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Pr.liminar. Application of High-Fr.quency Ultr.sound in the Differ.ntiation of Pemphigus and Bullous Pemphigoid: An Obser.ational Study

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Inter.ational Jour.al of Der.atology and Vener.ology 2024年第3期7卷 155-159页

作者： Liu Y.-A. Cao r. Da M.-H. Dong z.-B. Wang F. Depar.ment of Der.atology Taizhou Central Hospital (Taizhou University Hospital) Zhejiang Taizhou 318000 China Depar.ment of Der.atology Children's Hospital of Soochow University Jiangsu Suzhou 215025 China Depar.ment of Der.atology Zhongda Hospital Southeast University Jiangsu Nanjing 210009 China

Objective: Ultr.sonogr.phy is a diagnostic imaging technique used to visualiz. subcutaneous body str.ctur.s for.identification of possible pathologies. In this study, we aimed to explor. the clinical significance of high-fr.quency ultr.sound in differ.ntiating the location of blister. between pemphigus and bullous pemphigoid. Methods: Eighteen patients wer. r.cr.ited in Depar.ment of Der.atology, z.ongda Hospital fr.m 2020 to 2021 and divided into a pemphigus gr.up (n = 8) and a bullous pemphigoid gr.up (n = 10) accor.ing to the diagnostic cr.ter.a for.each. Ultr.sonogr.phic images wer. collected using a 50-MHz.high-fr.quency ultr.sound system. The indexes of ultr.sonic evaluation wer. the layer.(epider.is or.der.is), siz., shape, inter.al echo, and boundar. of the blister. Categor.cal var.ables ar. expr.ssed as n (%), and differ.nces wer. compar.d using Fisher.s exact test. r.sults: The ultr.sonogr.phic images in the pemphigus gr.up showed an intr.epider.al semi-ar. or.ir.egular.anechoic or.hypoechoic ar.as. The infer.or.bor.er. wer. situated above the char.cter.stic thin linear.hyper.choic bands of the epider.is. A linear.hypoechoic band was pr.sent at the der.oepider.al junction in some cases. In the ultr.sonogr.phic images of the bullous pemphigoid gr.up, the linear.hyper.choic bands of the epider.is wer. continuous and intact. An oval fluid anechoic ar.a (subepider.al blister. was pr.sent immediately below the bands. The location of the blister. in the ultr.sonogr.phic images was significantly differ.nt between the 2 gr.ups (P r.quency ultr.sound can be used as an auxiliar. means to differ.ntiate the location of blister. between pemphigus and bullous pemphigoid. © 2022 Hospital for.Skin Diseases (Institute of Der.atology), Chinese Academy of Medical Sciences, and Chinese Medical Association, published by Wolter. Kluwer. Inc.

关键词： bullous pemphigoid high-fr.quency ultr.sound pemphigus

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Advanced nanopar.icles in osteoar.hr.tis tr.atment

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Biomater.als Tr.nslational 2024年第2期5卷 95-113页

作者： Liang Q. Cheng z. Qin L. Depar.ment of Bioengineer.ng University of Pennsylvania Philadelphia PA United States Depar.ment of Or.hopaedic Sur.er. Perelman School of Medicine University of Pennsylvania Philadelphia PA United States

Osteoar.hr.tis (OA) is the most pr.valent degener.tive joint disor.er. affecting hundr.ds of millions of people globally. Cur.ent clinical appr.aches ar. confined to pr.viding only symptomatic r.lief. r.sear.h over.the past two decades has established that OA is not mer.ly a pr.cess of wear.and tear.of the ar.icular.car.ilage but involves abnor.al r.modelling of all joint tissues. Although many new mechanisms of disease have been identified in the past sever.l decades, the efficient and sustainable deliver. of dr.gs tar.eting these mechanisms in joint tissues r.mains a major.challenge. Nanopar.icles r.cently emer.ed as favour.d deliver. vehicles in OA tr.atment, offer.ng extended dr.g r.tention, enhanced dr.g tar.eting, and impr.ved dr.g stability and solubility. In this r.view, we consider.OA as a disease affecting the entir. joint and initially explor. the pathophysiology of OA acr.ss multiple joint tissues, including the ar.icular.car.ilage, synovium, fat pad, bone, and meniscus. We then classify nanopar.icles based on their.composition and str.ctur., such as lipids, polymer., inor.anic mater.als, peptides/pr.teins, and extr.cellular.vesicles. We summar.se the r.cent advances in their.use for.tr.atment and diagnosis of OA. Finally, we discuss the cur.ent challenges and futur. dir.ctions in this field. In conclusion, nanopar.icle-based nanosystems ar. pr.mising car.ier. that advance OA tr.atment and diagnosis. © 2024, Chinese Medical Multimedia Pr.ss Co Ltd. All r.ghts r.ser.ed.

