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The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

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Genes & Diseases 2024年第1期11卷 321-334页

作者： Md rakibul alam Md Mizanur rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microrNA,rNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

Effect of Fluidic Diode on Performance of Unidirectional Impulse Turbine

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Journal of Thermal Science 2024年第3期33卷 807-814页

作者： DODDAMANI Hithaish ABDUS Samad MANABU Takao SHINYA Okuhara M M ASHrAFUL alam Department of Ocean Engineering Indian Institute of Technology MadrasChennai600036India Department of Mechanical Engineering National Institute of TechnologyMatsue CollegeShimane6908518Japan Center of Support Practical Education National Institute of TechnologyMatsue CollegeShimane6908518Japan Department of Transportation Engineering Osaka Sangyo UniversityDaito5748530Japan

A pair of unidirectional turbines(UT)can operate in oscillatory airflow without additional ***,this arrangement suffers from poor flow rectification.A fluidic diode(FD)offers variable hydrodynamic resistance based on the flow direction,and this can be coupled with UT to improve flow *** this work,a numerical investigation on the effect of FD with UT is presented using the commercial fluid dynamics software ANSYS Fluent 16.1 with k-ωSST turbulence closure *** domains of UT and FD are numerically validated individually with experimental ***,both are coupled to obtain the combined effect,and these results are compared with the analytical *** was observed that coupling FD with UT improved the unit's performance at the lower flow coefficient(rformance decreased as the flow coefficient *** to the diode's presence,fluid leaving the turbine experiences higher resistance at a higher flow coefficient,which decreases the overall performance of the combined unit.

关键词： wave energy oscillating water column unidirectional impulse turbine fluidic diode flow rectification

review on inorganic and polymeric materials-coordinated metal-organic-framework photocatalysts for green hydrogen evolution

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Journal of Energy Chemistry 2024年第5期92卷 322-356页

作者： Dong-Eun Lee Mohtaram Danish Umair.alam Wan-Kuen Jo School of Architecture CivilEnvironmental and Energy Engineering Kyungpook National University80 Daehak-roBuk-guDaegu 41566Republic of Korea School of Chemical Engineering Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea

Metal-organic frameworks(MOFs)possess a distinct advantage over conventional heterogeneous photocatalysts because of their carefully defined architecture and particular pores,which facilitate the targeted incorporation of other efficient cocatalysts or semiconductor *** integration of MOFs with other materials has resulted in significant breakthroughs,as the coupled materials improve the performance due to the combined *** unique MOF structures allow them to host foreign materials,which results in harvesting the visible region of the solar spectrum and effectively mitigating charge recombination by promoting charge *** review presents an evaluation of the latest developments in the utilization of surface and/or pore chemistry of MOF-supported heterojunctions for photocatalytic green-hydrogen generation with a basic understanding of the mechanism *** review begins with the basic principles of photocatalysis,the significance of MOFs,their optical properties,the methods used for synthesizing MOFs,and their coordination with other inorganic and polymeric ***,methods to increase photocatalytic H2 evolution using MOF-supported heterojunction have been proposed as standard ***,to address environmental challenges,we highlight the future potential of MOF-supported heterojunctions for use in green-energy *** hope that this review provides guidance to researchers in the development of effective heterojunctions based on MOFs to address challenges in energy applications and catalytic processes.

关键词： renewable energy Environmental challenge Heterojunction Water splitting Photocatalysis

Experimental and analytical investigation on friction resistance force between buried coated pressurized steel pipes and soil

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 615-629页

作者： Shaurav alam Tanvir MANZUr John MATTHEWS Chris BArTLETT Erez ALLOUCHE Brent KEIL John KrAFT Department of Civil Engineering and Construction Engineering Technology Louisiana Tech UniversityRustonLA 71270USA Department of Civil Engineering Bangladesh University of Engineering and TechnologyDhaka 1000Bangladesh Georgia Tech research Institute AtlantaGA 30332USA Stantec Inc. Edmonton T5J0K4Canada North West Pipe Company VancouverWA 98684USA

This paper presents an analytical approach for estimating frictional resistance to pipe movement at soil and external pipe surface of buried coated pressurized steel pipes relative to the internal thrust *** proposed analytical method was developed based on 36 experiments,which involved three coating types(cement mortar(CM),polyurethane type-I(PT-I),prefabricated plastic tape(PPT))on pipes’surfaces,three different soils(pea-gravel(PG),sand(S),silty-clay(SC)),and four simulated over burden depths above the pipe’s *** showed frictional resistance decreased with increasing over burden depth above the pipe’s *** degree of frictional resistance at the pipe-soil interface was found to be in the order of PG>SC>S for all coating variations and overburden *** coated pipe buried in all three types of soil produced significantly higher frictional resistance as compared to other coating *** on experimental data,the developed analytical introduced a dimensionless factor“Z”,which included effects of types of coatings,soil,and overburden depths for simplified rapid *** showed that the method provided a better prediction of frictional resistance forces,in comparison to previous analytical methods,which were barely close in predicting friction resistance for different coating variations,soil types,and overburden *** resistance force values reported herein could be considered conservative.

