化中的基元步骤对催化剂晶面的选择性等。

关键词：催化作用结构化学过渡金属

剖宫产术后皮下连续输注布比卡因对切口处IL-10、P物质浓度的影响

在线全文

学校读者我要写书评

暂无评论

麻醉与镇痛 2012年第2期8卷 64-72页

作者： Brendan carvalho David J. clark David c. Yeomans Martin S. Angst 何欣（译）刘晓（译）郭曲练（校） Department of Anesthesia Stanford University School of Medicine Stanford VA Palo Alto Health care System Palo Alto California

背景最新的证据表明，局部给予局麻药可能产生组织损伤效应。例如，关节腔内注射局麻药可导致软骨溶解。炎症应答可能是这种组织毒性反应的机制之一。在本研究中，我们观察了剖宫产术后局部持续输注局麻药对皮肤切口处炎性介质和疼痛介... 详细信息

背景最新的证据表明，局部给予局麻药可能产生组织损伤效应。例如，关节腔内注射局麻药可导致软骨溶解。炎症应答可能是这种组织毒性反应的机制之一。在本研究中，我们观察了剖宫产术后局部持续输注局麻药对皮肤切口处炎性介质和疼痛介质释放的影响。方法本研究纳入38例蛛网膜下隙麻醉下行剖宫产的健康女性。剖宫产术后24小时内，随机在手术切口处以2ml/h的速度持续皮下输注5mg／ml的布比卡因或生理盐水。通过皮下g1流管分别在术后第1小时、3小时、5小时、7小时和24小时取伤口渗出物为标本，采用多样Bio-Plex（Bio-rad，Hercules，cA）和酶联免疫吸附法检测细胞因子、炎症趋化因子、P物质、前列腺素E2和神经生长因子的含量。结果与生理盐水相比，输注布比卡因可导致切口处IL-10降低，P物质增高（24小时的浓度．时间曲线下面积；P〈0．001）。而其他细胞因子、神经生长因子和前列腺素E2未发现显著的统计学差异。结论本研究表明，在切口处持续输注临床剂量的布比卡因会影响切口局部创伤调节物质的组成。研究中所观察到的IL-10变化与抗炎机制的破坏是一致的。这种与促炎症介质P物质释放相关联的调节活动是否会引起伤口的全面促炎反应还有待进一步的研究。

关键词：剖宫产术后皮下连续输注 IL-10 布比卡因物质浓度切口处神经生长因子前列腺素E2

直接血管成形术中远端栓塞:组织病理学特征和预测参数

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2006年第1期2卷 24-24页

作者： Limbruno U. De carlo M. Pistolesi S. r. De caterina 高登峰 Dr. Department of cardiology G. d'Annunzio University-Chieti C/o Ospedale S. Camillo de Lellis Via Forlanini 50 66100 Chieti Italy

Background: Distal embolization during primary percutaneous coronary interventions(PcIs) may affect myocardial reperfusion. We evaluated the prevalence and features of embolization during primary PcI and its relationship with clinical and angiographic variables. Methods: Forty-six consecutive patients with acute myocardial infarction underwent primary PcI with a filter-based distal protection device. Histopathologic analysis was performed on retrieved embolic fragments, assessing the presence and relative amount of fibrin, necrosis, lipid droplets, collagen, mucopolysaccharides, and leukocytes, as well as the total debris volume. Such variables were related to baseline clinical and angiographic variables. results: Embolic material was recovered in 41(89%) of 46 cases, with a mean total debris volume of 1.2±2.2 mm3. Prevalent histopathologic patterns were organized thrombus(47%), fresh thrombus(29%), and plaque fragments(24%). At multivariate analysis, none of the baseline clinical variables considered significantly predicted the total debris volume. Among angiographic variables, angiographic signs of high thrombus burden(cut-off coronary occlusion pattern or large intracoronary minus image) independently predicted the total debris volume at multivariate analysis(odds ratio 15.8, Pcompared with its nonuse, abciximab did not affect the total number and the mean total volume of embolized material(15±16 vs 10±8 fragments, 1.5±2.5 vs 1.0±1.9 mm3, respectively, for both P >.20), or its qualitative composition. conclusions: Distal embolization occurs in most patients during primary PcI and mainly consists of plaque fragments and partially organized thrombi, which are likely to be scarcely responsive to antiplatelet drugs. Baseline angiographic signs of a high thrombus burden are the only significant predictors of the extent of distal embolization.

关键词：组织病理学特征远端保护装置预测参数直接血管成形栓塞经皮冠状动脉介入术直接PcI 术中心肌梗死患者临床参数

肿瘤中hamartin和tuberin的不同分布以及核糖体S6激酶的磷酸化增加

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 57-57页

作者： Jansen F.E. Notenboom r.G.E. Nellist M. O. Van Nieuwenhuizen 高方 Department of child Neurology University Medical Ce nter Utrecht PO Box 85090 3508 AB Utrecht Netherlands Dr.

In a tuberous sclerosis patient with a mutation in the TSc1 tumor suppressor g ene, no second hit mutation was found in a resected cortical tuber. Tuber giant cells showed predominantly nuclear hamartin, cytosolic tuberin, and hyperphosph orylation of S6. Differential accumulation of hamartin and tuberin in separate c ellular compartments of giant cells may prevent formation of the hamartin tuber in complex, resulting in increased S6 phosphorylation. These data provide an alt ernative mechanism for tuberogenesis.