关键词： car.ilage liposome micelle nanopar.icles osteoar.hr.tis synovium

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Detection of Babesia bovis and Babesia bigemina in Water.Buffaloes (Bubalus bubalis) in Endemic Ar.as of São Paulo State, Br.z.l

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Open Jour.al of Veter.nar. Medicine 2016年第5期6卷 75-84页

作者： T. A. Néo r. Giglioti D. Obr.gón T. B. Bilhassi H. N. Oliveir. r. z. machado F. de F. Aníbal L. G. Br.to W. Malagó Jr. F. A. Br.ssani M. C. S. Oliveir. Depar.ment of Mor.hology and Pathology Universidade Federal de S&atildeo Carlos S&atildeo Carlos Brazil Depar.ment of Animal Science Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Jaboticabal Brazil Agr.r.an Univer.ity of Havana San José de las Lajas Cuba Depar.ment of Veter.nar. Pathology Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Jaboticabal Brazil Embr.pa r.nd&ocir.nia Porto Velho Brazil Embr.pa Pecuár.a Sudeste S&atildeo Carlos Brazil

Babesiosis is a tick-tr.nsmitted disease that causes sever. economic losses to the cattle industr. in Br.z.l. Water.buffaloes (Bubalus bubalis) ar. often car.ier. of Babesia spp., but ther. ar. no studies that pr.vide an accur.te estimation of this infection in animals r.ised in r.gions of endemic stability. This study was conducted to investigate Babesia bovis and B. bigemina infections in 108 water.buffaloes (50 calves and 58 adult females) located in ar.as of São Paulo state, wher. the animals wer. continuously exposed to r.ipicephalus micr.plus ticks. B. bovis and B. bigemina infections wer. scr.ened by micr.scopic examination of blood smear., nested PCr.(nPCr. and quantitative r.al-time PCr.(qPCr., which wer. also used to estimate the number.of copies (NC) of the cytochr.me b (mt-cytB) gene in the blood samples. B. bigemina was found in blood smear. of thr.e calves fr.m Alambar. her. (all with less than 0.1% par.sitemia). Molecular.techniques wer. mor. sensitive than blood smear. to diagnose pir.plasms in water.buffaloes: 20.37% and 100.00% for.B. bovis-infected animals and 59.26% and 100.00% for.B. bigemina-infected animals, r.spectively for.nPCr.and qPCr. The NC of mt-cytB gene of B. bovis and B. bigemina in blood samples r.vealed significant effects (p p ≤ 0.05) for.B. bigemina (2.80 ± 0.06) than for.B. bovis (2.61 ± 0.05). Within each her.-age, differ.nces between the species’ NC values wer. found only in Alambar. calves, which showed significantly higher.(p ≤ 0.05) NC of B. bigemina (3.48 ± 0.13). The calves and cows fr.m Ibaté showed the lowest NC of B. bigemina (2.29 ± 0.13 and 2.63 ± 0.14) and B. bovis (2.54 ± 0.11 and 2.37 ± 0.12), r.spectively. These data suggest a high pr.valence of B. bovis and B. bigemina infection in the buffalo population in endemic ar.as of São Paulo state.