关键词： friction resistance force thrust force coated pressurized steel pipe soil type overburden depth

Energy Harvesting in the Wake of An Inverted C-Shaped Bluff Body

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China Ocean Engineering 2024年第1期38卷 68-80页

作者： WANG Jun-lei LI Shen-fang Md.Mahbub alam ZHU Hong-jun HU Guo-biao School of Mechanical and Power Engineering Zhengzhou UniversityZhengzhou 450000China Center for Turbulence Control Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Oil and Gas reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China Internet of Things Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China

This paper proposes a novel wake-induced vibration(WIV)-based energy harvesting system consisting of two bluff *** inverted C-shaped bluff body is stationary installed at the upstream position to generate an interference wake street,and a cylinder bluff body equipped with a transducer is elastically suspended at the downstream position to harness WIV *** hydrodynamics and energy harvesting(EH)performance of the proposed system are investigated via experimental *** reduced velocity(U*)ranging from 2 to 14(the corresponding reynolds number ranging from 15100 to 106200)is considered in the present *** is found that the wake generated by the inverted C-shaped bluff body significantly affects the EH *** the opening angle(α)of the C-shaped bluff body increases the vibration amplitude of the downstream cylinder,thereby increasing the harvested *** the spacing(L)between two bluff bodies is two times the cylinder diameter(D),the wake-induced vibration(WIV)mode is observed,while the combined WIV and wake galloping(WG)mode occurs whenαis 150°,and L equals 3D or *** average drag coefficient becomes negative when L is 2D,3D,or *** carefully configuring a C-shaped bluff body,the wake generated by it can bring an augmenting effect on the vibration of the downstream EH *** example,the rMS power output of the proposed EH system reaches a maximum of 0.31 W at U*=8 and L=4D,which is 300%greater than that of its traditional ***,after a number of case stud-ies,it is identified that the proposed EH system can achieve the best performance whenαis 150°and L=2D.

关键词： wake-induced vibration vortex-induced vibration galloping energy harvesting bluff body

Implications of electrode modifications in aqueous organic redox flow batteries

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Journal of Energy Chemistry 2024年第8期95卷 499-510,I0011页

作者： Zahid Manzoor Bhat Mohammad Furquan Muhammad Aurang Zeb Gul Sial Umair.alam Atif Saeed Alzahrani Mohammad Qamar Interdisciplinary research Center for Hydrogen Technologies and Carbon Management(IrC-HTCM) King Fahd University of Petroleum&Minerals(KFUPM)Dhahran 31261Saudi Arabia Department of Materials Science and Engineering King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia Interdisciplinary research Center for Sustainable Energy Systems(IrC-SES) King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

Aqueous organic redox flow batteries(rFBs)exhibit favorable characteristics,such as tunability,multielectron transfer capability,and stability of the redox active molecules utilized as anolytes and catholytes,making them very viable contenders for large-scale grid storage *** attention has been paid on the development of efficient redox-active molecules and their performance optimization through chemical substitutions at various places on the backbone as part of the pursuit for high-performance *** the fact that electrodes are vital to optimal performance,they have not garnered significant *** research has been conducted on the effects of electrode modifications to improve the performance of *** primary emphasis has been given on the impact of electrode engineering to augment the efficiency of aqueous organic *** overview of electron transfer at the electrode-electrolyte interface is *** implications of electrode modification on the performance of redox flow batteries,with a particular focus on the anodic and cathodic half-cells separately,are then *** each section,significant discrepancies surrounding the effects of electrode engineering are thoroughly examined and ***,we have presented a comprehensive assessment along with our perspectives on the future trajectory.

关键词： redox flow batteries Electrode modification Organic redox molecules Outer sphere and inner sphere

Cellular interplay to 3D in vitro microphysiological disease model:cell patterning microbiota-gut-brain axis

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Bio-Design and Manufacturing 2024年第3期7卷 320-357页

作者： Kamare alam Lakshmi Nair Souvik Mukherjee Kulwinder Kaur Manjari Singh Santanu Kaity Velayutham ravichandiran Sugato Banerjee Subhadeep roy Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India Department of Pharmaceutical Sciences Assam UniversitySilchar 788011India Department of Pharmaceutical Sciences Guru Ghasidas UniversityKoniBilaspur 495009C.G.India School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublin D02 YN77Ireland Tissue Engineering research Group Department of Anatomy and Regenerative MedicineRCSI University of Medicine and Health SciencesDublin D02 YN77Ireland Department of Pharmaceutics National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India Department of Natural Products National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India