关键词： S6 hamartin tuberin 结节性脑硬化抑癌基因瘤巨细胞细胞腔

慢性HcV基因型-1感染的肥胖患者抗病毒治疗无应答与肝脏SOcS-3的表达上调有关

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 38-38页

作者： Walsh M.J. Jonsson J.r. richardson M.M. E.E.Powell 陈瑜 Princess Alexandra Hospital Ipswich RdWoolloongabbaQLD 4102AustraliaDr

Background: Interferon α(IFN-α) activated cellular sign- aling is negatively regulated by inhibitory factors, including the suppressor of cytokine signaling (SOcS) family. The effects of host factors such as obesity on hepatic expression of these inhibitory factors in subjects with chronic hepatitis c virus (HcV) are unknown. Objectives: To assess the independent effects of obesity, insulin resistance, and steatosis on response to IFN-αtherapy and to determine hepatic expression of factors inhibiting IFN-αsignaling in obese and non-obese subjects with chronic HcV. Methods: A total of 145 subjects were analysed to determine host factors associated with non-response to antiviral therapy. Treatment comprised IFN-αor peginterferon alpha, either alone or in combination with ribavirin. In a separate cohort of 73 patients, real time-polymerase chain reaction was performed to analyse hepatic mrNA expression. Immunohistochemistry for SOcS-3 was performed on liver biopsy samples from 38 patients with viral genotype 1 who had received antiviral treatment. results: Non-response (Nr) to treatment occurred in 55%of patients with HcV genotypes 1 or 4 and 22%with genotypes 2 or 3. Factors independently associated with Nr were viral genotype 1/4 (p cirrhosis on pretreatment biopsy (p = 0.025), and body mass index ≥30 kg/m2 (p = 0.010). Obese subjects with viral genotype 1 had increased hepatic mrNA expression of phosphoenolpyruvate carboxy kinase (p = 0.01) and SOcS-3 (p = 0.047), in comparison with lean subjects. Following multivariate analysis, SOcS-3 mrNA expression remained independently associated with obesity (p = 0.023). SOcS-3 immunoreactivity was significantly increased in obesity (p = 0.013) and in non-responders compared with responders (p = 0.014). conclusions: In patients with chronic HcV viral genotype 1, increased expression of factors that inhibit interferon signaling may be one mechanism by which obesity reduces the biological response to IFN-α.

关键词： SOcS-3 抗病毒 HcV基因宿主因素干扰素α 肝活检信号转导细胞因子慢性丙型肝炎胰岛

在线全文

学校读者我要写书评

暂无评论

皮肤脂肪瘤神经纤维瘤:特征和频率

世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 61-61页

作者： Val-Bernal J.F. Gonz'J.F.Val-Bernal alez-Vela M.c. 李政霄 Dr.Departamento de Anatomia Patologica Hosp.Univ.Marques de ValdecillaAvda. Valdecilla 1 ES-39008 Santander Spain

Background: There are numerous variants of cutaneous neurofibroma reflecting its manner of growth and histologic composition. Lipomatous neurofibroma is the latest described variant with only eight cases reported. Methods: A systematic study based on 320 consecutive specimens diagnosed of cutaneous neurofibroma was carried out. conventional microscopy, immunohistochemistry, and statistical methods were used to determine the presence of fat cells, their amount, distribution, and frequency. results: Intratumoral fat was observed in 22 (6.9% ) neurofibromas. All these were dermal neurofibromas. Intraneoplastic fat was divided into two groups: focal and diffuse (regularly interspersed). Eighteen tumors (5.6% ) presented adipocytes focally intermingled with the spindle cells. There were four (1.3% ) neurofibromas showing spindle cell proliferation with regularly scattered adipocytes. Lipomatous neurofibroma was more frequent located on head and neck than non- lipomatous neurofibroma (p=0.04). Neurofibromas without mature adipocytes were more frequently immunoreactive for cD34 compared with tumors showing intratumoral fat (p=0.02). conclusions: We suggest that both metaplasia and aberrant adipose differentiation from multipotential cells may result in lipomatous neurofibroma. Focal presence of adipose cells may be attributable to metaplasia as the pathogenic mechanism. The fatty tissue being intrinsic to the tumor structure in its diffuse form, the lesion represents a distinctive tumor of the peripheral nerve sheath.

关键词：神经纤维瘤梭形细胞神经鞘肿瘤显微镜检查法脂肪细胞免疫组织化学多潜能细胞生长方式免疫反应性存

自发性卵巢早衰女性生育脆性X染色体综合征儿

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 38-38页

作者： corrigan E.c. raygada M.J. Vanderhoof V.H. Nelson L.M. 李跃萍 DEB/NIcHD/NIH CRCMSC-1103 10 Center Drive Bethesda MD 20892-1103 United States Dr.

Objective: To inform clinicians about a reproductive risk associated with spontaneous premature ovarian failure and the fragile X mental retardation 1 gene (FMr1). Design: case report. Setting: National Institutes of Health clinical center. Patient(s): A 35-year-old woman with confirmed spontaneous premature ovarian failure. Intervention(s): FMr1 genetic testing. Main Outcome Measure(s): Number of cGG trinucleotide repeats in the 5′untranslated region of FMr1. result(s): Despite having ovarian failure the woman subsequently conceived and delivered a son with fragile X syndrome (>200 cGG repeats). She was then found to carry an FMr1 premutation (85 cGG repeats). conclusion(s): This is a real-life manifestation of a theoretical risk; a woman conceived subsequent to the diagnosis of spontaneous premature ovarian failure and has a child who manifests mental retardation due to fragile X syndrome. Women with spontaneous premature ovarian failure are at increased risk of having an FMr1 premutation and should be informed of the availability of fragile X testing. Should an FMr1 premutation be uncovered, this will allow patients to make informed reproductive decisions and help clinicians to properly diagnose family members who may have menstrual irregularity, developmental delay, or neurologic symptoms.

关键词：卵巢早衰女性生育前突变智力发育迟缓串联重复临床中心三核苷酸月经不调临床医生非翻译区