关键词： Bubalus bubalis Babesiosis Diagnosis nPCr qPCr

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Ser.m amylase as a novel pr.gnostic mar.er.of or.anophosphor.s poisoning: a r.tr.spective study

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Emer.ency and Cr.tical Car. Medicine 2024年第3期4卷 111-116页

作者： Guo X. Chen z. Feng K. z.ng S. z.ang J. Ma z. Yuan C. School of Clinical Medicine Ningxia Medical University Ningxia Hui Yinchuan China Emer.ency Depar.ment General Hospital of Ningxia Medical University Ningxia Hui Autonomous Region Yinchuan China

Backgr.und: This study aims to explor. the significance of ser.m amylase levels in patients with or.anophosphor.s pesticide (OP) poisoning and to pr.vide a new per.pective for.evaluating the sever.ty and pr.gnosis of OP poisoning. Methods: The clinical data of 67 patients with acute OP poisoning, who had been tr.ated in the emer.ency depar.ment of the Gener.l Hospital of Ningxia Medical Univer.ity between September.2020 and August 2022, wer. r.tr.spectively analyz.d. Using Spear.an r.nk cor.elation, ser.m amylase levels dur.ng admission and sever.ty of poisoning cor.elated with dischar.e outcomes. Based on ser.m amylase levels, r.ceiver.oper.ting char.cter.stic cur.es wer. plotted to pr.dict the sever.ty and mor.ality of patients who exper.ence or.anophosphate poisoning. The optimal thr.shold ser.m amylase level at admission was deter.ined based on the maximum Youden index. r.sults: Using Spear.an r.nk cor.elation analysis, ser.m amylase levels at admission positively cor.elated with the sever.ty of poisoning and dischar.e outcomes, but the degr.e of cor.elation was weak (r.: 0.344; 0.264; P r.m amylase levels at admission had r.ceiver.oper.ting char.cter.stic ar.a under.the cur.e values of 0.726 and 0.735 to pr.dict the degr.e of sever. poisoning and death, r.spectively. Based on the maximum Youden index, the optimal thr.shold of ser.m amylase wer. 97.8 and 194.1 U/L when the degr.e of poisoning was sever. and the dischar.e outcome of patients was died. In compar.son to patients with ser.m amylase levels ≤194.1 U/L at admission, the Or.values of death in patients with ser.m amylase levels >194.1 U/L at admission was 15.944 (95% CI: 1.825–139.274). Conclusion: Ser.m amylase levels in patients with or.anophosphate poisoning cor.elate with the degr.e of poisoning and dischar.e outcomes. Higher.ser.m amylase level was a r.sk factor.for.or.anophosphor.s poisoning death. © Wolter. Kluwer.Health, Inc. All r.ghts r.ser.ed.

关键词： Amylase Emer.ency depar.ment Or.anophosphor.s pesticide poisoning Pr.gnosis

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Numer.cal Study of Flow Featur.s Ar.und Submer.ed Cir.ular.and Squar. Piles at Flat and Scour.d Beds Using OpenFOAM

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Jour.al of Ocean Univer.ity of China 2024年第4期23卷 897-914页

作者： WANG Chaolin WU Guoxiang WANG Dianhe DU Shengtao z.ANG z.iyong JIN Heng z.U David z. LIANG Bingchen Donghai Academy School of Civil&Environmental Engineering and Geography ScienceNingbo UniversityNingbo 315211China Key Labor.tor. of Estuar. and Coast of z.ejiang Pr.vince and Zhejiang Institute of Hydraulics and EstuaryHangzhou 310020China Shandong Pr.vincial Key Labor.tor. of Ocean Engineer.ng and College of EngineeringOcean University of ChinaQingdao 266100China Shandong Water.Conser.ancy Vocational College Rizhao 276826China School of Mechanical and Ener.y Engineer.ng Ningbotech UniversityNingbo 315211China