The microbiota-gut-brain axis(MGBA)has emerged as a key prospect in the bidirectional communication between two major organ systems:the brain and the *** between the two organ systems allows the body to function without disease,whereas dysbiosis has long-standing evidence of etiopathological *** most common communication paths are the microbial release of metabolites,soluble neurotransmitters,and immune ***,each pathway is intertwined with a complex *** the emergence of in vitro models and the popularity of three-dimensional(3D)cultures and Transwells,engineering has become easier for the scientific understanding of neurodegenerative *** paper briefly retraces the possible communication pathways between the gut microbiome and the *** further elaborates on three major diseases:autism spectrum disorder,Parkinson’s disease,and Alzheimer’s disease,which are prevalent in children and the *** diseases also decrease patients’quality of ***,understanding them more deeply with respect to current advances in in vitro modeling is crucial for understanding the *** of MGBA in the laboratory uses many molecular technologies and biomaterial *** and organoids provide a more realistic picture of the cell and tissue structure than *** them with the Transwell system offers the advantage of compartmentalizing the two systems(apical and basal)while allowing physical and chemical cues between ***-edge technologies,such as bioprinting and microfluidic chips,might be the future of in vitro modeling,as they provide dynamicity.

关键词： Microbiota-gut-brain axis Neurodegeneration 3D disease model Organoid Transwell system

Developing Lexicons for Enhanced Sentiment Analysis in Software Engineering:An Innovative Multilingual Approach for Social Media reviews

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Computers, Materials & Continua 2024年第5期79卷 2771-2793页

作者： Zohaib Ahmad Khan Yuanqing Xia Ahmed Khan Muhammad Sadiq Mahmood alam Fuad AAwwad Emad A.A.Ismail School of Automation Beijing Institute of TechnologyBeijing100081China Department of Computer Science and Technology University of Science and Technology BannuKPKBannu28100Pakistan School of Computer Science and Engineering Central South UniversityChangsha410083China Department of Quantitative Analysis College of Business AdministrationKing Saud UniversityP.O.Box 71115Riyadh11587Saudi Arabia

Sentiment analysis is becoming increasingly important in today’s digital age, with social media being a significantsource of user-generated content. The development of sentiment lexicons that can support languages other thanEnglish is a challenging task, especially for analyzing sentiment analysis in social media reviews. Most existingsentiment analysis systems focus on English, leaving a significant research gap in other languages due to limitedresources and tools. This research aims to address this gap by building a sentiment lexicon for local languages,which is then used with a machine learning algorithm for efficient sentiment analysis. In the first step, a lexiconis developed that includes five languages: Urdu, roman Urdu, Pashto, roman Pashto, and English. The sentimentscores from SentiWordNet are associated with each word in the lexicon to produce an effective sentiment score. Inthe second step, a naive Bayesian algorithm is applied to the developed lexicon for efficient sentiment analysis ofroman Pashto. Both the sentiment lexicon and sentiment analysis steps were evaluated using information retrievalmetrics, with an accuracy score of 0.89 for the sentiment lexicon and 0.83 for the sentiment analysis. The resultsshowcase the potential for improving software engineering tasks related to user feedback analysis and productdevelopment.

关键词： Emotional assessment regional dialects SentiWordNet naive bayesian technique lexicons software engineering user feedback

SNr and rSSI Based an Optimized Machine Learning Based Indoor Localization Approach:Multistory round Building Scenario over Lora Network

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Computers, Materials & Continua 2024年第8期80卷 1927-1945页

作者： Muhammad Ayoub Kamal Muhammad Mansoor.alam Aznida Abu Bakar Sajak Mazliham Mohd Su’ud Malaysian Institute of Information Technology(MIIT) Universiti Kuala LumpurKuala Lumpur50250Malaysia Faculty of Computing and Informatics Multimedia UniversityCyberjaya63100Malaysia Depertment of Computer Science DHA Suffa UniversityKarachiSindh75500Pakistan riphah Institute of System Engineering(rISE) Faculty of ComputingRiphah International UniversityIslamabad46000Pakistan Malaysian France Institute(MFI) Universiti Kuala LumpurKuala Lumpur50250Malaysia Faculty of Engineering and Information Technology School of Computer ScienceUniversity of Technology SydneyUltimoNSW 2007Australia

In situations when the precise position of a machine is unknown,localization becomes *** research focuses on improving the position prediction accuracy over long-range(Lora)network using an optimized machine learning-based *** order to increase the prediction accuracy of the reference point position on the data collected using the fingerprinting method over Lora technology,this study proposed an optimized machine learning(ML)based *** signal strength indicator(rSSI)data from the sensors at different positions was first gathered via an experiment through the Lora network in a multistory round layout *** noise factor is also taken into account,and the signal-to-noise ratio(SNr)value is recorded for every rSSI *** study concludes the examination of reference point accuracy with the modified KNN method(MKNN).MKNN was created to more precisely anticipate the position of the reference *** findings showed that MKNN outperformed other algorithms in terms of accuracy and complexity.

关键词： Indoor localization MKNN Lora machine learning classification rSSI SNr localization