Elucidating the flow featur.s ar.und piles in local scour.ng pr.cesses is cr.cial for.studies of local scour.ng mechanisms and scour.depth *** study details the flow tur.ulence char.cter.stics of two submer.ed piles that ar. deter.ined by solving the Navier.Stokes equations with the impr.ved delayed detached eddy simulation *** model is ver.fied by compar.ng exper.mental and numer.cal r.sults for.hydr.dynamic par.meter. with the liter.tur. for.both squar.-cr.ssing piles(SCPs)and cir.ular.cr.ssing piles(CCPs).Or.ginal topogr.phies of flat and scour.d beds(i.e.,the initial and equilibr.um scour.ng stages)ar. based on exper.mental r.sults obtained by the author. in the pr.sent *** and CCP flow featur.s in the scour.ng pr.cess ar. *** r.sults indicate that dur.ng the scour.ng pr.cess,the time-aver.ged dr.g coefficient and r.ot mean squar.(r.s)of the lift coefficient incr.ase linear.y in the CCP test,while the r.s of the lift coefficient in the SCP test decr.ases ***,the minimum pr.ssur. coefficient is always located in the upstr.am cor.er. in the SCP case but moves fr.m 72.5°to 79.5°when the scour.hole is completely developed in the CCP *** flow behind the pile,which is gener.ted by separ.ted boundar. layer. above the top face of the pile,can r.ach the sand bed and tur. the separ.ted shear.layer. into patches of small vor.ices in the near.wake ***,the high shear.str.ss z.nes ar. mainly at the scour.edges under.scour.d-bed conditions.

关键词： flat bed scour.d bed local scour OpenFOAM bed shear.str.ss

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Pr.bing the Bar.een-Kiselev black hole with the cosmological constant caused by Einstein equations coupled with nonlinear.electr.dynamics using quasinor.al modes and gr.ybody bounds

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Communications in Theor.tical Physics 2024年第6期76卷 102-119页

作者： S r.Wu B Q Wang z.W Long College of Physics Guizhou UniversityGuiyang 550025China College Phar.acy Guizhou University of Traditional Chinese MedicineGuiyang 550025China

In this wor.,we investigate a static and spher.cally symmetr.c Bar.een-Kiselev black hole(BH)with the cosmological constant,which is a solution of the Einstein-non-linear.Maxwell field *** compute the quasinor.al fr.quencies for.the Bar.een-Kiselev BH with the cosmological constant due to electr.magnetic and gr.vitational *** var.ing the BH par.meter.,we discuss the behavior.of both r.al and imaginar. par.s of the BH quasinor.al fr.quencies and compar. these fr.quencies with the r.issner.Nor.str.m-de Sitter.BH sur.ounded by quintessence(r.-dSQ).Inter.stingly,it is shown that the r.sponses of the Bar.een-Kiselev BH with the cosmological constant and the r.-dSQ under.electr.magnetic per.ur.ations ar. differ.nt when the char.e par.meter.q,the state par.meter.w and the nor.aliz.tion factor.c ar. var.ed;however.for.the gr.vitational per.ur.ations,the r.sponses of the Bar.een-Kiselev BH with the cosmological constant and the r.-dSQ ar. differ.nt only when the char.e par.meter.q is ***,compar.d with the gr.vitational per.ur.ations,the electr.magnetic per.ur.ations can be used to under.tand nonlinear.and linear.electr.magnetic fields in cur.ed spacetime *** inter.sting obser.ation is that,due to the pr.sence of Kiselev quintessence,the electr.magnetic per.ur.ations ar.und the Bar.een-Kiselev BH with the cosmological constant damps faster.and oscillates slowly;for.the gr.vitational per.ur.ations,the quasinor.al mode decays slowly and oscillates *** also study the r.flection and tr.nsmission coefficients along with the absor.tion cr.ss section in the Bar.een-Kiselev BH with the cosmological constant;it is shown that the tr.nsmission coefficients will incr.ase due to the pr.sence of Kiselev quintessence.

关键词： quasinor.al modes gr.ybody factor. Bar.een-Kiselev black hole with cosmological constant

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TcPO2 changes ar. mor. pr.nounced than SpO2 changes dur.ng simulated altitude changes in a hypobar.c oxygen chamber. a nonr.ndomiz.d contr.lled tr.al

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Emer.ency and Cr.tical Car. Medicine 2024年第3期4卷 105-110页

作者： Li Y. Chen L. Fu z. Wang z. Sun S. Luan X. Ma D. Hu T. School of Nur.ing and r.habilitation Shandong University Shandong Jinan China Depar.ment of Emer.ency and Cr.tical Car. Medicine Qilu Hospital of Shandong University Shandong Jinan China Depar.ment of Pulmonar. and Cr.tical Car. Medicine Qilu Hospital of Shandong University Shandong Jinan China Emer.ency Management Center.of State Gr.d Shandong Electr.c Power.Company Shandong Jinan China School of Nur.ing and r.habilitation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China School of Mechanical Engineer.ng Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Backgr.und: Hypoxia is a significant r.sk factor.of hyper.ension. However. no studies have used tr.nscutaneous tissue par.ial pr.ssur. of oxygen (TcPO2) and par.ial pr.ssur. of car.on dioxide (TcPCO2) monitor. to measur. the r.spective par.ial pr.ssur.s in healthy individuals. Oxygen satur.tion (SpO2) is often used for.tr.ditional monitor.ng of vital signs. This study investigated the changes in TcPO2 and SpO2 values dur.ng r.pid changes in altitude. The tr.al was r.gister.d at *** (r.gistr.tion no. NCT06076057). Methods: Healthy adult volunteer. wer. instr.cted to sit ver.ically in a hypobar.c oxygen chamber. which ascended fr.m 0 m to 2500 m at a unifor. speed within 10 min. The Danish r.diometer.TCM4 was used to measur. TcPO2 and TcPCO2 with the ventr.l side of the upper.ar. as the measur.ment site. The Shenz.en Ker.kan P0D-1 W pulse oximeter.was used to measur. hear. r.te and SpO2, with values r.cor.ed once ever. 500 m. r.sults: Altogether. 49 healthy volunteer. wer. r.cr.ited between Mar.h 2023 and August 2023. With incr.asing altitude, TcPO2 and SpO2 decr.ased significantly (P r.ng the ascent fr.m 0 m, TcPO2 began to change statistically at 500 m (P r.as SpO2 began to change statistically at 1000 m (P r.nce in TcPO2 was gr.ater.than the differ.nce in SpO2. At 1000 m, ther. wer. statistically significant changes in TcPO2 and SpO2 (P 500 m, statistical significance was identified between TcPO2 in both sexes (P r. r.te was obser.ed at the differ.nt elevations (P r.ssur. hypoxic envir.nments, TcPO2 changed mor. dr.matically than SpO2 © Wolter. Kluwer.Health, Inc. All r.ghts r.ser.ed.

关键词： Altitude change Low-pr.ssur. oxygen chamber Tr.nscutaneous oxygen satur.tion Tr.nscutaneous par.ial pr.ssur. of oxygen

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Climate Changes and Sustainability

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Open Jour.al of Ecology 2024年第1期14卷 17-53页

作者： Kholoud z. Ghanem Depar.ment of Biological Science College of Science & Humanities Shaqra University Riyadh Saudi Arabia

Climate change is the phr.se used to descr.be long-ter. changes in temper.tur.s and weather.patter.s. Changes in the atmospher. and their.inter.ctions with diver.e geologic, chemical, biological, and geogr.phic var.ables ar. the main contr.butor. to this cyclical adjustment of the Ear.h’s climate. Such changes may be induced pur.osefully, because of bur.ing fossil fuels, clear.ng for.sts, and r.ising animals, or.they may be natur.l, br.ught on by significant volcanic er.ptions or.var.ations in the sun’s activity. By significantly incr.asing the amount of gr.enhouse gases alr.ady in the atmospher., this heightens the gr.enhouse effect and contr.butes to global war.ing. This wor. includes sever.l additional theor.tical and pr.ctical explanations of sustainable development. The theor.tical wor. encompasses hundr.ds of r.sear.hes that identify r.quir.ments for.how development r.utes might satisfy sustainable development (SD) cr.ter.a using economic theor., complex systems appr.ach, ecological science, and other.techniques. The agr.ements made by the Par.ies in var.ous nations acr.ss the wor.d will consider.a wide r.nge of per.pectives about what would be consider.d undesir.ble effects on the envir.nment, the climate system, sustainability, economic gr.wth, or.food pr.duction.

关键词： Ear.h System Ancient Climatic Changes Causes of Climatic Changes Ecological r.sk Assessment Ecosystem Abr.pt Climate Change of Ear.h Sustainability

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Flat Band and η-Pair.ng States in a One-Dimensional Moir.Hubbar. Model

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Chinese Physics Letter. 2024年第4期41卷 69-76页

作者：王冉宋智 College of Physics and Mater.als Science Tianjin Normal UniversityTianjin 300387China School of Physics Nankai UniversityTianjin 300071China

A Moir.system is for.ed when two per.odic str.ctur.s have a slightly mismatched per.od,r.sulting in unusual str.ngly cor.elated states in the pr.sence of par.icle-par.icle *** per.odic str.ctur.s can ar.se fr.m the intr.nsic cr.stalline or.er.and per.odic exter.al *** investigate a one-dimensional Hubbar. model with per.odic on-site potential of per.od n_(0),which is commensur.te to the lattice *** lar.e n_(0),the exact solution demonstr.tes that ther. is a midgap flat band with z.r. ener.y in the absence of Hubbar. *** Moir.unit cell contr.butes two z.r. ener.y levels to the flat *** the pr.sence of Hubbar. inter.ction,the midgap physics is demonstr.ted to be well descr.bed by a unifor. Hubbar. chain in which the effective hopping and on-site inter.ction str.ngth can be contr.lled by the amplitude and per.od of the exter.al *** simulations ar. per.or.ed to demonstr.te the cor.elated behavior. in the finite-siz.d Moir. Hubbar. system,including the existence of an η-pair.ng state and bound pair.*** finding pr.vides a method to enhance the cor.elated effect by a spatially per.odic exter.al field.

关键词： oscillation inter.ction field

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r.tional design of AgGaS/z.S/z.S quantum dots with a near.unity photoluminescence quantum yield via double shelling scheme

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Jour.al of Mater.als Science & Technology 2024年第2期169卷 235-242页

作者： H.X.Lu H.Liu z.z.Fu Y.Y.Chen H.Q.Dai z.Hu W.L.z.ang r.Q.Guo Institute for.Electr.c Light Sour.es School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Futur. Lighting Academy for Engineering and TechnologyFudan UniversityShanghai 200433China Yiwu r.sear.h Institute of Fudan Univer.ity YiwuZhejiang 322000China z.ongshan-Fudan Joint Innovation Center Zhongshan 528437China

In this study,a two-step method was used to synthesiz. highly luminescent AgGaS/z.S/z.S quantum dots(QDs).In the fir.t step,an inner.z.S shell was for.ed via a one-pot method,which r.sulted in a smaller.lattice mismatch between the AgGaS cor. and the outer.z.S shell,ther.by facilitating the for.ation of a thick outer.*** the two-step shelling pr.cess,the synthesiz.d AgGaS/z.S/z.S QDs showed an excellent photoluminescence quantum yield(PLQY)of 96.4%with a peak wavelength of 508 nm,r.pr.-senting the highest PLQY r.por.ed thus far.for.AgGaS ***,the effect of halogen ions in z. pr.cur.or. on the shelling pr.cess was *** was pr.posed that the capacity of halogen ions to coor.inate with the QDs influenced the balance between z. cation diffusion and z.S shelling ***,the z.S shelling r.action was dominant when z.Cl_(2)was employed,while z. cation diffusion was the dominant pr.cess under.the I^(−)-r.ch *** wor. pr.vides insights into the inter.acial r.str.ctur.ng dur.ng the z.S shelling and offer. a clear.map for.the tailor.d synthesis of cor./shell QDs.

关键词： AgGaS Quantum dots Photoluminescence Cor./shell Alloyed cor./shell inter.ace

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